基本信息
张源  女  硕导  中国科学院武汉病毒研究所
电子邮件: zhangyuan@wh.iov.cn
通信地址: Xiaohongshan Zhongqu 44#, WuChang district (武昌区,小洪山中区44号)
邮政编码: 430071

招生信息

   
招生专业
071010-生物化学与分子生物学
071005-微生物学
招生方向
病毒感染与宿主免疫
病毒的荧光标记及实时追踪
病毒疫苗研发

教育背景

2009-09--2014-07   中国科学院武汉病毒研究所   博士学位
2005-09--2009-06   武汉大学   学士学位

工作经历

   
工作简历
2017-09~现在, 中国科学院武汉病毒研究所, 副研究员
2014-07~2017-08,中国科学院武汉病毒研究所, 助理研究员
2009-09~2014-07,中国科学院武汉病毒研究所, 博士学位
2005-09~2009-06,武汉大学, 学士学位

出版信息

   
发表论文
(1) Development of a biosensor assessing SARS-CoV-2 main protease proteolytic activity in living cells for antiviral drugs screening, Development of a biosensor assessing SARS-CoV-2 main protease proteolytic activity in living cells for antiviral drugs screening, VIROLOGICA SINICA, 2022, 第 1 作者
(2) Metabolic labeling of enterovirus 71 with quantum dots for the study of virus receptor usage, JOURNAL OF NANOBIOTECHNOLOGY, 2021, 通讯作者
(3) A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice, VIRUSES, 2020, 第 2 作者
(4) A Single Mutation in the VP1 Gene of Enterovirus 71 Enhances Viral Binding to Heparan Sulfate and Impairs Viral Pathogenicity in Mice, VIRUSES-BASEL, 2020, 第 2 作者
(5) Epidemiological,Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan:A Single-centered,Retrospective Study, Epidemiological, Clinical and Serological Characteristics of Children with Coronavirus Disease 2019 in Wuhan: A Single-centered, Retrospective Study, VIROLOGICA SINICA, 2020, 第 19 作者
(6) In vivo imaging of Zika virus reveals dynamics of viral invasion in immune-sheltered tissues and vertical propagation during pregnancy, THERANOSTICS, 2020, 第 3 作者
(7) Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model, Baculovirus Surface Display of Zika Virus Envelope Protein Protects against Virus Challenge in Mouse Model, VIROLOGICA SINICA, 2020, 第 8 作者
(8) Zika virus promotes CCN1 expression via the CaMKII alpha-CREB pathway in astrocytes, VIRULENCE, 2020, 第 7 作者
(9) Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein, VIRUSES-BASEL, 2019, 第 6 作者
(10) ZIKV infection activates the IRE1-XBP1 and ATF6 pathways of unfolded protein response in neural cells, JOURNAL OF NEUROINFLAMMATION, 2018, 第 7 作者
(11) Viperin Inhibits Enterovirus A71 Replication by Interacting with Viral 2C Protein, VIRUSES, 2018, 第 6 作者
(12) Spycatcher-spytag mediated in situ labelling of progeny baculovirus with quantum dots for tracking viral infection in living cells, CHEMICAL COMMUNICATIONS, 2018, 通讯作者
(13) Zika Virus Attenuation by Codon Pair Deoptimization Induces Sterilizing Immunity in Mouse Models, JOURNAL OF VIROLOGY, 2018, 第 8 作者
(14) The 3C protease of enterovirus A71 counteracts the activity of host zinc-finger antiviral protein (ZAP), JOURNAL OF GENERAL VIROLOGY, 2018, 第 6 作者
(15) An improved method for identifying SUMOylation sites of viral proteins, VIROLOGICA SINICA, 2017, 第 4 作者
(16) Mir-16-5p mediates a positive feedback loop in ev71-induced apoptosis and suppresses virus replication, SCIENTIFIC REPORTS, 2017, 第 4 作者
(17) Fast and sensitive quantification of protein sumoylation using a dual luciferase biosensor, ANALYST, 2017, 第 1 作者
(18) Development of a luciferase-based biosensor to assess enterovirus 71 3C protease activity in living cells, SCIENTIFIC REPORTS, 2017, 第 1 作者
(19) SUMO Modification Stabilizes Enterovirus 71 Polymerase 3D To Facilitate Viral Replication, JOURNAL OF VIROLOGY, 2016, 第 5 作者
(20) Identification of AcMNPV GP64-binding proteins through a combinational use of a self-biotinylated virus and the cross-linking method, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2015, 第 2 作者
(21) Self-biotinylation and site-specific double labeling of baculovirus using quantum dots for single-virus in-situ tracking, BIOMATERIALS, 2013, 第 8 作者
(22) Encapsulating Quantum Dots into Enveloped Virus in Living Cells for Tracking Virus Infection, ACSNANO, 2013, 第 1 作者
(23) One-Pot Synthesized Aptamer-Functionalized CdTe:Zn2+ Quantum Dots for Tumor-Targeted Fluorescence Imaging in Vitro and in Vivo, ANALYTICAL CHEMISTRY, 2013, 第 3 作者
(24) Differential stepwise evolution of SARS coronavirus functional proteins in different host species, BMC EVOLUTIONARY BIOLOGY, 2009, 第 4 作者

科研活动

   
科研项目
( 1 ) 柯萨奇病毒B3型入侵神经细胞的动态过程及机制研究, 负责人, 国家任务, 2016-01--2018-12
( 2 ) 中科院青年创新促进会, 负责人, 中国科学院计划, 2015-01--2018-12
( 3 ) Vimentin在柯萨奇病毒B3持续性感染神经细胞中的作用, 参与, 国家任务, 2017-01--2020-12
( 4 ) 干扰素刺激蛋白Viperin在EV71神经组织感染中所起作用及其机制, 参与, 国家任务, 2015-01--2018-12
( 5 ) 一种新颖的基因缺陷型EV71活疫苗的研究, 参与, 国家任务, 2012-01--2015-12
( 6 ) 寨卡病毒感染人神经前体细胞(NPCs)的入侵机制及动态化研究, 负责人, 国家任务, 2019-01--2022-12