综合利用食品科学、分子生物学、分析化学、植物病理学等技术手段，开展食品中镰刀菌毒素等真菌毒素的安全性评价与控制研究：（1） 采用人源性细胞/靶动物等体内体外模型评价镰刀菌、链格孢菌等毒素及其隐蔽型污染的（联合）毒性，揭示其毒性作用与释放机制，为国家真菌毒素相关安全限量标准制（修）订提供基础数据与科学依据。（2）研究镰刀菌、链格孢菌等真菌毒素污染发生的调控机制及生物降解毒素关键基因功能，解析相关分子识别机制，形成基于菌剂、酶制剂的真菌毒素污染安全控制技术及规范。（3）研究多组分真菌毒素（含隐蔽型）同时定量与快速免疫检测新方法，研发标准物质与实用检测产品、技术标准等，开展真菌毒素内外暴露风险评估研究，为政府部门、大型企业等食品安全监管与真菌毒素防控提供技术支撑。

   

071009-细胞生物学
086000-生物与医药

细胞生物学-真菌毒素危害与控制
生物与医药-真菌毒素危害与控制

1999-09--2005-01   华中农业大学   博士
1995-09--1999-06   华中农业大学   本科

   

2017-01~现在, 中国科学院上海营养与健康研究所, 研究员
2015-02~2016-12,中国科学院上海生命科学研究院营养科学研究所, 研究员
2013-01~2014-12,上海市农业科学院质标所, 研究员
2011-04~2012-12,上海市农业科学院质标所, 副研究员
2007-12~2010-12,上海交通大学生命学院, 副教授
2005-04~2007-11,上海交通大学生命学院, 讲师

2023-01-01-今,食品添加剂联合专家委员会(联合国粮农组织和世界卫生组织) JECFA, 委员
2021-10-01-今,全国微生物学会微生物毒素专业委员会, 委员
2020-10-01-今,Toxins, 编委
2019-12-31-今,国家食品安全风险评估专家委员会, 委员
2017-11-20-今,中国预防医学会食品卫生分会, 委员
2014-12-30-今,Food Control, 编委

   

（1） 2017中国食品科学与技术学会创新奖——杰出青年奖, 其他, 2017
（2） 农药、真菌毒素等化学污染物筛查与确证检测技术研究, 其他, 2016
（3） 食品与饮水安全典型有害因子风险监测技术与设备, 一等奖, 省级, 2013

[1] 武爱波, 孙微, 刘娜, 余佃贞, 孙姝婷, 于松. 枳壳内生真菌及其在拮抗真菌及降解真菌毒素中的应用. CN: CN113773964A, 2021-12-10.
[2] 武爱波, 于松, 余佃贞, 刘娜. B族伏马菌素降解酶、其构建方法及其应用. CN: CN113774040A, 2021-12-10.
[3] 武爱波, 余佃贞, 李凯琳, 刘娜. 降解真菌毒素的多功能酶及其应用. CN: CN113755467A, 2021-12-07.
[4] 武爱波, 胡东强, 刘娜, 于松, 余佃贞, 唐艳, 王玉玲. 一种减少作物真菌病害与毒素污染的木霉源纳米硒叶面肥. CN: CN111484374B, 2021-11-30.
[5] 武爱波, 周海燕, 刘娜, 余佃贞. 一种检测茶叶样品中黄曲霉毒素含量的新型方法. CN: CN112034079A, 2020-12-04.

   

（1） Deciphering Alternaria metabolic responses in microbial confrontation via an integrated mass spectrometric targeted and non-targeted strategy, FOOD CHEMISTRY, 2023, 通讯作者
（2） Cytotoxicities of Co-occurring alternariol, alternariol monomethyl ether and tenuazonic acid on human gastric epithelial cells, FOOD AND CHEMICAL TOXICOLOGY, 2023, 通讯作者
（3） Mycotoxin deoxynivalenol-induced intestinal flora disorders, dysfunction and organ damage in broilers and pigs, JOURNAL OF HAZARDOUS MATERIALS, 2023, 通讯作者
（4） CotA laccase from Bacillus licheniformis ZOM-1 effectively degrades zearalenone, aflatoxin B1 and alternariol, FOOD CONTROL, 2023, 通讯作者
（5） Effects of Fumonisin B and Hydrolyzed Fumonisin B on Growth and Intestinal Microbiota in Broilers, TOXINS, 2022, 通讯作者
（6） Mycotoxin deoxynivalenol affects myoblast differentiation via downregulating cytoskeleton and ECM-integrin-FAK-RAC-PAK signaling pathway (vol 226, 112850, 2021), ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2022, 通讯作者
（7） AaTAS1 and AaMFS1 Genes for Biosynthesis or Efflux Transport of Tenuazonic Acid and Pathogenicity of Alternaria alternata, MOLECULAR PLANT-MICROBE INTERACTIONS, 2022, 通讯作者
（8） Cellobiose inhibits the release of deoxynivalenol from transformed deoxynivalenol-3-glucoside from Lactiplantibacillus plantarum, FOOD CHEMISTRY: MOLECULAR SCIENCES, 2022, 第 6 作者
（9） Biodegradation of Fumonisins by the Consecutive Action of a Fusion Enzyme, TOXINS, 2022, 通讯作者
（10） Exploration of Mycotoxin Accumulation and Transcriptomes of Different Wheat Cultivars during Fusarium graminearum Infection, TOXINS, 2022, 通讯作者
（11） Identification of Candidate Genes Associated with Trichothecene Biosynthesis in Fusarium graminearum Species Complex Combined with Transcriptomic and Proteomic Analysis, MICROORGANISMS, 2022, 通讯作者
（12） Elimination of Fusarium mycotoxin deoxynivalenol (DON) via microbial and enzymatic strategies: Current status and future perspectives, TRENDS IN FOOD SCIENCE & TECHNOLOGY, 2022, 通讯作者
（13） A prospective study of total urinary deoxynivalenol in adolescents in Shanghai, China, CHEMOSPHERE, 2022, 通讯作者
（14） Food bioactive compounds with prevention functionalities against fungi and mycotoxins: developments and challenges, CURRENT OPINION IN FOOD SCIENCE, 2022, 通讯作者
（15） Pre-warning of abiotic factors in maize required for potential contamination of fusarium mycotoxins via response surface analysis, FOOD CONTROL, 2021, 通讯作者
（16） Validation of LC-MS/MS Coupled with a Chiral Column for the Determination of 3- or 15-Acetyl Deoxynivalenol Mycotoxins from Fusarium graminearum in Wheat, TOXINS, 2021, 第 8 作者
（17） A data-driven integrative platform for computational prediction of toxin biotransformation with a case study, JOURNAL OF HAZARDOUS MATERIALS, 2021, 通讯作者
（18） Development and validation of the one-step purification method coupled to LC-MS/MS for simultaneous determination of four aflatoxins in fermented tea, FOOD CHEMISTRY, 2021, 通讯作者
（19） Fumonisin B1 triggers carcinogenesis via HDAC/PI3K/Akt signalling pathway in human esophageal epithelial cells, SCIENCE OF THE TOTAL ENVIRONMENT, 2021, 通讯作者
（20） Mycotoxin deoxynivalenol affects myoblast differentiation via downregulating cytoskeleton and ECM-integrin-FAK-RAC-PAK signaling pathway, ECOTOXICOLOGY AND ENVIRONMENTAL SAFETY, 2021, 通讯作者
（21） Metabolomic profiling reveals similar cytotoxic effects and protective functions of quercetin during deoxynivalenol- and 15-acetyl deoxynivalenol-induced cell apoptosis, TOXICOLOGY IN VITRO, 2020, 通讯作者
（22） Evaluation of the Individual and Combined Toxicity of Fumonisin Mycotoxins in Human Gastric Epithelial Cells, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2020, 通讯作者
（23） Confrontation assays and mycotoxin treatment reveal antagonistic activities of Trichoderma and the fate of Fusarium mycotoxins in microbial interaction, ENVIRONMENTAL POLLUTION, 2020, 通讯作者
（24） FRCD: A comprehensive food risk component database with molecular scaffold, chemical diversity, toxicity, and biodegradability analysis, FOOD CHEMISTRY, 2020, 第 15 作者
（25） Involvement of PERK-CHOP pathway in fumonisin B1- induced cytotoxicity in human gastric epithelial cells, FOOD AND CHEMICAL TOXICOLOGY, 2020, 通讯作者
（26） Risk profiling of exposures to multiclass contaminants through cereals and cereal-based products consumption: A case study for the inhabitants in Shanghai, China, FOOD CONTROL, 2020, 通讯作者
（27） 食品中展青霉素脱除方法研究进展, Advances on the clearance and detoxification of patulin in foods, 中国食品卫生杂志, 2019, 第 5 作者
（28） Species Composition and Toxigenic Potential of Fusarium Isolates Causing Fruit Rot of Sweet Pepper in China, TOXINS, 2019, 通讯作者
（29） Degrading Ochratoxin A and Zearalenone Mycotoxins Using a Multifunctional Recombinant Enzyme, TOXINS, 2019, 通讯作者
（30） Biogenic Trichoderma harzianum-derived selenium nanoparticles with control functionalities originating from diverse recognition metabolites against phytopathogens and mycotoxins, FOOD CONTROL, 2019, 通讯作者
（31） Two-dimensional fruit quality factors and soil nutrients reveals more favorable topographic plantation of Xinjiang jujubes in China, PLOS ONE, 2019, 第 5 作者
（32） Development and Application of a QuEChERS-Based Liquid Chromatography Tandem Mass Spectrometry Method to Quantitate Multi-Component Alternaria Toxins in Jujube, TOXINS, 2018, 第 5 作者
（33） Overview of analysis, risk assessment and control of Fusarium mycotoxins in contaminated foods, Overview of analysis, risk assessment and control of Fusarium mycotoxins in contaminated foods, 中国科学基金：英文版, 2018, 第 1 作者
（34） Antagonistic and Detoxification Potentials of Trichoderma Isolates for Control of Zearalenone (ZEN) Producing Fusarium graminearum, FRONTIERS IN MICROBIOLOGY, 2018, 通讯作者
（35） Transcription Factor FOXO3a Is a Negative Regulator of Cytotoxicity of Fusarium mycotoxin in GES-1 Cells, TOXICOLOGICAL SCIENCES, 2018, 通讯作者
（36） Occurrence and Quantitative Risk Assessment of Twelve Mycotoxins in Eggs and Chicken Tissues in China, TOXINS, 2018, 通讯作者
（37） A QuEChERS-Based Liquid Chromatography-Tandem Mass Spectrometry Method for the Simultaneous Determination of Nine Zearalenone-Like Mycotoxins in Pigs, TOXINS, 2018, 通讯作者
（38） Metabolic Profiling on Alternaria Toxins and Components of Xinjiang Jujubes Incubated with Pathogenic Alternaria alternata and Alternaria tenuissima via Orbitrap High-Resolution Mass Spectrometry, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, 第 9 作者
（39） An ultrasensitive amperometric immunosensor for zearalenones based on oriented antibody immobilization on a glassy carbon electrode modified with MWCNTs and AuPt nanoparticles, MICROCHIMICA ACTA, 2017, 通讯作者
（40） Individual and Combined Cytotoxic Effects of Co-Occurring Deoxynivalenol Family Mycotoxins on Human Gastric Epithelial Cells, TOXINS, 2017, 通讯作者
（41） Metabolic Profiling on Alternaria Toxins and Components of Xinjiang Jujubes Incubated with Pathogenic Alternaria alternata and Alternaria tenuissima via Orbitrap High -Resolution Mass Spectrometry, JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY, 2017, 通讯作者
（42） Functional Agents to Biologically Control Deoxynivalenol Contamination in Cereal Grains, FRONTIERS IN MICROBIOLOGY, 2016, 通讯作者
（43） Detoxification of Deoxynivalenol via Glycosylation Represents Novel Insights on Antagonistic Activities of Trichoderma when Confronted with Fusarium graminearum, TOXINS, 2016, 通讯作者
（44） Mycotoxigenic Potentials of Fusarium Species in Various Culture Matrices Revealed by Mycotoxin Profiling, TOXINS, 2016, 第 10 作者
（45） Simultaneous Raising of Rabbit Monoclonal Antibodies to Fluoroquinolones with Diverse Recognition Functionalities via Single Mixture Immunization, ANALYTICAL CHEMISTRY, 2016, 通讯作者
（46） A reliable liquid chromatography–tandem mass spectrometry method for simultaneous determination of multiple mycotoxins in fresh fish and dried seafoods, JOURNAL OF CHROMATOGRAPHY A, 2015, 通讯作者
（47） Ultrasensitive immunoassays based on biotinestreptavidin amplified system for quantitative determination of family zearalenones., Food Control, 2015, 通讯作者
（48） Cross-linked chitosan polymers as generic adsorbents for simultaneous adsorption of multiple mycotoxins, FOOD CONTROL, 2015, 通讯作者
（49） Food bioactive compounds with prevention functionalities against fungi and mycotoxins: developments and challenges, CURRENT OPINION IN FOOD SCIENCE, 第 8 作者
（50） Deciphering Alternaria metabolic responses in microbial confrontation via an integrated mass spectrometric targeted and non-targeted strategy, FOOD CHEMISTRY, 通讯作者

（1） Food Safety & Mycotoxins, Springer, 2019-11, 第 1 作者

   

（ 1 ） 秸秆及牧草主要养分转化机制与安全性调控, 负责人, 中国科学院计划, 2020-10--2024-10
（ 2 ） 真菌毒素与粮食食品安全, 负责人, 国家任务, 2021-01--2025-12

（1）食品呕吐毒素生物合成与安全控制新路径与新机理研究   第三届全国食品生物技术大会   2022-11-18
（2）Inhibition of mycotoxin production by antagonistic Trichoderma harzianum   2018-09-16
（3）Inhibitionof DON production by Fusarium graminearumvia exposure to Trichoderma harzianum   2017-09-14
（4）Risk assessment and biocontrol of deoxynivalenol family mycotoxins contaminated incereal grains   2016-12-12
（5）Risk screening and safety evaluation of major types of vomiting toxin   2016-06-28
（6）Risk assessment and control strategies of Fusarium mycotoxins in agricultural products   2014-05-23

已指导学生

田野  博士研究生  071010-生物化学与分子生物学  

杨昀夏  博士研究生  071010-生物化学与分子生物学  

胡东强  博士研究生  071010-生物化学与分子生物学  

唐艳  硕士研究生  071010-生物化学与分子生物学  

于松  博士研究生  071010-生物化学与分子生物学  

王岚  博士研究生  071010-生物化学与分子生物学  

赖文珊  硕士研究生  085238-生物工程  

贾冰璇  博士研究生  071009-细胞生物学  

现指导学生

周海燕  博士研究生  071009-细胞生物学  

李凯琳  博士研究生  071009-细胞生物学  

孙姝婷  博士研究生  071009-细胞生物学  

徐安琪  硕士研究生  071009-细胞生物学  

林惠康  博士研究生  071009-细胞生物学  

孙帆  博士研究生  071009-细胞生物学  

郭明珠  博士研究生  071009-细胞生物学  

唐沐海  硕士研究生  0710Z2-计算生物学