071010-生物化学与分子生物学

干细胞
衰老
表观遗传

2006-10--2010-07   中国科学院广州生物医药与健康研究院   博士学位
2002-09--2005-09   南开大学   硕士学位
1998-09--2002-07   长江大学   学士学位

   

2015-04~2017-04,Yale University, 研究科学家
2012-06~2015-04,UNC-CH, 博士后

   

（1） 2017年度中国科学院杰出科技成就奖, 部委级, 2017

[1] 裴端卿, 王涛, 黄璐圆, 陈可实, 朱洁滢, 刘兴国, 曾小明, 杨建国, 赵丹芸. Map2k3或Map2k6在提高诱导成体细胞生成多能性干细胞效率中的用途. CN: CN112063656A, 2020-12-11.

[2] 刘兴国, 裴端卿, 陈可实, 龙琪, 王涛. 改变细胞命运的方法. 中国: CN104250291A, 2014-12-31.

[3] 裴端卿, 王涛. 一种提高诱导生成多能性干细胞效率的方法. 中国: CN103173490A, 2013.06.26.

[4] 裴端卿, 王涛. 一种提高诱导生成多能性干细胞效率的方法. 中国: CN102417894A, 2012-04-18.

[5] 裴端卿, 米盖尔.埃斯特班, 王涛, 秦宝明, 杨佳银. 抗坏血酸的新用途. 中国: CN101744808A, 2010-06-23.

   

[1] Xing, Guangsuo, Liu, Zichao, Huang, Luyuan, Zhao, Danyun, Wang, Tao, Yuan, Hao, Wu, Yi, Li, Linpeng, Long, Qi, Zhou, Yanshuang, Hao, Zhihong, Liu, Yang, Lu, Jianghuan, Li, Shiting, Zhu, Jieying, Wang, Bo, Wang, Junwei, Liu, Jing, Chen, Jiekai, Pei, Duanqing, Liu, Xingguo, Chen, Keshi. MAP2K6 remodels chromatin and facilitates reprogramming by activating Gatad2b-phosphorylation dependent heterochromatin loosening. CELL DEATH AND DIFFERENTIATION[J]. 2021, [2] Wu, Linlin, Zhao, Guoqing, Xu, Shuyang, Kuang, Junqi, Ming, Jin, Wu, Guangmin, Wang, Tao, Wang, Bo, Zhu, Ping, Pei, Duanqing, Liu, Jing. The nuclear factor CECR2 promotes somatic cell reprogramming by reorganizing the chromatin structure. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2021, 296: http://dx.doi.org/10.1074/jbc.RA120.014598.
[3] Wang, Tao, Pei, Duanqing. Rejuvenation of beta cells by epigenetic editing. JOURNAL OF CLINICAL INVESTIGATIONnull. 2019, 129(1): 51-52, [4] Zhou, Zhiwei, Yang, Xuejie, He, Jiangping, Liu, Jing, Wu, Fang, Yu, Shengyong, Liu, Yuting, Lin, Runxia, Liu, He, Cui, Yuanbin, Zhou, Chunhua, Wang, Xiaoshan, Wu, Jian, Cao, Shangtao, Guo, Lin, Lin, Lihui, Wang, Tao, Peng, Xiaozhong, Qiang, Boqing, Hutchins, Andrew P, Pei, Duanqing, Chen, Jiekai. Kdm2b Regulates Somatic Reprogramming through Variant PRC1 Complex-Dependent Function. CELL REPORTS[J]. 2017, 21(8): 2160-2170, http://www.corc.org.cn/handle/1471x/2374237.
[5] Tao P Wu, Tao Wang, Matthew G Seetin, Yongquan Lai, Shijia Zhu, Kaixuan Lin, Yifei Liu, Stephanie D Byrum, Samuel G Mackintosh, Mei Zhong, Alan Tackett, Guilin Wang, Lawrence S Hon, Gang Fang, James A Swenberg, Andrew Z Xiao. DNA methylation on N 6 -adenine in mammalian embryonic stem cells. Nature. 2016, 532(7599): 329-333, [6] Chen, Keshi, Long, Qi, Wang, Tao, Zhao, Danyun, Zhou, Yanshuang, Qi, Juntao, Wu, Yi, Li, Shengbiao, Chen, Chunlan, Zeng, Xiaoming, Yang, Jianguo, Zhou, Zisong, Qin, Weiwen, Liu, Xiyin, Li, Yuxing, Li, Yingying, Huang, Xiaofen, Qin, Dajiang, Chen, Jiekai, Pan, Guangjin, Schoeler, Hans R, Xu, Guoliang, Liu, Xingguo, Pei, Duanqing. Gadd45a is a heterochromatin relaxer that enhances iPS cell generation. EMBO REPORTS[J]. 2016, 17(11): 1641-1656, http://ir.gibh.ac.cn/handle/344009/800.
[7] Chen, Jiekai, Liu, He, Liu, Jing, Qi, Jing, Wei, Bei, Yang, Jiaqi, Liang, Hanquan, Chen, You, Chen, Jing, Wu, Yaran, Guo, Lin, Zhu, Jieying, Zhao, Xiangjie, Peng, Tianran, Zhang, Yixin, Chen, Shen, Li, Xuejia, Li, Dongwei, Wang, Tao, Pei, Duanqing. H3K9 methylation is a barrier during somatic cell reprogramming into iPSCs. NATURE GENETICS[J]. 2013, 45(1): 34-U62, http://ir.foo.ac.cn/handle/2SETSVCV/321.
[8] Wang, Tao, Chen, Keshi, Zeng, Xiaoming, Yang, Jianguo, Wu, Yun, Shi, Xi, Qin, Baoming, Zeng, Lingwen, Esteban, Miguel Angel, Pan, Guangjin, Pei, Duanqing. The Histone Demethylases Jhdm1a/1b Enhance Somatic Cell Reprogramming in a Vitamin-C-Dependent Manner. CELL STEM CELL[J]. 2011, 9(6): 575-587, http://dx.doi.org/10.1016/j.stem.2011.10.005.
[9] Esteban, Miguel Angel, Wang, Tao, Qin, Baoming, Yang, Jiayin, Qin, Dajiang, Cai, Jinglei, Li, Wen, Weng, Zhihui, Chen, Jiekai, Ni, Su, Chen, Keshi, Li, Yuan, Liu, Xiaopeng, Xu, Jianyong, Zhang, Shiqiang, Li, Feng, He, Wenzhi, Labuda, Krystyna, Song, Yancheng, Peterbauer, Anja, Wolbank, Susanne, Redl, Heinz, Zhong, Mei, Cai, Daozhang, Zeng, Lingwen, Pei, Duanqing. Vitamin C Enhances the Generation of Mouse and Human Induced Pluripotent Stem Cells. CELL STEM CELL[J]. 2010, 6(1): 71-79, http://dx.doi.org/10.1016/j.stem.2009.12.001.
[10] 王涛. 维生素C促进小鼠体细胞重编程. 2010, 67-, http://ir.foo.ac.cn/handle/2SETSVCV/957.
[11] Zhang, Xiaofei, Zhang, Juan, Wang, Tao, Esteban, Miguel A, Pei, Duanqing. Esrrb Activates Oct4 Transcription and Sustains Self-renewal and Pluripotency in Embryonic Stem Cells. JOURNAL OF BIOLOGICAL CHEMISTRY[J]. 2008, 283(51): 35825-35833, http://dx.doi.org/10.1074/jbc.M803481200.

   

（ 1 ） 6mA-DNA 甲基化在肿瘤发生中的作用, 主持, 省级, 2018-04--2020-03
（ 2 ） 启动经费, 主持, 研究所（学校）, 2017-03--2022-03
（ 3 ） 基于类器官芯片建立干细胞扩增及分化体系, 主持, 国家级, 2018-07--2022-12

现指导学生

付雨栋  博士研究生  071008-发育生物学