基本信息
陈宇  男  博导  中国科学院深圳先进技术研究院
电子邮件： yu.chen@siat.ac.cn
通信地址： 深圳市南山区西丽深圳大学城学苑大道1068号
邮政编码： 518055

研究领域

        人类的认知功能取决于大脑中神经元所形成的精细网络，而神经元间的交流则依赖于突触传递。突触功能障碍与阿尔兹海默病、帕金森病等在内的诸多神经退行性疾病密切相关。因而，突触蛋白的精准分布、突触信号传递在时间和空间上的精细调控是神经生物学研究的中心议题。
        陈宇博士长期专注于神经系统突触发育、可塑性的分子基础，以及神经退行性疾病（如阿尔兹海默病）的病理机制等方面的研究。他发现了一系列调控树突和突触功能的重要蛋白，提示了在神经系统发育和功能执行过程中神经信号从细胞表面受体通过支架蛋白、激酶等向细胞内传递的关键步骤。其研究方向主要包括以下几个方面：
（1）突触的基础研究：对细胞表面受体、支架蛋白、激酶等介导的突触信号进行研究，结合光遗传调控手段，解释突触发育和可塑性调控过程中的动态变化及其分子基础。
（2） 神经退行性疾病机制研究：通过运用不同的疾病模型，包括非人灵长类动物模型，研究突触功能在阿尔兹海默病病变条件下发生的变化，以及内在的分子生物学机制和关键信号通路，提示可能的干预靶点。
（3） 阿尔兹海默病生物标志物和干预措施研究：利用交叉学科手段，研究适用于中国人群的、易于采集和测量的生物标志物，并发展可能的干预手段；同时协助临床医务工作者实施国际规范的操作流程，提升在诊断、样品采集和分析方面的水平。


招生信息

   
招生专业
071006-神经生物学
071010-生物化学与分子生物学
071009-细胞生物学
招生方向
神经发育、可塑性和退行性病变的调控机制
神经发育和可塑性调控的分子细胞机制

教育背景

2003-09--2007-08   香港科技大学   哲学博士
1998-09--2002-08   中山大学   理学学士

工作经历

   
工作简历
2021-06~现在, 深港脑科学创新研究院, 副院长
2021-06~现在, 中国科学院深圳先进技术研究院, 脑所 副所长
2019-07~2021-05,深港脑科学创新研究院, 院长助理（兼）
2017-04~现在, 中国科学院深圳先进技术研究院, 脑疾病中心主任
2016-12~2021-05,中国科学院深圳先进技术研究院, 脑所 所长助理
2015-04~现在, 中国科学院深圳先进技术研究院, 研究员
2010-11~2015-04,香港科技大学, 研究助理教授
2009-09~2010-10,香港科技大学, 访问学者
2007-09~2009-08,香港科技大学, 副研究员
2003-03~2003-08,香港科技大学, 初级研究员
社会兼职
2019-12-18-今,中国青年科技工作者协会, 会员

教授课程

神经生物学基础

专利与奖励


奖励信息
（1） 2021年度中国神经科学重大进展, 其他, 2021
（2） 香港青年科学家奖（finalist）, , 其他, 2007

出版信息

  1. Yinhu Li#, Yijing Chen#,  Yingying Fan, Yuewen Chen, Yu Chen*. (2023) Dynamic network modeling of gut microbiota during Alzheimer’s disease progression in mice. Gut Microbes 15(1):2172672. (#equal contribution，*corresponding author)

  2. Mingfeng Guan#, Yue Chai#, Ran Yi, Yuewen Chen, Jacque P.K. Ip, Tao Ye*, Yu Chen*. (2022) Generation of a homozygous ABCA7-knockout human iPSC line using the CRISPR/Cas9 system. Stem Cell Research 66:103000. (#equal contribution，*corresponding author)

  3. Yuewen Chen#, Zhenyan Xu#, Jing Chen#, Yue Qiu, Lin Yuan, Peng Liu, Jing Duan, Li Chen*, and Yu Chen*. (2022) Coronin 2B Regulates Neuronal Migration via Rac1-Dependent Multipolar–Bipolar Transition. Journal of Neuroscience 43 (2) 211-220. (#equal contribution，*corresponding author)

  4. Yuanbing Jiang, Xiaopu Zhou, Hiu Yi Wong, Li Ouyang, Fanny C. F. Ip, Vicky M. N. Chau, Shun-Fat Lau, Wei Wu, Daniel Y. K. Wong, Heukjin Seo, Wing-Yu Fu, Nicole C. H. Lai, Yuewen Chen, Yu Chen, Estella P. S. Tong, Alzheimer’s Disease Neuroimaging Initiative, Vincent C. T. Mok, Timothy C. Y. Kwok, Kin Y. Mok, Maryam Shoai, Benoit Lehallier, Patricia Morán Losada, Eleanor O’Brien, Tenielle Porter, Simon M. Laws, John Hardy, Tony Wyss-Coray, Colin L. Masters, Amy K. Y. Fu*, Nancy Y. Ip*. (2022) An IL1RL1 genetic variant lowers soluble ST2 levels and the risk effects of APOE-ε4 in female patients with Alzheimer’s disease. Nature Aging volume 2, pages616–634. (*corresponding author)

  5. Xueqi Qu, Li Lin, Wanying Yi, Changyu Sun, Yuewen Chen, Yu Chen*. (2022) Early Changes in Transcriptomic Profiles in Synaptodendrosomes Reveal Aberrant Synaptic Functions in Alzheimer’s Disease. International Journal of Molecular Sciences 23(16), 8888. (*corresponding author)

  6.  Han Cao, Xiaopu Zhou, Yu Chen, Fanny C F Ip, Yuewen Chen, Nicole C H Lai, Ronnie M N Lo, Estella P S Tong, Vincent C T Mok, Timothy C Y Kwok, Alzheimer’s Disease Neuroimaging Initiative; Amy K Y Fu, Nancy Y Ip*. (2022) Association of SPI1 Haplotypes with Altered SPI1 Gene Expression and Alzheimer's Disease Risk. Journal of Alzheimer’s Disease 86(4):1861-1873. (*corresponding author)

  7. Kin Y Mok, East Asian Parkinson Disease Genomics Consortium. (2021) The East Asian Parkinson Disease Genomics Consortium. The Lancet Neurology 20(12):982.

  8. David Goertsen#, Nicholas C Flytzanis#, Nick Goeden#, Miguel R Chuapoco, Alexander Cummins, Yijing Chen, Yingying Fan, Qiangge Zhang, Jitendra Sharma, Yangyang Duan, Liping Wang, Guoping Feng, Yu Chen, Nancy Y Ip, James Pickel, Viviana Gradinaru*. (2021) AAV capsid variants with brain-wide transgene expression and decreased liver targeting after intravenous delivery in mouse and marmoset. Nature Neuroscience 25(1):106-115. (#equal contribution，*corresponding author)

  9. Lin Yuan, Wanying Yi, Changyu Sun, Shuangshuang Ma, Jiali Wang, Saijuan Liu, Yijing Chen, Yuewen Chen*, Yu Chen*. (2021) EphB2 activates CREB-dependent expression of Annexin A1 to regulate dendritic spine morphogenesis. Biochemical and Biophysical Research Communications 584:107-115. (*corresponding author)

  10. Chunyan Liao, Jinying Xu, Yu Chen*, Nancy Y Ip*. (2021) Retinal Dysfunction in Alzheimer's Disease and Implications for Biomarkers. Biomolecules 11(8):1215. (*corresponding author)

  11. Yijing Chen, Jinying Xu, Yu Chen*. (2021) Regulation of Neurotransmitters by the Gut Microbiota and Effects on Cognition in Neurological Disorders. Nutrients 13(6):2099. (*corresponding author)

  12. Yangyang Duan#, Tao Ye#, Zhe Qu, Yuewen Chen, Abigail Miranda, Xiaopu Zhou, Ka-Chun Lok, Yu Chen, Amy K Y Fu, Viviana Gradinaru, Nancy Y Ip*. (2021) Brain-wide Cas9-mediated cleavage of a gene causing familial Alzheimer’s disease alleviates amyloid-related pathologies in mice. Nature Biomedical Engineering 6(2):168-180. (#equal contribution, * corresponding author)

  13. Tao Ye, Yangyang Duan, Hayley W S Tsang, He Xu, Yuewen Chen, Han Cao, Yu Chen, Amy K Y Fu, Nancy Y Ip*. (2021) Efficient manipulation of gene dosage in human iPSCs using CRISPR/Cas9 nickases. Communications Biology 4(1):195. (*corresponding author)

  14. Zhen Zhang#, Liang Cui#, Yanlu Huang, Yu Chen, Yuehua Li*, Qihao Guo*. (2021) Changes of Regional Neural Activity Homogeneity in Preclinical Alzheimer's Disease: Compensation and Dysfunction. Frontiers in Neuroscience 15:646414. (#equal contribution, *corresponding author)

  15. Yuanbing Jiang, Xiaopu Zhou, Fanny C Ip, Philip Chan, Yu Chen, Nicole C H Lai, Kit Cheung, Ronnie M N Lo, Estella P S Tong, Bonnie W Y Wong, Andrew L T Chan, Vincent C T Mok, Timothy C Y Kwok, Kin Y Mok, John Hardy, Henrik Zetterberg, Amy K Y Fu, Nancy Y Ip*. (2021) Large-scale plasma proteomic profiling identifies a high-performance biomarker panel for Alzheimer's disease screening and staging. Alzheimer’s＆Dementia 18(1):88-102. (*corresponding author)

  16. Li Ouyang#, Yu Chen#, Ye Wang, Yuewen Chen, Amy K Y Fu, Wing-Yu Fu Nancy Y Ip*. (2020) p39-associated Cdk5 activity regulates dendritic morphogenesis. Scientific Reports 10(1):18746.   (#equal contribution, *corresponding author)

  17. Xiaopu Zhou, Yu Chen, Fanny C F Ip, Nicole C H Lai, Yolanda Y T Li, Yuanbing Jiang, Huan Zhong, Yuewen Chen, Yulin Zhang, Shuangshuang Ma, Ronnie M N Lo, Kit Cheung, Estella P S Tong, Ho Ko, Maryam Shoai, Kin Y Mok, John Hardy, Vincent C T Mok, Timothy C Y Kwok, Amy K Y Fu, Nancy Y Ip*. (2020) Genetic and polygenic risk score analysis for Alzheimer's disease in the Chinese population. Alzheimer’s ＆Dementia (Amsterdam Netherlands) 12(1):e12074. (*corresponding author)

  18. Yuewen Chen#, Jinying Xu#, Yulin Zhang, Shuangshuang Ma, Wanying Yi, Saijuan Liu, Xiaojun Yu, Jiali Wang, Yu Chen*. (2020) Coronin 2B regulates dendrite outgrowth by modulating actin dynamics. FEBS Letters 594(18):2975-2987. (#equal contribution, *corresponding author)

  19. Yijing Chen, Lihua Fang, Shuo Chen, Haokui Zhou, Yingying Fan, Li Lin, Jing Li, Jinying Xu, Yuewen Chen, Yingfei Ma*, Yu Chen*. (2020) Gut Microbiome Alterations Precede Cerebral Amyloidosis and Microglial Pathology in a Mouse Model of Alzheimer’s Disease. BioMed Research International 2020:8456596. (*corresponding author)

  20. Yuewen Chen#*, Jinying Xu#, Xiaopu Zhou, Saijuan Liu, Yulin Zhang, Shuangshuang Ma, Amy K.Y. Fu, Nancy Y. Ip, Yu Chen*. (2019) Changes of Protein Phosphorylation Are Associated with Synaptic Functions during the Early Stage of Alzheimer's Disease. ACS Chemical Neuroscience 10(9):3986-3996. (#equal contribution, *corresponding author)

  21. Xiaopu Zhou, Yu Chen, Kin Y. Mok, Timothy C. Y. Kwok, Vincent C. T. Mok, Qihao Guo, Fanny C. Ip, Yuewen Chen, Nandita Mullapudi, Alzheimer’s Disease Neuroimaging Initiative, Paola Giusti-Rodríguez, Patrick F. Sullivan, John Hardy, Amy K. Y. Fu, Yun Li, Nancy Y. Ip*. (2019) Non-coding variability at the APOE locus contributes to the Alzheimer's risk. Nature Communications 10(1):3310. (*corresponding author)

  22. Zhenyan Xu, Yuewen Chen, Yu Chen*. (2019) Spatiotemporal Regulation of Rho GTPases in Neuronal Migration. Cells 8(6), 5684. (*corresponding author)

  23. Yu Chen*, Amy K.Y. Fu, Nancy Y. Ip*. (2018) Synaptic dysfunction in Alzheimer's disease: Mechanisms and therapeutic strategies. Pharmacology & Therapeutics 195:186-198. (*corresponding author)

  24. Xiaopu Zhou#, Yu Chen#, Kin Y. Mok, Qianhua Zhao, Keliang Chen, Yuewen Chen, John Hardy, Yun Li, Amy K. Y. Fu, Qihao Guo*, Nancy Y. Ip*, for the Alzheimer’s Disease Neuroimaging Initiative. (2018) Identification of genetic risk factors in the Chinese population implicates a role of immune system in Alzheimer’s disease pathogenesis. Proceedings of the National Academy of Sciences of the United States of America 115(8): 1697–1706. (#equal contribution, *corresponding author)

  25. Yu Chen*, Zhuoyi Liang, Erkang Fei, Yuewen Chen, Xiaopu Zhou, Weiqun Fang, Wing-Yu Fu, Amy K.Y. Fu, Nancy Y. Ip*. (2015) Axin Regulates Dendritic Spine Morphogenesis through Cdc42-Dependent Signaling. PLoS One 10(7): e0133115. (*corresponding author)

  26. Yu Chen, Amy K.Y. Fu, Nancy Y. Ip*. (2013) Axin: An Emerging Key Scaffold at the Synapse. IUBMB Life 65(8):685-91. (*corresponding author)

  27. Yu Chen, Wing-Yu Fu, Jacque P.K. Ip*, Tao Ye, Amy K.Y. Fu, Moses. V. Chao, Nancy Y. Ip. (2012) Ankyrin Repeat-rich Membrane Spanning Protein (Kidins220) Is Required for Neurotrophin and Ephrin Receptor-Dependent Dendrite Development. Journal of Neuroscience 32(24):8263-9. (*corresponding author)

  28. Yu Chen, Amy K.Y. Fu, Nancy Y. Ip*. (2012) Eph receptors at synapses: Implications in neurodegenerative diseases. Cellular Signalling 24(3):606-11. [Highlighted in Faculty of 1000(http://f1000.com/prime/716297950)] (*corresponding author)

  29. Jacque P. K. Ip, Lei Shi, Yu Chen, Yasuhiro Itoh, Wing-Yu Fu, Andrea Betz, Wing-Ho Yung, Yukiko Gotoh, Amy K.Y. Fu, Nancy Y. Ip*. (2012) a2-chimaerin controls neuronal migration and functioning of the cerebral cortex through CRMP-2. Nature Neuroscience 15(1):39-47. (*corresponding author)

  30. Wei-Qun Fang, Jacque P.K. Ip, Rui Li, Yu-Pong Ng, Sheng-Cai Lin, Yu Chen, Amy K.Y. Fu*, Nancy Y. Ip*. (2011) Cdk5-Mediated Phosphorylation of Axin Directs Axon Formation during Cerebral Cortex Development. Journal of Neuroscience 31(38):13613-24. (*corresponding author)

  31. Hovik Farghaian, Yu Chen, Ada W.Y. Fu, Amy K.Y. Fu, Jacque P.K. Ip, Nancy Y. Ip, Ann M. Turnley, Adam R. Cole*. (2011) Scapinin-induced Inhibition of Axon Elongation Is Attenuated by Phosphorylation and Translocation to the Cytoplasm. Journal of Biological Chemistry 286(22):19724-34. (*corresponding author)

  32. Amy K Fu, Kwok-Wang Hung, Wing-Yu Fu, Chong Shen, Yu Chen, Jun Xia, Kwok-On Lai, Nancy Y. Ip*. (2011) APCCdh1 mediates EphA4-dependent downregulation of AMPA receptors in homeostatic plasticity. Nature Neuroscience 14(2):181-9. (*corresponding author)

  33. Peng Zhang, Pei-Chun Yu, Anthony H. K. Tsang, Yu Chen, Amy K. Y. Fu, Wing-Yu Fu, Kenny K. Chung*, Nancy Y. Ip*. (2010) S-Nitrosylation of Cyclin-Dependent Kinase 5 (Cdk5) Regulates Its Kinase Activity and Dendrite Growth During Neuronal Development. Journal of Neuroscience 30(43):14366-70. (*corresponding author)

  34. Yu Chen#*, Wing-Yu Fu#*. (2009) EphB Maintains Dendritic Spine Morphology through Focal Adhesion Kinase. Journal of Neuroscience 29(42):13091-3. (#equal contribution, *corresponding author)

  35. Yu Chen, Amy K Y Fu, Nancy Y Ip*. (2009) Bidirectional signaling of ErbB and Eph receptors at synapses. Neuron Glia Biology 4(3):211-2. (*corresponding author)

  36. Zelda H Cheung, Wing Hong Chin, Yu Chen, Yu Pong Ng, Nancy Y Ip*. (2007) Cdk5 Is Involved in BDNF-Stimulated Dendritic Growth in Hippocampal Neurons. PLoS Biology 5(4):e63. (*corresponding author)

  37. Wing-Yu Fu#, Yu Chen#, Mustafa Sahin, Xiao-Su Zhao, Lei Shi, Jay B Bikoff, Kwok-On Lai, Wing-Ho Yung, Amy K Y Fu, Michael E Greenberg, Nancy Y Ip*. (2007) Cdk5 regulates EphA4-mediated dendritic spine retraction through an ephexin1-dependent mechanism. Nature Neuroscience 10(1):67-76. [Highlighted in Alzheimer Research Forum on 3 December 2006 (http://www.alzforum.org/new/detail.asp?id=1490) and in Journal of Cell Biology 2007, 176(1): 5 (http://jcb.rupress.org/cgi/content/full/176/1/5)] (#equal contribution, *corresponding author)

  38. Shuo Luo#, Yu Chen#, Kwok-On Lai, Juan Carlos Arévalo, Stanley C Froehner, Marvin E Adams, Moses V Chao, Nancy Y Ip*. (2005) α-Syntrophin regulates ARMS localization at the neuromuscular junction and enhances EphA4 signaling in an ARMS-dependent manner. Journal of Cell Biology 169(5):813-24. (# equal contribution, *corresponding author)

  39. Kwok-On Lai, Yu Chen, Hoi-Man Po, Ka-Chun Lok, Ke Gong, Nancy Y Ip*. (2004) Identification of the Jak/Stat Proteins as Novel Downstream Targets of EphA4 signaling in Muscle: implications in the regulation of acetylcholinesterase expression. Journal of Biological Chemistry 279(14):13383-92. (*corresponding author)