蝙蝠免疫；病毒宿主相互作用；病原发现

   

071005-微生物学
071010-生物化学与分子生物学

蝙蝠病毒学
蝙蝠生物学

2009-09--2010-09   澳大利亚动物健康实验室   联合培养博士
2004-09--2010-12   中国科学院武汉病毒所   博士学位
2000-09--2004-07   河南大学   学士学位

   

2016-02~现在, 中国科学院武汉病毒研究所, 研究员
2014-08~2016-02,新加坡Duke-Nus 医学院, 博士后
2011-07~2014-06,澳大利亚动物健康实验室, 博士后
2010-12~2011-07,中国科学院武汉病毒所, 助理研究员

   

（1） 中国蝙蝠携带重要病毒研究, 一等奖, 省级, 2017

   

[1] Zhou, Peng, Shi, ZhengLi. SARS-CoV-2 spillover events. SCIENCEnull. 2021, 371(6525): 120-122, http://dx.doi.org/10.1126/science.abf6097.

[2] Peng Zhou, Xing-Lou Yang, Ben Hu, Lei Zhang, Wei Zhang, Hao-Rui Si, Yan Zhu, Bei Li, Jing Chen, Yun Luo, Hua Guo, Ren-Di Jiang, Mei-Qin Liu, Ying Chen, Xu-Rui Shen, Xi Wang, Xiao-Shuang Zheng, Kai Zhao, Quan-Jiao Chen, Fei Deng, Bing Yan, Yan-Yi Wang, Geng-Fu Xiao, Zheng-Li Shi, Xian-Guang Wang, Chao-Lin Huang, Hui-Dong Chen, Lin-Lin Liu, Fa-Xian Zhan. A pneumonia outbreak associated with a new coronavirus of probable bat origin. Nature. 2020, https://www-nature-com/articles/s41586-020-2012-7.

[3] Zhang, Wei, Du, RongHui, Li, Bei, Zheng, XiaoShuang, Yang, XingLou, Hu, Ben, Wang, YanYi, Xiao, GengFu, Yan, Bing, Shi, ZhengLi, Zhou, Peng. Molecular and serological investigation of 2019-nCoV infected patients: implication of multiple shedding routes. EMERGING MICROBES & INFECTIONS[J]. 2020, 9(1): 386-389, http://dx.doi.org/10.1080/22221751.2020.1729071.

[4] Li, Bei, Si, HaoRui, Zhu, Yan, Yang, XingLou, Anderson, Danielle E, Shi, ZhengLi, Wang, LinFa, Zhou, Peng. Discovery of Bat Coronaviruses through Surveillance and Probe Capture-Based Next-Generation Sequencing. MSPHERE[J]. 2020, 5(1): https://doaj.org/article/61b10f9d33cf4cc69012ef5a1ec1969b.

[5] Fan, Yi, Zhao, Kai, Shi, ZhengLi, Zhou, Peng. Bat Coronaviruses in China. VIRUSES-BASEL[J]. 2019, 11(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000464402800006.

[6] Zhang, Wei, Zheng, XiaoShuang, Agwanda, Bernard, Ommeh, Sheila, Zhao, Kai, Lichoti, Jacqueline, Wang, Ning, Chen, Jing, Li, Bei, Yang, XingLou, Mani, Shailendra, Ngeiywa, KisaJuma, Zhu, Yan, Hu, Ben, Onyuok, Samson Omondi, Yan, Bing, Anderson, Danielle E, Wang, LinFa, Zhou, Peng, Shi, ZhengLi. Serological evidence of MERS-CoV and HKU8-related CoV co-infection in Kenyan camels. EMERGING MICROBES & INFECTIONS[J]. 2019, 8(1): 1528-1534, https://www.webofscience.com/wos/woscc/full-record/WOS:000492190400001.

[7] Xie, Jiazheng, Li, Yang, Shen, Xurui, Goh, Geraldine, Zhu, Yan, Cui, Jie, Wang, LinFa, Shi, ZhengLi, Zhou, Peng. Dampened STING-Dependent Interferon Activation in Bats. CELL HOST & MICROBE[J]. 2018, 23(3): 297-+, http://dx.doi.org/10.1016/j.chom.2018.01.006.

[8] Shi Zhengli. Fatal Swine Acute Diarrhea Syndrome caused by an HKU2-related Coronavirus of Bat Origin. Nature. 2018, 
[9] Zhou, Peng, Chionh, Yok Teng, Irac, Sergio Erdal, Ahn, Matae, Ng, Justin Han Jia, Fossum, Even, Bogen, Bjarne, Ginhoux, Florent, Irving, Aaron T, Dutertre, CharlesAntoine, Wang, LinFa. Unlocking bat immunology: establishment of Pteropus alecto bone marrow-derived dendritic cells and macrophages. SCIENTIFIC REPORTS[J]. 2016, 6: https://www.webofscience.com/wos/woscc/full-record/WOS:000389820900001.

[10] Peng Zhou, Mary Tachedjian, James W Wynne, Victoria Boyd, Jie Cui, Ina Smith, Christopher Cowled, Justin H J Ng, Lawrence Mok, Wojtek P Michalski, Ian H Mendenhall, Gilda Tachedjian, LinFa Wang, Michelle L Baker. Contraction of the type I IFN locus and unusual constitutive expression of IFN-α in bats. Proceedings of the National Academy of Sciences of the United States of America. 2016, 113(10): 2696-2701, 
[11] Zhou, Peng, Cowled, Chris, Mansell, Ashley, Monaghan, Paul, Green, Diane, Wu, Lijun, Shi, Zhengli, Wang, LinFa, Baker, Michelle L. IRF7 in the Australian Black Flying Fox, Pteropus alecto: Evidence for a Unique Expression Pattern and Functional Conservation. PLOS ONE[J]. 2014, 9(8): https://doaj.org/article/13ce24245de647ae98f2a63fd1d1c9e2.

[12] Zhou, Peng, Cowled, Christopher, Wang, LinFa, Baker, Michelle L. Bat Mx1 and Oas1, but not Pkr are highly induced by bat interferon and viral infection. DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY[J]. 2013, 40(3-4): 240-247, http://dx.doi.org/10.1016/j.dci.2013.03.006.

[13] Wu, Lijun, Zhou, Peng, Ge, Xingyi, Wang, LinFa, Baker, Michelle L, Shi, Zhengli. Deep RNA Sequencing Reveals Complex Transcriptional Landscape of a Bat Adenovirus. JOURNAL OF VIROLOGY[J]. 2013, 87(1): 503-511, https://www.webofscience.com/wos/woscc/full-record/WOS:000312455500045.

[14] Zhou, Peng, Li, Hongxia, Wang, Hanzhong, Wang, LinFa, Shi, Zhengli. Bat severe acute respiratory syndrome-like coronavirus ORF3b homologues display different interferon antagonist activities. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 93: 275-281, https://www.webofscience.com/wos/woscc/full-record/WOS:000300139500006.

[15] Zhou, Peng, Cowled, Chris, Marsh, Glenn A, Shi, Zhengli, Wang, LinFa, Baker, Michelle L. Type III IFN Receptor Expression and Functional Characterisation in the Pteropid Bat, Pteropus alecto. PLOS ONE[J]. 2011, 6(9): http://www.corc.org.cn/handle/1471x/2375937.

[16] Zhou, Peng, Cowled, Chris, Todd, Shawn, Crameri, Gary, Virtue, Elena R, Marsh, Glenn A, Klein, Reuben, Shi, Zhengli, Wang, LinFa, Baker, Michelle L. Type III IFNs in Pteropid Bats: Differential Expression Patterns Provide Evidence for Distinct Roles in Antiviral Immunity. JOURNAL OF IMMUNOLOGY[J]. 2011, 186(5): 3138-3147, http://www.corc.org.cn/handle/1471x/2375858.

（1） Bat Immunology (Chapter 14 of Bats and Viruses: A New Frontier of Emerging Infectious Diseases), Wiley, 2015-07, 第 2 作者
（2） Immune (Adaptive) Response in Bats(Chapter 9 of Bat and Viruses: Current Research and Future Trends), Caister Academic Press, 2020-01, 第 1 作者

   

（ 1 ） SARS样冠状病毒感染蝙蝠细胞后的干扰素应答研究, 主持, 国家级, 2018-01--2021-12
（ 2 ） 应对SARS或MERS样新发传染病的新型病原检测技术, 主持, 国家级, 2017-01--2019-12
（ 3 ） 蝙蝠病毒学, 主持, 国家级, 2019-01--2021-12
（ 4 ） 潜在疫源病毒组学研究, 主持, 国家级, 2018-01--2020-12
（ 5 ） 新发病原自然宿主抗病毒及介导跨种感染的机制研究, 主持, 部委级, 2018-07--2023-06
（ 6 ） 2019-nCoV蝙蝠及人群代表性流行株致病能力的比较研究, 主持, 国家级, 2020-03--2022-02

（1）Research Advance in mechanism of bat Anti-Nipah immunity   尼帕病毒国际会议   2019-12-09
（2）Antiviral immune studies of bats: natural reservoir hosts of emerging infectious diseases   第29届德国病毒学会年会   2019-03-21
（3）Dampening of STING-dependent IFN production: an implication of virus tolerance in bats?   2017《细胞》研讨会：新发和再发病毒会议   2017-10-01
（4）Bat immunity: is it special?   第二届“蝙蝠源传染病国际研讨会”   2017-06-30
（5）Bat type I IFN: contraction of the genetic locus and constitutive expression of IFNα    2015-10-11
（6）Type I interferon in bats: is it special?   2013-09-30
（7）Type I interferon in bats: is it special?   2011-12-08