基本信息
王莹 女 博导 中国科学院上海营养与健康研究所
email: yingwang@sibs.ac.cn
address: 上海市岳阳路320号
postalCode:
email: yingwang@sibs.ac.cn
address: 上海市岳阳路320号
postalCode:
招生信息
招生专业
071009-细胞生物学100102-免疫学086000-生物与医药
招生方向
细胞生物学-慢性疾病组织微环境的特征与功能调控免疫学-慢性疾病组织微环境的特征与功能调控生物与医药-慢性疾病组织微环境的特征与功能调控
教育背景
2006-09--2009-06 上海交通大学 博士学位2003-08--2006-06 上海交通大学 硕士学位
工作经历
工作简历
2015-12~现在, 中国科学院上海生命科学研究院, 研究员2011-11~2015-11,中国科学院上海生命科学研究院, 副研究员2009-11~2011-06,德国明斯特大学, 博士后2006-09~2009-06,上海交通大学, 博士学位2003-08~2006-06,上海交通大学, 硕士学位
社会兼职
2021-01-01-今,出生缺陷防控关键技术国家工程实验室技术委员会, 委员
2020-07-01-2023-12-31,Cellular Immunology, 副主编
2017-11-27-2020-12-31,上海医师协会整合医学会, 理事
2017-10-22-今,中国整形美容协会干细胞研究与应用分会, 常务理事
2017-01-16-今,NPG旗下Cell Death and Diseases期刊, 专栏主编
2017-01-01-今,Journal of Immunology and Regenerative Medicine, 编委
2016-12-31-今,Cellular Immunology, 特邀主编
2020-07-01-2023-12-31,Cellular Immunology, 副主编
2017-11-27-2020-12-31,上海医师协会整合医学会, 理事
2017-10-22-今,中国整形美容协会干细胞研究与应用分会, 常务理事
2017-01-16-今,NPG旗下Cell Death and Diseases期刊, 专栏主编
2017-01-01-今,Journal of Immunology and Regenerative Medicine, 编委
2016-12-31-今,Cellular Immunology, 特邀主编
专利与奖励
奖励信息
(1) 国家"万人计划"青年拔尖人才, 国家级, 2020(2) 中国细胞生物学会干细胞生物学分会“青年研究员奖”, 其他, 2019(3) 中国科学院青年促进会“优秀会员”, 院级, 2017(4) 上海市青年科技启明星, 市地级, 2014
专利成果
( 1 ) 非IGF1R结合型的物质在预防和/或治疗炎症性疾病中的应用, 2021, 第 2 作者, 专利号: CN113164606A( 2 ) 含胰岛素样生长因子-2的药物组合物及其应用, 2021, 第 2 作者, 专利号: CN108114271B( 3 ) 预激活间充质干细胞在治疗皮肤创伤的免疫生物学方面的应用, 2021, 第 2 作者, 专利号: CN112402454A( 4 ) 低氧处理的间充质干细胞及其应用, 2020, 第 4 作者, 专利号: CN106167789B
出版信息
发表论文
(1) Steroids enable mesenchymal stromal cells to promote CD8+T cell proliferation via VEGF-C., Advanced Science, 2021, 通讯作者(2) Loss of p53 in mesenchymal stem cells promotes alteration of bone remodeling through negative regulation of osteoprotegerin., Cell Death and Differentiation, 2021, 通讯作者(3) IGF2R-initiated proton rechanneling dictates an anti-inflammatory property in macrophages., Science Advances, 2020, 通讯作者(4) Phosphatase SHP1 impedes mesenchymal stromal cell immunosuppressive capacity modulated by JAK1/STAT3 and P38 signals., Cell and Bioscience, 2020, 通讯作者(5) Interleukin-17 promotes nitric oxide-dependent expression of PD-L1 in mesenchymal stem cells., Cell and Bioscience, 2020, 通讯作者(6) Scd1 controls de novo beige fat biogenesis through succinate-dependent regulation of mitochondrial complex II., Proc Natl Acad Sci U S A., 2020, 通讯作者(7) Fibrotic liver microenvironment promotes Dll4 and SDF-1-dependent T-cell lineage development., Cell Death and Disease, 2019, 通讯作者(8) Single cell transcriptomic analysis of human mesenchymal stem cells reveals limited heterogeneity., Cell Death and Disease, 2019, 通讯作者(9) IGF-2 Preprograms Maturing Macrophages to Acquire Oxidative Phosphorylation-dependent Anti-inflammatory Properties., Cell Metabolism, 2019, 通讯作者(10) Immune Regulatory Mechanisms of Mesenchymal Stem Cells., Nature Reviews Nephrology, 2018, 通讯作者(11) Kynurenic acid, an IDO metabolite, controls TSG-6-mediated immunosuppression of human mesenchymal stem cells., Cell Death and Differentiation, 2018, 通讯作者(12) Downregulation of CXCL12 in Mesenchymal Stromal Cells by TGFβ Promotes Breast Cancer Metastasis., Oncogene, 2017, 通讯作者(13) TNFα-activated Mesenchymal Stromal Cells Promote Breast Cancer Metastasis through Recruiting CXCR2+ Neutrophils., Oncogene, 2017, 通讯作者(14) Tumour Associated Mesenchymal Stem/Stromal Cells: Emerging Therapeutic Targets., Nature Reviews Drug Discovery., 2017, 通讯作者(15) SHP1 regulates bone mass by directing mesenchymal stem cell differentiation., Cell Reports., 2016, 通讯作者(16) Type I interferons exert anti-tumor effect via reversing immunosuppression mediated by mesenchymal stromal cells., Oncogene, 2016, 通讯作者(17) Fate decision of mesenchymal stem cells: adipocytes or osteoblasts?, Cell Death and Differentiation, 2016, 通讯作者(18) Local proliferation initiates macrophage accumulation in adipose tissue during obesity., Cell Death and Disease, 2016, 通讯作者(19) Tumour cell-derived exosomes endow mesenchymal stromal cells with tumour-promotion capabilities., Oncogene, 2016, 通讯作者(20) CD11b regulates obesity-induced insulin resistance via limiting alternative activation and proliferation of adipose tissue macrophages., Proc Natl Acad Sci U S A., 2015, 通讯作者(21) Histone deacetylase inhibitors prevent activation-induced cell death and promote anti-tumor immunity., Oncogene, 2015, 通讯作者(22) Rethinking regeneration: empowerment of stem cells by inflammation., Cell Death and Differentiation, 2015, 通讯作者(23) Plasticity of mesenchymal stem cells in immunomodulation: pathological and therapeutic implications., Nature Immunology., 2014, 第 1 作者
科研活动
科研项目
( 1 ) CD11b调控巨噬细胞状态对肥胖及其相关的胰岛素抵抗的影响及机制, 负责人, 国家任务, 2016-01--2019-12( 2 ) 细胞间粘附分子-1在脂肪前体细胞识别和分化调节中的作用及机制, 负责人, 国家任务, 2018-01--2021-12( 3 ) 造血干细胞移植的免疫学基础研究, 参与, 国家任务, 2015-01--2019-08( 4 ) p53家族调控骨重塑和骨肉瘤的机制研究, 负责人, 国家任务, 2018-01--2020-12( 5 ) 中国科学院青年创新促进会优秀会员项目, 负责人, 中国科学院计划, 2018-01--2020-12( 6 ) 炎症微环境与MSCs相互作用调控肝肾纤维化进程的机制, 负责人, 国家任务, 2018-07--2022-12( 7 ) 血管内皮生长因子-C在糖皮质激素干扰间充质干细胞免疫抑制功能中的机制研究, 负责人, 国家任务, 2021-01--2024-12( 8 ) 万人计划青年拔尖人才, 负责人, 国家任务, 2020-01--2022-12( 9 ) 上海人才发展基金, 负责人, 地方任务, 2020-01--2022-12
参与会议
(1)Immunomodulation of Mesenchymal Stem Cells: Pathological and Therapeutic Implications 第一届张江细胞治疗国际峰会 2019-11-14(2)Switching macrophages: a novel therapeutic strategy for autoimmune diseases 第九届Cell Death and Disease会议 2019-11-04(3)Switching macrophages: a novel therapeutic strategy for autoimmune diseases Springer-NPG PRESS Cell Death and Differentiation “Cancer, Immunity & Inflammation” Annual Meeting 2019-09-10(4)Inflammation controls the differentiation potential of mesenchymal stem cells in adipose tissue 第十七届全球华人科学家大会 2019-07-22(5)Immunoregulation by mesenchymal stem cells through metabolism 第六届Macau Symposium on Biomedical Sciences 2019-06-12(6)Immunoregulation by Mesenchymal Stem Cells through Metabolism 2018年吉林省干细胞第三届学术论坛——暨海峡两岸干细胞交流会议 2018-05-27(7)间充质干细胞的免疫调节特性和临床应用 手术与细胞治疗学术委员会成立暨全国首届学术研讨会 2017-10-28(8)Inflammation Controls the Differentiation Potential of Mesenchymal Stem Cells in Adipose Tissue 第七届中国干细胞年会 2017-07-07(9)The Interplay between Mesenchymal Stem Cells and Immune Cells in Adipose Tissue 第7届Cell Death and Disease会议 2016-10-18(10)Crosstalk between Mesenchymal Stem Cells and Inflammation in the Tumor Microenvironment 第五届中国干细胞年会 2015-11-13(11)免疫微环境中的间充质干细胞与免疫应答 第一精准医疗与免疫诊断研讨会 2015-04-04(12)Interplay between Mesenchymal Stem Cells and Inflammation in the Tumor Microenvironment DIA(药物信息协会)第六届年会 2014-05-11