Systematically isolated RNA binding protein ,study the funtions and molecular mechanisms of RNA-protein interactions in cell fate ,pahtology and physiological regulation.

2006.09-2011.06  University of Science and Technology of China (USTC)  phD

2002.09-2006.06  AnHui University  Bachelor

​2018.01- till now, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences,  PI

2013.01-2017.12, Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences, Associate researcher

2011.07-2012.12,  Guangzhou Institutes of Biomedicine and Health, Chinese Academy of Sciences,  Assistant researcher 

1. Ruiqi Zhao#; Xin Fang#; Zhibiao Mai#; Xi Chen; Jing Mo; Yingying Lin; Rui Xiao; Xichen  Bao*;Xiaocheng Weng*; Xiang Zhou*; Transcriptome-wide identification of single-stranded RNA binding proteins, CHEMICAL SCIENCE, 2023, 14(15): 4038-4047. 

2. Zheng M, Lin Y, Wang W, Zhao Y, Bao X*. Application of nucleoside or nucleotide analogues in RNA dynamics and RNA-binding protein analysis. Wiley Interdiscip Rev RNA. 2022 Feb 25:e1722. doi: 10.1002/wrna.1722. Epub ahead of print. PMID: 35218164. 

3.  Guo X#, Tariq M#, Lai Y#, Kanwal S#, Lv Y#, Wang X#, Li N, Jiang M, Meng J, Hu J, Yuan J, Luo Z, Ward C, Volpe G, Wang D, Yin M, Qin B, Zhang B*, Bao X*, Esteban MA*. Capture of the newly transcribed RNA interactome using click chemistry. Nat Protoc. 2021 Oct 25.  

4.  Lv Y#, Bu C#, Meng J, Ward C, Volpe G, Hu J, Jiang M, Guo L, Chen J, Esteban MA*, Bao X*, Cheng Z*. Global Profiling of the Lysine Crotonylome in Different Pluripotent States. Genomics Proteomics Bioinformatics. 2021 Feb;19(1):80-93. 

5. Shahzina Kanwal , Xiangpeng Guo , Carl Ward, Giacomo Volpe, Baoming Qin , Miguel A. Esteban *, Xichen Bao*Role of Long Non-coding RNAs in Reprogramming to Induced Pluripotency，Genomics Proteomics Bioinformatics，2020 18，16-25

6. Hou L*, Wei Y, Lin Y, Wang X, Lai Y, Yin M, Chen Y, Guo X, Wu S, Zhu Y, Yuan J, Tariq M, Li N, Sun H, Wang H, Zhang X, Chen J, Bao X*, Jauch R*. Concurrent binding to DNA and RNA facilitates the pluripotency reprogramming activity of Sox2. Nucleic Acids Res. 2020 Feb 4:gkaa067. 

7.  Bao X*,#, Guo X#, Yin M#, Tariq M, Lai Y, Kanwal S, Zhou J, Li N, Lv Y, Pulido-Quetglas C, Wang X, Ji L, Khan MJ, Zhu X, Luo Z, Shao C, Lim DH, Liu X, LiN, Wang W, He M, Liu YL, Ward C, Wang T, Zhang G, Wang D, Yang J, Chen Y, ZhangC, Jauch R, Yang YG, Wang Y, Qin B, Anko ML, Hutchins AP, Sun H, Wang H, Fu XD, Zhang B*, Esteban MA*. Capturing the interactome of newly transcribed RNA. Nat Methods. 2018 Mar;15(3):213-220.

8.  Bao X*,#, Wu H#, Zhu X#, Guo X, Hutchins AP, Luo Z, Song H, Chen Y, Lai K, Yin M, Xu L, Zhou L, Chen J, Wang D, Qin B, Frampton J, Tse HF, Pei D, Wang H, Zhang B, Esteban MA*. The p53-induced lincRNA-p21 derails somatic cell reprogramming by sustaining H3K9me3 and CpG methylation at pluripotency gene promoters. Cell Res. 2015 Jan; 25(1): 80-92. 

9.  Bao X, Zhu X, Liao B, Benda C, Zhuang Q, Pei D, Qin B, Esteban MA. MicroRNAs in somatic cell reprogramming. Curr Opin Cell Biol. 2013 Apr; 25(2): 208-14.

10.  Liao B#, Bao X#, Liu L, Feng S, Zovoilis A, Liu W, Xue Y, Cai J, Guo X, Qin B, Zhang R, Wu J, Lai L, Teng M, Niu L, Zhang B, Esteban MA, Pei D. MicroRNA cluster 302-367 enhances somatic cell reprogramming by accelerating a mesenchymal-to-epithelial transition. J Biol Chem. 2011 May 13; 286(19): 17359-64. One hundred highly cited papers of Chinese Academy of Sciences

11.  Liu J#, Gao M#, He J#, Wu K, Lin S, Jin L, Chen Y, Liu H, Shi J, Wang X, Chang L, Lin Y, Zhao YL, Zhang X, Zhang M, Luo GZ, Wu G, Pei D, Wang J, Bao X, Chen J. The RNA m6A reader YTHDC1 silences retrotransposons and guards ES cell identity. Nature. 2021 Mar;591(7849):322-326.

12.  Liu X, Wang X, Li J, Hu S, Deng Y, Yin H, Bao X, Zhang QC, Wang G, Wang B, Shi Q, Shan G. Identification of mecciRNAs and their roles in the mitochondrial entry of proteins. Sci China Life Sci. 2020 Jan 21:10.1007/s11427-020-1631-9.

13. Zhao Y, Zhou J, He L, Li Y, Yuan J, Sun K, Chen X, Bao X, Esteban MA, Sun H, Wang H. MyoD induced enhancer RNA interacts with hnRNPL to activate target gene transcription during myogenic differentiation. Nat Commun. 2019 Dec 19;10(1):5787.

14. Wu Y, Li Y, Zhang H, Huang Y, Zhao P, Tang Y, Qiu X, Ying Y, Li W, Ni S, Zhang M, Liu L, Xu Y, Zhuang Q, Luo Z, Benda C, Song H, Liu B, Lai L, Liu X, Tse HF, Bao X, Chan WY, Esteban MA, Qin B, Pei D. Autophagy and mTORC1 regulate the stochastic phase of somatic cell reprogramming. Nat Cell Biol. 2015 Jun;17(6):715-25.

15. Liu L, Xu Y, He M, Zhang M, Cui F, Lu L, Yao M, Tian W, Benda C, Zhuang Q, Huang Z, Li W, Li X, Zhao P, Fan W, Luo Z, Li Y, Wu Y, Hutchins AP, Wang D, Tse HF, Schambach A, Frampton J, Qin B, Bao X, Yao H, Zhang B, Sun H, Pei D, Wang H, Wang J, Esteban MA. Transcriptional pause release is a rate-limiting step for somatic cell reprogramming. Cell Stem Cell. 2014 Nov 6;15(5):574-88.

1: 裴端卿；米格尔·埃斯特班；鲍习琛；廖宝剑；张必良。一种将微小核糖核酸簇用于改变细胞命运的方法, 专利号: ZL 2011 1 0067834.0，已授权。

2: 张必良；米格尔·埃斯特班；鲍习琛；郭亨彭；尹梦回；王玮；克雷格·梅洛。一种捕获核酸结合蛋白的方法及其试剂盒，专利号：CN201710080808.9。

3: 鲍习琛； 赵文学；熊志；殷超；张玉琪；潘蔚绮；林莹莹；王茜玮；何俊。用于抑制SARS-CoV-2的组合物及载体系统，专利号：ZL 2021 1 0448000.8, 已授权。

RNA molecular biology:  We focus on the functions and mechnisms of RNA-protein interaction in cell fate , developmental physiology and pathology which is  in stem cell  such as embryonic stem cells, to develop new RNA-based technologies for disease treatment or prevention.

1）The role of RNA-protein interactions in the maintenance and withdrawal of stem cell pluripotency, pathologic and physiological conditions of disease occurrence .

2) The use of RNA-related technologies to achieve the treatment and prevention of deseases.

Now, the lab has 3 phD , 5 Master students, 5 postdoc. 1 associate researcher , two workers.

1）2019 Excellent member of Youth Innovation Promotion Association of Chinese Academy of Sciences

2）2019 Outstanding youth of Guangdong Province

3）2016 Guangzhou Pearl River technology star

4）2019  Guangdong Province Natural Science Award (3/15) , first prize

5)   2015  Guangdong Province Science and Technology Award(4/8) , first prize

6)   2015  GuangZhou Science and Technology Award(4/7), first prize

7)   2022   ZhenXi life and science outstanding educator of Chinese Academy of Sciences University