基本信息
李明  男  博导  中国科学院昆明动物研究所
电子邮件: limingkiz@mail.kiz.ac.cn
通信地址: 云南省昆明市盘龙区茨坝街道龙欣路17号
邮政编码: 650223

招生信息

   
招生专业
071006-神经生物学
071007-遗传学
招生方向
精神疾病的生物学机制

教育背景

2008-09--2013-07   中国科学院昆明动物研究所   博士学位
2004-09--2008-07   武汉大学生命科学学院   学士学位

工作经历

   
工作简历
2016-08~现在, 中国科学院昆明动物所, 研究员
2013-08~2016-08,美国Lieber脑发育研究所, 博士后
2008-09~2013-07,中国科学院昆明动物研究所, 博士学位
2004-09~2008-07,武汉大学生命科学学院, 学士学位
社会兼职
2021-02-09-今,Frontiers期刊 - Neurogenomics Section, 副主编
2017-07-11-今,Complex Psychiatry期刊, 编委
2016-06-06-今,Functional & Integrative Genomics期刊, 副主编
2015-06-02-今,Scientific Reports期刊, 学术主编

出版信息

   
发表论文
(1) Novel risk loci associated with genetic risk for bipolar disorder among Han Chinese individuals: A genome-wide association study and meta-analysis, JAMA Psychiatry, 2021, 通讯作者
(2) Functional genomics identify a regulatory risk variation rs4420550 in the 16p11.2 schizophrenia-associated locus, Molecular Psychiatry, 2021, 通讯作者
(3) Translational genomics and beyond in bipolar disorder, Molecular Psychiatry, 2021, 通讯作者
(4) Whole genome analyses reveal significant convergence in obsessive-compulsive disorder between humans and dogs, Science Bulletin, 2021, 通讯作者
(5) A human-specific schizophrenia risk tandem repeat affects alternative splicing of a human-unique isoform AS3MTd2d3 and mushroom dendritic spine density, Schizophrenia Bulletin, 2021, 通讯作者
(6) Independent replications and integrative analyses confirm TRANK1 as a susceptibility gene for bipolar disorder, Neuropsychopharmacology, 2021, 通讯作者
(7) The genome-wide risk alleles for psychiatric disorders at 3p21.1 show convergent effects on mRNA expression, cognitive function and mushroom dendritic spine, Molecular Psychiatry, 2020, 通讯作者
(8) Genome-wide association study of creativity reveals genetic overlap with psychiatric disorders, risk tolerance, and risky behaviors, Schizophrenia Bulletin, 2020, 通讯作者
(9) Identification of a functional human-unique 351-bp Alu insertion polymorphism associated with major depressive disorder in the 1p31.1 GWAS risk loci, Neuropsychopharmacology, 2020, 通讯作者
(10) Further confirmation of netrin 1 receptor (DCC) as a depression risk gene via integrations of multi-omics data, Translational Psychiatry, 2020, 通讯作者
(11) The schizophrenia risk isoform ZNF804AE3E4 affects dendritic spine, Schizophrenia Research, 2020, 通讯作者
(12) Transcriptomic analyses of humans and mice provide insights into depression, Zoological Research, 2020, 通讯作者
(13) Identification of a functional 339 bp Alu insertion polymorphism in the schizophrenia-associated locus at 10q24.32, Zoological Research, 2020, 通讯作者
(14) Integrative analyses of major histocompatibility complex loci in the genome-wide association studies of major depressive disorder, Neuropsychopharmacology, 2019, 通讯作者
(15) The cAMP responsive element-binding (CREB)-1 gene increases risk of major psychiatric disorders, Molecular Psychiatry, 2018, 通讯作者
(16) The Protocadherin 17 Gene Affects Cognition, Personality, Amygdala Structure and Function, Synapse Development and Risk of Major Mood Disorders, Molecular Psychiatry, 2018, 通讯作者
(17) The gene encoding protocadherin 9 (PCDH9), a novel risk factor for major depressive disorder, Neuropsychopharmacology, 2018, 通讯作者
(18) Replicated associations of FADS1, MAD1L1, and a rare variant at 10q26.13 with bipolar disorder in Chinese population, Translational Psychiatry, 2018, 通讯作者
(19) The schizophrenia risk gene ZNF804A: clinical associations, biological mechanisms and neuronal functions, Molecular Psychiatry, 2017, 通讯作者
(20) A human-specific AS3MT isoform and BORCS7 are molecular risk factors in the 10q24.32 schizophrenia associated locus, Nature Medicine, 2016, 第 1 作者
(21) Recent positive selection drives the expansion of a schizophrenia risk non-synonymous variant at SLC39A8 in Europeans, Schizophrenia Bulletin, 2016, 通讯作者
(22) Impact of a cis-associated gene expression SNP on chromosome 20q11.22 on bipolar disorder susceptibility, hippocampal structure and cognitive performance, British Journal of Psychiatry, 2016, 通讯作者
(23) Adaptive evolution of interleukin-3 (IL3), a gene associated with brain volume variation in general human populations, Human Genetics, 2016, 第 1 作者
(24) No association between schizophrenia susceptibility variants and macroscopic structural brain volume variation in healthy subjects, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2016, 第 1 作者
(25) The impact of CACNA1C allelic variation on regional gray matter volume in Chinese population, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2016, 通讯作者
(26) A comprehensive meta-analysis of ZNF804A SNPs in the risk of schizophrenia among Asian populations, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2016, 通讯作者
(27) Replication of Han Chinese GWAS loci for schizophrenia via meta-analysis of four independent samples, Schizophrenia Research, 2016, 第 2 作者
(28) Convergent Lines of Evidence Support LRP8 as a Susceptibility Gene for Psychosis, Molecular Neurobiology, 2015, 通讯作者
(29) MAOA Variants and Genetic Susceptibility to Major Psychiatric Disorders, Molecular Neurobiology, 2015, 通讯作者
(30) Common variants of IRF3 conferring risk of schizophrenia, Journal of Psychiatric Research, 2015, 通讯作者
(31) Allelic variation at 5-HTTLPR is associated with brain morphology in a Chinese population, Psychiatry Research, 2015, 通讯作者
(32) Systematic Integration of Brain eQTL and GWAS Identifies ZNF323 as a Novel Schizophrenia Risk Gene and Suggests Recent Positive Selection Based on Compensatory Advantage on Pulmonary Function, Schizophrenia Bulletin, 2015, 第 3 作者
(33) DEGS2 polymorphism associated with cognition in schizophrenia is associated with gene expression in brain, Translational Psychiatry, 2015, 第 3 作者
(34) Allelic differences between Europeans and Chinese for CREB1 SNPs and their implications in gene expression regulation, hippocampal structure and function, and bipolar disorder susceptibility, Molecular Psychiatry, 2014, 第 1 作者
(35) Convergent lines of evidence support CAMKK2 as a schizophrenia susceptibility gene, Molecular Psychiatry, 2014, 第 2 作者
(36) Failure of replicating the association between hippocampal volume and 3 single-nucleotide polymorphisms identified from the European genome-wide association study in Asian populations, Neurobiology of Aging, 2014, 第 1 作者
(37) Protein-protein interaction and pathway analyses of top schizophrenia genes reveal schizophrenia susceptibility genes converge on common molecular networks and enrichment of nucleosome (chromatin) assembly genes in schizophrenia susceptibility loci, Schizophrenia Bulletin, 2014, 第 4 作者
(38) A functional MiR-124 binding-site polymorphism in IQGAP1 affects human cognitive performance, PLOS ONE, 2014, 第 3 作者
(39) SLC6A15 rs1545843 and depression: implications from brain imaging data, The American Journal of Psychiatry, 2013, 第 1 作者
(40) Up-Regulation of NOTCH4 Gene Expression in Bipolar Disorder: Future Studies, The American Journal of Psychiatry, 2013, 第 1 作者
(41) Analysis of common genetic variants identifies RELN as a risk gene for schizophrenia in Chinese population, The World Journal of Biological Psychiatry, 2013, 第 1 作者
(42) Meta-analysis supports association of a non-synonymous SNP in ZNF804A with schizophrenia, Schizophrenia Research, 2013, 第 1 作者
(43) Meta-analysis indicates that the European GWAS-identified risk SNP rs1344706 within ZNF804A is not associated with schizophrenia in Han Chinese population, PLOS ONE, 2013, 第 1 作者
(44) An evaluation of association between a novel hippocampal biology related SNP (rs7294919) and schizophrenia, PLOS ONE, 2013, 通讯作者
(45) Impact of the genome-wide schizophrenia risk single nucleotide polymorphism (rs1625579) in miR-137 on brain structures in healthy individuals, Psychiatric Genetics, 2013, 第 1 作者
(46) Functional divergence of the brain-size regulating gene MCPH1 during primate evolution and human origin, BMC Biology, 2013, 第 2 作者
(47) Protein-protein interaction analysis reveals common molecular processes/pathways that contribute to risk of schizophrenia, Schizophrenia Research, 2013, 第 3 作者
(48) Genetic analysis of common variants in the CMYA5 (cardiomyopathy-associated 5) gene with schizophrenia, Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2013, 第 3 作者
(49) Meta-analysis and brain imaging data support the involvement of VRK2 in schizophrenia susceptibility, Schizophrenia Research, 2012, 第 1 作者
(50) ZNF804A and schizophrenia susceptibility in Asian populations, American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2012, 第 1 作者
(51) The interleukin 3 gene (IL3) contributes to human brain volume variation by regulating proliferation and survival of neural progenitors, PLOS ONE, 2012, 第 2 作者
(52) Allelic differences between Han Chinese and Europeans for functional variants in ZNF804A and their association with schizophrenia, The American Journal of Psychiatry, 2011, 第 1 作者
(53) Genetic association and identification of a functional SNP at GSK3b for schizophrenia susceptibility, Schizophrenia Research, 2011, 第 1 作者
(54) A common variant of the cardiomyopathy associated 5 gene (CMYA5) is associated with schizophrenia in Chinese population, Schizophrenia Research, 2011, 第 1 作者
(55) Replicated associations of TNFAIP3, TNIP1 and ETS1 with systemic lupus erythematosus in a southwestern Chinese population, Arthritis Research Therapy, 2011, 第 3 作者
(56) MCPH1/BRIT1 represses transcription of the human telomerase reverse transcriptase gene, Gene, 2011, 第 2 作者
(57) 

科研活动

   
科研项目
( 1 ) 中科院率先行动“****”C类, 主持, 部委级, 2016-08--2021-07
( 2 ) 中科院昆明动物研究所“****”启动项目, 主持, 市地级, 2016-08--2021-07
( 3 ) 灵长类脑容量与结构进化eGPS路线图的解析, 参与, 部委级, 2017-05--2019-04
( 4 ) 院重点实验室启动经费, 主持, 市地级, 2016-12--2018-11
( 5 ) 灵长类脑容量与结构进化eGPS路线图的解析2, 主持, 部委级, 2017-05--2018-06
( 6 ) 精神疾病的功能基因组学, 主持, 国家级, 2018-01--2020-12
( 7 ) 中组部青年****, 主持, 研究所(学校), 2018-02--2021-02
( 8 ) 剪接体AS3MTd2d3在中国人群影响精神分裂症发生的生物学机制, 主持, 国家级, 2020-01--2023-12
参与会议
(1)Characterization of an AS3MT Human Unique Isoform as a Potential Mechanism for Genetic Risk of Psychosis   中国精神疾病遗传学峰会   Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR   2015-04-11
(2)A Human-specific Isoform of AS3MT Regulated by a Human-unique Variation Explains Susceptibility to Psychiatric Illness   Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR   2014-12-07
(3)Cis-acting Regulation of a Novel AS3MT Transcript by a Genome-wide Supported Risk Variant for Schizophrenia   Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR   2014-11-15
(4)Cis-acting Regulation of a Novel AS3MT Transcript by a Genome-wide Supported Risk Variant for Schizophrenia   Li M, Jaffe AE, Straub RE, Tao R, Shin JH, Wang Y, Chen Q, Li C, Jia Y, Ohi K, Maher BJ, Brandon NJ, Cross A, Chenoweth J, Hoeppner DJ, Wei H, Hyde TM, McKay R, Kleinman JE, Weinberger DR   2014-05-08