微生物学、结构生物学、生物化学与分子生物学

   

071005-微生物学
071011-生物物理学

病原微生物致病机制的结构生物学
基于结构的靶向干预手段的研究

2006-09--2010-07   中国科学院生物物理研究所   博士学位
2002-09--2005-07   南京农业大学   硕士学位
1997-09--2001-07   山东农业大学   学士学位

2016-07~现在, 中科院上海巴斯德所, 研究员、博士生导师
2010-10~2015-09,美国加州大学圣迭戈分校, 博士后

2018-01-01-今,上海市医药卫生青年联合会委员,
2017-12-15-今,上海市侨界知识分子联谊会第九届理事会理事,
2017-01-01-今,中国生物物理学会会员,
2017-01-01-今,中国生物化学与分子生物学会会员,

巴斯德国际网络培训课程－结构为基础的新型防治手段
高级微生物学
结构病毒学

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（1） 上海市“浦江人才”, 省级, 2017 （2） 上海市“东方学者特聘教授”称号, 省级, 2016

   

1.Zhou, H., *, Wang, F., *, Wang, H., §, Chen, C., Zhang, T, Han, X., Wang, D., Chen, C., Wu, C., Xie, W., Wang, Z., Wang, L. #& Yang, H. # The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget 8(9): 14830–14834 (2017) (#, co-Corresponding Author ) 

2.Li, M., Wang, X., Wang, Q., Yu, L., Wang, L., Yan, J., Zhang, F., Zhang, L., Gao, GF, Jin, X. Both structure and function of human monoclonal antibodies contribute to enhancement of Zika virus infectivity in vitro. Sci China Life Sci 60: 1396-1398 (2017) 

3.Wang, L., §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D.*, and Wang, D.* Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author) 

4. Walmacq, C., Wang, L., Chong, J., Scibelli, K., Lubkowska, L., Gnatt, A., Brooks, P. J., Wang, D. * &Kashlev, M. * Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. ProcNatlAcadSci U S A 112, E410-419 (2015). 

5. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. ProcNatlAcadSci U S A 111, 18566-18571 (2014). (§, Co-First Author) 
6. Xu, L., Chen, Y. C., Nakajima, S., Chong, J., Wang, L., Lan, L., Zhang, C. & Wang, D. A Chemical Probe Targets DNA 5- Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. ChemSci5, 567-574 (2014) 
7. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. &Rao, Z. Crystal structures of NAC domains of human nascent polypeptide- associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).

   

1. The structural mechanism of eukaryotic RNA polymerase II (Pol II) related transcriptional regulations   首届华东结构生物学学术会议暨第十九次上海市结构生物学合作网络会议   2017-04-05 

2. The mechanism of RNA Polymerase II processes DNA modifications and lesions   国际生物物理前沿青年科学家成都菁蓉论坛   2016-09-02