基本信息
徐明  男  硕导  中国科学院生态环境研究中心
email: mingxu@rcees.ac.cn
address: 北京市海淀区双清路18号,中国科学院生态环境研究中心
postalCode: 100085
部门/实验室:人事教育处

研究领域

   

招生信息

   
招生专业
0703J1-纳米科学与技术
0703Z1-化学生物学
070302-分析化学
招生方向
典型环境污染物的靶蛋白识别与毒性机理
环境污染物与人体健康

教育背景

2006-09--2011-06   厦门大学,化学化工学院   理学博士
2002-09--2006-06   厦门大学,化学化工学院   理学学士
学历
   
学位
   

工作经历

   
工作简历
2016-01~现在, 中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室, 副研究员
2014-02~2015-12,中国科学院生态环境研究中心,环境化学与生态毒理学国家重点实验室, 助理研究员
2011-09~2013-12,法国国家科学研究院(CNRS), 博士后
2006-09~2011-06,厦门大学,化学化工学院, 理学博士
2002-09~2006-06,厦门大学,化学化工学院, 理学学士
社会兼职
   

教授课程

现代生物学技术在环境健康研究中的应用

专利与奖励

   
奖励信息
   
专利成果
   

出版信息

   
发表论文
(1) 大气细颗粒物导致呼吸系统疾病及相关生物机制的研究进展, 中国科学:化学, 2018, 第 11 作者
(2) Computational Investigations of the Interaction between the Cell Membrane and Nanoparticles Coated with Pulmonary Surfactant, ACS Applied Materials & Interfaces, 2018, 第 2 作者
(3) Reduction of Graphene Oxide Alters Its Cyto-Compatibility Towards Primary and Immortalized Macrophages, Nanoscale, 2018, 第 5 作者
(4) Towards the prediction of protein corona formation and in vitro and in vivo interactions of gold nanoparticles based on their physicochemical properties, ACS Nano, 2018, 第 1 作者
(5) Preliminary investigation on cytotoxicity of fluorinated polymer nanoparticles, Journal of Environmental Sciences-China, 2018, 第 11 作者
(6) Low-dose exposure of graphene oxide significantly increases metal toxicity to macrophages by altering their cellular priming state, Nano Research, 2018, 第 1 作者
(7) Molybdenum disulfide (MoS2)/graphene oxide (GO) nanocomposites show favorable lung targeting and enhanced drug loading/tumor-killing efficacy with improved biocompatibility, NPG Asia Materials, 2018, 第 4 作者
(8) LncRNA UCA1 attenuates autophagy-dependent cell death through blocking autophagic flux under arsenic stress, Toxicology Letters, 2018, 第 3 作者
(9) Graphene oxide regulates cox2 in human embryonic kidney 293T cells via epigenetic mechanisms: dynamic chromosomal interactions, Nanotoxicology, 2018, 第 4 作者
(10) Long non-coding RNA MT1DP shunts the cellular defense to cytotoxicity through crosstalk with MT1H and RhoC in cadmium stress, Cell Discovery, 2018, 第 4 作者
(11) LncRNA MT1DP Aggravates Cadmium‐Induced Oxidative Stress by Repressing the Function of Nrf2 and is Dependent on Interaction with miR‐365, Advanced Science, 2018, 第 3 作者
(12) Graphene Oxide Induced Perturbation to Plasma Membrane and Cytoskeletal Meshwork Sensitize Cancer Cells to Chemotherapeutic Agents, ACS Nano, 2017, 第 11 作者
(13) A protective role of Heme-regulated eIF2a kinase in cadmium-induced liver and kidney injuries, Chemosphere, 2017, 第 4 作者
(14) Genome-Wide DNA Methylation Variations upon Exposure to Engineered Nanomaterials and Their Implications in Nanosafety Assessment, Advanced Materials, 2017, 第 2 作者
(15) Nrf-2-driven long noncoding RNA ODRUL contributes to modulating silver nanoparticle-induced effects on erythroid cells, Biomaterials, 2017, 第 5 作者
(16) 纳米银生物过程及影响的研究进展, 中国材料进展, 2016, 第 1 作者
(17) Improved In Vitro and In Vivo Biocompatibility of Graphene Oxide through Surface Modification: Poly(Acrylic Acid)-Functionalization is Superior to PEGylation, ACS Nano, 2016, 第 1 作者
(18) Se-Hg Dual-element Labeling Strategy for Selectively Recognizing Selenoprotein and Selenopeptide, Chinese Journal of Analytical Chemistry, 2015, 第 1 作者
(19) Disruption of iron homeostasis and resultant health effects upon exposure to various environmental pollutants: A critical review, Journal of Environmental Sciences-China, 2015, 第 11 作者
(20) Silver nanoparticle-induced hemoglobin decrease involves alteration of histone 3 methylation status, Biomaterials, 2015, 第 4 作者
(21) Development of a non-denaturing 2D gel electrophoresis protocol for screening in vivo uranium-protein targets in Procambarus clarkii with laser ablation ICP MS followed by protein identification by HPLC–Orbitrap MS, Talanta, 2014, 第 1 作者
(22) Non-denaturating isoelectric focusing gel electrophoresis for uranium–protein complexes quantitative analysis with LA-ICP MS, Analytical and Bioanalytical Chemistry, 2014, 第 1 作者
(23) Investigating the response of cuproproteins from oysters (Crassostrea gigas) after waterborne copper exposure by metallomic and proteomic, Metallomics, 2014, 第 1 作者
(24) Nanosilver incurs an adaptive shunt of energy metabolism mode to glycolysis in tumor and nontumor cells, ACS Nano, 2014, 第 3 作者
(25) Chemical interactions of mercury species and some transition and noble metals towards metallothionein (Zn7MT-2) evaluated using SEC/ICP-MS, RP-HPLC/ESI-MS and MALDI-TOF-MS, Metallomics, 2013, 第 1 作者
(26) A way to probe the microenvironment of free sulfhydryls in intact proteins with a series of monofunctional organic mercurials, Chemistry - A European Journal, 2012, 第 1 作者
(27) A dual-labelling strategy for integrated ICPMS and LIF for the determination of peptides, Journal of Analytical Atomic Spectrometry, 2011, 第 3 作者
(28) Strategies for Protein Quantification by Integrated Elemental and Molecular Mass Spectrometry, Clinical Chemistry and Laboratory Medicine, 2011, 第 2 作者
(29) Dynamic labeling strategy with 204Hg-isotopic methylmercurithiosalicylate for absolute peptide and protein quantification, Analytical Chemistry, 2010, 第 1 作者
(30) Free cadmium ions released from CdTe-based nanoparticles and their cytotoxicity on Phaeodactylum tricornutum, Metallomics, 2010, 第 1 作者
(31) Absolute quantification of intact proteins via 1,4,7,10-tetraazacyclododecane-1,4,7-trisacetic acid-10-maleimidoethylacetamide-europium labeling and HPLC coupled with species-unspecific isotope dilution ICPMS, Analytical Chemistry, 2010, 第 2 作者
(32) Strategy for absolute quantification of proteins: CH3Hg+ labeling integrated molecular and elemental mass spectrometry, Journal of Analytical Atomic Spectrometry, 2009, 第 2 作者
(33) Quantification of selenium-tagged proteins in human plasma using species-unspecific isotope dilution ICP-DRC-qMS coupled on-line with anion exchange chromatography, Journal of Analytical Atomic Spectrometry, 2008, 第 1 作者
发表著作
   

科研活动

   
科研项目
( 1 ) 基于金属组学揭示纳米银肝细胞毒性的分子机制, 主持, 国家级, 2015-01--2017-12
( 2 ) 探索纳米银与重要蛋白相互作用的分子机制, 主持, 市地级, 2015-01--2015-12
( 3 ) 耐极端条件的有机含氟纳米材料的研究, 主持, 国家级, 2015-01--2019-08
( 4 ) 典型人工纳米材料的水环境过程、生物效应及其调控研究, 主持, 国家级, 2014-01--2018-12
参与会议
(1)Molecular mechanism of silver nanoparticles-induced hepatotoxicity   Ming Xu, Lining Xu, Sijin Liu   2018-10-18
(2)基于元素质谱技术揭示金纳米颗粒的理化特性与生物作用规律   第五届全国原子光谱及相关技术学术会议   徐明,刘思金   2018-09-20
(3)基于MoS2/GO纳米复合物良好生物相容性的肺部靶向载药抗肿瘤研究   中国化学会第31届学术年会   2018-05-05
(4)利用组学方法揭示纳米银生物毒性的蛋白分子作用机制   第一届全国环境化学青年学者论坛   2018-04-20
(5)纳米银的肝细胞毒性及分子作用机理   第二届全国环境纳米技术及生物效应学术研讨会   2018-04-18
(6)纳米材料在体内的转化、归趋和排泄   第四届青年学者环境纳米效应研讨会   2017-09-01
(7)Investigation of Graphene Oxide-Induced Biological Effects and Underlying Molecular Mechanisms   2017-08-19
(8)利用组学研究策略揭示纳米银生物毒性的分子机制   第四届全国原子光谱及相关技术学术会   2016-09-23
(9)氧化石墨烯与细胞膜作用机制研究   全国环境纳米技术及生物效应学术研讨会   2016-04-08
(10)氧化石墨烯的生物安全性研究   第八届全国环境化学大会   2015-11-05

合作情况

   
项目协作单位
   

指导学生