基本信息

孙蕾  女  博士 研究员  中国科学院微生物研究所
电子邮件: sunlei362@im.ac.cn
通信地址: 北京市朝阳区北辰西路1号院3号
邮政编码: 100101

研究领域

流感病毒致病机理、抗病毒天然免疫及抗病毒制品的研究。


招生信息

   
招生专业
071005-微生物学
招生方向
抗病毒天然免疫
分子病毒学

教育背景

2000-07--2005-06   扬州大学   博士
1996-09--2000-06   山东农业大学   学士

工作经历

   
工作简历
2019-10~现在, 中国科学院微生物研究所, 研究员
2011-08~2012-11,美国康奈尔大学医学院, 访问助理教授
2009-06~现在, 中国科学院微生物研究所, 副研究员
2005-07~2009-06,中国科学院微生物研究所, 助理研究员

教授课程

医学病毒学

出版信息

   
发表论文
(1) RIG-I 敲除293T 细胞系的建立及其对B 型流感病毒复 制的影响, 生物工程学报, 2019-09, 通讯作者
(2) Phosphorylation Status of Tyrosine 78 Residue Regulates the Nuclear Export and Ubiquitination of Influenza A Virus Nucleoprotein, Frontiers in Microbiology, 2019-08, 通讯作者
(3) Naproxen exhibits broad anti-influenza virus activity in mice by impeding viral nucleoprotein nuclear export, Cell Reports, 2019, 通讯作者
(4) Latent Membrane Protein 1 of Epstein–Barr Virus Promotes RIG-I Degradation Mediated by Proteasome Pathway, Frontiers in Immunology, 2018, 第 2 作者
(5) 胞外亲环素 A 对炎症发生的影响及其抗体在抑制炎症反应中的作用, 生物工程学报, 2018, 通讯作者
(6) CDC25B promotes influenza A virus replication by regulating the phosphorylation of nucleoprotein, Virology, 2018, 通讯作者
(7) CypA Regulates AIP4-mediated M1 Ubiquitination of Influenza A Virus, Virologica Sinica, 2018, 通讯作者
(8) A promising IFN-deficient system to manufacture IFN-sensitive influenza vaccine virus, Frontiers in Cellular and Infection Microbiology, 2018, 通讯作者
(9) Phosphorylation and dephosphorylation of threonine 188 in nucleoprotein is crucial for the replication of influenza A virus, Virology, 2018, 通讯作者
(10) Cyclophilin A-regulated ubiquitination is critical for RIG-I-mediated antiviral immune responses, eLife, 2017, 通讯作者
(11) Robust Lys 63-linked Ubiquitination of RIG-I Promotes Cytokine Eruption in Early Influenza B Virus Infection, Journal of Virology, 2016, 第 7 作者
(12) 脊椎动物Cyclophilin A肽基脯氨酰顺反异构酶活性及遗传变异分析, 遗传, 2016, 通讯作者
(13) Threonine 80 phosphorylation of Non-structural protein NS1 regulates the replication of influenza a virus by reducing the binding affinity with RIG-I, Cellular Microbiology, 2016, 通讯作者
(14) Differential Nucleocytoplasmic Shuttling of the Nucleoprotein of Influenza A Viruses and Association with Host Tropism, Cellular Microbiology, 2016, 通讯作者
(15) Characteristics of Nucleocytoplasmic Transport of H1N1 Influenza A Virus Nuclear Export Protein, Journal of Virology, 2014, 第 4 作者
(16) Tyrosine 132 Phosphorylation of Influenza A Virus M1 Protein Is Crucial for Virus Replication by Controlling the Nuclear Import of M1, Journal of Virology, 2013, 第 4 作者
(17) Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein, PLos One, 2012, 第 4 作者
(18) Recombinant chicken interferon alpha inhibits H9N2 avian influenza virus replication in vivo by oral administration, Journal of Interferon Cytokine Research, 2011, 通讯作者
(19) Novel genetic reassortants in H9N2 influenza A viruses and their diverse pathogenicity to mice, Virology Journal, 2011, 通讯作者
(20) Subcellular localization and topology of porcine reproductive and respiratory syndrome virus E protein, Virus Research, 2010, 第 3 作者
(21) Chicken cyclophilin A is an inhibitory factor to influenza virus replication, Virology Journal, 2010, 第 4 作者
(22) Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication, Cellular Microbiology, 2009, 第 2 作者
(23) Genetic correlation between H3N2 human and swine influenza viruses, Journal of Clinical Virology, 2009, 第 1 作者
(24) Genetic correlation between current circulating H1N1 swine and human influenza viruses, Journal of Clinical Virology, 2009, 通讯作者
(25) F gene recombination between genotype II and VII Newcastle disease virus, Virus Research, 2008, 第 1 作者
(26) Cloning and characterization of a novel feline IFN-omega, Journal of Interferon Cytokine Research, 2007, 第 3 作者
(27) A Massachusetts prototype like coronavirus isolated from wild peafowls is pathogenic to chickens, Virus Research, 2007, 第 1 作者