基本信息
王岚峰  男  博导  中国科学院上海巴斯德研究所
电子邮件: lanfwang@ips.ac.cn
通信地址: 上海市徐汇区岳阳路320号生命科学实验楼A322
邮政编码: 200031

招生信息

   
招生专业
071005-微生物学
071011-生物物理学
招生方向
病原微生物致病机制的结构生物学
基于结构的靶向干预手段的研究

教育背景

2006-09--2010-07   中国科学院生物物理研究所   博士学位
2002-09--2005-07   南京农业大学   硕士学位
1997-09--2001-07   山东农业大学   学士学位

工作经历


工作简历
2016-07~现在, 中科院上海巴斯德所, 研究员、博士生导师
2010-10~2015-09,美国加州大学圣迭戈分校, 博士后
社会兼职
2018-01-01-今,上海市医药卫生青年联合会委员,
2017-12-15-今,上海市侨界知识分子联谊会第九届理事会理事,
2017-01-01-今,中国生物物理学会会员,
2017-01-01-今,中国生物化学与分子生物学会会员,

专利与奖励


奖励信息
(1) 上海市“浦江人才”, 省级, 2017 (2) 上海市“东方学者特聘教授”称号, 省级, 2016

出版信息

   
发表论文

1.Zhou, H., *, Wang, F., *, Wang, H., §, Chen, C., Zhang, T, Han, X., Wang, D., Chen, C., Wu, C., Xie, W., Wang, Z., Wang, L. #& Yang, H. # The conformational changes of Zika virus methyltransferase upon converting SAM to SAH. Oncotarget 8(9): 14830–14834 (2017) (#, co-Corresponding Author ) 

2.Li, M., Wang, X., Wang, Q., Yu, L., Wang, L., Yan, J., Zhang, F., Zhang, L., Gao, GF, Jin, X. Both structure and function of human monoclonal antibodies contribute to enhancement of Zika virus infectivity in vitro. Sci China Life Sci 60: 1396-1398 (2017) 

3.Wang, L., §, Zhou, Y.,§, Xu, L.,§, Xiao, R.,§, Lu, X., Chen, L., Chong, J., Li, H., He, C., Fu, X-D.*, and Wang, D.* Molecular Basis for 5-Carboxycytosine Recognition by RNA Polymerase II Elongation Complex. Nature 523, 621–625 (2015). (§, Co-First Author) 

4. Walmacq, C., Wang, L., Chong, J., Scibelli, K., Lubkowska, L., Gnatt, A., Brooks, P. J., Wang, D. * &Kashlev, M. * Mechanism of RNA polymerase II bypass of oxidative cyclopurine DNA lesions. ProcNatlAcadSci U S A 112, E410-419 (2015). 

5. Wang, L., §, Limbo, O., §, Fei, J., Chen, L., Kim, B., Luo, J., Chong, J., Conaway, R. C., Conaway, J. W., Ranish, J. A., Kadonaga, J. T., Russell, P. & Wang, D. Regulation of the Rhp26ERCC6/CSB chromatin remodeler by a novel conserved leucine latch motif. ProcNatlAcadSci U S A 111, 18566-18571 (2014). (§, Co-First Author) 
6. Xu, L., Chen, Y. C., Nakajima, S., Chong, J., Wang, L., Lan, L., Zhang, C. & Wang, D. A Chemical Probe Targets DNA 5- Formylcytosine Sites and Inhibits TDG Excision, Polymerases Bypass, and Gene Expression. ChemSci5, 567-574 (2014) 
7. Wang, L., Zhang, W., Wang, L., Zhang, X. C., Li, X. &Rao, Z. Crystal structures of NAC domains of human nascent polypeptide- associated complex (NAC) and its alphaNAC subunit. Protein & Cell 1, 406-416 (2010).


科研活动

   
会议报告

1. The structural mechanism of eukaryotic RNA polymerase II (Pol II) related transcriptional regulations   首届华东结构生物学学术会议暨第十九次上海市结构生物学合作网络会议   2017-04-05 

2. The mechanism of RNA Polymerase II processes DNA modifications and lesions   国际生物物理前沿青年科学家成都菁蓉论坛   2016-09-02