071002-动物学
071008-发育生物学
071009-细胞生物学

发育生物学
细胞生物学
功能基因组

2006-08--2010-12   佛罗里达大学   博士
2004-09--2006-07   中国农业大学   硕士
2000-09--2004-07   中国农业大学   学士

   

2014-12~现在, 中国科学院西北高原生物研究所, 研究员
2014-05~2014-11,华盛顿州立大学, 研究助理教授
2011-06~2014-04,华盛顿州立大学, 博士后
2006-08~2010-12,佛罗里达大学, 博士
2004-09~2006-07,中国农业大学, 硕士
2000-09~2004-07,中国农业大学, 学士

2023-08-01-2027-08-01,中国动物学会动物生理生态学分会, 副主任委员
2021-08-15-2025-12-31,中国畜牧兽医学会动物繁殖学分会, 理事

   

（1） Single-cell transcriptome analyses reveal critical regulators of spermatogonial stem cell fate transitions, BMC GENOMICS, 2024, 通讯作者
（2） Single-cell transcriptomic characterization of sheep conceptus elongation and implantation, CELL REPORTS, 2023, 通讯作者
（3） Elevated Id2 expression causes defective meiosis and spermatogenesis in mice, DEVELOPMENTAL DYNAMICS, 2023, 通讯作者
（4） Comparative proteomic analysis identifies differentially expressed proteins associated with meiotic arrest in cattle-yak hybrids, PROTEOMICS, 2023, 通讯作者
（5） ARHGEF15 is expressed in undifferentiated spermatogonia but is not required for spermatogenesis in mice, REPRODUCTIVE BIOLOGY, 2023, 通讯作者
（6） Pancreatic lipase-related protein 2 is selectively expressed by peritubular myoid cells in the murine testis and sustains long-term spermatogenesis, Cellular and Molecular Life Sciences, 2023, 通讯作者
（7） Transcription factor E4F1 dictates spermatogonial stem cell fate decisions by regulating mitochondrial functions and cell cycle progression, Cell & Bioscience, 2023, 通讯作者
（8） Hypobaric hypoxia exposure alters transcriptome in mouse testis and impairs spermatogenesis in offspring, Gene, 2022, 通讯作者
（9） Long read genome assemblies complemented by single cell RNA-sequencing reveal genetic and cellular mechanisms underlying the adaptive evolution of yak, NATURE COMMUNICATIONS, 2022, 通讯作者
（10） Ldha-Dependent Metabolic Programs in Sertoli Cells Regulate Spermiogenesis in Mouse Testis, BIOLOGY, 2022, 通讯作者
（11） Paternal hypoxia exposure impairs fertilization process and preimplantation embryo development, Zygote, 2021, 通讯作者
（12） Transcriptome analysis revealed key signaling networks regulating ovarian activities in the domestic yak, THERIOGENOLOGY, 2020, 第 6 作者
（13） WTAP Function in Sertoli Cells Is Essential for Sustaining the Spermatogonial Stem Cell Niche, STEM CELL REPORTS, 2020, 通讯作者
（14） Function and transcriptomic dynamics of Sertoli cells during prospermatogonia development in mouse testis, REPRODUCTIVE BIOLOGY, 2020, 通讯作者
（15） 青藏高原牦牛遗传资源保护和利用：问题与展望, Conservation and utilization of yak genetic resources in Qinghai-Tibet plateau: problems and perspectives, 生态学报, 2020, 第 6 作者
（16） E4 Transcription Factor 1 (E4F1) Regulates Sertoli Cell Proliferation and Fertility in Mice, ANIMALS, 2020, 通讯作者
（17） The expression of histone methyltransferases and distribution of selected histone methylations in testes of yak and cattle-yak hybrid, THERIOGENOLOGY, 2020, 通讯作者
（18） Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak, JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2019, 通讯作者
（19） Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak, Gene expression dynamics during the gonocyte to spermatogonia transition and spermatogenesis in the domestic yak, JOURNAL OF ANIMAL SCIENCE AND BIOTECHNOLOGY, 2019, 通讯作者
（20） Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae), THERIOGENOLOGY, 2019, 通讯作者
（21） The CXCL12-CXCR4 signaling promotes oocyte maturation by regulating cumulus expansion in sheep, THERIOGENOLOGY, 2018, 通讯作者
（22） ID4 levels dictate the stem cell state in mouse spermatogonia, DEVELOPMENT, 2017, 第 2 作者
（23） Conditions for Long-Term Culture of Cattle Undifferentiated Spermatogonia, BIOLOGY OF REPRODUCTION, 2016, 第 3 作者
（24） The requirement for protein kinase C delta (PRKCD) during preimplantation bovine embryo development, REPRODUCTION, FERTILITY AND DEVELOPMENT, 2016, 第 1 作者
（25） Inactivation of Retinoblastoma Protein (Rb1) in the Oocyte: Evidence That Dysregulated Follicle Growth Drives Ovarian Teratoma Formation in Mice, PLOS GENETICS, 2015, 第 1 作者
（26） Chapter Nine - Spermatogonial Stem Cell Functions in Physiological and Pathological Conditions, CURRENT TOPICS IN DEVELOPMENTAL BIOLOGY, 2014, 第 1 作者
（27） Functional and molecular features of the Id4 + germline stem cell population in mouse testes, GENES & DEVELOPMENT, 2014, 第 4 作者
（28） Retinol dehydrogenase 10 is indispensible for spermatogenesis in juvenile males, PNAS, 2013, 第 2 作者
（29） Retinoblastoma Protein (RB1) Controls Fate Determination in Stem Cells and Progenitors of the Mouse Male Germline, BIOLOGY OF REPRODUCTION, 2013, 第 1 作者
（30） MicroRNAs 221 and 222 regulate the undifferentiated state in mammalian male germ cells, DEVELOPMENT, 2013, 第 1 作者
（31） CXCL12/CXCR4 signaling is essential for the maintenance of mouse spermatogonial stem cells, Journal of Cell Science, 2013, 第 1 作者
（32） Fibroblast growth factors activate mitogen-activated protein kinase pathways to promote migration in ovine trophoblast cells, REPRODUCTION, 2011, 第 1 作者
（33） Fibroblast Growth Factor 2 Promotes Primitive Endoderm Development in Bovine Blastocyst Outgrowths, BIOLOGY OF REPRODUCTION, 2011, 第 1 作者
（34） Protein Kinase C Delta Mediates Fibroblast Growth Factor-2-Induced Interferon-Tau Expression in Bovine Trophoblast, BIOLOGY OF REPRODUCTION, 2011, 第 1 作者
（35） Stepwise in-straw dilution and direct transfer using open pulled straws (OPS) in the mouse: A potential model for field manipulation of vitrified embryos, JOURNAL OF REPRODUCTION AND DEVELOPMENT, 2007, 第 1 作者

（ 1 ） 动物配子与胚胎冷冻保存原理及应用, 科学出版社, 2016-11, 第 其他 作者

   

（ 1 ） 单个型精原细胞特异表达转录因子Tbr2调控精原干细胞命运决定的分子机制, 负责人, 国家任务, 2018-01--2021-12
（ 2 ） 三江源区代表性动物基因资源保护与利用, 负责人, 地方任务, 2019-01--2021-12
（ 3 ） 犏牛精母细胞减数分裂前期DNA双链断裂修复障碍的成因解析, 负责人, 国家任务, 2020-01--2023-12
（ 4 ） 青海省自然基金团队项目, 负责人, 地方任务, 2020-01--2022-12
（ 5 ） 牛羊生殖发育的关键分子调控机理解析与高效扩繁群建立, 参与, 中国科学院计划, 2020-11--2025-12
（ 6 ） 青海牦牛遗传多样性评估和极端环境适应关键基因鉴定, 负责人, 国家任务, 2023-01--2026-12

（1）Germ Cell Fate Decision, Meiosis and Hybrid Sterility   第六届国际牦牛大会   2018-08-27