(1) The cellular and molecular basis of neural development

(2) The mechanisms underlying neurodevelopmental disorders

(1) 2009-2012, Jinan University, Ph.D.

(2) 2005-2008, Peking Union Medical College, MPhil.

(3) 2001-2005, Lanzhou University, BSc in Biology.

(1) 2017~now, Associated investigator at SIAT, CAS since 2017.

(2) 2014-2017, HKUST Shenzhen Research Institute, Research & Project Manager.

(3) 2012-2014, Jinan University, Postdoc.

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(1)Yuewen Chen#*, Jinying Xu#, Xiaopu Zhou, Saijuan Liu, Yulin Zhang, Shuangshuang Ma, Amy K. Y. Fu, Nancy Y. Ip, Yu Chen*. Changes of protein phosphorylation are associated with synaptic functions during the early stage of Alzheimer's disease. ACS Chemical Neuroscience. 10(9):3986-3996, 2019.

(2) Xiaopu Zhou, Yu Chen, Kin Y. Mok, Timothy C. Y. Kwok, Vincent C. T. Mok, Qihao Guo, Fanny C. Ip, Yuewen Chen, Nandita Mullapudi, Alzheimer’s Disease Neuroimaging Initiative, Paola Giusti-Rodríguez, Patrick F. Sullivan, John Hardy, Amy K. Y. Fu, Yun Li, Nancy Y. Ip. Non-coding variability at the APOE locus contributes to the Alzheimer's risk. Nature Communications. 10(1):3310, 2019.

(3) Zhenyan Xu, Yuewen Chen, Yu Chen. Spatiotemporal Regulation of Rho GTPases in Neuronal Migration. Cells. 8(6). pii: E568, 2019.

(4) Xiaopu Zhou#, Yu Chen#, Kin Y. Mok, Qianhua Zhao, Keliang Chen, Yuewen Chen, John Hardy, Yun Li, Amy K. Y. Fu, Qihao Guo*, Nancy Y. Ip*, for the Alzheimer’s Disease Neuroimaging Initiative. Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis, Proceedings of the National Academy of Sciences of the United States of America, 115(8): 1697–1706, 2018.

(5) Yuewen Chen, Fanny C.F. Ip, Lei Shi, Zhe Zhang, Huibin Tang, Yu Pong Ng, Wen-Cai Ye, Amy K.Y. Fu and Nancy Y. Ip, Coronin 6 regulates acetylcholine receptor clustering through modulating receptor anchorage to actin cytoskeleton, Journal of Neuroscience. 34(7):2413–21, 2014.

(6) Yangui Xiao#, Yinghui Peng#, Jun Wan#, Genyun Tang, Yuewen Chen, Jing Tang, Wen-Cai Ye, Nancy Y. Ip, Lei Shi, The atypical guanine nucleotide exchange factor Dock4 regulates neurite differentiation through modulation of Rac1 GTPase and actin dynamics, Journal of Biological Chemistry, 288(27): 20034–20045, 2013.

(7) Yu Pong Ng#, Yuewen Chen#, Yueqing Hu, Fanny C. F. Ip, Nancy Y. Ip, Olean-12-eno[2,3-c] [1,2,5]oxadiazol-28-oic acid (OEOA) induces G1 cell cycle arrest and differentiation in human leukemia cell lines, PLoS One, 8(5): e63580, 2013.

(8) Yuewen Chen#, Qi Wu#, Yong Shao, Jie Zhang, Ming Guan, Jun Wan, Bo Yu*, Wei Zhang*, Identify the association between polymorphisms of BLK and systemic lupus erythematosus through unlabelled probe-based high-resolution melting analysis. International Journal of Immunogenetics, 39(4):321-327, 2012

(9) Yuewen Chen#, Jianwei Ye#, Lingzhi Cao, Yong Zhang, Weibo Xia, Dahai Zhu, Myostatin regulates glucose metabolism via the AMP-activated protein kinase pathway in skeletal muscle cells, The International Journal of Biochemistry & Cell Biology, 42(12): 2072-2081, 2010.

(10) Yuewen Chen#, Linzhi Cao#, Jianwei Ye, Dahai Zhu, Upregulation of myostatin gene expression in streptozotocin-induced type 1 diabetes mice is attenuated by insulin, 388(1):112-116, 2009.

(# equal contribution, * corresponding author)

(1) Deciphering key modulators responsible for cytoskeleton dynamics during neuronal development and neurodevelopmental disorders; 

(2) Elucidating the regulation of cytoskeleton dynamics by several extracellular signaling pathways during synapse formation, elimination, and plasticity at the early stage of neurodegenerative diseases.

现指导学生

陈静  硕士研究生  071008-发育生物学