General

Junlei CHANG, PhD, Professor

 

Center for Antibody Drug, Institute of Biomedicine and Biotechnology

Shenzhen Institutes of Advanced Technology,

Chinese Academy of Sciences

1068 Xueyuan Boulevard, Room B1108

Xili Nanshan, Shenzhen 518055, China

Email: jl.chang@siat.ac.cn

Research Areas

1. Cellular and molecular mechanisms controlling the central nervous system angiogenesis and blood-brain barrier.

2. Development of new therapeutics for brain vascular diseases including ischemic stroke and glioblastoma.


Education

2007.09 - 2012.02   Joint PhD program of The University of Hong Kong (2007-2008) and Harvard Medical School/MGH (2008-2012), Major: Diabetes and Metabolic Syndrome.

2005.09 - 2007.07   Tsinghua University, Master of Science, Major: Cell Biology.

2001.09 - 2005.07   Tsinghua University, Bachelor of Science, Major: Biological Sciences and Biotechnology.


Experience

   
Work Experience

2017.01 - Now   Shenzhen Institutes of Advanced Technolgy, Chinese Academy of Sciences, Professor.

2012.02 - 2016.16   Stanford University School of Medicine, Dept of Medicine, Postdoctoral Fellow, Mentor: Calvin J. Kuo.

Teaching Experience

2017.11 - 2018.02   Fundamentals of Neurobiology.

Publications

15. Ma YZ, Li L, Kong LL, Zhu ZM, Zhang W, Song JK, Chang JL* and Du GH*.  Pinocembrin protects blood–brain barrier function and expands the therapeutic time window for tissue-type plasminogen activator treatment in a rat thromboembolic stroke model. BioMed Research International, In press (2018). (*corresponding author). (IF 2.476)

14. Yan KS, Janda CY, Chang JL, Zheng GX, Larkin KA, Luca VC, Chia LA, Mah AT, Han A, Terry JM, Ootani A, Roelf K, Lee M, Yuan J, Li X, Bolen CR, Wilhelmy J, Davies PS, Ueno H, von Furstenberg RJ, Belgrader P, Ziraldo SB, Ordonez H, Henning SJ, Wong MH, Snyder MP, Weissman IL, Hsueh AJ, Mikkelsen TS, Garcia KC and Kuo CJ.  Non-equivalence of Wnt and R-spondin ligands during Lgr5+ intestinal stem-cell self-renewal.   Nature, May; 545(7653): 238-242 (2017).

13. Janda CY#, Dang LT#, You CJ, Chang JL, de Lau W, Zhong ZA, Yan KS, Marecic O, Siepe D, Li XN, Moody JD, Williams BO, Clevers H, Piehler J, Baker D, Kuo CJ and Garcia KC. Surrogate Wnt agonists that phenocopy canonical Wnt and b-catenin signaling.  Nature, May; 545(7653): 234-237 (2017). (#co-first author)

12. Chang JL#, Mancuso MR#, Maier C, Liang XB, Kanako Y, Yang L, Kwong JK, Wang J, Rao V, Vallon M, Kosinski C, Zhang HJ, Mah A, Xu LJ, Li L, Gholamin S, Reyes T, Li R, Kuhnert F, Han XY, Yuan JJ, Chiou SH, Brettman AD, Daly L, Corney DC, Cheshier S, Shortliffe LD, Wu XW, Snyder M, Chang HY, Giffard R, Chan P, Andreasson KI and Kuo CJ.  Gpr124 is essential for blood-brain barrier integrity in central nervous system disease. Nature Medicine, Apr; 23(4): 450-460 (2017). Article. (#co-first author) ***Recommended by the Faculty of 1000.

11. Furman D, Chang JL, Lartigue L, Bolen CR, Haddad F, Gaudilliere B, Ganio EA, Fragiadakis GK, Spitzer MH, Douchet I, Daburon S, Moreau JF, Nolan GP, Blanco P, Dechanet-Merville J, Dekker CL, Jojic V, Kuo CJ, Davis MM, Faustin B. Expression of specific inflammasome gene modules stratifies older individuals into two extreme clinical and immunological states.  Nature Medicine, Jan; 23(2): 174-184 (2017). Article.

10. Lange C, Garcia MT, Decimo I, Bifari F, Quaegebeur A, Boon R, Zhao H, Boeckx B, Chang JL, Wu C, Le Noble F, Lambrechts D, Dewerchin M, Kuo CJ, Huttner WB and Carmeliet P.  Relief of hypoxia by angiogenesis promotes neural stem cell differentiation by targeting glycolysis.   EMBO Journal, Feb; 35(9): 924-941 (2016).  ***Cover article.

9. Tsai HH, Niu JQ, Munji R, Davalos D, Chang JL, Zhang HJ, Tien AC, Kuo CJ, Chan JR, Daneman R and Fancy SP.  Oligodendrocyte precursors migrate along vasculature in the developing nervous system.  Science, Jan; 351(6271): 379-84 (2016).

8. Diao S, Blackburn JL, Hong GS, Antaris AL, Chang JL, Wu JZ, Zhang B, Cheng K, Kuo CJ and Dai HJ.  Fluorescence imaging in vivo at wavelengths beyond 1500 nm.  Angew Chem Int Ed Engl. Oct 13; 54(49): 14758-14762 (2015).

7. Hong GS#, Diao S#, Chang JL#, Antaris AL, Chen CX, Zhang B, Zhao S, Atochin DN, Huang PL, Andreasson KI, Kuo CJ and Dai HJ.   Through skull fluorescence imaging of the brain in a new near-infrared window.  Nature Photonics. Sep; 8(9): 723-730 (2014). (#co-first author).

6. Vallon M#, Chang JL#, Zhang HJ and Kuo CJ. Developmental and pathological angiogenesis in the central nervous system. Cellular and Molecular Life Sciences. Apr; 71:3489-3506 (2014). (#co-first author). ***Cover article.

5. Chang JL, Atochin DN, Li Q, Lam KSL, Xu AM and Huang PL.  Bone marrow-derived circulating endothelial progenitor cells contribute to eNOS-regulated endothelial repair and vasodilation after arterial injury in vivo. Journal of Cardiology and Vascular Medicine, Aug; 1: 1-8 (2013).

4. Chang JL, Li YM, Huang Y, Lam KSL, Hoo RLC, Wong WT, Cheng KKY, Wang YQ, Vanhoutte PM and Xu AM. Adiponectin prevents diabetic premature senescence of endothelial progenitor cells and promotes endothelial repair by suppressing the p38 MAP kinase/p16INK4A signaling pathway. Diabetes, Nov; 59(11): 2949-59 (2010).

3. Atochin DN, Yuzawa I, Li Q, Rauwerdink KM, Malhotra R, Chang JL, Broukaert P, Ayata C, Moskowitz MA, Bloch KD, Huang PL and Buys ES.  Soluble guanylate cyclase a1b1 limits stroke size and attenuates neurological injury.  Stroke. Aug; 41(8): 1815-9 (2010).

2. Du J, Chang JL, Guo SX, Zhang Q, and Wang Z.  ApoE 4 reduces the expression of Ab degrading enzyme IDE by activating the NMDA receptor in hippocampal neurons. Neuroscience Letters. Oct; 23; 464(2):140-145 (2009).

1. Hu QL, Chang JL, Tao LT, Yan GL, Xie MC and Wang Z. Endoplasmic Reticulum mediated necrosis-like apoptosis of HeLa cells induced by Ca2+ oscillation. Journal of Biochemistry and Molecular Biology, Nov; 38(6): 709-716 (2005).

Honors & Distinctions

2017  Pioneer Hundred Talents Program, Chinese Academy of Sciences, Beijing, China

2015   AHA Postdoctoral Fellowship, American Heart Association, Dallas, TX, USA

2007  University Postgraduate Fellowship, The University of Hong Kong, Hong Kong