深海微生物活性物质研究。主要集中在马里亚纳海沟，南海冷泉和海山，西南印度洋热液等深海极端环境微生物的生物活性功能分子研究。

   

070703-海洋生物学
070721-海洋药物学
070321-化学生物学

海洋微生物次级代谢产物，化学生物学，化学生态学

2010-02--2013-02   香港科技大学   联合培养博士
2009-09--2013-07   中国科学院大学   理学博士

   

2019-09~2020-11,Boston University, Visiting Scholar
2018-01~现在, 中国科学院深海科学与工程研究所, 副研究员
2013-12~2014-12,香港科技大学, 访问学者
2013-06~2017-12,中国科学院深海科学与工程研究所, 助理研究员

   

（1） 中国科学院“院长优秀奖”, 一等奖, 院级, 2013
（2） 海南热带药用植物及其共附生微生物资源研究, 一等奖, 省级, 2009

[1] 韩壮, 王佳伟, 翟吉安, 高兆明. 深海链霉菌、Tianyamycin系列化合物及其应用. CN: CN113308407A, 2021-08-27.

[2] 钱培元, 黄相中, 徐颖, 张煜, 黄裕谦, 尹燕, 韩壮. 酰胺类化合物在防止海洋生物污损中的用途. CN: CN102757673A, 2012-10-31.

   

[1] Wang, JiaWei, Shang, Kun, Wu, ShengYi, Zhu, Bo Yu, Han, MeiGui, Zhao, Yuan, Chen, YiQiu, Xie, Jia, Huang, Bo, Han, Zhuang. Complete genome sequence of piezotolerant Stutzerimonas kunmingensis 7850S isolated from the sediment of the Mariana Trench. MARINE GENOMICS[J]. 2022, 66: http://dx.doi.org/10.1016/j.margen.2022.100996.
[2] Ip, Jack ChiHo, Xu, Ting, Sun, Jin, Li, Runsheng, Chen, Chong, Lan, Yi, Han, Zhuang, Zhang, Haibin, Wei, Jiangong, Wang, Hongbin, Tao, Jun, Cai, Zongwei, Qian, PeiYuan, Qiu, JianWen. Host-Endosymbiont Genome Integration in a Deep-Sea Chemosymbiotic Clam. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2021, 38(2): 502-518, http://dx.doi.org/10.1093/molbev/msaa241.
[3] Sun, Yanan, Sun, Jin, Yang, Yi, Lan, Yi, Ip, Jack ChiHo, Wong, Wai Chuen, Kwan, Yick Hang, Zhang, Yanjie, Han, Zhuang, Qiu, JianWen, Qian, PeiYuan. Genomic Signatures Supporting the Symbiosis and Formation of Chitinous Tube in the Deep-Sea Tubeworm Paraescarpia echinospica. MOLECULAR BIOLOGY AND EVOLUTION[J]. 2021, 38(10): 4116-4134, http://dx.doi.org/10.1093/molbev/msab203.
[4] Kong, Weina, Zhao, Cheng, Gao, Xingwang, Wang, Liping, Tian, Qianqian, Liu, Yu, Xue, Shuwen, Han, Zhuang, Chen, Fulin, Wang, Shiwei. Characterization and Transcriptome Analysis of a Long-Chain n-Alkane-Degrading Strain Acinetobacter pittii SW-1. INTERNATIONAL JOURNAL OF ENVIRONMENTAL RESEARCH AND PUBLIC HEALTH[J]. 2021, 18(12): http://dx.doi.org/10.3390/ijerph18126365.
[5] Yang, LuJia, Peng, XiaoYue, Zhang, YaHui, Liu, ZhiQing, Li, Xin, Gu, YuCheng, Shao, ChangLun, Han, Zhuang, Wang, ChangYun. Antimicrobial and Antioxidant Polyketides from a Deep-Sea-Derived Fungus Aspergillus versicolor SH0105. MARINE DRUGS[J]. 2020, 18(12): https://www.webofscience.com/wos/woscc/full-record/WOS:000602132400001.
[6] Li, Wen Li, Huang, JiaoMei, Zhang, PeiWei, Cui, GuoJie, Wei, ZhanFei, Wu, YuZhi, Gao, ZhaoMing, Han, Zhuang, Wang, Yong. Periodic and Spatial Spreading of Alkanes and Alcanivorax Bacteria in Deep Waters of the Mariana Trench. APPLIED AND ENVIRONMENTAL MICROBIOLOGY[J]. 2019, 85(3): http://dx.doi.org/10.1128/AEM.02089-18.
[7] Wang, Shaolu, Li, Yunliang, Han, Zhuang, Chen, Xi, Chen, Qijia, Wang, Yong, He, Lisheng. Molecular Characterization of a Novel N-Acetylneuraminate Lyase from a Deep-Sea Symbiotic Mycoplasma. MARINE DRUGS[J]. 2018, 16(3): http://ir.idsse.ac.cn/handle/183446/5966.
[8] Han, Zhuang, Li, YongXin, Liu, LingLi, Lu, Liang, Guo, XianRong, Zhang, XiXiang, Zhang, XiaoYong, Qi, ShuHua, Xu, Ying, Qian, PeiYuan. Thielavins W-Z(7), New Antifouling Thielavins from the Marine-Derived Fungus Thielavia sp. UST030930-004. MARINE DRUGS[J]. 2017, 15(5): https://doaj.org/article/6bc01fa5749f40af9ecb94fd48c66b71.
[9] 方清建, 韩壮. 深海放线菌Nocardiopsis sp.CS001化学成分的研究. 2016, http://ir.idsse.ac.cn/handle/183446/5239.
[10] Wang, KaiLing, Zhang, Gen, Sun, Jin, Xu, Ying, Han, Zhuang, Liu, LingLi, Shao, ChangLun, Liu, QingAi, Wang, ChangYun, Qian, PeiYuan. Cochliomycin A inhibits the larval settlement of Amphibalanus amphitrite by activating the NO/cGMP pathway. BIOFOULING[J]. 2016, 32(1): 35-44, http://ir.idsse.ac.cn/handle/183446/1346.
[11] Wang, KaiLing, Xu, Ying, Lu, Liang, Li, Yongxin, Han, Zhuang, Zhang, Jun, Shao, ChangLun, Wang, ChangYun, Qian, PeiYuan. Low-Toxicity Diindol-3-ylmethanes as Potent Antifouling Compounds. MARINE BIOTECHNOLOGY[J]. 2015, 17(5): 624-632, http://124.16.218.2:8080/handle/183446/784.
[12] Lianguo Chen, Huoming Zhang, Jin Sun, Yue-Him Wong, Zhuang Han, Doris W.T. Au, Vladimir B. Bajic, Pei-Yuan Qian. Proteomic changes in brain tissues of marine medaka (Oryzias melastigma) after chronic exposure to two antifouling compounds: Butenolide and 4,5-dichloro-2-n-octyl-4-isothiazolin-3-one (DCOIT). AQUATIC TOXICOLOGY. 2014, 157: 47-56, http://dx.doi.org/10.1016/j.aquatox.2014.09.010.
[13] Lei, Hui, Sun, JianFan, Han, Zhuang, Zhou, XueFeng, Yang, Bin, Liu, Yonghong. Fragilisinins A-L, new briarane-type diterpenoids from gorgonian Junceella fragilis. RSC ADVANCES[J]. 2014, 4(10): 5261-5271, https://www.webofscience.com/wos/woscc/full-record/WOS:000329254100068.
[14] Bao, Jie, Sun, YuLin, Zhang, XiaoYong, Han, Zhuang, Gao, HaiChun, He, Fei, Qian, PeiYuan, Qi, ShuHua. Antifouling and antibacterial polyketides from marine gorgonian coral-associated fungus Penicillium sp SCSGAF 0023. JOURNAL OF ANTIBIOTICS[J]. 2013, 66(4): 219-223, https://www.webofscience.com/wos/woscc/full-record/WOS:000318348100004.
[15] Han, Zhuang, Sun, Jin, Zhang, Yu, He, Fei, Xu, Ying, Matsumura, Kiyotaka, He, LiSheng, Qiu, JianWen, Qi, ShuHua, Qian, PeiYuan. iTRAQ-Based Proteomic Profiling of the Barnacle Balanus amphitrite in Response to the Antifouling Compound Meleagrin. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 12(5): 2090-2100, https://www.webofscience.com/wos/woscc/full-record/WOS:000318589000008.
[16] Sun, JianFan, Han, Zhuang, Zhou, XueFeng, Yang, Bin, Lin, Xiuping, Liu, Juan, Peng, Yan, Yang, XianWen, Liu, Yonghong. Antifouling briarane type diterpenoids from South China Sea gorgonians Dichotella gemmacea. TETRAHEDRON[J]. 2013, 69(2): 871-880, http://dx.doi.org/10.1016/j.tet.2012.10.102.
[17] He, Fei, Han, Zhuang, Peng, Jiang, Qian, PeiYuan, Qi, ShuHua. Antifouling Indole Alkaloids from Two Marine Derived Fungi. NATURAL PRODUCT COMMUNICATIONS[J]. 2013, 8(3): 329-332, https://www.webofscience.com/wos/woscc/full-record/WOS:000316778500013.
[18] Han, Zhuang, Xu, Ying, McConnell, Oliver, Liu, Lingli, Li, Yongxin, Qi, Shuhua, Huang, Xiangzhong, Qian, Peiyuan. Two Antimycin A Analogues from Marine-Derived Actinomycete Streptomyces lusitanus. MARINE DRUGS[J]. 2012, 10(3): 668-676, http://www.irgrid.ac.cn/handle/1471x/767852.
[19] 阙东枚, 梅文莉, 吴娇, 韩壮, 戴好富. 见血封喉根中类黄酮的结构鉴定. 有机化学[J]. 2009, 1371-1375, http://lib.cqvip.com/Qikan/Article/Detail?id=31690253.
[20] 韩壮, 梅文莉, 崔海滨, 林海鹏, 洪葵, 戴好富. 红树林植物海莲内生真菌Penicillium sp.091402化学成分的研究. 中国海洋药物[J]. 2008, 27(4): 9-13, http://lib.cqvip.com/Qikan/Article/Detail?id=28253539.
[21] 刘胜兰, 戴好富, 曾艳波, 韩壮, 梅文莉. 海南粗榧中的苯丙素类化合物及其抗氧化活性. 中国药物化学杂志[J]. 2008, 18(3): 215-218, http://lib.cqvip.com/Qikan/Article/Detail?id=27500746.
[22] 刘胜兰, 曾艳波, 韩壮, 梅文莉, 戴好富. 海南粗榧中的木脂素及其抗氧化活性. 河南大学学报：医学版[J]. 2008, 27(3): 29-31, http://lib.cqvip.com/Qikan/Article/Detail?id=28143565.
[23] 干玉娟, 梅文莉, 曾艳波, 韩壮, 戴好富. 见血封喉乳汁脂溶性成分及其抗氧化活性研究. 热带亚热带植物学报[J]. 2008, 16(2): 144-147, http://lib.cqvip.com/Qikan/Article/Detail?id=26782297.

   

（ 1 ） 深渊微生物活性物质评价与利用, 主持, 部委级, 2014-01--2018-12
（ 2 ） 中国科学院青年创新促进会会员人才经费, 主持, 部委级, 2015-01--2018-12
（ 3 ） 深海放线菌中新型抗耐药菌活性物质的研究, 主持, 省级, 2017-01--2018-12
（ 4 ） 深渊微生物介导地球化学循环的调控机制, 主持, 国家级, 2018-08--2021-12
（ 5 ） 深海海参及沉积物来源微生物活性次级代谢产物研究, 主持, 省级, 2019-12--2022-12

已指导学生

翟吉安  硕士研究生  085238-生物工程  

现指导学生

朱柏羽  硕士研究生  070703-海洋生物学  

韩梅桂  硕士研究生  070703-海洋生物学