071006-神经生物学
071007-遗传学

精神疾病的生物学机制

2008-09--2013-07   中国科学院昆明动物研究所   博士学位
2004-09--2008-07   武汉大学生命科学学院   学士学位

   

2016-08~现在, 中国科学院昆明动物所, 研究员
2013-08~2016-08,美国Lieber脑发育研究所, 博士后
2008-09~2013-07,中国科学院昆明动物研究所, 博士学位
2004-09~2008-07,武汉大学生命科学学院, 学士学位

2022-09-16-今,BMC Medicine, 副主编
2022-01-01-今,Zoological Research, 青年编委
2021-08-04-今,Journal of Psychiatric Research, 编委
2021-02-08-2022-12-31,Frontiers期刊 - Neurogenomics Section, 副主编
2017-07-10-2022-12-31,Complex Psychiatry期刊, 编委
2016-06-05-2022-12-31,Functional & Integrative Genomics期刊, 副主编
2015-06-01-2022-12-31,Scientific Reports期刊, 学术主编

   

（1） A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression, MOLECULAR PSYCHIATRY, 2021, 第 15 作者
（2） A Human-Specific Schizophrenia Risk Tandem Repeat Affects Alternative Splicing of a Human-Unique Isoform AS3MT(d2d3) and Mushroom Dendritic Spine Density, SCHIZOPHRENIA BULLETIN, 2021, 通讯作者
（3） Translational genomics and beyond in bipolar disorder, Molecular Psychiatry, 2021, 通讯作者
（4） Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs, SCIENCE BULLETIN, 2021, 通讯作者
（5） Independent replications and integrative analyses confirmTRANK1as a susceptibility gene for bipolar disorder, NEUROPSYCHOPHARMACOLOGY, 2021, 通讯作者
（6） Functional Genomics Identify a Regulatory Risk Variation rs4420550 in the 16p11.2 Schizophrenia-Associated Locus, BIOLOGICAL PSYCHIATRY, 2021, 通讯作者
（7） Novel Risk Loci Associated With Genetic Risk for Bipolar Disorder Among Han Chinese Individuals A Genome-Wide Association Study and Meta-analysis, JAMA PSYCHIATRY, 2021, 通讯作者
（8） Regulation of TRANK1 by GSK-3 in the brain: unexpected interactions, MOLECULAR PSYCHIATRY, 2021, 通讯作者
（9） Identification of a functional 339 bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32, Identification of a functional 339 bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32, ZOOLOGICAL RESEARCH, 2020, 通讯作者
（10） Further confirmation of netrin 1 receptor ( DCC ) as a depression risk gene via integrations of multi-omics data, TRANSLATIONALPSYCHIATRY, 2020, 通讯作者
（11） A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population, A functional missense variant in ITIH3 affects protein expression and neurodevelopment and confers schizophrenia risk in the Han Chinese population, JOURNAL OF GENETICS AND GENOMICS, 2020, 通讯作者
（12） Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci, NEUROPSYCHOPHARMACOLOGY, 2020, 通讯作者
（13） Transcriptomic analyses of humans and mice provide insights into depression, Transcriptomic analyses of humans and mice provide insights into depression, ZOOLOGICAL RESEARCH, 2020, 通讯作者
（14） Genome-wide Association Study of Creativity Reveals Genetic Overlap With Psychiatric Disorders, Risk Tolerance, and Risky Behaviors, SCHIZOPHRENIA BULLETIN, 2020, 通讯作者
（15） The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function, and mushroom dendritic spine, MOLECULAR PSYCHIATRY, 2020, 通讯作者
（16） The schizophrenia risk isoform ZNF804AE3E4 affects dendritic spine, SCHIZOPHRENIA RESEARCH, 2020, 通讯作者
（17） Association of SYNE1 locus with bipolar disorder in Chinese population, HEREDITAS, 2019, 通讯作者
（18） Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder, NEUROPSYCHOPHARMACOLOGY, 2019, 通讯作者
（19） Interactome Analyses implicated CAMK2A in the genetic predisposition and pharmacological mechanism of Bipolar Disorder, JOURNAL OF PSYCHIATRIC RESEARCH, 2019, 通讯作者
（20） Genetic insights and neurobiological implications from NRXN1 in neuropsychiatric disorders, MOLECULAR PSYCHIATRY, 2019, 通讯作者
（21） Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese, Complement C7 is a novel risk gene for Alzheimer's disease in Han Chinese, NATIONAL SCIENCE REVIEW, 2019, 第 13 作者
（22） Systems-level analysis of risk genes reveals the modular nature of schizophrenia, SCHIZOPHRENIA RESEARCH, 2018, 第 2 作者
（23） The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders, MOLECULAR PSYCHIATRY, 2018, 
（24） The protocadherin 17 gene affects cognition, personality, amygdala structure and function, synapse development and risk of major mood disorders, MOLECULAR PSYCHIATRY, 2018, 
（25） Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population, TRANSLATIONAL PSYCHIATRY, 2018, 通讯作者
（26） Common variants on 6q16.2, 12q24.31 and 16p13.3 are associated with major depressive disorder, NEUROPSYCHOPHARMACOLOGY, 2018, 第 9 作者
（27） The Gene Encoding Protocadherin 9 (PCDH9), a Novel Risk Factor for Major Depressive Disorder, NEUROPSYCHOPHARMACOLOGY, 2018, 通讯作者
（28） Comprehensive integrative analyses identify GLT8D1 and CSNK2B as schizophrenia risk genes (vol 9, 838, 2018), NATURE COMMUNICATIONS, 2018, 第 15 作者
（29） Genetic association and meta-analysis of a schizophrenia GWAS variant rs10489202 in East Asian populations, TRANSLATIONAL PSYCHIATRY, 2018, 通讯作者
（30） Regional Selection of the Brain Size Regulating Gene CASC5 Provides New Insight into Human Brain Evolution, HUMAN GENETICS, 2017, 第 6 作者
（31） The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions, MOLECULAR PSYCHIATRY, 2017, 
（32） Identification of a Bipolar Disorder Vulnerable Gene CHDH at 3p21.1, MOLECULAR NEUROBIOLOGY, 2017, 通讯作者
（33） No association between schizophrenia susceptibility variants and macroscopic structural brain volume variation in healthy subjects, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2016, 第 1 作者
（34） MAOA Variants and Genetic Susceptibility to Major Psychiatric Disorders, MOLECULAR NEUROBIOLOGY, 2016, 通讯作者
（35） Replication of Han Chinese GWAS loci for schizophrenia via meta-analysis of four independent samples, SCHIZOPHRENIA RESEARCH, 2016, 第 2 作者
（36） Recent Positive Selection Drives the Expansion of a Schizophrenia Risk Nonsynonymous Variant at SLC39A8 in Europeans, SCHIZOPHRENIA BULLETIN, 2016, 通讯作者
（37） A Genetic Mechanism for Convergent Skin Lightening during Recent Human Evolution, MOLECULAR BIOLOGY AND EVOLUTION, 2016, 第 18 作者
（38） A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2016, 通讯作者
（39） Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance, BRITISH JOURNAL OF PSYCHIATRY, 2016, 通讯作者
（40） A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia-associated locus, NATURE MEDICINE, 2016, 第 1 作者
（41） Adaptive evolution of interleukin-3 (IL3), a gene associated with brain volume variation in general human populations, HUMAN GENETICS, 2016, 第 1 作者
（42） The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2016, 通讯作者
（43） Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function, SCHIZOPHRENIA BULLETIN, 2015, 第 3 作者
（44） Common variants of IRF3 conferring risk of schizophrenia, JOURNAL OF PSYCHIATRIC RESEARCH, 2015, 通讯作者
（45） DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain, TRANSLATIONAL PSYCHIATRY, 2015, 
（46） Allelic variation at 5-HTTLPR is associated with brain morphology in a Chinese population, PSYCHIATRY RESEARCH, 2015, 通讯作者
（47） A Functional MiR-124 Binding-Site Polymorphism in IQGAP1 Affects Human Cognitive Performance, PLOS ONE, 2014, 第 3 作者
（48） Protein-Protein Interaction and Pathway Analyses of Top Schizophrenia Genes Reveal Schizophrenia Susceptibility Genes Converge on Common Molecular Networks and Enrichment of Nucleosome (Chromatin) Assembly Genes in Schizophrenia Susceptibility Loci, SCHIZOPHRENIA BULLETIN, 2014, 第 4 作者
（49） Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene, MOLECULAR PSYCHIATRY, 2014, 
（50） Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility, MOLECULAR PSYCHIATRY, 2014, 
（51） Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from the European genome-wide association study in Asian populations, NEUROBIOLOGY OF AGING, 2014, 第 1 作者
（52） Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder: Future Studies, AMERICAN JOURNAL OF PSYCHIATRY, 2013, 通讯作者
（53） SLC6A15 rs1545843 and Depression: Implications From Brain Imaging Data, AMERICAN JOURNAL OF PSYCHIATRY, 2013, 通讯作者
（54） Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and human origin, BMC Biology, 2013, 第 1 作者
（55） Impact of the genome-wide schizophrenia risk single nucleotide polymorphism (rs1625579) in miR-137 on brain structures in healthy individuals, PSYCHIATRIC GENETICS, 2013, 第 1 作者
（56） Identification of a Tibetan-Specific Mutation in the Hypoxic Gene EGLN1 and Its Contribution to High-Altitude Adaptation, MOLECULAR BIOLOGY AND EVOLUTION, 2013, 第 8 作者
（57） Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population, WORLD JOURNAL OF BIOLOGICAL PSYCHIATRY, 2013, 第 1 作者
（58） Genetic analysis of common variants in the CMYA5 (cardiomyopathy-associated 5) gene with schizophrenia, PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY, 2013, 第 3 作者
（59） Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia, SCHIZOPHRENIA RESEARCH, 2013, 第 3 作者
（60） Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and the origin of humans, BMC BIOLOGY, 2013, 第 2 作者
（61） Meta-analysis supports association of a non-synonymous SNP in ZNF804A with schizophrenia, SCHIZOPHRENIA RESEARCH, 2013, 第 1 作者
（62） Meta-Analysis Indicates That the European GWAS-Identified Risk SNP rs1344706 within ZNF804A Is Not Associated with Schizophrenia in Han Chinese Population, PLOS ONE, 2013, 第 1 作者
（63） An Evaluation of Association between a Novel Hippocampal Biology Related SNP (rs7294919) and Schizophrenia, PLOS ONE, 2013, 通讯作者
（64） ZNF804A and schizophrenia susceptibility in Asian populations, AMERICAN JOURNAL OF MEDICAL GENETICS PART B-NEUROPSYCHIATRIC GENETICS, 2012, 第 1 作者
（65） Meta-analysis and brain imaging data support the involvement of VRK2 (rs2312147) in schizophrenia susceptibility, SCHIZOPHRENIA RESEARCH, 2012, 第 1 作者
（66） MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene, GENE, 2012, 第 2 作者
（67） The Interleukin 3 Gene (IL3) Contributes to Human Brain Volume Variation by Regulating Proliferation and Survival of Neural Progenitors, PLOS ONE, 2012, 第 2 作者
（68） A common variant of the cardiomyopathy associated 5 gene (CMYA5) is associated with schizophrenia in Chinese population, SCHIZOPHRENIA RESEARCH, 2011, 第 1 作者
（69） Allelic Differences Between Han Chinese and Europeans for Functional Variants in ZNF804A and Their Association With Schizophrenia, AMERICAN JOURNAL OF PSYCHIATRY, 2011, 第 1 作者
（70） Genetic association and identification of a functional SNP at GSK3 beta for schizophrenia susceptibility, SCHIZOPHRENIA RESEARCH, 2011, 第 1 作者
（71） Genetic association and identification of a functional SNP at GSK3b for schizophrenia susceptibility, Schizophrenia Research, 2011, 第 1 作者
（72） Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population, ARTHRITIS RESEARCH & THERAPY, 2011, 第 3 作者
（73） Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis, MOLECULAR NEUROBIOLOGY, 

   

（ 1 ） 中科院率先行动“****”C类, 负责人, 中国科学院计划, 2016-08--2021-07
（ 2 ） 精神疾病的功能基因组学, 负责人, 国家任务, 2018-01--2020-12
（ 3 ） 中组部青年****, 负责人, 其他国际合作项目, 2018-02--2022-02
（ 4 ） 剪接体AS3MTd2d3在中国人群影响精神分裂症发生的生物学机制, 负责人, 国家任务, 2020-01--2023-12
（ 5 ） 精神分裂症风险蛋白AS3MT突变体影响神经发育和认知功能的机制研究, 负责人, 地方任务, 2022-06--2025-05
（ 6 ） 双相障碍的病因学, 负责人, 国家任务, 2023-01--2027-12
（ 7 ） 春城计划高层次创新创业团队, 参与, 地方任务, 2023-01--2027-12

（1）Characterization of an AS3MT Human Unique Isoform as a Potential Mechanism for Genetic Risk of Psychosis   中国精神疾病遗传学峰会   Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR   2015-04-11
（2）A Human-specific Isoform of AS3MT Regulated by a Human-unique Variation Explains Susceptibility to Psychiatric Illness   Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR   2014-12-07
（3）Cis-acting Regulation of a Novel AS3MT Transcript by a Genome-wide Supported Risk Variant for Schizophrenia   Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR   2014-11-15
（4）Cis-acting Regulation of a Novel AS3MT Transcript by a Genome-wide Supported Risk Variant for Schizophrenia   Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR   2014-05-08