基本信息
王泽峰  男  博导  中国科学院上海营养与健康研究所
电子邮件: wangzefeng@picb.ac.cn
通信地址: 上海徐汇区岳阳路320号生理楼404房间
邮政编码:
部门/实验室:计算生物学伙伴研究所

招生信息

   
招生专业
0710Z2-计算生物学
100104-病理学与病理生理学
086000-生物与医药
招生方向
RNA 系统生物学,RNA加工与人类疾病

教育背景

1997-09--2002-06   约翰霍普金斯医学院   生化博士
1994-09--1997-06   中科院生物物理所   分子生物学硕士
1991-09--1994-06   清华大学   工学学士
1989-09--1994-06   清华大学   理学学士

工作经历

   
工作简历
2014-09~现在, 中国科学院上海生命科学研究院计算生物学研究所, 研究员、所长
2013-05~2014-09,北卡罗来那大学(教堂山)医学院药理系, 副教授(终身教职)
2007-01~2013-04,北卡罗来那大学(教堂山)医学院药理系, 助理教授
2002-09~2006-12,麻省理工学院生物系, 博士后研究员
1997-09~2002-06,约翰霍普金斯医学院, 生化博士
1994-09~1997-06,中科院生物物理所, 分子生物学硕士
1991-09~1994-06,清华大学, 工学学士
1989-09~1994-06,清华大学, 理学学士
社会兼职
2019-01-01-今,上海市生物信息学会第四届理事会副理事长,
2018-01-01-今,第七届分子生物学国家重点实验室学术委员会委员,
2017-12-29-2022-12-28,《SCIENCE BULLETION》副主编, 副主编
2017-12-01-今,精准医学研究院学术委员会委员,
2017-07-01-2022-06-30,《Journal of Biological Chemistry》编委,
2017-07-01-今,中国生物物理学会的生物信息学专业委员会委员,
2017-07-01-今,中国研究型医院学会分子肿瘤与免疫治疗专业委员会常务委员,
2017-01-01-2021-12-31,《Journal of Molecular Cell Biology》 副主编,
2016-12-01-今,中关村卓益防治慢病科技创新研究院第一届理事会副理事长,
2016-11-01-今,中国生物化学与分子生物学学会RNA专业委员会理事,
2016-11-01-今,中国细胞生物学学会功能基因组信息学与系统生物学分会理事,
2016-01-01-2020-12-31,中国科学院计算生物学重点实验室学术委员会委员,
2016-01-01-2020-12-31,中国科学院系统生物学重点实验室学术委员会委员,
2016-01-01-今,法国科学研究中心学术评估委员会评委,
2014-12-31-2015-12-28,英国皇家学会(Royal Society)基金评委,
2014-12-30-2015-12-29,加拿大国家科学工程协会Natural Sciences and Engineering Research Council (NSERC) 基金评委,
2014-12-29-2015-12-28,《PloS Genetics》客座编委,
2014-01-01-2014-12-31,英国医学研究基金评委,
2013-02-19-今,《Journal of Proteomics & Bioinformatics》编委,
2012-03-15-今,《Journal of Receptors and Signal Transduction》编委,
2011-12-31-2015-12-30,美国国家健康中心基金评委,
2010-01-15-今,《International Journal of Genomic Medicine》编委,
2009-03-01-今,《RNA & Disease》编委,
2006-03-10-今,国际RNA学会会员,

教授课程

细胞生物学
Antiviral Drugs
Principles of Pharmacology and Toxicology
Sequence Analysis
Introduction to Molecular Pharmacology

专利与奖励

   
奖励信息
(1) 中国科学院大学教育基金会"配天"研究员(教授)奖励基金获得者, 其他, 2018
(2) Mercator fellow, 其他, 2017
(3) Max-Planck Fellow, 其他, 2016
(4) 上海****创新长期项目, 一等奖, 省级, 2015
(5) Jefferson-Pilot Fellowships in Academic Medicine Award, 一等奖, 其他, 2012
(6) Kimmel Scholar Award, 一等奖, 其他, 2009
(7) Beckman Young Investigator Award, 一等奖, 其他, 2008
(8) Alfred Sloan Research FellowFellowship, 一等奖, 其他, 2008
(9) RNA Society/Scaringe Young Scientist Award, 一等奖, 其他, 2007
(10) 《自然评论:分子细胞生物》优秀墙报奖, 一等奖, 其他, 2006
(11) Damon Runyon Postdoctoral Fellowship, 一等奖, 其他, 2003
(12) Paul Ehrlich Research Award, 一等奖, 其他, 2002
(13) Burroughs Wellcome Fellowship, 一等奖, 其他, 1999
(14) 中科院地奥奖学金, 一等奖, 研究所(学校), 1996
(15) 优秀毕业生, 特等奖, 研究所(学校), 1994
(16) 北京市优秀毕业生奖, 一等奖, 市地级, 1994
(17) 清华大学光华奖学金, 一等奖, 研究所(学校), 1993
(18) 优秀生奖学金, 一等奖, 研究所(学校), 1990
专利成果
( 1 ) 一种构建人工特异性RNA内切酶的方法, 2013, 第 1 作者, 专利号: US20130129701A1
( 2 ) 使用PUF结构域构建人工剪接因子, 2010, 第 1 作者, 专利号: WO2010075303A1

出版信息

   
发表论文
(1) Modeling and predicting the activities of trans-acting splicing factors with machine learning, Cell Systems, 2018, 通讯作者
(2) Diverse roles of regulatory non-coding RNAs, Journal of Molecular Cell Biology, 2018, 通讯作者
(3) Expanding RNA binding specificity and affinity of engineered PUF domains, NUCLEIC ACIDS RESEARCH, 2018, 通讯作者
(4) Alternative splicing in cancers: From aberrant regulation to new therapeutics., SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY, 2018, 通讯作者
(5) Novel RNA-Affinity Proteogenomics Dissects Tumor Heterogeneity for Revealing Personalized Markers in Precision Prognosis of Cancer, CELL CHEMICAL BIOLOGY, 2018, 其他(合作组作者)
(6) Engineering Artificial Factors to Specifically Manipulate Alternative Splicing in Human Cells., JOVE-JOURNAL OF VISUALIZED EXPERIMENTS, 2017, 通讯作者
(7) Extensive translation of circular RNAs driven by N-6-methyladenosine, CELL RESEARCH, 2017, 通讯作者
(8) Autoregulation of RBM10 and cross-regulation of RBM10/RBM5 via alternative splicing-coupled nonsense-mediated decay., NUCLEIC ACIDS RESEARCH, 2017, 其他(合作组作者)
(9) SPSB1-mediated HnRNP A1 ubiquitylation regulates alternative splicing and cell migration in EGF signaling, CELL RESEARCH, 2017, 其他(合作组作者)
(10) Engineering Translational Activators with CRISPR-Cas System, ACS Synthetic Biology, 2016, 通讯作者
(11) AKAP95 regulates splicing through scaffolding RNAs and RNA processing factors, NATURE COMMUNICATIONS, 2016, 其他(合作组作者)
(12) A high-resolution transcriptome map of cell cycle reveals novel connections between periodic genes and cancer, Cell Research, 2016, 通讯作者
(13) Schematic model how splicing switch regulate Hippo-Yap signaling, Nature Communications, 2016, 通讯作者
(14) An Extensive Program of Periodic Alternative Splicing Linked to Cell Cycle Progression, eLife, 2016, 通讯作者
(15) A splicing isoform of TEAD4 attenuates Hippo-YAP signaling to inhibit tumor, Nature Communications, 2016, 通讯作者
(16) Transcriptome-wide identification and study of cancer-specific splicing events across multiple tumors, Oncotarget, 2015, 通讯作者
(17) Not just a sponge: new functions of circular RNAs discovered, Science China Life Sciences, 2015, 通讯作者
(18) Efficient backsplicing produces translatable circular mRNAs, RNA-A Publication of the RNA Society, 2015, 通讯作者
(19) Engineering RNA-binding proteins with diverse activities, Wiley Interdiscip Rev RNA, 2015, 通讯作者
(20) In vivo analysis of trypanosome mitochondrial RNA function by artificial site-specific RNA endonuclease-mediated knockdown, RNA-A Publication of the RNA Society, 2015, 第 2 作者
(21) The splicing factor RBM4 controls apoptosis, proliferation, and migration to suppress tumor, Cancer Cell, 2014, 通讯作者
(22) The splicing activator DAZAP1 integrates splicing control into MEK/Erk-regulated cell proliferation and migration, Nature Communications, 2014, 通讯作者
(23) A day in the life of the spliceosome, Nat Rev Mol Cell Biol, 2014, 通讯作者
(24) Treatment of type 1 myotonic dystrophy by engineering site-specific RNA endonucleases that target (CUG)(n) repeats, Molecular Therapy, 2014, 通讯作者
(25) Prevalent RNA recognition motif duplication in the human genome, RNA-A Publication of the RNA Society, 2014, 通讯作者
(26) Manipulation of RNA using engineered proteins with customized specificity, Advances in Experimental Medicine and Biology, 2014, 通讯作者
(27) Systematical identification of splicing regulatory cis-elements and cognate trans-factors, Methods, 2014, 通讯作者
(28) A complex network of factors with overlapping affinities represses splicing through intronic elements, Nat Struct Mol Biol, 2013, 通讯作者
(29) Engineered proteins with Pumilio/fem-3 mRNA binding factor scaffold to manipulate RNA metabolism, FEBS Journal, 2013, 通讯作者
(30) Engineering RNA endonucleases with customized sequence specificities, Nature Communications, 2012, 通讯作者
(31) Intronic splicing enhancers, cognate splicing factors and context-dependent regulation rules, Nat Struct Mol Biol, 2012, 通讯作者
(32) Quantitative analysis of focused a-to-I RNA editing sites by ultra-high-throughput sequencing in psychiatric disorders, PLos One, 2012, 第 1 作者
(33) Specific and modular binding code for cytosine recognition in Pumilio/FBF (PUF) RNA-binding domains, Journal of Biological Chemistry, 2011, 通讯作者
(34) Assessing serotonin receptor mRNA editing frequency by a novel ultra high-throughput sequencing method, Nucleic Acids Research, 2010, 第 2 作者
(35) Expression of linear and novel circular forms of an INK4/ARF-associated non-coding RNA correlates with atherosclerosis risk, PLoS Genetics, 2010, 第 4 作者
(36) Splice site strength-dependent activity and genetic buffering by poly-G runs, Nat Struct MolBiol, 2009, 第 3 作者
(37) Engineering splicing factors with designed specificities, Nature Methods, 2009, 通讯作者
(38) Splicing regulation: from a parts list of regulatory elements to an integrated splicing code, RNA-A Publication of the RNA Society, 2008, 通讯作者
(39) Coevolutionary networks of splicing cis-regulatory elements, Proceedings of the National Academy of Sciences of the United States of America, 2007, 通讯作者
(40) General and specific functions of exonic splicing silencers in splicing control, Molecular Cell, 2006, 第 1 作者
(41) Systematic identification and analysis ofexonic splicing silencers, Cell, 2004, 第 1 作者
(42) The adenosine analog tubercidin inhibits glycolysis in Trypanosoma brucei as revealed by an RNAinterference library, Journal of Biological Chemistry, 2003, 第 1 作者
(43) A trypanosome mitochondrial RNA polymerase isrequired for transcription and replication, Journal of Biological Chemistry, 2002, 第 3 作者
(44) Glycolysis modulates trypanosome glycoprotein expression as revealed by an RNAi library, The EMBO Journal, 2002, 第 1 作者
(45) Asymm etrical division of the kinetoplast DNA network of the trypanosome, The EMBO Journal, 2002, 第 1 作者
(46) Replication of kinetoplast DNA: an update for the new millennium, International Journal for Parasitology, 2001, 第 4 作者
(47) Unlocking the secrets of trypanosomekine to plast DNA network replication, Protist, 2001, 第 4 作者
(48) Inhibition of bloodstream form Trypanosoma brucei gene expression by RNAinterference using the pZJM dual T7 vector, Molecular and Biochemical Parasitology, 2001, 第 1 作者
(49) RNA interference of a trypanosome topoisomerase II causes progressive loss of mitochondrial DNA, ,The EMBO Journal, 2001, 第 1 作者
(50) Inhibition ofTrypanosoma brucei gene expression by RNA interference using an integratablevector with opposing T7 promoters, Journal of Biological Chemistry, 2000, 第 1 作者
(51) A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA, A new twist in trypanosome RNA metabolism: cis-splicing of pre-mRNA, 2000, 第 4 作者
(52) Kinetics of irreversible inhibition of aminoacylase by MNP, Progress in Natural Science, 1996, 第 2 作者
(53) Secondary structure of holo-aminoacylase and apo-aminoacylase from prediction,circular-dichroism, and ft-raman spectroscopy, Journal of Biochemistry, 1995, 第 4 作者
(54) Unfolding,conformational change of active-sites and inactivation of creatine-kinase insds solutions, Biochimica et Biophysica Acta - Protein Structure and Molecular Enzymology, 1995, 第 1 作者
(55) Replication of kinetoplast DNA: an update for the new millennium, Biochimie, 1995, 第 1 作者
(56) Kinetics of irreversible inhibitionof creatine-kinase during modification by o-phthaldehyde, Enzyme and Protein, 1994, 第 1 作者
发表著作
An RNAi-Based Genomic Library for Forward Genetics in the African Trypanosome, Chapman & Hall/CRC Press, 2004-03, 第 2 作者
Inducible RNAi as a forward genetic tool in Trypanosoma brucei, Cambridge University Press, 2005-01, 第 4 作者
Manipulation of RNA Using Engineered Proteins with Customized Specificity, Springer, New York, NY, 2014-08, 第 1 作者
Design of RNA-Binding Proteins: Manipulate Alternative Splicing in Human Cells with Artificial Splicing Factors, Humana Press, 2016-03, 第 1 作者
Constructing GFP-Based Reporter to Study Back Splicing and Translation of Circular RNA, Humana Press, 2018-01, 第 1 作者

科研活动

   
科研项目
( 1 ) RNA可变剪接在细胞周期时序性调控机制与功能, 主持, 国家级, 2016-01--2019-12
( 2 ) 致癌和抑癌的剪接因子对癌症中选择性剪接的协调控制, 主持, 国家级, 2017-01--2019-12
( 3 ) 系统性研究癌症中RNA剪接异常的病理功能和分子机理, 主持, 国家级, 2018-01--2022-12
( 4 ) 利用多维组学大数据的人工智能分析进行癌症表型的预测, 主持, 部委级, 2019-01--2020-12
( 5 ) Race-related alternative splicing: novel targets in prostate cancer, 参与, 研究所(学校), 2017-07--2022-06
( 6 ) 多能干细胞命运决定异质性的转录调控网络解析, 参与, 国家级, 2018-07--2022-12
( 7 ) 人工构建模块化RNA结合因子作为基因治疗新工具来操控RNA代谢, 主持, 省级, 2017-09--2020-08
( 8 ) 工程化剪接因子(ESFs)对癌症特异性可变剪接调控的研究, 主持, 省级, 2018-05--2021-04
参与会议
(1)RNA选择性剪接调控的系统研究   中国细胞生物学学会2018年全国学术大会•南京    2019-04-10
(2)Increasing complexity of human proteome by unconventional translation - a tale of circular RNAs   中国生物化学与分子生物学会 第十二届会员代表大会暨2018年全国学术会议   2018-10-27
(3)Re-thinking the coding capacity of non-coding RNA    第四届发育和疾病的表观遗传学上海国际研讨会   2018-09-18
(4)Towards a splicing code: regulation and dysregulation of alternative splicing   2017-12-05
(5) Computational Biology in Big data era, new challenges and opportunities   2017-11-14
(6)Specific manipulation of Alterative splicing   2017-11-06
(7)Rethink the coding capacity of non-coding RNA: extensive translation of circRNAs   2017-10-04
(8)Towards a splicing code - regulation and mis-regulation of alternative splicing   2016-12-29
(9) Backsplicing and translation of Circular RNA.   2016-11-14
(10) Extensive translation of circular RNAs driven by N6-methyladenosine   中国生物化学与分子生物学会2016全国学术会议   2016-10-22
(11)系统性研究RNA剪接加工在癌症中调控及功能   科学大数据前沿国际研讨会    2016-07-09
(12)RNA选择性剪接在细胞周期中的时序性调控   第十一次全国基因功能与表观遗传调控学术研讨会   2015-10-15
(13)人工RNA特异性内切酶的设计并构造   第十一届全国酶学学术讨论会   2013-05-16