General

Dr. Lijing Fang, Associate Professor,  Institute of Biomedicine and Biotechnology, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

Research Areas

Chemical biology; Organic synthesis; Medicinal chemistry.

Education

2002-2007     Ph.D. in Organic Chemistry, Lanzhou University

1998-2002     B.S. Lanzhou University

Experience

2016-Present   Associate Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

2011-2015     Assistant Professor, Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences.

2007-2010     Postdoctoral Associate, Texas A&M University, USA.
Teaching Experience

Advances in Chemical Biology

Publications

1. Guiyang Yao; Wei Wang, Lijiao Ao, Zhehong Cheng, Chunlei Wu, Zhengyin Pan, Ke Liu, Hongchang Li, Wu Su*, Lijing Fang*, Improved Total Synthesis and Biological Evaluation of Coibamide A Analogues. J. Med. Chem., 2018, 61, 8809-8916.

2. Zhehong Cheng, Wei Wang, Chunlei Wu, Xiaohua Zou, Lijing Fang*, Wu Su*, Pu Wang*, Novel Pyrrole−Imidazole Polyamide Hoechst Conjugate Suppresses Epstein−Barr Virus Replication and Virus-Positive Tumor Growth. J. Med. Chem., 2018, 61, 6674-6684.

3. Ke Liu#, Lijing Fang#, Haiyan Sun#, Zhengyin Pan, Jianchao Zhang, Juntao Chen, Ximing Shao, Wei Wang, Yuanyan Tan, Zhihao Ding, Lijiao Ao, Chunlei, Wu, Xiaoqi Liu, Huashun Li, Rui Wang*, Wu Su* and Hongchang Li*. Targeting Polo-like Kinase 1 by a Novel Pyrrole-imidazole Polyamide-Hoechst Conjugate Suppresses Tumor Growth in vivo. Mol. Cancer Ther., 2018, 17, 988‒1002.

4. Zhengyin Pan, Chunlei Wu, Wei Wang, Zhehong Cheng, Guiyang Yao, Ke Liu, Hongchang Li, Lijing Fang*, Wu Su*. Total Synthesis and Stereochemical Assignment of Gymnopeptides A and B. Org. Lett., 2017, 19, 4420‒4423.

5. Chunlei Wu; Zhengyin Pan; Guiyang Yao; Wei Wang; Lijing Fang*; Wu Su*. Synthesis and structure–activity relationship studies of teixobactin analogues. RSC Advances 2017, 7, 1923–6.

6. Guiyang Yao, Zhengyin Pan, Chunlei Wu, Wei Wang, Lijing Fang*, Wu Su*, Efficient synthesis and stereochemical revision of coibamide A, J. Am. Chem. Soc. 2015, 137, 13488–91.

7. Lijing Fang; Guiyang Yao; Zhengyin Pan; Chunlei Wu; Heng-Shan Wang; Glenn A. Burley; Wu Su*. Fully automated synthesis of DNA-binding Py-Im polyamides using a triphosgene coupling strategy. Org. Lett. 2015, 17, 158–61.

8. Lijing Fang; Chunlei Wu; Zaidan Yu; Peng Shang; Yongxian Cheng; Yuefeng Peng*; Wu Su*. Triphosgene-mediated couplings in the solid phase: total synthesis of brachystemin A. Eur. J. Org. Chem. 2014, 7572–6.

9. Lijing Fang; Jiong Yang* Fei Yang, Enantioselective synthesis of a diastereomer of iriomoteolide- 1a. What is the correct structure of the natural product? Org. Lett. 2010, 12, 3124.

10. Lijing Fang; Haoran Xue Jiong Yang*, Synthesis of the C1−C12 Fragment of Iriomoteolide 1a by Sequential Catalytic Asymmetric Vinylogous Aldol Reactions. Org. Lett. 2008, 10, 4645.

Research Interests

1) Design and synthesis of peptide drug.

2) Synthesis and structure-activity relationship of bioactive organic molecules.


Students

Lijiao Ao, Ph.D. (2014.9-2018.12), Biochemistry and molecular biology

Zhehong Cheng, Master (2015.9-2018.6), Bioengineering