基本信息
肖海华  男  博导  中国科学院化学研究所
email: hhxiao@iccas.ac.cn
address: 北京市海淀区中关村北一街2号
postalCode: 100190

招生信息

   
招生专业
070305-高分子化学与物理
1001Z1-精准医学
招生方向
纳米药物、药剂学、肿瘤靶向治疗、生物医用材料、生物安全材料

教育背景

2006-09--2012-07   中国科学院长春应用化学研究所   理学博士
2002-09--2006-07   湘潭大学   工学学士

工作经历

   
工作简历
2017-12~现在, 中国科学院化学研究所, 研究员/博士生导师
2017-09~2017-11,中国科学院化学研究所, 高级访问学者
2014-09~2017-08,美国麻省理工学院, 博士后
2012-09~2014-08,美国圣母大学, 博士后
2006-09~2012-07,中国科学院长春应用化学研究所, 理学博士
2002-09~2006-07,湘潭大学, 工学学士
社会兼职
2022-03-01-2024-03-31,Biomedical Engineering Frontiers (Science合作期刊), 副主编
2021-10-01-2025-09-30,中国医药生物技术协会生物制药技术分会, 委员
2019-09-30-2023-10-31,中国医药生物技术协会造影技术分会, 委员
2017-11-01-今,中国抗癌协会, 委员

专利与奖励

   
奖励信息
(1) 湖北省科技厅(科技进步奖), 一等奖, 省级, 2019
(2) 吉林省自然科学学术成果奖, 二等奖, 省级, 2015
专利成果
( 1 ) 一种人血清白蛋白负载的四价铂纳米粒子及其制备方法, 2021, 第 1 作者, 专利号: CN112957342A

( 2 ) 一种可降解共聚物及其制备方法与应用, 2021, 第 1 作者, 专利号: CN112341607A

( 3 ) 具有近红外二区光响应性可降解共聚物制备方法与应用, 2021, 第 1 作者, 专利号: CN112194787A

( 4 ) 一种共聚物载体及其制备方法与应用, 2019, 第 1 作者, 专利号: CN110183636A

( 5 ) 一种铂类衍生物及含铂纳米粒子的制备方法及其应用, 2019, 第 1 作者, 专利号: CN109678909A

( 6 ) 一种对具有游离羟基的化合物进行脂质体修饰的方法, 2019, 第 1 作者, 专利号: CN109675047A

( 7 ) 一种抗癌前药脂质体及青蒿素类脂质体纳米药物, 2019, 第 1 作者, 专利号: CN109675048A

( 8 ) 一种脂质体修饰的阿霉素及含阿霉素的纳米粒子, 2019, 第 1 作者, 专利号: CN109568599A

出版信息

   
发表论文
(1) Immunogenic Cell Death Inducing Metal Complexes for Cancer Therapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2023, 通讯作者
(2) Self-Sacrificially Degradable Pseudo-Semiconducting Polymer Nanoparticles that Integrate NIR-II Fluorescence Bioimaging, Photodynamic Immunotherapy, and Photo-Activated Chemotherapy, ADVANCED MATERIALS, 2022, 通讯作者
(3) Biodegradable Polymer with Effective Near-Infrared-II Absorption as a Photothermal Agent for Deep Tumor Therapy, ADVANCED MATERIALS, 2022, 通讯作者
(4) Restoration of the Immunogenicity of Tumor Cells for Enhanced Cancer Therapy via Nanoparticle-Mediated Copper Chaperone Inhibition, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 通讯作者
(5) Targeting Cancer Metabolism Plasticity with JX06 Nanoparticles via Inhibiting PDK1 Combined with Metformin for Endometrial Cancer Patients with Diabetes, ADVANCED SCIENCE, 2022, 通讯作者
(6) Photo-Reduction with NIR Light of Nucleus-Targeting Pt-IV Nanoparticles for Combined Tumor-Targeted Chemotherapy and Photodynamic Immunotherapy, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2022, 通讯作者
(7) Nanoparticle-mediated convection-enhanced delivery of a DNA intercalator to gliomas circumvents temozolomide resistance, NATURE BIOMEDICAL ENGINEERING, 2021, 通讯作者
(8) Core Role of Hydrophobic Core of Polymeric Nanomicelle in Endosomal Escape of siRNA, NANO LETTERS, 2021, 第11作者
(9) 应对生物恐怖袭击和生物战的生物安全材料, Biosafety Materials for Bioterrorism Attacks and Biological Warfare, 应用化学, 2021, 第 4 作者
(10) Biodegradable Polymer with Effective Near-Infrared-II Absorption as a Photothermal Agent for Deep Tumor Therapy, ADVANCEDMATERIALS, 2021, 通讯作者
(11) Exploiting the acquired vulnerability of cisplatin-resistant tumors with a hypoxia-amplifying DNA repair-inhibiting (HYDRI) nanomedicine, SCIENCE ADVANCES, 2021, 第 6 作者
(12) Nanoparticle-based drug delivery systems with platinum drugs for overcoming cancer drug resistance, JOURNAL OF MATERIALS CHEMISTRY B, 2021, 通讯作者
(13) The stepwise organization of nanoparticles into a Pickering emulsion, SOFT MATTER, 2021, 第 4 作者
(14) A Systematic Strategy of Combinational Blow for Overcoming Cascade Drug Resistance via NIR-Light-Triggered Hyperthermia, ADVANCED MATERIALS, 2021, 通讯作者
(15) NIR-light triggered dual-cascade targeting core-shell nanoparticles enhanced photodynamic therapy and immunotherapy, NANO TODAY, 2021, 通讯作者
(16) UCNP@BSA@Ru nanoparticles with tumor-specific and NIR-triggered efficient PACT activity in vivo, DALTON TRANSACTIONS, 2021, 第 5 作者
(17) Light-activatable liposomes for repetitive on-demand drug release and immunopotentiation in hypoxic tumor therapy, BIOMATERIALS, 2021, 第 7 作者
(18) A Near-Infrared-II Polymer with Tandem Fluorophores Demonstrates Superior Biodegradability for Simultaneous Drug Tracking and Treatment Efficacy Feedback, ACS NANO, 2021, 通讯作者
(19) Enhancing the chemotherapeutic efficacy of platinum prodrug nanoparticles and inhibiting cancer metastasis by targeting iron homeostasis, NANOSCALE HORIZONS, 2020, 通讯作者
(20) Near-Infrared Light Irradiation Induced Mild Hyperthermia Enhances Glutathione Depletion and DNA Interstrand Cross-Link Formation for Efficient Chemotherapy, ACS NANO, 2020, 通讯作者
(21) Microneedles loaded with anti-PD-1-cisplatin nanoparticles for synergistic cancer immuno-chemotherapy, NANOSCALE, 2020, 第 5 作者
(22) Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle, Efficient hepatic delivery and protein expression enabled by optimized mRNA and ionizable lipid nanoparticle, BIOACTIVE MATERIALS, 2020, 第 8 作者
(23) Breaking the Intracellular Redox Balance with Diselenium Nanoparticles for Maximizing Chemotherapy Efficacy on Patient-Derived Xenograft Models, ACS NANO, 2020, 通讯作者
(24) The challenge and prospect of mRNA therapeutics landscape, BIOTECHNOLOGY ADVANCES, 2020, 第 7 作者
(25) 发展生物安全材料学,筑牢中国国家安全城墙, Developing Biosafety Materials Science and Building the National Security Wall of China, 应用化学, 2020, 第 7 作者
(26) Bactericidal and antifouling electrospun PVA nanofibers modified with a quaternary ammonium salt and zwitterionic sulfopropylbetaine, MATERIALS SCIENCE & ENGINEERING C-MATERIALS FOR BIOLOGICAL APPLICATIONS, 2020, 第 6 作者
(27) Biosafety materials: an emerging new research direction of materials science from the COVID-19 outbreak, MATERIALS CHEMISTRY FRONTIERS, 2020, 通讯作者
(28) pH/redox sensitive nanoparticles with platinum(iv) prodrugs and doxorubicin enhance chemotherapy in ovarian cancer, RSC ADVANCES, 2019, 通讯作者
(29) Design of zwitterionic polyester based nano-carriers for platinum(iv) prodrug delivery, POLYMER CHEMISTRY, 2019, 通讯作者
(30) Secreted Protein Acidic and Rich in Cysteine Mediated Biomimetic Delivery of Methotrexate by Albumin-Based Nanomedicines for Rheumatoid Arthritis Therapy, ACS NANO, 2019, 第 8 作者
(31) A Nanobody-Conjugated DNA Nanoplatform for Targeted Platinum-Drug Delivery, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2019, 第 10 作者
(32) Evaluation of Polymer Nanoformulations in Hepatoma Therapy by Established Rodent Models, THERANOSTICS, 2019, 第 7 作者
(33) Electrospun polymer biomaterials, PROGRESS IN POLYMER SCIENCE, 2019, 通讯作者
(34) RNAi therapeutic and its innovative biotechnological evolution, BIOTECHNOLOGY ADVANCES, 2019, 第 2 作者
(35) Cancer Cell Membrane-Coated Nanoparticles for Personalized Therapy in Patient-Derived Xenograft Models, ADVANCED FUNCTIONAL MATERIALS, 2019, 通讯作者
(36) MnFe2O4-decorated large-pore mesoporous silica-coated upconversion nanoparticles for near-infrared light-induced and O-2 self-sufficient photodynamic therapy, NANOSCALE, 2019, 第 3 作者
(37) A mitochondria targeting artesunate prodrug-loaded nanoparticle exerting anticancer activity via iron-mediated generation of the reactive oxygen species, CHEMICAL COMMUNICATIONS, 2019, 第 4 作者
(38) Tailoring Platinum(IV) Amphiphiles for Self-Targeting All-in-One Assemblies as Precise Multimodal Theranostic Nanomedicine, ACS NANO, 2018, 通讯作者
(39) Sandwich-Like Fibers/Sponge Composite Combining Chemotherapy and Hemostasis for Efficient Postoperative Prevention of Tumor Recurrence and Metastasis, ADVANCED MATERIALS, 2018, 第 5 作者
(40) Phenanthriplatin(IV) conjugated multifunctional up-converting nanoparticles for drug delivery and biomedical imaging, JOURNAL OF MATERIALS CHEMISTRY B, 2018, 通讯作者
(41) A Targeted and Stable Polymeric Nanoformulation Enhances Systemic Delivery of mRNA to Tumors, MOLECULAR THERAPY, 2017, 第 6 作者

科研活动

   
科研项目
( 1 ) 重要生物威胁病原体防控的纳米新技术研究, 负责人, 国家任务, 2022-11--2025-12
( 2 ) 利用合成致死性原理构建Pt(IV)和PARP抑制剂复合体系精准治疗高级浆液性卵巢癌, 负责人, 国家任务, 2019-01--2022-12
( 3 ) 含冠醚和四价铂的高分子纳米药物来调控钾离子和逆转T细胞耗竭实现化疗和免疫治疗的联合治疗, 负责人, 国家任务, 2022-01--2025-12
( 4 ) 基于四价铂前药的多模态成像精准纳米诊疗体系, 负责人, 国家任务, 2020-01--2022-12
( 5 ) 高等级生物安全实验室用生物安全 纳米抗病毒防护手套,艾滋病和病 毒性肝炎等重大传染病防治专项, 参与, 国家任务, 2019-01--2021-09