基本信息
李佳阳 女 博导 国家纳米科学中心
电子邮件: lijiayang@nanoctr.cn
通信地址: 中关村北一条11号 科研楼1009室
邮政编码:
电子邮件: lijiayang@nanoctr.cn
通信地址: 中关村北一条11号 科研楼1009室
邮政编码:
招生信息
招生专业
0703J1-纳米科学与技术070303-有机化学
招生方向
短肽小分子自组装纳米材料;抗肿瘤纳米药物;肿瘤靶向治疗
教育背景
2007-09--2013-05 Brandeis University 博士2004-09--2007-08 香港科技大学 学士
工作经历
工作简历
2013-10~2014-02,Cornell University, 短期博士后2007-09~2013-05,Brandeis University, 博士2004-09~2007-08,香港科技大学, 学士
专利与奖励
专利成果
( 1 ) 一种靶向乏氧肿瘤的短肽小分子自组装纳米材料及其制备方法和应用, 2020, 第 2 作者, 专利号: PCT/CN2020/107860( 2 ) 一种靶向乏氧肿瘤的短肽小分子自组装纳米材料及其制备方法和应用, 2019, 第 2 作者, 专利号: 201910784941.1( 3 ) 一种金钆复合纳米材料、制备方法及其用途, 2019, 第 5 作者, 专利号: ZL201511031874.( 4 ) Hydrogelators comprising D-amino acids, 2014, 第 2 作者, 专利号: WO 2014/074789 A1
出版信息
发表论文
(1) Hypoxia-Triggered Self-Assembly of Ultrasmall Iron Oxide Nanoparticles to Amplify the Imaging Signal of a Tumor, Journal of the American Chemical Society, 2021, 第 1 作者(2) Graphdiyne-templated palladium-nanoparticle assembly as a robustoxygen generator to attenuate tumor hypoxia., Nano Today, 2020, 其他(合作组作者)(3) Few-Layer Bismuthene for Checkpoint Knockdown Enhanced Cancer Immunotherapy with Rapid Clearance and Sequentially Triggered One-for-All Strategy., ACS Nano, 2020, 其他(合作组作者)(4) Metal ions modulation of the self-assembly of short peptide conjugated nonsteroidal anti-inflammatory drugs (NSAIDs), Nanoscale, 2020, 通讯作者(5) New power of self-assembling carbonic anhydrase inhibitor: Short peptide–constructed nanofibers inspire hypoxic cancer therapy, Science Advances, 2019, 第 1 作者(6) Graphdiyne Nanosheet-Based Drug Delivery Platform for Photothermal/Chemotherapy Combination Treatment of Cancer, ACS Applied Materials and Interfaces, 2018, 第 6 作者(7) Remote Control and Modulation of Cellular Events by Plasmonic Gold Nanoparticles: Implications and Opportunities for Biomedical Applications, ACS Nano, 2017, 第 1 作者(8) In vivo aggregation-induced transition between T1 and T2 relaxations of magnetic ultra-small iron oxide nanoparticles in tumor microenvironment, Nanoscale, 2017, 第 3 作者(9) In vivo pharmacokinetic features and biodistribution of star and rod shaped gold nanoparticles by multispectral optoacoustic tomography, RSC Advances, 2015, 通讯作者(10) Substoichiometric Hydroxynonenylation of a Single Protein Recapitulates Whole-Cell-Stimulated Antioxidant Response, Journal of the American Chemical Society, 2015, 第 3 作者(11) D-Amino Acids Boost the Selectivity and Confer Supramolecular Hydrogels of a Nonsteroidal Anti-Inflammatory Drug (NSAID), Journal of the American Chemical Society, 2013, 第 1 作者(12) Dephosphorylation of D-Peptide Derivatives to Form Biofunctional, Supramolecular Nanofibers/Hydrogels and Their Potential Applications for Intracellular Imaging and Intratumoral Chemotherapy, Journal of the American Chemical Society, 2013, 第 1 作者(13) Self-Delivery Multifunctional Anti-HIV Hydrogels for Sustained Release, Advanced Healthcare Materials, 2013, 第 1 作者(14) The conjugation of nonsteroidal anti-inflammatory drugs (NSAID) to small peptides for generating multifunctional supramolecular nanofibers/hydrogels, Beilstein Journal of Organic Chemistry, 2013, 第 1 作者(15) Introducing D-Amino Acid or Simple Glycoside into Small Peptides to Enable Supramolecular Hydrogelators to Resist Proteolysis, Langmuir, 2012, 第 3 作者(16) Molecular Nanofibers of Olsalazine Form Supramolecular Hydrogels for Reductive Release of an Anti-inflammatory Agent, Journal of the American Chemical Society, 2010, 第 2 作者
科研活动
科研项目
( 1 ) 药物多肽小分子自组装材料于肿瘤干细胞治疗的构建与研究, 负责人, 国家任务, 2016-01--2019-12( 2 ) 核技术及其应用, 参与, 国家任务, 2015-01--2019-12( 3 ) 超小超顺磁纳米氧化铁自组装材料在乏氧微环境肿瘤干细胞诊断与治疗中的新应用, 负责人, 国家任务, 2019-01--2022-12( 4 ) 纳米技术用于治疗神经性退行性疾病, 负责人, 中国科学院计划, 2019-01--2020-12( 5 ) 影响医用及工业应用纳米材料跨膜运转及细胞内行为的关键纳米特性参数, 参与, 国家任务, 2016-07--2021-12( 6 ) 多尺度纳米材料与暴露模型开发及预测毒理研究方法, 参与, 其他国际合作项目, 2019-12--2022-12
参与会议
(1)Dephosphorylation of D‑Peptide Derivatives to Form Biofunctional, Supramolecular Hydrogels and Their Potential Applications for Intracellular Imaging and Therapy 2014全国纳米生物与医学学术会议 2014-11-05