100706-药理学

药物分子影像学
肿瘤细胞生物学
纳米科学

1999-09--2004-08   中国科学院上海生命科学研究院   理学博士
1994-09--1999-07   中国科学技术大学   理学学士

   

2016-03~现在, 中国科学院上海药物研究所, 研究员
2012-09~2016-03,Memorial Sloan Kettering Cancer Center, Senoir Reseach Scientist
2009-09~2012-09,Memorial Sloan Kettering Cancer Center, Research Associate
2008-07~2009-08,Memorial Sloan Kettering Cancer Center, Research Scholar
2004-10~2008-07,Memorial Sloan Kettering Cancer Center, Research Fellow
1999-09~2004-08,中国科学院上海生命科学研究院, 理学博士
1994-09~1999-07,中国科学技术大学, 理学学士

中药分析专论

   

（1） 中国科学院力高研究员基金, 部委级, 2018
（2） Travel award from World Molecular Imaging Congress, 其他, 2014
（3） Travel award from World Molecular Imaging Congress, 其他, 2012
（4） Poster award from World Molecular Imaging Congress, 其他, 2012
（5） Travel award from World Molecular Imaging Congress, 其他, 2008
（6） Travel award from the Fifth Annual Meeting of the Society for Molecular Imaging, 其他, 2006
（7） Travel award from the magic bullet a century later: the third La Jolla conference, 其他, 2005
（8） 中国科学院院长优秀奖, 一等奖, 院级, 2004
（9） 中国科学技术大学郭沫若奖学金, 一等奖, 研究所（学校）, 1998

（ 1 ） 靶向酪氨酸激酶识别的可逆性荧光化合物及其制备方法和应用, 2021, 第 2 作者, 专利号: CN111848657B

（ 2 ） 多通道毛细管色谱柱电喷雾离子源装置, 2021, 第 7 作者, 专利号: CN113514593A

（ 3 ） 一种色谱阀联动的移动式电喷雾离子源精准定位装置, 2021, 第 7 作者, 专利号: CN113514592A

（ 4 ） 稳定生物单元的固定装置, 2021, 第 1 作者, 专利号: CN214201159U

（ 5 ） EGFR特异识别的荧光化合物，其制备方法和用途, 2021, 第 2 作者, 专利号: CN112574240A

（ 6 ） 生物单元成像系统, 2020, 第 1 作者, 专利号: CN212160221U

（ 7 ） 多通道毛细管色谱柱控温加电装置, 2020, 第 7 作者, 专利号: CN211825882U

（ 8 ） 用于观测生物单元的固定装置, 2019, 第 2 作者, 专利号: CN209148956U

（ 9 ） 用于观测生物单元的固定装置, 2019, 第 2 作者, 专利号: CN109975969A

（ 10 ） 生物单元成像系统, 2019, 第 1 作者, 专利号: CN109782428A

   

（1） A c-MET-Targeted Topical Fluorescent Probe cMBP-ICG Improves Oral Squamous Cell Carcinoma Detection in Humans, ANNALS OF SURGICAL ONCOLOGY, 2023, 通讯作者
（2） Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO, NATURE COMMUNICATIONS, 2023, 第 9 作者
（3） 18 F-FDG PET as an imaging biomarker for the response to FGFR-targeted therapy of cancer cells via FGFR-initiated mTOR, THERANOSTICS, 2022, 通讯作者
（4） Identification of ST3GAL5 as a prognostic biomarker correlating with CD8(+) T cell exhaustion in clear cell renal cell carcinoma, FRONTIERS IN IMMUNOLOGY, 2022, 通讯作者
（5） Rauwolfia vomitoria extract suppresses benign prostatic hyperplasia by inducing autophagic apoptosis through endoplasmic reticulum stress, BMCCOMPLEMENTARYMEDICINEANDTHERAPIES, 2022, 通讯作者
（6） Information Entropy-Based Strategy for the Quantitative Evaluation of Extensive Hyperspectral Images to Better Unveil Spatial Heterogeneity in Mass Spectrometry Imaging, ANALYTICAL CHEMISTRY, 2022, 通讯作者
（7） Comprehensive landscape of the ST3GAL family reveals the significance of ST3GAL6-AS1/ST3GAL6 axis on EGFR signaling in lung adenocarcinoma cell invasion, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2022, 通讯作者
（8） Identification of hexosamine biosynthesis pathway as a novel prognostic signature and its correlation with immune infiltration in bladder cancer, FRONTIERS IN MOLECULAR BIOSCIENCES, 2022, 通讯作者
（9） Nuclear miR-30b-5p suppresses TFEB-mediated lysosomal biogenesis and autophagy, CELL DEATH AND DIFFERENTIATION, 2021, 通讯作者
（10） Oxidized Low-Density Lipoprotein Links Hypercholesterolemia and Bladder Cancer Aggressiveness by Promoting Cancer Stemness, CANCER RESEARCH, 2021, 通讯作者
（11） Genetically Encoded Benzoyllysines Serve as Versatile Probes for Interrogating Histone Benzoylation and Interactions in Living Cells, ACS CHEMICAL BIOLOGY, 2021, 第 7 作者
（12） CBX7 suppresses urinary bladder cancer progression via modulating AKR1B10-ERK signaling, CELL DEATH & DISEASE, 2021, 通讯作者
（13） Reprogramming the immunosuppressive microenvironment of IDH1 wild-type glioblastoma by blocking Wnt signaling between microglia and cancer cells, ONCOIMMUNOLOGY, 2021, 通讯作者
（14） PDE4B Induces Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Is Transcriptionally Suppressed by CBX7, FRONTIERS IN CELL AND DEVELOPMENTAL BIOLOGY, 2021, 第 7 作者
（15） Discovery of Potent and Selective CDK9 Degraders for Targeting Transcription Regulation in Triple-Negative Breast Cancer, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
（16） Define Mesenchymal Stem Cell from Its Fate: Biodisposition of Human Mesenchymal Stem Cells in Normal and Concanavalin A-Induced Liver Injury Mice, JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2021, 第 10 作者
（17） Single cell Raman spectroscopy to identify different stages of proliferating human hepatocytes for cell therapy, STEM CELL RESEARCH & THERAPY, 2021, 通讯作者
（18） Identification of glycogene-type and validation of ST3GAL6 as a biomarker predicts clinical outcome and cancer cell invasion in urinary bladder cancer, THERANOSTICS, 2020, 通讯作者
（19） Identification of Highly Selective Lipoprotein-Associated Phospholipase A2 (Lp-PLA2) Inhibitors by a Covalent Fragment-Based Approach, JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 10 作者
（20） Pao Pereira extract suppresses benign prostatic hyperplasia by inhibiting inflammation-associated NF kappa B signaling, BMC COMPLEMENTARY MEDICINE AND THERAPIES, 2020, 通讯作者
（21） Light-induced primary amines and o-nitrobenzyl alcohols cyclization as a versatile photoclick reaction for modular conjugation, NATURE COMMUNICATIONS, 2020, 其他（合作组作者）
（22） Downregulation of TET1 Promotes Bladder Cancer Cell Proliferation and Invasion by Reducing DNA Hydroxymethylation of AJAP1, FRONTIERS IN ONCOLOGY, 2020, 通讯作者
（23） A pH ratiometrically responsive surface enhanced resonance Raman scattering probe for tumor acidic margin delineation and image-guided surgery, CHEMICAL SCIENCE, 2020, 第 13 作者
（24） MiR-629-5p promotes the invasion of lung adenocarcinoma via increasing both tumor cell invasion and endothelial cell permeability, ONCOGENE, 2020, 通讯作者
（25） Solution-processed upconversion photodetectors based on quantum dots, NATURE ELECTRONICS, 2020, 第 9 作者
（26） Three dimensional drift control at nano-scale in single molecule localization microscopy, OPTICS EXPRESS, 2020, 通讯作者
（27） Selective N-glycan editing on living cell surfaces to probe glycoconjugate function, NATURE CHEMICAL BIOLOGY, 2020, 第 15 作者
（28） Detection of Premalignant Gastrointestinal Lesions Using Surface-Enhanced Resonance Raman Scattering−Nanoparticle Endoscopy, ACS NANO, 2019, 第 3 作者
（29） Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells., ACTA PHARMACOLOGICA SINICA, 2019, 通讯作者
（30） Imaging Tumorous Methylglyoxal by an Activatable Near-Infrared Fluorescent Probe for Monitoring Glyoxalase 1 Activity, ANALYTICAL CHEMISTRY, 2019, 第 9 作者
（31） Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells, Inhibition of G9a by a small molecule inhibitor, UNC0642, induces apoptosis of human bladder cancer cells, 中国药理学报:英文版, 2019, 通讯作者
（32） Metabolic Evaluation of MYCN-Amplified Neuroblastoma by 4-18FFGln PET Imaging., MOLECULAR IMAGING AND BIOLOGY, 2019, 第 6 作者
（33） MiR-1205 functions as a tumor suppressor by disconnecting the synergy between KRAS and MDM4/E2F1 in non-small cell lung cancer., AMERICAN JOURNAL OF CANCER RESEARCH, 2019, 通讯作者
（34） Identification of metabolic vulnerabilities of receptor tyrosine kinases-driven cancer, NATURE COMMUNICATIONS, 2019, 第 16 作者
（35） INHIBITION OF G9A BY A SMALL MOLECULE INHIBITOR, UNC0642, INDUCES APOPTOSIS OF HUMAN BLADDER CANCER CELLS, JOURNAL OF UROLOGY, 2019, 
（36） Metabolic Evaluation of MYCN-Amplified Neuroblastoma by 4-F-18FGln PET Imaging, MOLECULAR IMAGING AND BIOLOGY, 2019, 第 6 作者
（37） Pao Pereira Extract Attenuates Testosterone-Induced Benign Prostatic Hyperplasia in Rats by inhibiting 5 alpha-Reductase, SCIENTIFIC REPORTS, 2019, 通讯作者
（38） Uncovering kappa-opioid receptor agonist-induced PAK1/2 phosphorylation by quantitative phosphoproteomics, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2019, 通讯作者
（39） Direct C-H functionalization of difluoroboron dipyrromethenes (BODIPYs) at beta-position by iodonium salts, RSC ADVANCES, 2018, 通讯作者
（40） Metabolic benefits of inhibition of p38α in white adipose tissue in obesity., PLOS BIOLOGY, 2018, 第 15 作者
（41） Wnt7a activates canonical Wnt signaling, promotes bladder cancer cell invasion, and is suppressed by miR-370-3p, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 第11作者
（42） Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3, ACTA PHARMACOLOGICA SINICA, 2018, 通讯作者
（43） Metabolic benefits of inhibition of p38 alpha in white adipose tissue in obesity, PLOS BIOLOGY, 2018, 第 15 作者
（44） A novel USP9X substrate TTK contributes to tumorigenesis in non-small-cell lung cancer., THERANOSTICS, 2018, 第11作者
（45） Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3, Modified citrus pectin inhibited bladder tumor growth through downregulation of galectin-3, 中国药理学报:英文版, 2018, 第11作者
（46） Design, synthesis and biological evaluation of a series of novel 2-benzamide-4-(6-oxy-N-methyl-1-naphthamide)-pyridine derivatives as potent fibroblast growth factor receptor (FGFR) inhibitors, ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY, 2018, 
（47） Fluorescent Imaging of beta-Amyloid Using BODIPY Based Near-Infrared Off-On Fluorescent Probe, BIOCONJUGATE CHEMISTRY, 2018, 通讯作者
（48） Combination chemotherapy with Zyflamend reduced the acquired resistance of bladder cancer cells to cisplatin through inhibiting NFκB signaling pathway., ONCOTARGETS AND THERAPY, 2018, 第 9 作者
（49） A regulatory circuit HP1γ/miR-451a/c-Myc promotes prostate cancer progression., Oncogene, 2018, 第 1 作者
（50） Combination chemotherapy with Zyflamend reduced the acquired resistance of bladder cancer cells to cisplatin through inhibiting NF kappa B signaling pathway, ONCOTARGETS AND THERAPY, 2018, 通讯作者
（51） Dual-Modality Surface-Enhanced Resonance Raman Scattering and Multispectral Optoacoustic Tomography Nanoparticle Approach for Brain Tumor Delineation, SMALL, 2018, 第 6 作者
（52） Triptolide Inhibits the AR Signaling Pathway to Suppress the Proliferation of Enzalutamide Resistant Prostate Cancer Cells, THERANOSTICS, 2017, 第 6 作者
（53） Cancer imaging using surface-enhanced resonance Raman scattering nanoparticles, NATURE PROTOCOLS, 2017, 第 3 作者
（54） Honokiol inhibits bladder cancer cell invasion through repressing SRC‑3expression and epithelial‑mesenchymal transition, ONCOLOGY LETTERS, 2017, 第 3 作者
（55） TGF beta 1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer, THERANOSTICS, 2017, 第 10 作者
（56） TGFβ1 Promotes Gemcitabine Resistance through Regulating the LncRNA-LET/NF90/miR-145 Signaling Axis in Bladder Cancer., Theranostics, 2017, 第 1 作者
（57） Detection of Lymph Node Metastases with SERRS Nanoparticles, MOLECULAR IMAGING AND BIOLOGY, 2016, 第 3 作者
（58） High Precision Imaging of Microscopic Spread of Glioblastoma with a Targeted Ultrasensitive SERRS Molecular Imaging Probe, THERANOSTICS, 2016, 第 1 作者
（59） Surface-Enhanced Resonance Raman Scattering Nanostars for High Precision Cancer Imaging, SCIENCE TRANSLATIONAL MEDICINE, 2015, 第 2 作者
（60） Imaging the norepinephrine transporter in neuroblastoma: a comparison of 18F-MFBG and 123I-MIBG., CLINICAL CANCER RESEARCH : AN OFFICIAL JOURNAL OF THE AMERICAN ASSOCIATION FOR CANCER RESEARCH, 2014, 第 2 作者
（61） Integrin αvβ3-targeted IRDye 800CW near-infrared imaging of glioblastoma., Clinical Cancer Research, 2012, 第 1 作者
（62） ATP binding cassette transporters modulate both coelenterazine- and D-luciferin- based bioluminescence imaging, MOLECULAR IMAGING, 2011, 第 1 作者
（63） A specific splicing variant of SVH, a novel human armadillo repeat protein, is up-regulated in hepatocellular carcinomas, CANCER RESEARCH, 2003, 
（64） Upstream binding factor up-regulated in hepatocellular carcinoma is related to the survival and cisplatin-sensitivity of cancer cells, FASEB JOURNAL, 2002, 
（65） MYCN and MYC regulate tumor proliferation and tumorigenesis directly through BMI1 in human neuroblastomas, THE FASEB JOURNAL, 第 1 作者

Molecular imaging: reporter gene imaging., SpringerLink, 2008-12, 第 3 作者

   

（ 1 ） 中国科学院****, 负责人, 中国科学院计划, 2017-01--2021-12
（ 2 ） 近红外荧光/光声双模态体内成像技术对阿尔茨海默病老年斑特异识别诊疗探针的评估研究, 负责人, 研究所自主部署, 2016-09--2018-08
（ 3 ） HP1γ作为膀胱癌吉西他滨/顺铂耐药后新靶标的机制研究, 负责人, 研究所自主部署, 2016-09--2018-08
（ 4 ） 应用肿瘤代谢显像技术对靶向抗肿瘤候选新药敏感标志物的预测与监控研究, 负责人, 中国科学院计划, 2017-01--2019-12
（ 5 ） c-Met靶向荧光关开型小分子探针在肿瘤细胞的分子分型中的应用研究, 负责人, 研究所自主部署, 2017-05--2018-04
（ 6 ） 开发抗体类药物的正电子核素标记技术, 负责人, 研究所自主部署, 2017-12--2019-11
（ 7 ） 具有表面增强拉曼共振活性的纳米探针在结直肠癌前病变早期检测和治疗中的应用研究, 负责人, 国家任务, 2018-01--2021-12
（ 8 ） 创建基于新药敏感与疗效标志物的临床研究及转化的分子影像和分子诊断技术体系, 负责人, 国家任务, 2018-01--2020-12
（ 9 ） 应用多模态影像技术监控由药靶活性改变和代谢重编程介导的肿瘤对c-Met靶向治疗耐药的研究, 负责人, 国家任务, 2019-01--2021-12
（ 10 ） 糖基修饰相关酶在肿瘤中的功能机制研究, 负责人, 地方任务, 2021-01--2024-12
（ 11 ） 基于新型靶向共价结合荧光探针的可视化表皮生长因子受体（EGFR）复合体系统的动态单分子成像研究, 负责人, 国家任务, 2022-01--2025-12
（ 12 ） 糖基转移酶ST3GAL6作为膀胱癌新靶点及调控肿瘤侵袭转移的机制研究, 负责人, 地方任务, 2020-10--2023-09
（ 13 ） miR-629-5p在肺腺癌浸润中作为小核酸药物靶标的可视化研究, 负责人, 研究所自主部署, 2020-04--2021-04

（1）分子影像学在肿瘤生物学中的应用   上海交通大学基础医学院创新论坛   2018-06-01
（2）超灵敏拉曼纳米颗粒在微小肿瘤检测中的应用   浙江大学明德弘药论坛   2017-05-02
（3）Ultra-Sensitive Raman Nanoparticles for Detection of Microscopic Cancer   西安电子科技大学生命科学技术学院年会   2016-11-12
（4）RGD Peptide-Conjugated Molecular Imaging Probes for Microscopic Brain Tumor   2016-07-04
（5）Integrin-targeting Surface-Enhanced Resonant Raman Spectroscopy Nanoparticle    2014-09-18
（6）Detection of Microscopic Sarcoma   2014-09-18
（7）Ultra-Sensitive Raman Nanoparticles for Detection of Microscopic Cancer   2014-09-17
（8）Monitoring activity of Notch signaling pathway by bioluminescence and fluorescence imaging   2006-04-05
（9）Establishing a reporter system in transgenic mice to assess Bmi1 activity by non-Invasive imaging during medulloblastoma oncogenesis.   2005-02-10