以布尼亚病毒、冠状病毒及其他新发突发病毒为研究对象

1）利用系统生物学手段研究病毒宿主相互作用，阐明病毒复制机制和致病机理

2）发展抗病毒药物

   

071005-微生物学

抗病毒药物
病毒复制机制

2008-09--2013-06   武汉大学生命科学学院   理学博士
2004-09--2008-06   武汉大学生命科学学院   理学学士

研究生

理学博士

   

2021.11-至今，中国科学院武汉病毒研究所，研究员

2016.9-2021.10，中国科学院武汉病毒研究所，副研究员

2013.9-2016.8，中国科学院武汉病毒研究所，助理研究员

   

[1] 彭珂, 李淑芬, 肖庚富, 刘玮, 陈远侨, 张磊砢, 黎浩, 张玉兰, 万伟玮. 贝尼地平在制备预防和/或治疗布尼亚病毒感染性疾病药物中的应用. CN: CN110237074B, 2021-09-21.

[2] 左建平, 唐炜, 童贤崑, 杨莉, 何佩岚, 周宇, 赵维民, 肖庚富, 张磊砢, 蒋华良. 双黄连制剂在抗病毒感染中的应用. CN: CN113197886A, 2021-08-03.

[3] 谢元超, 肖庚富, 何洋, 张磊砢, 蒋华良, 沈敬山. 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用. CN: CN112778310A8, 2021-07-30.

[4] 刘玮, 彭珂, 黎浩, 李淑芬, 肖庚富, 张磊砢, 陈远侨, 张玉兰, 万伟玮. 一种组合物在制备预防和/或治疗发热伴血小板减少综合征病毒的药物中的应用. CN: CN110279693B, 2021-06-15.

[5] 王薇, 王培林, 汪少伯, 刘洋, 肖庚富, 张磊砢. 拉西地平在制备治疗沙粒病毒感染的药物中的应用. 中国: CN106511343A, 2017-03-22.

   

[1] Xiong, Rui, Zhang, Leike, Li, Shiliang, Sun, Yuan, Ding, Minyi, Wang, Yong, Zhao, Yongliang, Wu, Yan, Shang, Weijuan, Jiang, Xiaming, Shan, Jiwei, Shen, Zihao, Tong, Yi, Xu, Liuxin, Chen, Yu, Liu, Yingle, Zou, Gang, Lavillete, Dimitri, Zhao, Zhenjiang, Wang, Rui, Zhu, Lili, Xiao, Gengfu, Lan, Ke, Li, Honglin, Xu, Ke. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2 (vol 11, pg 723, 2020). PROTEIN & CELL. 2022, 13(10): 778-778, http://dx.doi.org/10.1007/s13238-020-00801-y.
[2] Long, Yiru, Sun, Jianhua, Song, TianZhang, Liu, Tingting, Tang, Feng, Zhang, Xinxin, Ding, Longfei, Miao, Yunqiu, Zhu, Weiliang, Pan, Xiaoyan, An, Qi, Qin, Mian, Tong, Xiankun, Peng, Xionghua, Yu, Pan, Zhu, Peng, Xu, Jianqing, Zhang, Xiaoyan, Zhang, Yachun, Liu, Datao, Chen, Ben, Chen, Huilin, Zhang, Leike, Xiao, Gengfu, Zuo, Jianping, Tang, Wei, Zhou, Ji, Li, Heng, Xu, Zhijian, Zheng, HongYi, Long, XinYan, Qin, Qiuping, Gan, Yong, Ren, Jin, Huang, Wei, Zheng, YongTang, Jin, Guangyi, Gong, Likun. CoVac501, a self-adjuvanting peptide vaccine conjugated with TLR7 agonists, against SARS-CoV-2 induces protective immunity. CELL DISCOVERY[J]. 2022, 8(1): https://doaj.org/article/3c59c092141d418c8f84164569078712.
[3] Ren, Pengxuan, Shang, Weijuan, Yin, Wanchao, Ge, Huan, Wang, Lin, Zhang, Xianglei, Li, Bingqian, Li, Honglin, Xu, Yechun, Xu, Eric H, Jiang, Hualiang, Zhu, Lili, Zhang, Leike, Bai, Fang. A multi-targeting drug design strategy for identifying potent anti-SARS-CoV-2 inhibitors. ACTA PHARMACOLOGICA SINICA[J]. 2022, 43(2): 483-493, http://lib.cqvip.com/Qikan/Article/Detail?id=7107734679.
[4] Dai, Wenhao, Jochmans, Dirk, Xie, Hang, Yang, Hang, Li, Jian, Su, Haixia, Chang, Di, Wang, Jiang, Peng, Jingjing, Zhu, Lili, Nian, Yong, Hilgenfeld, Rolf, Jiang, Hualiang, Chen, Kaixian, Zhang, Leike, Xu, Yechun, Neyts, Johan, Liu, Hong. Design, Synthesis, and Biological Evaluation of Peptidomimetic Aldehydes as Broad-Spectrum Inhibitors against Enterovirus and SARS-CoV-2. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 65(4): 2794-2808, http://dx.doi.org/10.1021/acs.jmedchem.0c02258.
[5] Zhang, Ruxue, Zhang, Yumin, Zheng, Wei, Shang, Weijuan, Wu, Yan, Li, Ning, Xiong, Jun, Jiang, Hualiang, Shen, Jingshan, Xiao, Gengfu, Xie, Yuanchao, Zhang, Leike. Oral remdesivir derivative VV116 is a potent inhibitor of respiratory syncytial virus with efficacy in mouse model. SIGNAL TRANSDUCTION AND TARGETED THERAPYnull. 2022, 7(1): 1386-1388, http://lib.cqvip.com/Qikan/Article/Detail?id=7107659241.
[6] Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Zhang, Yumin, Liu, Jia, Shao, Qiang, Wang, Qingxing, Li, Minjun, Xie, Hang, Shang, Weijuan, Ke, Changqiang, Feng, Lu, Jiang, Xiangrui, Shen, Jingshan, Xiao, Gengfu, Jiang, Hualiang, Zhang, Leike, Ye, Yang, Xu, Yechun. Identification of pyrogallol as a warhead in design of covalent inhibitors for the SARS-CoV-2 3CL protease. NATURE COMMUNICATIONS[J]. 2021, 12(1): https://doaj.org/article/ff68234682c746f3aa209aef3785fbf8.
[7] Yuanchao Xie, Wanchao Yin, Yumin Zhang, Weijuan Shang, Zhen Wang, Xiaodong Luan, Guanghui Tian, Haji AAisa, Yechun Xu, Gengfu Xiao, Jia Li, Hualiang Jiang, Shuyang Zhanq, Leike Zhang, HEric Xu, Jingshan Shen. Design and development of an oral remdesivir derivative W116 against SARS-CoV-2. 细胞研究:英文版[J]. 2021, 31(11): 1212-1214, http://lib.cqvip.com/Qikan/Article/Detail?id=7106196189.
[8] Wu, Jing, Shi, Yuheng, Pan, Xiaoyan, Wu, Shuang, Hou, Ruixia, Zhang, Yong, Zhong, Tiansheng, Tang, Hao, Du, Wei, Wang, Luying, Wo, Jing, Mu, Jingfang, Qiu, Yang, Yang, Ke, Zhang, LeiKe, Ye, BangCe, Qi, Nan. SARS-CoV-2 ORF9b inhibits RIG-I-MAVS antiviral signaling by interrupting K63-linked ubiquitination of NEMO. CELL REPORTS[J]. 2021, 34(7): 108761-108761, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7857071/.
[9] Wan, Weiwei, Zhu, Shenglin, Li, Shufen, Shang, Weijuan, Zhang, Ruxue, Li, Hao, Liu, Wei, Xiao, Gengfu, Peng, Ke, Zhang, Leike. High-Throughput Screening of an FDA-Approved Drug Library Identifies Inhibitors against Arenaviruses and SARS-CoV-2. ACS INFECTIOUS DISEASES[J]. 2021, 7(6): 1409-1422, http://dx.doi.org/10.1021/acsinfecdis.0c00486.
[10] Xie, Yuanchao, Yin, Wanchao, Zhang, Yumin, Shang, Weijuan, Wang, Zhen, Luan, Xiaodong, Tian, Guanghui, Aisa, Haji A, Xu, Yechun, Xiao, Gengfu, Li, Jia, Jiang, Hualiang, Zhang, Shuyang, Zhang, Leike, Xu, H Eric, Shen, Jingshan. Design and development of an oral remdesivir derivative VV116 against SARS-CoV-2. CELL RESEARCH. 2021, 31(11): 1212-1214, http://dx.doi.org/10.1038/s41422-021-00570-1.
[11] Yin, Wanchao, Luan, Xiaodong, Li, Zhihai, Zhou, Ziwei, Wang, Qingxing, Gao, Minqi, Wang, Xiaoxi, Zhou, Fulai, Shi, Jingjing, You, Erli, Liu, Mingliang, Wang, Qingxia, Jiang, Yi, Jiang, Hualiang, Xiao, Gengfu, Zhang, Leike, Yu, Xuekui, Zhang, Shuyang, Eric Xu, H. Structural basis for inhibition of the SARS-CoV-2 RNA polymerase by suramin. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2021, 28(3): http://dx.doi.org/10.1038/s41594-021-00570-0.
[12] Li, Hao, Jiang, XiaMing, Cui, Ning, Yuan, Chun, Zhang, ShaoFei, Lu, QingBin, Yang, ZhenDong, Xin, QinLin, Song, YaBin, Zhang, XiaoAi, Liu, HaiZhou, Du, Juan, Fan, XueJuan, Yuan, Lan, Yuan, YiMei, Wang, Zhen, Wang, Juan, Zhang, Lan, Zhang, DongNa, Wang, ZhiBo, Dai, Ke, Bai, JieYing, Hao, ZhaoNian, Fan, Hang, Fang, LiQun, Xiao, Gengfu, Yang, Yang, Peng, Ke, Wang, HongQuan, Li, JianXiong, Zhang, LeiKe, Liu, Wei. Clinical effect and antiviral mechanism of T-705 in treating severe fever with thrombocytopenia syndrome. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2021, 6(1): 1546-1558, https://doaj.org/article/83f2897df9254ec193925125c0fcfc7a.
[13] Zhang, LeiKe, Sun, Yuan, Zeng, Haolong, Wang, Qingxing, Jiang, Xiaming, Shang, WeiJuan, Wu, Yan, Li, Shufen, Zhang, YuLan, Hao, ZhaoNian, Chen, Hongbo, Jin, Runming, Liu, Wei, Li, Hao, Peng, Ke, Xiao, Gengfu. Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension (vol 6, 96, 2020). CELL DISCOVERYnull. 2021, 7(1): http://dx.doi.org/10.1038/s41421-021-00267-0.
[14] Zhao, Yao, Du, Xiaoyu, Duan, Yinkai, Pan, Xiaoyan, Sun, Yifang, You, Tian, Han, Lin, Jin, Zhenming, Shang, Weijuan, Yu, Jing, Guo, Hangtian, Liu, Qianying, Wu, Yan, Peng, Chao, Wang, Jun, Zhu, Chenghao, Yang, Xiuna, Yang, Kailin, Lei, Ying, Guddat, Luke W, Xu, Wenqing, Xiao, Gengfu, Sun, Lei, Zhang, Leike, Rao, Zihe, Yang, Haitao. High-throughput screening identifies established drugs as SARS-CoV-2 PLpro inhibitors. PROTEIN & CELL[J]. 2021, 12(11): 877-888, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8052528/.
[15] Zhou, LiKun, Zhou, Zhen, Jiang, XiaMing, Zheng, Yishan, Chen, Xi, Fu, Zheng, Xiao, Gengfu, Zhang, ChenYu, Zhang, LeiKe, Yi, Yongxiang. Absorbed plant MIR2911 in honeysuckle decoction inhibits SARS-CoV-2 replication and accelerates the negative conversion of infected patients. CELL DISCOVERY. 2020, 6(1): http://dx.doi.org/10.1038/s41421-020-00197-3.
[16] Su, Haixia, Yao, Sheng, Zhao, Wenfeng, Li, Minjun, Liu, Jia, Shang, Weijuan, Xie, Hang, Ke, Changqiang, Hu, Hangchen, Gao, Meina, Yu, Kunqian, Liu, Hong, Shen, Jingshan, Tang, Wei, Zhang, Leike, Xiao, Gengfu, Ni, Li, Wang, Daowen, Zuo, Jianping, Jiang, Hualiang, Bai, Fang, Wu, Yan, Ye, Yang, Xu, Yechun. Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients. ACTA PHARMACOLOGICA SINICA[J]. 2020, 41(9): 1167-1177, http://lib.cqvip.com/Qikan/Article/Detail?id=7103065052.
[17] Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong, Gengfu Xiao . Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research[J]. 2020, https://www.nature.com/articles/s41422-020-0282-0.
[18] Dai, Wenhao, Zhang, Bing, Jiang, XiaMing, Su, Haixia, Li, Jian, Zhao, Yao, Xie, Xiong, Jin, Zhenming, Peng, Jingjing, Liu, Fengjiang, Li, Chunpu, Li, You, Bai, Fang, Wang, Haofeng, Cheng, Xi, Cen, Xiaobo, Hu, Shulei, Yang, Xiuna, Wang, Jiang, Liu, Xiang, Xiao, Gengfu, Jiang, Hualiang, Rao, Zihe, Zhang, LeiKe, Xu, Yechun, Yang, Haitao, Liu, Hong. Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease. SCIENCE[J]. 2020, 368(6497): 1331-+, http://dx.doi.org/10.1126/science.abb4489.
[19] Zhou, Zhen, Zhou, Yu, Jiang, XiaMing, Wang, Yanbo, Chen, Xi, Xiao, Gengfu, Zhang, ChenYu, Yi, Yongxiang, Zhang, LeiKe, Li, Liang. Decreased HD-MIR2911 absorption in human subjects with the SIDT1 polymorphism fails to inhibit SARS-CoV-2 replication. CELL DISCOVERY. 2020, 6(1): http://dx.doi.org/10.1038/s41421-020-00206-5.
[20] Jin, Zhenming, Du, Xiaoyu, Xu, Yechun, Deng, Yongqiang, Liu, Meiqin, Zhao, Yao, Zhang, Bing, Li, Xiaofeng, Zhang, Leike, Peng, Chao, Duan, Yinkai, Yu, Jing, Wang, Lin, Yang, Kailin, Liu, Fengjiang, Jiang, Rendi, Yang, Xinglou, You, Tian, Liu, Xiaoce, Yang, Xiuna, Bai, Fang, Liu, Hong, Liu, Xiang, Guddat, Luke W, Xu, Wenqing, Xiao, Gengfu, Qin, Chengfeng, Shi, Zhengli, Jiang, Hualiang, Rao, Zihe, Yang, Haitao. Structure of M-pro from SARS-CoV-2 and discovery of its inhibitors. NATURE[J]. 2020, 582(7811): 289-+, http://dx.doi.org/10.1038/s41586-020-2223-y.
[21] Zhang, LeiKe, Sun, Yuan, Zeng, Haolong, Wang, Qingxing, Jiang, Xiaming, Shang, WeiJuan, Wu, Yan, Li, Shufen, Zhang, YuLan, Hao, ZhaoNian, Chen, Hongbo, Jin, Runming, Liu, Wei, Li, Hao, Peng, Ke, Xiao, Gengfu. Calcium channel blocker amlodipine besylate therapy is associated with reduced case fatality rate of COVID-19 patients with hypertension. CELL DISCOVERY[J]. 2020, 6(1): http://dx.doi.org/10.1038/s41421-020-00235-0.
[22] Li, Yang, Shang, Weijuan, Xiao, Gengfu, Zhang, LeiKe, Zheng, Congyi. A Comparative Quantitative Proteomic Analysis of HCMV-Infected Cells Highlights pUL138 as a Multifunctional Protein. MOLECULES[J]. 2020, 25(11): https://doaj.org/article/a1df62a1ab4a4e5ea2f321972ca47341.
[23] Zhang, Leike, Liu, Jia, Cao, Ruiyuan, Xu, Mingyue, Wu, Yan, Shang, Weijuan, Wang, Xi, Zhang, Huanyu, Jiang, Xiaming, Sun, Yuan, Hu, Hengrui, Li, Yufeng, Zou, Gang, Zhang, Min, Zhao, Lei, Li, Wei, Guo, Xiaojia, Zhuang, Xiaomei, Yang, XingLou, Shi, ZhengLi, Deng, Fei, Hu, Zhihong, Xiao, Gengfu, Wang, Manli, Zhong, Wu. Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2In Vitro. VIROLOGICA SINICA[J]. 2020, 35(6): 776-784, http://lib.cqvip.com/Qikan/Article/Detail?id=7104025370.
[24] Xiong, Rui, Zhang, Leike, Li, Shiliang, Sun, Yuan, Ding, Minyi, Wang, Yong, Zhao, Yongliang, Wu, Yan, Shang, Weijuan, Jiang, Xiaming, Shan, Jiwei, Shen, Zihao, Tong, Yi, Xu, Liuxin, Chen, Yu, Liu, Yingle, Zou, Gang, Lavillete, Dimitri, Zhao, Zhenjiang, Wang, Rui, Zhu, Lili, Xiao, Gengfu, Lan, Ke, Li, Honglin, Xu, Ke. Novel and potent inhibitors targeting DHODH are broad-spectrum antivirals against RNA viruses including newly-emerged coronavirus SARS-CoV-2. PROTEIN & CELL[J]. 2020, 11(10): 723-739, https://doaj.org/article/7cc08278afd440c58f310a8ae77636f7.
[25] Zhenming Jin, Yao Zhao, Yuan Sun. Structural basis for the inhibition of SARS-CoV-2 main protease by antineoplastic drug carmofur. Nature Structural & Molecular Biology. 2020, The antineoplastic drug carmofur is shown to inhibit the SARS-CoV-2 main protease (Mpro). Here, the X-ray crystal structure of Mpro in complex with carmofur reveals that the carbonyl reactive group of carmofur is covalently bound to catalytic Cys145, whereas its fatty acid tail occupies the hydrophobic S2 subsite. Carmofur inhibits viral replication in cells (EC50 = 24.30 μM) and is a promising lead compound to develop new antiviral treatment for COVID-19..
[26] Li, Shufen, Li, Hao, Zhang, YuLan, Xin, QiLin, Guan, ZhenQiong, Chen, Xi, Zhang, XiaoAi, Li, XiaoKun, Xiao, GengFu, Lozach, PierreYves, Cui, Jun, Liu, Wei, Zhang, LeiKe, Peng, Ke. SFTSV Infection Induces BAK/BAX-Dependent Mitochondrial DNA Release to Trigger NLRP3 Inflammasome Activation. CELL REPORTS[J]. 2020, 30(13): 4370-+, http://dx.doi.org/10.1016/j.celrep.2020.02.105.
[27] Zhang, LeiKe, Wang, Bo, Xin, Qilin, Shang, Weijuan, Shen, Shu, Xiao, Gengfu, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli. Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection. JOURNAL OF VIROLOGY[J]. 2019, 93(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000466417500011.
[28] Li Hao, Zhang Leike, Li Shufen, Zhang Shaofei, Wan Weiwei, Zhang Yulan, Xin Qilin, Dai Ke, Hu Yuanyuan, Wang Zhibo, Zhu Xiangtao, Fang Yujie, Cui Ning, Zhang Panhe, Yuan Chun, Lu Qingbin, Bai Jieying, Deng Fei, Xiao Gengfu, Liu Wei, Peng Ke. Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality. CELL RESEARCH[J]. 2019, 29(9): 739-753, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6567339&detailType=1.
[29] Hao Li, LeiKe Zhang, ShuFen Li, ShaoFei Zhang, WeiWei Wan, YuLan Zhang, QiLin Xin, Ke Dai, YuanYuan Hu, ZhiBo Wang, XiangTao Zhu, YuJie Fang, Ning Cui, PanHe Zhang, Chun Yuan, QingBin Lu, JieYing Bai, Fei Deng, GengFu Xiao, Wei Liu, Ke Peng. Calcium channel blockers reduce severe fever with thrombocytopenia syndrome virus (SFTSV) related fatality. 细胞研究：英文版[J]. 2019, 29(9): 739-753, http://lib.cqvip.com/Qikan/Article/Detail?id=7003036384.
[30] Wan, Weiwei, Wang, Liangjie, Chen, Xi, Zhu, Shenglin, Shang, Weijuan, Xiao, Gengfu, Zhang, LeiKe. A Subcellular Quantitative Proteomic Analysis of Herpes Simplex Virus Type 1-Infected HEK 293T Cells. MOLECULES[J]. 2019, 24(23): [31] Zhu, Shenglin, Wan, Weiwei, Zhang, Yanjun, Shang, Weijuan, Pan, Xiaoyan, Zhang, LeiKe, Xiao, Gengfu. Comprehensive Interactome Analysis Reveals that STT3B Is Required for N-Glycosylation of Lassa Virus Glycoprotein. JOURNAL OF VIROLOGY[J]. 2019, 93(23): http://dx.doi.org/10.1128/JVI.01443-19.
[32] Xin, QiLin, Deng, ChengLin, Chen, Xi, Wang, Jun, Wang, ShaoBo, Wang, Wei, Deng, Fei, Zhang, Bo, Xiao, Gengfu, Zhang, LeiKe. Quantitative Proteomic Analysis of Mosquito C6/36 Cells Reveals Host Proteins Involved in Zika Virus Infection. JOURNAL OF VIROLOGY[J]. 2017, 91(12): http://www.corc.org.cn/handle/1471x/2373430.
[33] Zhu, ShengLin, Chen, Xi, Wang, LiangJie, Wan, WeiWei, Xin, QiLin, Wang, Wei, Xiao, Gengfu, Zhang, LeiKe. Global quantitative proteomic analysis profiles host protein expression in response to Sendai virus infection. PROTEOMICS[J]. 2017, 17(5): http://www.corc.org.cn/handle/1471x/2373455.
[34] Hou, Dianhai, Chen, Xi, Zhang, LeiKe. Proteomic Analysis of Mamestra Brassicae Nucleopolyhedrovirus Progeny Virions from Two Different Hosts. PLOS ONE[J]. 2016, 11(4): https://doaj.org/article/1941acead63348a683f51bb17757f719.
[35] Zhang, LeiKe, Xin, QiLin, Zhu, ShengLin, Wan, WeiWei, Wang, Wei, Xiao, Gengfu. Activation of the RLR/MAVS Signaling Pathway by the L Protein of Mopeia Virus. JOURNAL OF VIROLOGY[J]. 2016, 90(22): 10259-10270, http://www.corc.org.cn/handle/1471x/2373491.
[36] Chai, Fan, Li, HaoYu, Wang, Wei, Zhu, XiuJuan, Li, Yang, Wang, Shaobo, Guo, Lin, Zhang, LeiKe, Xiao, Gengfu. Subcellular quantitative proteomic analysis reveals host proteins involved in human cytomegalovirus infection. BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS[J]. 2015, 1854(8): 967-978, http://www.corc.org.cn/handle/1471x/2375171.
[37] Zhang, LeiKe, Lin, Tao, Zhu, ShengLin, Xianyu, LingZhi, Lu, SongYa. Global quantitative proteomic analysis of human glioma cells profiled host protein expression in response to enterovirus type 71 infection. PROTEOMICS[J]. 2015, 15(22): 3784-3796, https://www.webofscience.com/wos/woscc/full-record/WOS:000367727800004.
[38] Zeng, HaoLong, Rao, Xiaoping, Zhang, LeiKe, Zhao, Xiaolu, Zhang, WeiPing, Wang, Jie, Xu, Fuqiang, Guo, Lin. Quantitative proteomics reveals olfactory input-dependent alterations in the mouse olfactory bulb proteome. JOURNAL OF PROTEOMICS[J]. 2014, 109: 125-142, http://dx.doi.org/10.1016/j.jprot.2014.06.023.
[39] Hou, Dianhai, Zhang, Leike, Deng, Fei, Fang, Wei, Wang, Ranran, Liu, Xijia, Guo, Lin, Rayner, Simon, Chen, Xinwen, Wang, Hualin, Hu, Zhihong. Comparative Proteomics Reveal Fundamental Structural and Functional Differences between the Two Progeny Phenotypes of a Baculovirus. JOURNAL OF VIROLOGY[J]. 2013, 87(2): 829-839, http://dx.doi.org/10.1128/JVI.02329-12.
[40] Zhang, LeiKe, Chai, Fan, Li, HaoYu, Xiao, Gengfu, Guo, Lin. Identification of Host Proteins Involved in Japanese Encephalitis Virus Infection by Quantitative Proteomics Analysis. JOURNAL OF PROTEOME RESEARCH[J]. 2013, 12(6): 2666-2678, http://dx.doi.org/10.1021/pr400011k.

   

（ 1 ） UB2V2等与人巨细胞病毒相互作用的宿主蛋白的鉴定及功能分析, 主持, 国家级, 2016-01--2018-12
（ 2 ） 核转运蛋白参与沙粒病毒出芽过程的机制研究, 主持, 国家级, 2020-01--2023-12
（ 3 ） 一种广谱抗沙粒病毒、布尼亚病毒药物的机制研究, 主持, 部委级, 2018-08--2020-12
（ 4 ） 院青年创新促进会, 主持, 部委级, 2018-01--2021-12
（ 5 ） 新型冠状病毒感染诱发重度细胞因子风暴机制及对症救治新技术, 主持, 国家级, 2020-02--2021-02
（ 6 ） 现有广谱抗病毒药物的 作用机制和优化改造, 主持, 国家级, 2021-12--2024-11

已指导学生

王清星  博士研究生  071010-生物化学与分子生物学  

万伟玮  博士研究生  071010-生物化学与分子生物学  

现指导学生

姜夏铭  博士研究生  071010-生物化学与分子生物学