General
Du Yang Institute of Automation, Chinese Academy of Sciences
Email: yang.du@ia.ac.cn
Telephone: 010-62611658-907
Address: No. 95 Zhongguancun East Road,Intelligent Building, Room 907
Postcode: 100190
部门/实验室:复杂系统管理与控制国家重点实验

Research Areas

Multimodality molecular imaging and its applicaton on biomedical study.

Education

(1) PhD, The University of Hong Kong, 2005.9-2009.9
(2) Master Degree, Dalian Medical University, 2002.9-2005.7
(3) Bacholer Degree, Dalian Medical University, 1997.9-2002.7

Experience

   
Work Experience

(1) Professor,Institute of Automation Chinese Academy of Sciences,Key Laboratory of Molecular Imaging. 2017.10-till now

(2) Associate professor,Institute of Automation Chinese Academy of Sciences,Key Laboratory of Molecular Imaging. 2012.11-2017.10
(3) Postdoctor,The University of Texas Southwestern Medical Center at Dallas, Pharmaology, 2010.4-2012.10
(4) Postdoctor,The University of Texas MD Anderson Cancer Center at Houston, Biochemistry and Molecular biology, 2009.11-2010.3

Teaching Experience
   

Honors & Distinctions

   

Publications

   
Papers

(1) Liposomal Nanohybrid Cerasomes Targeted to PD-L1 Enable Dual-Modality Imaging and Improve Antitumor Treatments, Cancer Letters, 2018, 1st author
(2) Glioma-targeted imaging and therapy by Y1 receptors ligands stabilized nanomicelles across the blood brain barrier, Nanoscale, 2018, co-1st author
(3) The fluorescence molecular imaging and tomography of matrix metalloproteinase-activatable near infrared fluorescence probe and image-guided orthotopic glioma resection, Mol Imaging Biol, 2018, ​2nd author
(4) Sparse reconstruction of fluorescence molecular tomography using variable splitting and alternating direction scheme, Mol Imaging Biol, 2017, 2nd author
(5) Improved resection and prolonged overall survival with PD-1-IRDye800CW fluorescence probe-guided surgery and PD-1 adjuvant immunotherapy in 4T1 mouse model, International Journal of Nanomedicine, 2017, 1st author
(6) Nuclear and fluorescent labeled PD-1-Liposome-DOX-64Cu/IRDye800CW allows improved breast tumor targeted imaging and therapy, Mol Pharmacuetics, 2017, 1st author
(7) Evaluation of the anti-neoplastic effect of sorafenib on liver cancer through bioluminescence tomography, SPIE Medical Imaging, 2017, 3rd author
(8) Theranostic Gold Nanorod‒DNA Origami Hybrids for Enhanced in vivo Optoacoustic Imaging and Photothermal Therapy, Advanced Materials, 2016, 1st author
(9) Precise diagnosis in different scenarios using photoacoustic and fluorescence imaging with dual-modality nanoparticles, Nanoscale, 2016, 2nd author
(10) Infra Red Dye and Endostar Loaded Poly Lactic Acid Nano Particles as a Novel Theranostic Nanomedicine for Breast Cancer, Journal of Biomedical Nanotechnology, 2016, 2nd author
(11) Core-Shell Gold Nanorod@Metal-Organic Framework Nanoprobes for Multimodality Diagnosis of Glioma, Advanced Materials, 2016, 3rd author
(12) Activation of Mesenchymal Stem Cells by Macrophages Promotes Tumor Progression through Immune Suppressive Effects, Oncotarget, 2016, 4th author
(13) Self-assembled Gold DNA Nanoparticles for Cancer Theranostics, Small, 2015, co-correspondence author
(14) Increased precision of orthotopic and metastatic breast cancer surgery guided by matrix metalloproteinase-activatable near-infrared fluorescence probes, Scentific Reports, 2015, co-correspondence author
(15) GX1-conjugated poly(lactic acid) nanoparticles encapsulating Endostar for improved in vivo anticolorectal cancer treatment, International Journal of Nanomedicine, 2015, 1st author
(16) Zoledronic Acid Prevents the Tumor-promoting effects of Mesenchymal Stem, Oncotarget, 2015, co-1st author
(17) Monitoring Tumor Targeting and Treatment Effects of IRDye 800CW and GX1-conjugated Poly Lactic Acid Nanoparticles Encapsulating Endostar on Glioma by Optical Molecular Imaging, Molecular imaging, 2015, 1st author
(18) Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation, Endocrinology, 2015, 2nd author
(19) DNA origami as an in vivo drug delivery vehicle for cancer therapy, ACS Nano, 2014, co-correspondence author
(20) The PEG Coated TiO2 Nanocarriers with Enhanced Chemotherapeutic Effects of Doxorubicin in vivo: Evidence from Orthotopic Breast Tumor Bearing Mouse Model, Journal of Materials Chemistry B, 2014, 1st author
(21) Comprehensive evaluation of the anti-angiogenic and anti-neoplastic effects of Endostar on liver cancer through optical molecular imaging, PLoS One, 2014, 1st author
(22) Intraoperative imaging-guided cancer surgery: from current fluorescence molecular imaging methods to future multi-modality imaging technology, Theranostics, 2014, 2nd author
(23) Maternal Adiponectin Controls Milk Composition to Prevent Neonatal Inflammation, Endocrinology, 2014, 2nd author
(24) Reconstruction of fluorescence molecular tomography via a nonmonotone spectral projected gradient pursuit method, Journal of Biomedical Optics, 2014, 2nd author
(25) (18)F-fluorodeoxyglucose uptake and tumor hypoxia: revisit (18)f-fluorodeoxyglucose in oncology application, Translational Oncology, 2014, 2nd author
(26) Mitochondrial complex I activity suppresses inflammation and enhances bone resorption by shifting macrophage-osteoclast polarization, Cell Metabolism, 2014, 4th author
(27) Macrophage VLDL receptor promotes PAFAH secretion in mothers milk and suppresses systemic inflammation in nursing neonates, Nature Communications, 2012, 1st author
(28) Maternal western diet causes inflammatory milk and TLR2/4-dependent neonatal toxicity, Genes and development, 2012, 1st author

Patents
   

Research Interests

The application of molecular imaging on the early diagnosis and treatment of tumors

Conferences

(1) Yang Du*, Qian Zhang, Jie Tian* “AS1411 aptamer guided QD655 labeled DNA Origami working as a novel nanoprobe for fluorescence molecular imaging in breast tumor mouse model”. World Molecular Imaging Congress (WMIC),Oral presentation,2015.9, USA Hawaii
(2) Yang Du, Nicolas Beziere, Qian Zhang, Dong Peng, Ntziachristos Vasilis, Jie Tian* “The gold nanorods decorated with DNA Origami working as a novel photoacoustic imaging probe in 4T1 breast tumor model” World Molecular Imaging Congress (WMIC),Oral presentation,2014.9, Korea
(3) Kun Wang, Yang Du, Enezhong Li, Jie Tian, Optical molecular imaging: a review of recent progression and applications in oncology, 2014, 19th world Congress on Advances in Oncology and 17th International Symposium on Molecular Medicine, 2014,Oct 09-11,Greece
(4) Yang Du,“Application of Molecular Imaging Technology in Tumor Study”, Japanese Society of Molecular Imaging,Oral presentation,2013.5, Japan
(5) Yang Du, GX1-conjugated IRDye 800CW: a new optical molecular imaging agent for anti-colorectal cancer in vivo. CMR Meeting,Oral presentation, 2013.11. China Beijing
(6) Qian Zhang, Yaqian Li, Xin Yang, Xingde Li, Yang Du*, Jie Tian*, “GX1-conjugated Endostar nanoparticle: a new drug delivery system for anti-colorectal cancer in vivo.” World Molecular Imaging Congress (WMIC), 2013.9, USA Savannah
(7) Qian Zhang, Yang Du*, Hente Ke, Jie Tian*, “Molecular imaging in photothermal therapy evaluation.” WMIC, 2013.9 USA Savannah
(8) Du Y, Yip H. K “Bone Morphogenetic Protein Signaling Activates Id Genes in the Mouse Retinal Progenitor Cells”, poster presentation at the 41st Meeting of the European Brain and Behaviour Society (EBBS) and the 23rd Meeting of the Hellenic Society for Neuroscience (HSfN). 2009.9, Greece
(9) Du Y, Yip H. K, “BMP-4 Regulates the Expression of Ids and Induces Mouse Retinal Progenitor Cell Differentiation in vitro”, the Annual Meeting of Society of Neuroscience, 2008.11, USA Washington DC.
(10) Du Y, Yip H. K, “Retinal Cell Development is possibly mediated by BMP-Smad-Id Pathway”, poster presentation at the 6th Federation of European Neuroscience Society Meeting, 2008.7, Switerland Geneva

Collaboration

(1) National Center for Nanoscience and Technology CAS Prof. Baoquan Ding
(2) Peking University, Department of Biomedical Engineering Prof. Zhifei Dai
(3) University of Texas Southwestern Medical Center, Department of Pharmacology, Prof. Yihong Wan
(4) Institute for Biological and Medical Imaging (IBMI), Helmholtz Zentrum München and Technische Universität München, Prof. Vasilis Ntziachristos
(5) University of Louisville, Department of Diagnostic Radiology, Prof. Xiao-Feng Li
(6) Stanford University, Department of Radiology, Prof. Cheng Zhen

Students

现指导学生

梁倩  硕士研究生  085211-计算机技术  

孔令鑫  硕士研究生  081104-模式识别与智能系统  

边畅  硕士研究生  081104-模式识别与智能系统