General

Associate Professor

Key Laboratory of Molecular Imaging

Institute of Automation

Chinese Academy of Sciences

Floor 9, Intelligent Building 

No. 95 Zhongguancun East Road 

Beijing, China, Zip code: 100190

Tel: +86-135-8199-8316

Email: zhenhua.hu@ia.ac.cn

Research Areas

Bio-medical Imaging Technology

Experience

   
Work Experience

Nov. 2017 – Present        Associate Director, Key Laboratory of Molecular Imaging, 

                                        Institute of Automation, Chinese Academy of Sciences


Oct. 2016 – Present         Professor, Key Laboratory of Molecular Imaging, Institute of Automation, 

                                        Chinese Academy of Sciences

                                         Program Director: Jie Tian


Nov. 2014 – Sep. 2016     Associate Professor, Key Laboratory of Molecular Imaging, Institute of Automation,  

                                         Chinese Academy of Sciences

                                         Program Director: Jie Tian


Sept. 2012 – Oct. 2014     Assistant Professor, Key Laboratory of Molecular Imaging, Institute of Automation, 

                                         Chinese Academy of Sciences

                                         Program Director: Jie Tian



Teaching Experience

Mar. 2009 – Aug. 2012        Ph.D. Degree in Intelligent Information Processing

                                             Xidian University, Xian, China; PhD advisor: Dr. Jie Tian


Sept. 2006 – Dec. 2008        M.A.Sc. Degree in Power Electronics and Drives

                                             Xihua University, Chengdu, China; MS advisor: Dr. Haibin Wang


Sept. 2001 – July 2005         B.S. in Electronic Engineering

                                          Shandong Normal University, Jinan, China


Publications

   
Papers

  1. Hu Z, Fang C, Li B, Zhang Z, Cao C, Cai M, Su S, Sun X, Shi X, Li C, Zhou T, Zhang Y, Chi C, He P, Xia X, Chen Y, Gambhir SS*, Cheng Z*, Tian J*. First-in-human liver-tumour surgery guided by multispectral fluorescence imaging in the visible and near-infrared-I/II windows. Nature Biomedical Engineering. 2020; 4(3): 259-271.
  1. Hu Z, Chen W, Tian J*, Cheng Z*. NIRF nanoprobes for cancer molecular imaging: approaching clinic. Trends in Molecular Medicine. 2020; 26(5): 469-482. (Highlighted as Featured Article)
  1. Cai M, Zhang Z, Shi X, Yang J, Hu Z*, Tian J*. Non-negative iterative convex refinement approach for accurate and robust reconstruction in Cerenkov luminescence tomography. IEEE Transactions on Medical Imaging. 2020; doi:10.1109/TMI.2020.2987640.
  1. Cai M, Zhang Z, Shi X, Hu Z*, Tian J*. NIR-II/NIR-I fluorescence molecular tomography of heterogeneous mice based on gaussian weighted neighborhood fused lasso method. IEEE Transactions on Medical Imaging. 2020; doi:10.1109/TMI.2020.2964853.
  1. Zheng S, Zhang Z, Qu Y, Zhang X, Guo H, Shi X, Cai M, Cao C, Hu Z*, Liu H*, Tian J*. Radiopharmaceuticals and Fluorescein Sodium Mediated TripleModality Molecular Imaging Allows Precise ImageGuided Tumor Surgery. Advanced Science. 2019:1900159. (Highlighted as Back Cover Article)
  1. Zhang Z, Cai M, Bao C, Hu Z*, Tian J*. Endoscopic Cerenkov luminescence imaging and image-guided tumor resection on hepatocellular carcinoma-bearing mouse models. Nanomedicine: Nanotechnology, Biology and Medicine. 2019; 17:62-70. (Highlighted as Featured Article and Cover Article)
  1. Zhang Z, Qu Y, Cao Y, Shi X, Guo H, Zhang X, Zheng S, Liu H*, Hu Z*, Tian J*. A novel in vivo Cerenkov luminescence image-guided surgery on primary and metastatic colorectal cancer. Journal of Biophotonics. 2020; 13(3): e201960152. (Highlighted as Featured Article and Back Cover Article)
  1. Zhang Z, Cai M, Gao Y, Shi X, Zhang X, Hu Z*, Tian J*. A novel Cerenkov luminescence tomography approach using multilayer fully connected neural network. Physics in Medicine and Biology. 2019; 64(24): 245010.
  1. Liu M, Zheng S, Zhang X, Guo H, Shi X, Kang X, Qu Y, Hu Z*, Tian J*. Cerenkov luminescence imaging on evaluation of early response to chemotherapy of drug-resistant gastric cancer. Nanomedicine: Nanotechnology, Biology, and Medicine. 2018; 14(1):205-213. (Highlighted as Featured Article and Cover Article)
  1. Hu Z, Zhao M, Qu Y, Zhang X, Zhang M, Liu M, Guo H, Zhang Z, Wang J*, Yang W*, Tian J*. In vivo three-dimensional radiopharmaceutical excited fluorescence tomography. Journal of Nuclear Medicine. 2017; 58(1):169-174.
  1. Hu Z, Chi C, Liu M, Guo H, Zhang Z, Zeng C, Ye J, Wang J, Tian J*, Yang W*, Xu W*. Nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging allows precise image-guided tumor-removal surgery. Nanomedicine: Nanotechnology, Biology and Medicine. 2017; 13(4):1323-1331.
  1. Guo H, He X*, Liu M, Zhang Z, Hu Z*, Tian J*. Weight multispectral reconstruction strategy for enhanced reconstruction accuracy and stability with Cerenkov luminescence tomography. IEEE Transactions on Medical Imaging. 2017; 36(6):1337-1346.
  1. Liu M, Guo H, Liu H, Zhang Z, Chi C, Hui H, Dong D, Hu Z*, Tian J*. In vivo pentamodal tomographic imaging for small animals. Biomedical Optics Express. 2017; 8(3):1356-1371.
  1. Guo H, Hu Z*, He X*, Zhang X, Liu M, Zhang Z, Shi X, Zheng S, Tian J*. Non-convex sparse regularization approach framework for high multiple-source resolution in Cerenkov luminescence tomography. Optics Express, 2017, 25(23):28068-28085.
  1. Hu Z, Qu Y, Wang K, Zhang X, Zha J, Song T, Bao C, Liu H, Wang Z, Wang J, Liu Z, Liu H*, Tian J*. In vivo nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging. Nature Communications. 2015; 6:7560.
  1. Wang K, Chi C, Hu Z, Liu M, Hui H, Shang W, Peng D, Zhang S, Ye J, Liu H, Tian J*.Optical molecular imaging frontiers in oncology: the pursuit of accuracy and sensitivity. Engineering. 2015;1(3): 309-323.
  1. Liu H, Yang X, Song T, Bao C, Shi L, Hu Z*, Wang K*, Tian J*. Multispectral hybrid Cerenkov luminescence tomography based on the finite element SPn method. Journal of Biomedical Optics. 2015; 20(8):086007.
  1. Song T, Liu X*, Qu Y, Liu H, Bao C, Leng C, Hu Z*, Wang K*, Tian J*. A novel endoscopic Cerenkov luminescence imaging system for intraoperative surgical navigation. Molecular Imaging. 2015; 14:443-449.
  1. Hu Z, Yang W, Liu H, Wang K, Bao C, Song T, Wang J*, Tian J*. From PET/CT to PET/MRI: advances in instrumentation and clinical applications. Molecular Pharmaceutics. 2014; 11(11):3798-3809.
  1. Ding X, Wang K, Jie B, Luo Y, Hu Z*, Tian J. Probability method for Cerenkov luminescence tomography based on conformance error minimization. Biomedical Optics Express. 2014; 5(7):2091-2112.
  1. Hu Z, Yang W, Ma X, Ma W, Qu X, Liang J*, Wang J*, Tian J*. Cerenkov luminescence tomography of aminopeptidase N (APN/CD13) expression in mice bearing HT1080 tumors. Molecular Imaging. 2013; 12(3):173-181.
  1. Hu Z, Ma X, Qu X, Yang W, Liang J, Wang J*, Tian J*. Three-dimensional noninvasive monitoring iodine-131 uptake in the thyroid using a modified Cerenkov luminescence tomography approach. PLoS ONE. 2012; 7(5): e37623.
  1. Hu Z, Chen X, Liang J*, Qu X, Chen D, Yang W, Wang J, Cao F, Tian J*. Single photon emission computed tomography-guided Cerenkov luminescence tomography. Journal of Applied Physics. 2012; 112(2):024703.
  1. Yang W, Qin W, Hu Z, Suo Y, Zhao R, Ma X, Ma W, Wang T, Liang J, Tian J, Wang J*. Comparison of Cerenkov luminescence imaging (CLI) and gamma camera imaging for visualization of let-7 expression in lung adenocarcinoma A549 cells. Nuclear Medicine and Biology. 2012; 39(7):948-953.
  1. Qin C, Zhong J, Hu Z, Yang X, Tian J*. Recent advances in Cerenkov luminescence and tomography imaging. IEEE Journal of Selected Topics in Quantum Electronics. 2012; 18(3):1084-1093.
  1. Ren N, Zhao H, Zhu S, Qu X, Liu H, Hu ZLiang J*, Tian J*. Voxel classification methodology for rapid Monte Carlo simulation of light propagation in complex media. Chinese Optics Letters. 2011; 9(4):041701-1-4.
  1. Zhang Q, Zhao H, Chen D, Qu X, Chen X, He X, Li W, Hu Z, Liu J, Liang J*, Tian J*. Source sparsity based primal-dual interior-point method for three-dimensional bioluminescence tomography. Optical Communication. 2011; 284(24):5871-5876.
  1. Hu Z, Liang J, Yang W, Fan W, Li C, Ma X, Chen X, Ma X, Li X, Qu X, Wang J*, Cao F*, Tian J*. Experimental Cerenkov luminescence tomography of the mouse model with SPECT imaging validation. Optics Express. 2010; 18(24):24441-24450. 
  1. Liu J, Wang Y, Qu X, Li X, Ma X, Han R, Hu Z, Chen X, Sun D, Zhang R, Chen D, Chen D, Chen X, Liang J*, Cao F*, Tian J*. In vivo quantitative bioluminescence tomography using heterogeneous and homogeneous mouse models. Optical Express. 2010; 18(12):13102-13113. 


Patents
  1. Tian J, Hu Z, Cai M, Cao C. Second near-infrared window / first near-infrared window dual-mode fluorescence tomography system and method. (United States Patent) US16/845,267, patent was filled on 2020.04.10.

  2. Tian J, Hu Z, Cao C, Zhang Z, Cai M. Intraoperative near-infrared-I and near-infrared-II multispectral fluorescent navigation system and method of using the same (United States Patent). US16/545,023, patent was filled on 2019.08.20.

  3. Tian J, Hu Z, Yang J, Cao C, Zhang Z. An NIR-II single-channel time-division-multiplexing imaging system and method. CN110833399A, patent was disclosured on 02/25/2020.

  4. Tian J, Hu Z, Cai M, Cao C. A dual-modelity NIR-II/I fluorescence tomographic imaging system and method. CN110327020A, patent was disclosured on 10/15/2019.

  5. Tian J, Hu Z, Zhang Z, Shi X, Cao C. An intraoperative Cerenkov luminescence imaging system and the Cerenkov luminescence image processing method. CN110327019A, patent was disclosured on 10/15/2019.

  6. Tian J, Hu Z, Cao C, Zhang Z, Cai M. An intraoperative NIR fluorescence imaging system and method. CN109480776A, patent was disclosured on 03/19/2019.

  7. ​Tian J, Hu Z, Shi X, Zhang Z, Cai M. An intraoperative Cerenkov luminescence imaging system and method. CN109480874A, patent was disclosured on 03/19/2019. 


Research Interests

Cerenkov Luminescence Imaging/Tomography

Optical Guided Surgery

Conferences

  1. Shi X, Zhang Z, Hu Z*, Tian J*. A doped nanoparticle mediate 18F-FDG excited fluorescence molecular imaging. The 2019 SPIE Photonics West, San Francisco, USA, February. 2-7 (oral presentation)
  1. Hu Z, Zhang Z, Guo H, Tian J. Intraoperative Cerenkov luminescence imaging for image-guided resection of low rectal cancer on swine models. The 2018 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Philadelphia, USA, Jun. 23-26 (oral presentation)
  1. Hu Z, Zhang Z, Guo H, Liu M, Shi X, Tian J. Construction of a novel intraoperative Cerenkov luminescence imaging system for image-guided resection of colorectal cancer on patients. The 2017 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Denver, USA, Jun. 10-14 (oral presentation) (2017 Young Investigator Award from the Chinese American Society of Nuclear Medicine).
  1. Hu Z, Liu M, Guo H, Zhang Z, Tian J. Image-guided cancer surgery using a novel nanoparticle-mediated radiopharmaceutical-excited fluorescence molecular imaging. The 2016 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, San Diego, USA, Jun. 11-15 (oral presentation) (2016 Young Investigator Award from the Chinese American Society of Nuclear Medicine).
  1. Hu Z, Ding X, Jia X, Tian J. Comparison of Cerenkov luminescence imaging and positron emission tomography for the detection of subcutaneous breast tumor in animal models. The 2015 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Baltimore, USA, Jun. 6-10.
  1. Hu Z, Tan T, Qu Y, Zhang X, Liu H, Tian J. High resolution micro-endoscopy for the diagnosis of gastric carcinoma and precancerous lesions. The 2015 World Molecular Imaging Congress, Honolulu, USA, Sept. 2-5.
  1. Hu Z, Qu Y, Wang K, Song T, Zhang X, Liu H, Tian J. A preliminary study: radiopharmaceuticals induced fluorescence imaging in vivo. The 2014 World Molecular Imaging Congress, Seoul, Korea, Sept. 17-20 (KSMI Travel Stipend Award for the World Molecular Imaging Congress).
  1.  Hu Z, Wang K, Song T, Tian J. A new optical imaging strategy: 18F-FDG induced rare earth luminescence imaging. The 2014 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, St. Louis, USA, Jun. 7-11.
  1. Hu Z, Qu Y, Wang K, Zhang X, Liu H, Tian J. In vivo radiopharmaceutical excitation fluorescence imaging. The 2014 IEEE nuclear science symposium and medical imaging conference, Seattle, USA, Nov. 8-15.
  1. Hu Z, Wang K, Liu H, Mu W, Zhang Q, Du Y, Tian J. Endoscopic Cerenkov luminescence tomography of rats with gastric tumors. The 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Vancouver, Canada, Jul. 8-12 (oral presentation) (2013 Young Investigator Award for the Chinese American Society of Nuclear Medicine).
  1. Hu Z, Liu H, Wang K, Mu W, Ding X, Tian J. Bronchoscopic Cerenkov luminescence imaging of the radioactive source with 18F-FDG. The 2013 World Molecular Imaging Congress, Georgia, USA, Sept. 18-21.
  1.  Hu Z, Yang W, Ma X, Ma W, Chen Z, Qu X, Wang J, Liang J, Tian J. Cerenkov-based optical tomography of APN/CD13 expression in the nude mice bearing HT1080 fibrosarcoma tumours. The 2012 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Miami, USA, Jul. 9-13.
  1. Hu Z, Zhou Y, Lin X, Yang W, Qu X, Liang J, Wang J, Tian J. Penetration depth limits of Cerenkov luminescence generation from electron-emitting radiotracer. The 2011 World Molecular Imaging Congress, San Diego, USA, Sept. 7-10.
  1. Song T, Hu Z, Lu J, Wang K, Liu X, Tian J. In vitro and in vivo endoscopic Cerenkov luminescence imaging. The 2014 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, St. Louis, USA, Jun. 7-11 (oral presentation).
  1. Song T, Bao C, Hu Z, Wang K, Liu X, Tian J. Endoscopic Cerenkov luminescence imaging: in vivo small animal tumor model validation. The 2015 Society of Photo-Optical Instrumentation Engineers Medical Imaging, Orlando, USA, Feb. 21-26.
  1. Liu H, Hu Z, Wang K, Tian J. Cerenkov luminescence tomography based on preconditioning orthogonal matching pursuit. The 2015 Society of Photo-Optical Instrumentation Engineers Medical Imaging, Orlando, USA, Feb. 21-26.
  1.  Liu H, Hu Z, Wang K, Song T, Bao C, Tian J. Cerenkov luminescence tomography based on the high-order simplified spherical harmonics approximation. The 2014 World Molecular Imaging Congress, Seoul, Korea, Sept. 17-20.
  1. Song T, Hu Z, Wang K, Liu X, Tian J. A research of small animal Cerenkov surgical navigation system. The 2014 World Molecular Imaging Congress, Seoul, Korea, Sept. 17-20.
  1.  Liu H, Hu Z, Wang K, Mu W, Tian J. An improved multispectral Cerenkov luminescence tomography for the mouse with the implanted radioactive source. The 2013 Annual Meeting of the Society of Nuclear Medicine and Molecular Imaging, Vancouver, Canada, Jul. 8-12.
  1. Wang K, Hu Z, Liu H, Mu W, Tian J. In vivo hybrid spectral Cerenkov luminescence tomography using positron-emitting radiopharmaceutical 18F-FDG. The 2013 World Molecular Imaging Congress, Georgia, USA, Sept. 18-21.
  1. Mu W, Liu H, Shen W, Hu Z, Wang K, Tian J. Automatic extraction of Region of Interest from the emerging Cerenkov Luminescence Endoscopy Images. The 2013 World Molecular Imaging Congress, Georgia, USA, Sept. 18-21.
  1. Mu W, Liu H, Ding X, Song T, Hu Z, Wang K, Tian J. Uncoupled Endoscopic Cerenkov luminescence Imaging of Small Animals. The 13th Annual Conference of Chinese Biophysics Society, Nanchang, Jiangxi, 2013, Oct. 28-Nov. 1. 

Collaboration

The General Hospital of People’s Liberation Army (301 hospital)

General Hospital of Chinese People’s Armed Police Forces

Xijing Hospital, Fourth Military Medical University

Peking University Cancer Hospital

Zhujiang Hospital of Southern Medical University

Nanomedicine and Biosensor Laboratory, Peking University

Students

已指导学生

曹财广  博士研究生  081104-模式识别与智能系统  

李聪  硕士研究生  081104-模式识别与智能系统  

沈碧螺  硕士研究生  085211-计算机技术  

史小静  博士研究生  081104-模式识别与智能系统  

钟连珍  博士研究生  081203-计算机应用技术  

现指导学生

肖安琪  博士研究生  081104-模式识别与智能系统  

符礼丹  博士研究生  081203-计算机应用技术  

韩可依  博士研究生  081104-模式识别与智能系统  

裴子郁  硕士研究生  081104-模式识别与智能系统  

鲍杰  硕士研究生  085400-电子信息  

Honors & Distinctions

  1. ​2019     Distinguished Young Scholars Award, Beijing Natural Science Foundation
  2. 2018     Beijing Science and Technology Star Award, Beijing, China
  3. 2017     Young Investigator Award, The Chinese American Society of Nuclear Medicine and Molecular Imaging
  4. 2016     Outstanding Young Scholars Award, National Natural Science Foundation of China
  5. 2016     Young Investigator Award, The Chinese American Society of Nuclear Medicine and Molecular Imaging
  6. 2014     Gold Prize of the Invention Entrepreneurship Award, The 8th International Exhibition of Inventions (listed in the 8th place)
  7. 2014     KSMI Travel Stipend Award from the World Molecular Imaging Congress