080101-一般力学与力学基础

生物力学

2006-09--2012-07   中国科学院力学研究所   工学博士
2002-09--2006-07   中国科学技术大学   学士

   

2018-11~现在, 中国科学院力学研究所, 副研究员
2012-07~2018-11,中国科学院力学研究所, 助理研究员

   

[1] Wu, Yi, Li, Ning, Shu, Xinyu, Li, Wang, Zhang, Xiaoyu, Lü, Dongyuan, Long, Mian. Biomechanics in liver regeneration after partial hepatectomy. FRONTIERS IN BIOENGINEERING AND BIOTECHNOLOGY[J]. 2023, 11: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10196191/.
[2] Zhao, ChuanRong, Li, Jingyi, Jiang, ZhiTong, Zhu, JuanJuan, Zhao, JiaNan, Yang, QianRu, Yao, Weijuan, Pang, Wei, Li, Ning, Yu, Miaorong, Gan, Yong, Zhou, Jing. Disturbed Flow-Facilitated Margination and Targeting of Nanodisks Protect against Atherosclerosis. SMALL[J]. 2023, 19(2): http://dx.doi.org/10.1002/smll.202204694.
[3] Ning Li, Xiaoyu Zhang, Jin Zhou, Wang Li, Xinyu Shu, Yi Wu, Mian Long. Multiscale biomechanics and mechanotransduction from liver fibrosis to cancer. Advanced Drug Delivery Reviews[J]. 2022, 188: 114448-, http://dx.doi.org/10.1016/j.addr.2022.114448.
[4] 李宁, 龙勉. 细胞力学2021年度研究进展. 医用生物力学[J]. 2022, 37(4): 584-591, [5] Jin Wang, Sian Xie, Ning Li, Tao Zhang, Weijuan Yao, Hucheng Zhao, Wei Pang, Lili Han, Jiayu Liu, Jing Zhou. Matrix stiffness exacerbates the proinflammatory responses of vascular smooth muscle cell through the DDR1-DNMT1 mechanotransduction axis. BIOACTIVE MATERIALS[J]. 2022, 17: 406-424, [6] Xinyu Shu, Ning Li, Yi Wu, Wang Li, Xiaoyu Zhang, Peiwen Li, Dongyuan Lü, Shouqin Lü, Long, Mian. Mechanotransduction of liver sinusoidal endothelial cells under varied mechanical stimuli. ACTA MECHANICA SINICA[J]. 2021, 37(2): 201-217, http://dx.doi.org/10.1007/s10409-021-01057-3.
[7] Li, Wang, Li, Peiwen, Li, Ning, Du, Yu, Lu, Shouqin, Elad, David, Long, Mian. Matrix stiffness and shear stresses modulate hepatocyte functions in a fibrotic liver sinusoidal model. AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY[J]. 2020, 320(3): G272-G282, http://dx.doi.org/10.1152/ajpgi.00379.2019.
[8] Peiwen Li, Jin Zhou, Wang Li, Huan Wu, Jinrong Hu, Qihan Ding, Shouqin Lü, Jun Pan, Chunyu Zhang, Ning Li, Mian Long. Characterizing liver sinusoidal endothelial cell fenestrae on soft substrates upon AFM imaging and deep learning. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS[J]. 2020, 1864(12): 129702-, http://dx.doi.org/10.1016/j.bbagen.2020.129702.
[9] Xinyu Shu, Ning Li, Dandan Huang, Yan Zhang, Shouqin Lü, Mian Long. Mechanical strength determines Ca2+ transients triggered by the engagement of beta(2) integrins to their ligands. EXPERIMENTAL CELL RESEARCH[J]. 2020, 387(2): 111807-, http://dx.doi.org/10.1016/j.yexcr.2019.111807.
[10] Shuang Peng, Shenbao Chen, Linda Li, Chunfang Tong, Ning Li, Shouqin Lü, Mian Long. Impact of real-time shedding on binding kinetics of membrane-remaining L-selectin to PSGL-1. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY[J]. 2019, 316(5): C678-C689, http://dx.doi.org/10.1152/ajpcell.00212.2018.
[11] Sun, Shujin, Wang, Chengzhi, Bi, Yuzhen, Li, Ning, Lü, Dongyuan, Chen, Qin, Chen, Juan, Long, Mian. An integration design of gas exchange, bubble separation, and flow control in a space cell culture system on board the SJ-10 satellite. REVIEW OF SCIENTIFIC INSTRUMENTS[J]. 2019, 90(7): 075114-, http://dx.doi.org/10.1063/1.5087770.
[12] D. Moser, Shujin Sun, Ning Li, K. Biere, M. Hoerl, S. Matzel, M. Feuerecker, J.I. Buchheim, Strewe, C, C.S. Thiel, Yuxin Gao, Chengzhi Wang, O. Ullrich, Mian Long, A. Chouker. Cells' flow and immune cell priming under alternating g-forces in parabolic flight. SCIENTIFIC REPORTS[J]. 2019, 9(1): 11276-, http://dx.doi.org/10.1038/s41598-019-47655-x.
[13] Lü, Dongyuan, Sun, Shujin, Zhang, Fan, Luo, Chunhua, Zheng, Lu, Wu, Yi, Li, Ning, Zhang, Chen, Wang, Chengzhi, Chen, Qin, Long, Mian. Microgravity-induced hepatogenic differentiation of rBMSCs on board the SJ-10 satellite. FASEB JOURNAL[J]. 2019, 33(3): 4273-4286, http://dx.doi.org/10.1096/fj.201802075R.
[14] Yu Du, Ning Li, Mian Long. Liver sinusoid on a chip. MICROFLUIDICS IN CELL BIOLOGY, PT A: MICROFLUIDICS FOR MULTICELLULAR SYSTEMS[J]. 2018, 146: 105-134, http://dx.doi.org/10.1016/bs.mcb.2018.06.002.
[15] Ning Li, Hao Yang, Manliu Wang, Shouqin Lü, Yan Zhang, Mian Long. Ligand-specific binding forces of LFA-1 and Mac-1 in neutrophil adhesion and crawling. MOLECULAR BIOLOGY OF THE CELL[J]. 2018, 29(4): 408-418, http://dx.doi.org/10.1091/mbc.E16-12-0827.
[16] Ning Li, Xiao Zhang, Peiwen Li, Hao Yang, Chunfang Tong, Shouqin Lü, Yan Zhang, Zhiyi Ye, Jun Pan, Mian Long. Mechanical strength and structural basis of beta(2) integrin to mediate neutrophil accumulation on liver sinusoidal endothelial cells: a study using atomic force microscopy and molecular dynamics simulations. CMES-COMPUTER MODELING IN ENGINEERING & SCIENCES[J]. 2018, 116(2): 263-279, http://dx.doi.org/10.31614/cmes.2018.04079.
[17] Chunfang Tong, Yan Zhang, Shouqin Lü, Ning Li, Yixin Gong, Hao Yang, Shiliang Feng, Yu Du, Dandan Huang, Mian Long. Binding of intercellular adhesion molecule 1 to β2-integrin regulates distinct cell adhesion processes on hepatic and cerebral endothelium. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY[J]. 2018, 315(3): C409-C421, http://dx.doi.org/10.1152/ajpcell.00083.2017.
[18] Xiao Zhang, Linda Li, Ning Li, Xinyu Shu, Luwen Zhou, Shouqin Lü, Shenbao Chen, Debin Mao, Mian Long. Salt bridge interactions within the beta(2) integrin alpha(7) helix mediate force-induced binding and shear resistance ability. FEBS JOURNAL[J]. 2018, 285(2): 261-274, http://dx.doi.org/10.1111/febs.14335.
[19] Li, Ning, Wang, Chengzhi, Sun, Shujin, Zhang, Chen, Lu, Dongyuan, Chen, Qin, Long, Mian. Microgravity-Induced Alterations of Inflammation-Related Mechanotransduction in Endothelial Cells on Board SJ-10 Satellite. FRONTIERS IN PHYSIOLOGY[J]. 2018, 9: https://doaj.org/article/6eb7c62ba8e940b7ac987bdad85cd4e4.
[20] Yang, Hao, Li, Ning, Du, Yu, Tong, Chunfang, Lu, Shouqin, Hu, Jinrong, Zhang, Yan, Long, Mian. Neutrophil adhesion and crawling dynamics on liver sinusoidal endothelial cells under shear flow. EXPERIMENTAL CELL RESEARCH[J]. 2017, 351(1): 91-99, http://dx.doi.org/10.1016/j.yexcr.2017.01.002.
[21] Chen Zhang, Luwen Zhou, Fan Zhang, Dongyuan Lü, Ning Li, Lu Zheng, Yanhong Xu, Zhan Li, Shujin Sun, Mian Long. Mechanical remodeling of normally sized mammalian cells under a gravity vector. THE FASEB JOURNAL[J]. 2017, 31(2): 802-813, http://dx.doi.org/10.1096/fj.201600897RR.
[22] Yu Du, Ning Li, Hao Yang, Chunhua Luo, Yixin Gong, Chunfang Tong, Yuxin Gao, Shouqin Lü, Mian Long. Mimicking liver sinusoidal structures and functions using a 3D-configured microfluidic chip. LAB ON A CHIP[J]. 2017, 17(5): 782-794, http://dx.doi.org/10.1039/c6lc01374k.
[23] Zhang, Chen, Zhou, Lüwen, Zhang, Fan, Lü, Dongyuan, Li, Ning, Zheng, Lu, Xu, Yanhong, Li, Zhan, Sun, Shujin, Long, Mian. Mechanical remodeling of normally sized mammalian cells under a gravity vector. FASEB JOURNAL[J]. 2017, 31(2): 802-813, http://dx.doi.org/10.1096/fj.201600897RR.
[24] Hao Yang, Chunfang Tong, Changliang Fu, Yanhong Xu, Xiaofeng Liu, Qin Chen, Yan Zhang, Shouqin Lü, Ning Li, Mian Long. Analyses of movement and contact of two nucleated cells using a gas-driven micropipette aspiration technique. JOURNAL OF IMMUNOLOGICAL METHODS[J]. 2016, 428: 20-29, http://dx.doi.org/10.1016/j.jim.2015.11.007.
[25] 王成之, 李宁, 陈勤, 龙勉, 孙树津, 吕东媛. 微重力下的细胞生长与物质输运. 力学与实践[J]. 2016, 38(2): 221-224, http://dspace.imech.ac.cn/handle/311007/72085.
[26] Ning Li, Shouqin Lü, Yan Zhang, Mian Long. Mechanokinetics of receptor-ligand interactions in cell adhesion. ACTA MECHANICA SINICA[J]. 2015, 31(2): 248-258, http://dx.doi.org/10.1007/s10409-015-0407-8.
[27] Chengzhi Wang, Ning Li, Chen Zhang, Shujin Sun, Yuxin Gao, Mian Long. Effects of simulated microgravity on functions of neutrophil-like HL-60 cells. MICROGRAVITY SCIENCE AND TECHNOLOGY[J]. 2015, 27(6): 515-527, http://dx.doi.org/10.1007/s12217-015-9473-6.
[28] Jinhong Ding, Ning Li, Manliu Wang, Yan Zhang, Shouqin Lü, Mian Long. The impact of N-terminal phosphorylation on LHCII conformation in state transition. ACTA MECHANICA SINICA[J]. 2014, 30(3): 447-456, http://dx.doi.org/10.1007/s10409-014-0044-7.
[29] Ning Li, Debin Mao, Shouqin Lü, Chunfang Tong, Yan Zhang, Mian Long. Distinct binding affinities of Mac-1 and LFA-1 in neutrophil activation. JOURNALOFIMMUNOLOGY[J]. 2013, 190(8): 4371-4381, http://dx.doi.org/10.4049/jimmunol.1201374.
[30] Mao, Debin, Lu, Shouqin, Li, Ning, Zhang, Yan, Long, Mian. Conformational Stability Analyses of Alpha Subunit I Domain of LFA-1 and Mac-1. PLOS ONE[J]. 2011, 6(8): http://www.irgrid.ac.cn/handle/1471x/389868.
[31] 李宁, 章燕, 孙淦云, 龙勉. 非特异性相互作用的断裂力与寿命测量. 医用生物力学[J]. 2007, 22(1): 35-39, http://lib.cqvip.com/Qikan/Article/Detail?id=24305599.

（1） 《免疫学前沿进展》第四版-第28章：生物力学和免疫应答, 人民卫生出版社, 2017-06, 第 1 作者
（2） 《细胞分子生物力学》-第2章：细胞、亚细胞、生物大分子, 上海交通大学出版社, 2018-01, 第 1 作者

   

（ 1 ） 基底硬度对肝血窦内皮细胞毛细血管化及其力学信号转导的调控机制, 负责人, 国家任务, 2019-01--2022-12
（ 2 ） 不同配体-β2整合素相互作用对炎症级联反应中白细胞爬行的影响, 负责人, 国家任务, 2014-01--2016-12
（ 3 ） 空间生物相分离对脂质代谢的影响, 负责人, 中国科学院计划, 2022-06--2024-05