About Fan Liu

Dr. Fan Liu is a professor at the Key Laboratory of Genomic and Precision Medicine, Beijing Institute of Genomics (BIG), Chinese Academy of Sciences (CAS). Dr. Liu received BSc in 1999 in clinical medicine from Shandong Medical University in China. He obtained MSc (2003), DSc (2004), and PhD (2009) in genetic epidemiology from Erasmus University Medical Center Rotterdam, the Netherlands (promotor: Prof. Dr. Cornelia van Duijn). In 2009, Dr. Liu pursued his postdoctoral research at the department of Forensic Molecular Biology (department head: Prof. Dr. Manfred Kayser). He was awarded with Erasmus University Research Fellowship in 2012 and was promoted to assistant professor with tenure. In 2015, Dr. Liu was awarded with a prestige Chinese talent program “The 1000 Talents Program for Young Scholars" and consequently joint BIG. Over years, Dr. Liu made systematic discoveries in the field of genomics in explaining the heritability and identifying novel genetic factors for human complex traits and disorders. He led an entire research line in identifying genes and developing predictive DNA markers for human appearance traits; his work laid the foundation for two DNA test systems for predicting eye color and hair color, which are already in use for forensic and anthropological applications internationally. He has published over 50 scientific articles including 17 first/corresponding author papers with overall more than 1000 citations; all on SCI journals, such as Am J Hum Genet, Curr Bio, PLoS Genet, Hum Genet, and Forensic Sci Int Genet; with 7 being highlighted by media such as BBC or CNN. He was involved as a key member in 2 applications for US patent, development of 6 software packages, and 5 granted applications for European research funding exceeding millions of euros. He has accumulated a wealth of experience in leading large-scaled internationally collaborative research projects, providing workshop lectures and thematic reports at international conferences, and reviewing papers for scientific journals including Nature and Science.

Research lines

We aim to study the complex structure of the human genome and various types of genetic and non-genetic variation; develop efficient and powerful pipelines to uncover associations between genome variation and human complex traits including common diseases; and to access the use of next-generation sequencing for solving diagnostic dilemmas. Our research lines also have a clinical focus, where we aim to develop and evaluate the clinical utility of new tests; prenatal carrier testing and newborn screening for Mendelian diseases; predictive tests for common and complex diseases; and pharmacogenomic testing for selecting the most effective drug with the minimal adverse effect. Besides medicine related applications, we aim to develop prediction models for human externally visible traits that are useful in forensic investigations.

1994-1999 Shandon University School of Medicine BSc 
2002-2003 Erasmus University Medical Center MSc 
2003-2004 Erasmus University Medical Center DSc 
2004-2009 Erasmus University Medical Center PhD

2015.10-Now       Beijing Institute Genomics, Chinese Academy of Sciences 　Principle Investigator

　　　　　　　     University of Chinese Academy of Sciences　Professor

2013.01-2015.09  Erasmus University Medical Center  Assitant Professor

Fist-author / corresponding-author* papers  

1.         Liu, F., Hamer, M.A., Deelen, J., Lall, J.S., Jacobs, L., van Heemst, D., Murray, P.G., Wollstein, A., de Craen, A.J., Uh, H.W., Zeng, C., Hofman, A., Uitterlinden, A.G., Houwing-Duistermaat, J.J., Pardo, L.M., Beekman, M., Slagboom, P.E., Nijsten, T., Kayser, M., and Gunn, D.A. (2016). The MC1R Gene and Youthful Looks. Curr Biol 26, 1213-1220.

2.         Zhong, K., Karssen, L.C., Kayser, M., and Liu, F.* (2016). CollapsABEL: an R library for detecting compound heterozygote alleles in genome-wide association studies. BMC Bioinformatics 17, 156.

3.         Liu, F., Hamer, M.A., Heilmann, S., Herold, C., Moebus, S., Hofman, A., Uitterlinden, A.G., Nothen, M.M., van Duijn, C.M., Nijsten, T.E., and Kayser, M. (2016). Prediction of male-pattern baldness from genotypes. Eur J Hum Genet 24, 895-902.

4.         Liu, F.,* Visser, M., Duffy, D.L., Hysi, P.G., Jacobs, L.C., Lao, O., Zhong, K., Walsh, S., Chaitanya, L., Wollstein, A., Zhu, G., Montgomery, G.W., Henders, A.K., Mangino, M., Glass, D., Bataille, V., Sturm, R.A., Rivadeneira, F., Hofman, A., van, I.W.F., Uitterlinden, A.G., Palstra, R.J., Spector, T.D., Martin, N.G., Nijsten, T.E., and Kayser, M. (2015). Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up. Hum Genet 134,

5.         Liu, F.,* Hendriks, A.E., Ralf, A., Boot, A.M., Benyi, E., Savendahl, L., Oostra, B.A., van Duijn, C., Hofman, A., Rivadeneira, F., Uitterlinden, A.G., Drop, S.L., and Kayser, M. (2014). Common DNA variants predict tall stature in Europeans. Hum Genet 133, 587-597.

6.         Liu, F.,* Walsh, S., and Kayser, M. (2014). Of sex and IrisPlex eye colour prediction: a reply to Martinez-Cadenas et al. Forensic Sci Int Genet 9, e5-6.

7.         Liu, F.,* Wen, B., and Kayser, M. (2013). Colorful DNA polymorphisms in humans. Semin Cell Dev Biol 24, 562-575.

8.         Jacobs, L.C., Wollstein, A., Lao, O., Hofman, A., Klaver, C.C., Uitterlinden, A.G., Nijsten, T., Kayser, M., and Liu, F.* (2013). Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans. Hum Genet 132, 147-158.

9.         Liu, F., van der Lijn, F., Schurmann, C., Zhu, G., Chakravarty, M.M., Hysi, P.G., Wollstein, A., Lao, O., de Bruijne, M., Ikram, M.A., van der Lugt, A., Rivadeneira, F., Uitterlinden, A.G., Hofman, A., Niessen, W.J., Homuth, G., de Zubicaray, G., McMahon, K.L., Thompson, P.M., Daboul, A., Puls, R., Hegenscheid, K., Bevan, L., Pausova, Z., Medland, S.E., Montgomery, G.W., Wright, M.J., Wicking, C., Boehringer, S., Spector, T.D., Paus, T., Martin, N.G., Biffar, R., and Kayser, M. (2012). A genome-wide association study identifies five loci influencing facial morphology in Europeans. PLoS Genet 8, e1002932.

10.     Liu, F.,* Struchalin, M.V., Duijn, K., Hofman, A., Uitterlinden, A.G., Duijn, C., Aulchenko, Y.S., and Kayser, M. (2011). Detecting low frequent loss-of-function alleles in genome wide association studies with red hair color as example. PLoS One 6, e28145.

11.     Liu, F., Wollstein, A., Hysi, P.G., Ankra-Badu, G.A., Spector, T.D., Park, D., Zhu, G., Larsson, M., Duffy, D.L., Montgomery, G.W., Mackey, D.A., Walsh, S., Lao, O., Hofman, A., Rivadeneira, F., Vingerling, J.R., Uitterlinden, A.G., Martin, N.G., Hammond, C.J., and Kayser, M. (2010). Digital quantification of human eye color highlights genetic association of three new loci. PLoS Genet 6, e1000934.

12.     Liu, F., Pardo, L.M., Schuur, M., Sanchez-Juan, P., Isaacs, A., Sleegers, K., de Koning, I., Zorkoltseva, I.V., Axenovich, T.I., Witteman, J.C., Janssens, A.C., van Swieten, J.C., Aulchenko, Y.S., Oostra, B.A., and van Duijn, C.M. (2010). The apolipoprotein E gene and its age-specific effects on cognitive function. Neurobiol Aging 31, 1831-1833.

13.     Liu, F., Ikram, M.A., Janssens, A.C., Schuur, M., de Koning, I., Isaacs, A., Struchalin, M., Uitterlinden, A.G., den Dunnen, J.T., Sleegers, K., Bettens, K., Van Broeckhoven, C., van Swieten, J., Hofman, A., Oostra, B.A., Aulchenko, Y.S., Breteler, M.M., and van Duijn, C.M. (2009). A study of the SORL1 gene in Alzheimer's disease and cognitive function. J Alzheimers Dis 18, 51-64.

14.     Liu, F., van Duijn, K., Vingerling, J.R., Hofman, A., Uitterlinden, A.G., Janssens, A.C., and Kayser, M. (2009). Eye color and the prediction of complex phenotypes from genotypes. Curr Biol 19, R192-193.

15.     Liu, F., Kirichenko, A., Axenovich, T.I., van Duijn, C.M., and Aulchenko, Y.S. (2008). An approach for cutting large and complex pedigrees for linkage analysis. Eur J Hum Genet 16, 854-860.

16.     Liu, F., Arias-Vasquez, A., Sleegers, K., Aulchenko, Y.S., Kayser, M., Sanchez-Juan, P., Feng, B.J., Bertoli-Avella, A.M., van Swieten, J., Axenovich, T.I., Heutink, P., van Broeckhoven, C., Oostra, B.A., and van Duijn, C.M. (2007). A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. Am J Hum Genet 81, 17-31.

1.         Liu, F., Hamer, M.A., Deelen, J., Lall, J.S., Jacobs, L., van Heemst, D., Murray, P.G., Wollstein, A., de Craen, A.J., Uh, H.W., Zeng, C., Hofman, A., Uitterlinden, A.G., Houwing-Duistermaat, J.J., Pardo, L.M., Beekman, M., Slagboom, P.E., Nijsten, T., Kayser, M., and Gunn, D.A. (2016). The MC1R Gene and Youthful Looks. Curr Biol 26, 1213-1220.

2.         Zhong, K., Karssen, L.C., Kayser, M., and Liu, F.* (2016). CollapsABEL: an R library for detecting compound heterozygote alleles in genome-wide association studies. BMC Bioinformatics 17, 156.

3.         Liu, F., Hamer, M.A., Heilmann, S., Herold, C., Moebus, S., Hofman, A., Uitterlinden, A.G., Nothen, M.M., van Duijn, C.M., Nijsten, T.E., and Kayser, M. (2016). Prediction of male-pattern baldness from genotypes. Eur J Hum Genet 24, 895-902.

4.         Liu, F.,* Visser, M., Duffy, D.L., Hysi, P.G., Jacobs, L.C., Lao, O., Zhong, K., Walsh, S., Chaitanya, L., Wollstein, A., Zhu, G., Montgomery, G.W., Henders, A.K., Mangino, M., Glass, D., Bataille, V., Sturm, R.A., Rivadeneira, F., Hofman, A., van, I.W.F., Uitterlinden, A.G., Palstra, R.J., Spector, T.D., Martin, N.G., Nijsten, T.E., and Kayser, M. (2015). Genetics of skin color variation in Europeans: genome-wide association studies with functional follow-up. Hum Genet 134,

5.         Liu, F.,* Hendriks, A.E., Ralf, A., Boot, A.M., Benyi, E., Savendahl, L., Oostra, B.A., van Duijn, C., Hofman, A., Rivadeneira, F., Uitterlinden, A.G., Drop, S.L., and Kayser, M. (2014). Common DNA variants predict tall stature in Europeans. Hum Genet 133, 587-597.

6.         Liu, F.,* Walsh, S., and Kayser, M. (2014). Of sex and IrisPlex eye colour prediction: a reply to Martinez-Cadenas et al. Forensic Sci Int Genet 9, e5-6.

7.         Liu, F.,* Wen, B., and Kayser, M. (2013). Colorful DNA polymorphisms in humans. Semin Cell Dev Biol 24, 562-575.

8.         Jacobs, L.C., Wollstein, A., Lao, O., Hofman, A., Klaver, C.C., Uitterlinden, A.G., Nijsten, T., Kayser, M., and Liu, F.* (2013). Comprehensive candidate gene study highlights UGT1A and BNC2 as new genes determining continuous skin color variation in Europeans. Hum Genet 132, 147-158.

9.         Liu, F., van der Lijn, F., Schurmann, C., Zhu, G., Chakravarty, M.M., Hysi, P.G., Wollstein, A., Lao, O., de Bruijne, M., Ikram, M.A., van der Lugt, A., Rivadeneira, F., Uitterlinden, A.G., Hofman, A., Niessen, W.J., Homuth, G., de Zubicaray, G., McMahon, K.L., Thompson, P.M., Daboul, A., Puls, R., Hegenscheid, K., Bevan, L., Pausova, Z., Medland, S.E., Montgomery, G.W., Wright, M.J., Wicking, C., Boehringer, S., Spector, T.D., Paus, T., Martin, N.G., Biffar, R., and Kayser, M. (2012). A genome-wide association study identifies five loci influencing facial morphology in Europeans. PLoS Genet 8, e1002932.

10.     Liu, F.,* Struchalin, M.V., Duijn, K., Hofman, A., Uitterlinden, A.G., Duijn, C., Aulchenko, Y.S., and Kayser, M. (2011). Detecting low frequent loss-of-function alleles in genome wide association studies with red hair color as example. PLoS One 6, e28145.

11.     Liu, F., Wollstein, A., Hysi, P.G., Ankra-Badu, G.A., Spector, T.D., Park, D., Zhu, G., Larsson, M., Duffy, D.L., Montgomery, G.W., Mackey, D.A., Walsh, S., Lao, O., Hofman, A., Rivadeneira, F., Vingerling, J.R., Uitterlinden, A.G., Martin, N.G., Hammond, C.J., and Kayser, M. (2010). Digital quantification of human eye color highlights genetic association of three new loci. PLoS Genet 6, e1000934.

12.     Liu, F., Pardo, L.M., Schuur, M., Sanchez-Juan, P., Isaacs, A., Sleegers, K., de Koning, I., Zorkoltseva, I.V., Axenovich, T.I., Witteman, J.C., Janssens, A.C., van Swieten, J.C., Aulchenko, Y.S., Oostra, B.A., and van Duijn, C.M. (2010). The apolipoprotein E gene and its age-specific effects on cognitive function. Neurobiol Aging 31, 1831-1833.

13.     Liu, F., Ikram, M.A., Janssens, A.C., Schuur, M., de Koning, I., Isaacs, A., Struchalin, M., Uitterlinden, A.G., den Dunnen, J.T., Sleegers, K., Bettens, K., Van Broeckhoven, C., van Swieten, J., Hofman, A., Oostra, B.A., Aulchenko, Y.S., Breteler, M.M., and van Duijn, C.M. (2009). A study of the SORL1 gene in Alzheimer's disease and cognitive function. J Alzheimers Dis 18, 51-64.

14.     Liu, F., van Duijn, K., Vingerling, J.R., Hofman, A., Uitterlinden, A.G., Janssens, A.C., and Kayser, M. (2009). Eye color and the prediction of complex phenotypes from genotypes. Curr Biol 19, R192-193.

15.     Liu, F., Kirichenko, A., Axenovich, T.I., van Duijn, C.M., and Aulchenko, Y.S. (2008). An approach for cutting large and complex pedigrees for linkage analysis. Eur J Hum Genet 16, 854-860.

16.     Liu, F., Arias-Vasquez, A., Sleegers, K., Aulchenko, Y.S., Kayser, M., Sanchez-Juan, P., Feng, B.J., Bertoli-Avella, A.M., van Swieten, J., Axenovich, T.I., Heutink, P., van Broeckhoven, C., Oostra, B.A., and van Duijn, C.M. (2007). A genomewide screen for late-onset Alzheimer disease in a genetically isolated Dutch population. Am J Hum Genet 81, 17-31.

17.     Liu, F., Elefante, S., van Duijn, C.M., and Aulchenko, Y.S. (2006). Ignoring distant genealogic loops leads to false-positives in homozygosity mapping. Ann Hum Genet 70, 965-970

Co-author papers

1.         Zhong, K., Verkouteren, J.A., Jacobs, L.C., Uitterlinden, A.G., Hofman, A., Liu, F., Nijsten, T., and Kayser, M. (2016). Pigmentation-Independent Susceptibility Loci for Actinic Keratosis Highlighted by Compound Heterozygosity Analysis. J Invest Dermatol.

2.         Zubakov, D., Liu, F., Kokmeijer, I., Choi, Y., van Meurs, J.B., van, I.W.F., Uitterlinden, A.G., Hofman, A., Broer, L., van Duijn, C.M., Lewin, J., and Kayser, M. (2016). Human age estimation from blood using mRNA, DNA methylation, DNA rearrangement, and telomere length. Forensic Sci Int Genet 24, 33-43.

3.         Lech, K., Liu, F., Ackermann, K., Revell, V.L., Lao, O., Skene, D.J., and Kayser, M. (2016). Evaluation of mRNA markers for estimating blood deposition time: Towards alibi testing from human forensic stains with rhythmic biomarkers. Forensic Sci Int Genet 21, 119-125.

4.         de Jong, M.A., Wollstein, A., Ruff, C., Dunaway, D., Hysi, P., Spector, T., Fan, L., Niessen, W., Koudstaal, M.J., Kayser, M., Wolvius, E.B., and Bohringer, S. (2016). An Automatic 3D Facial Landmarking Algorithm Using 2D Gabor Wavelets. IEEE Trans Image Process 25, 580-588.

5.         Jacobs, L.C., Liu, F., Pardo, L.M., Hofman, A., Uitterlinden, A.G., Kayser, M., and Nijsten, T. (2015). IRF4, MC1R and TYR genes are risk factors for actinic keratosis independent of skin color. Hum Mol Genet 24, 3296-3303.

6.         Tagliabue, E., Fargnoli, M.C., Gandini, S., Maisonneuve, P., Liu, F., Kayser, M., Nijsten, T., Han, J., Kumar, R., Gruis, N.A., Ferrucci, L., Branicki, W., Dwyer, T., Blizzard, L., Helsing, P., Autier, P., Garcia-Borron, J.C., Kanetsky, P.A., Landi, M.T., Little, J., Newton-Bishop, J., Sera, F., and Raimondi, S. (2015). MC1R gene variants and non-melanoma skin cancer: a pooled-analysis from the M-SKIP project. Br J Cancer 113, 354-363.

7.         Jacobs, L.C., Hamer, M.A., Verkouteren, J.A., Pardo, L.M., Liu, F., and Nijsten, T. (2015). Perceived skin colour seems a swift, valid and reliable measurement. Br J Dermatol 173, 1084-1086.

8.         Jacobs, L.C., Hamer, M.A., Gunn, D.A., Deelen, J., Lall, J.S., van Heemst, D., Uh, H.W., Hofman, A., Uitterlinden, A.G., Griffiths, C.E., Beekman, M., Slagboom, P.E., Kayser, M., Liu, F., and Nijsten, T. (2015). A Genome-Wide Association Study Identifies the Skin Color Genes IRF4, MC1R, ASIP, and BNC2 Influencing Facial Pigmented Spots. J Invest Dermatol 135, 1735-1742.

9.         Hamer, M.A., Jacobs, L.C., Lall, J.S., Wollstein, A., Hollestein, L.M., Rae, A.R., Gossage, K.W., Hofman, A., Liu, F., Kayser, M., Nijsten, T., and Gunn, D.A. (2015). Validation of image analysis techniques to measure skin aging features from facial photographs. Skin Res Technol 21, 392-402.

10.     Jacobs, L.C., Liu, F., Bleyen, I., Gunn, D.A., Hofman, A., Klaver, C.C., Uitterlinden, A.G., Neumann, H.A., Bataille, V., Spector, T.D., Kayser, M., and Nijsten, T. (2014). Intrinsic and extrinsic risk factors for sagging eyelids. JAMA Dermatol 150, 836-843.

11.     Lao, O., Liu, F., Wollstein, A., and Kayser, M. (2014). GAGA: a new algorithm for genomic inference of geographic ancestry reveals fine level population substructure in Europeans. PLoS Comput Biol 10, e1003480.

12.     Jacobs, L.C., Liu, F., Pardo, L.M., Hofman, A., Uitterlinden, A.G., Kayser, M., and Nijsten, T. (2015). IRF4, MC1R and TYR genes are risk factors for actinic keratosis independent of skin color. Hum Mol Genet 24, 3296-3303.

13.     Walsh, S., Chaitanya, L., Clarisse, L., Wirken, L., Draus-Barini, J., Kovatsi, L., Maeda, H., Ishikawa, T., Sijen, T., de Knijff, P., Branicki, W., Liu, F., and Kayser, M. (2014). Developmental validation of the HIrisPlex system: DNA-based eye and hair colour prediction for forensic and anthropological usage. Forensic Sci Int Genet 9, 150-161.

14.     Liebrechts-Akkerman, G., Liu, F., Lao, O., Ooms, A.H., van Duijn, K., Vermeulen, M., Jaddoe, V.W., Hofman, A., Engelberts, A.C., and Kayser, M. (2014). PHOX2B polyalanine repeat length is associated with sudden infant death syndrome and unclassified sudden infant death in the Dutch population. Int J Legal Med 128, 621-629.

15.     Keating, B., Bansal, A.T., Walsh, S., Millman, J., Newman, J., Kidd, K., Budowle, B., Eisenberg, A., Donfack, J., Gasparini, P., Budimlija, Z., Henders, A.K., Chandrupatla, H., Duffy, D.L., Gordon, S.D., Hysi, P., Liu, F., Medland, S.E., Rubin, L., Martin, N.G., Spector, T.D., and Kayser, M. (2013). First all-in-one diagnostic tool for DNA intelligence: genome-wide inference of biogeographic ancestry, appearance, relatedness, and sex with the Identitas v1 Forensic Chip. Int J Legal Med 127, 559-572.

16.     Walsh, S., Liu, F., Wollstein, A., Kovatsi, L., Ralf, A., Kosiniak-Kamysz, A., Branicki, W., and Kayser, M. (2013). The HIrisPlex system for simultaneous prediction of hair and eye colour from DNA. Forensic Sci Int Genet 7, 98-115.

17.     Raimondi, S., Gandini, S., Fargnoli, M.C., Bagnardi, V., Maisonneuve, P., Specchia, C., Kumar, R., Nagore, E., Han, J., Hansson, J., Kanetsky, P.A., Ghiorzo, P., Gruis, N.A., Dwyer, T., Blizzard, L., Fernandez-de-Misa, R., Branicki, W., Debniak, T., Morling, N., Landi, M.T., Palmieri, G., Ribas, G., Stratigos, A., Cornelius, L., Motokawa, T., Anno, S., Helsing, P., Wong, T.H., Autier, P., Garcia-Borron, J.C., Little, J., Newton-Bishop, J., Sera, F., Liu, F., Kayser, M., and Nijsten, T. (2012). Melanocortin-1 receptor, skin cancer and phenotypic characteristics (M-SKIP) project: study design and methods for pooling results of genetic epidemiological studies. BMC Med Res Methodol 12, 116.

18.     Walsh, S., Wollstein, A., Liu, F., Chakravarthy, U., Rahu, M., Seland, J.H., Soubrane, G., Tomazzoli, L., Topouzis, F., Vingerling, J.R., Vioque, J., Fletcher, A.E., Ballantyne, K.N., and Kayser, M. (2012). DNA-based eye colour prediction across Europe with the IrisPlex system. Forensic Sci Int Genet 6, 330-340.

19.     Boehringer, S., van der Lijn, F., Liu, F., Gunther, M., Sinigerova, S., Nowak, S., Ludwig, K.U., Herberz, R., Klein, S., Hofman, A., Uitterlinden, A.G., Niessen, W.J., Breteler, M.M., van der Lugt, A., Wurtz, R.P., Nothen, M.M., Horsthemke, B., Wieczorek, D., Mangold, E., and Kayser, M. (2011). Genetic determination of human facial morphology: links between cleft-lips and normal variation. Eur J Hum Genet 19, 1192-1197.

20.     Liebrechts-Akkerman, G., Lao, O., Liu, F., van Sleuwen, B.E., Engelberts, A.C., L'Hoir M, P., Tiemeier, H.W., and Kayser, M. (2011). Postnatal parental smoking: an important risk factor for SIDS. Eur J Pediatr 170, 1281-1291.

21.     Broer, L., Ikram, M.A., Schuur, M., DeStefano, A.L., Bis, J.C., Liu, F., Rivadeneira, F., Uitterlinden, A.G., Beiser, A.S., Longstreth, W.T., Hofman, A., Aulchenko, Y., Seshadri, S., Fitzpatrick, A.L., Oostra, B.A., Breteler, M.M., and van Duijn, C.M. (2011). Association of HSP70 and its co-chaperones with Alzheimer's disease. J Alzheimers Dis 25, 93-102.

22.     Branicki, W., Liu, F., van Duijn, K., Draus-Barini, J., Pospiech, E., Walsh, S., Kupiec, T., Wojas-Pelc, A., and Kayser, M. (2011). Model-based prediction of human hair color using DNA variants. Hum Genet 129, 443-454.

23.     Schuur, M., van Swieten, J.C., Schol-Gelok, S., Ikram, M.A., Vernooij, M.W., Liu, F., Isaacs, A., de Boer, R., de Koning, I., Niessen, W.J., Vrooman, H., Oostra, B.A., van der Lugt, A., Breteler, M.M., and van Duijn, C.M. (2011). Genetic risk factors for cerebral small-vessel disease in hypertensive patients from a genetically isolated population. J Neurol Neurosurg Psychiatry 82, 41-44.

24.     Walsh, S., Liu, F., Ballantyne, K.N., van Oven, M., Lao, O., and Kayser, M. (2011). IrisPlex: a sensitive DNA tool for accurate prediction of blue and brown eye colour in the absence of ancestry information. Forensic Sci Int Genet 5, 170-180.

25.     Zubakov, D., Liu, F., van Zelm, M.C., Vermeulen, J., Oostra, B.A., van Duijn, C.M., Driessen, G.J., van Dongen, J.J., Kayser, M., and Langerak, A.W. (2010). Estimating human age from T-cell DNA rearrangements. Curr Biol 20, R970-971.

26.     Schol-Gelok, S., Janssens, A.C., Tiemeier, H., Liu, F., Lopez-Leon, S., Zorkoltseva, I.V., Axenovich, T.I., van Swieten, J.C., Uitterlinden, A.G., Hofman, A., Aulchenko, Y.S., Oostra, B.A., and van Duijn, C.M. (2010). A genome-wide screen for depression in two independent Dutch populations. Biol Psychiatry 68, 187-196.

27.     Estrada, K., Krawczak, M., Schreiber, S., van Duijn, K., Stolk, L., van Meurs, J.B., Liu, F., Penninx, B.W., Smit, J.H., Vogelzangs, N., Hottenga, J.J., Willemsen, G., de Geus, E.J., Lorentzon, M., von Eller-Eberstein, H., Lips, P., Schoor, N., Pop, V., de Keijzer, J., Hofman, A., Aulchenko, Y.S., Oostra, B.A., Ohlsson, C., Boomsma, D.I., Uitterlinden, A.G., van Duijn, C.M., Rivadeneira, F., and Kayser, M. (2009). A genome-wide association study of northwestern Europeans involves the C-type natriuretic peptide signaling pathway in the etiology of human height variation. Hum Mol Genet 18, 3516-3524.

28.     Ikram, M.A., Liu, F., Oostra, B.A., Hofman, A., van Duijn, C.M., and Breteler, M.M. (2009). The GAB2 gene and the risk of Alzheimer's disease: replication and meta-analysis. Biol Psychiatry 65, 995-999.

29.     van den Boogaard, M.J., de Costa, D., Krapels, I.P., Liu, F., van Duijn, C., Sinke, R.J., Lindhout, D., and Steegers-Theunissen, R.P. (2008). The MSX1 allele 4 homozygous child exposed to smoking at periconception is most sensitive in developing nonsyndromic orofacial clefts. Hum Genet 124, 525-534.

30.     Berends, A.L., Steegers, E.A., Isaacs, A., Aulchenko, Y.S., Liu, F., de Groot, C.J., Oostra, B.A., and van Duijn, C.M. (2008). Familial aggregation of preeclampsia and intrauterine growth restriction in a genetically isolated population in The Netherlands. Eur J Hum Genet 16, 1437-1442.

31.     Hoppenbrouwers, I.A., Liu, F., Aulchenko, Y.S., Ebers, G.C., Oostra, B.A., van Duijn, C.M., and Hintzen, R.Q. (2008). Maternal transmission of multiple sclerosis in a dutch population. Arch Neurol 65, 345-348.

32.     Kayser, M., Liu, F., Janssens, A.C., Rivadeneira, F., Lao, O., van Duijn, K., Vermeulen, M., Arp, P., Jhamai, M.M., van Ijcken, W.F., den Dunnen, J.T., Heath, S., Zelenika, D., Despriet, D.D., Klaver, C.C., Vingerling, J.R., de Jong, P.T., Hofman, A., Aulchenko, Y.S., Uitterlinden, A.G., Oostra, B.A., and van Duijn, C.M. (2008). Three genome-wide association studies and a linkage analysis identify HERC2 as a human iris color gene. Am J Hum Genet 82, 411-423.

33.     Axenovich, T.I., Zorkoltseva, I.V., Liu, F., Kirichenko, A.V., and Aulchenko, Y.S. (2008). Breaking loops in large complex pedigrees. Hum Hered 65, 57-65.

34.     Arias-Vasquez, A., de Lau, L., Pardo, L., Liu, F., Feng, B.J., Bertoli-Avella, A., Isaacs, A., Aulchenko, Y., Hofman, A., Oostra, B., Breteler, M., and van Duijn, C. (2007). Relationship of the Ubiquilin 1 gene with Alzheimer's and Parkinson's disease and cognitive function. Neurosci Lett 424, 1-5.

35.     Gonzalez-Zuloeta Ladd, A.M., Liu, F., Houben, M.P., Arias Vasquez, A., Siemes, C., Janssens, A.C., Coebergh, J.W., Hofman, A., Janssen, J.A., Stricker, B.H., and van Duijn, C.M. (2007). IGF-1 CA repeat variant and breast cancer risk in postmenopausal women. Eur J Cancer 43, 1718-1722.

US2011312534 A1 20111222 METHOD FOR PREDICTION OF HUMAN IRIS COLOR
WO2011107973 A2 20110909 METHOD FOR PREDICTION OF HUMAN IRIS COLOR

Our department has extensive collaborations with EMC in the Netherlands, with a series of ongoing research projects in the feilds of genetic epidemiology and forensic genetics.

已指导学生

熊子义  硕士研究生  0710J3-生物信息学  

刘宗智  博士研究生  071010-生物化学与分子生物学  

彭付端  博士研究生  0710J3-生物信息学  

陶现明  博士研究生  0710J3-生物信息学  

鲁豪杰  硕士研究生  0710J3-生物信息学  

现指导学生

高行健  博士研究生  0710J3-生物信息学  

张亚宁  博士研究生  0710J3-生物信息学  

谭晓彤  博士研究生  0710J3-生物信息学  

景晓溪  博士研究生  071007-遗传学  

陈燕  博士研究生  0710J3-生物信息学  

凡秀  博士研究生  0710J3-生物信息学  

刘鑫璇  博士研究生  0710Z1-基因组学  

刘佳林  硕士研究生  0710J3-生物信息学  

于迪  硕士研究生  0710Z1-基因组学  

孙红伟  硕士研究生  0710J3-生物信息学  

钱雨  博士研究生  0710Z1-基因组学  

李祎  博士研究生  0710J3-生物信息学  

程远  硕士研究生  0710J3-生物信息学  

李鹤  硕士研究生  1001Z1-精准医学  

林诗祺  硕士研究生  0710J3-生物信息学  

潘思宇  博士研究生  0710J3-生物信息学