基本信息
王江  女    上海科技大学
email: jwang@simm.ac.cn
address: 上海市浦东张江祖冲之路555号
postalCode:

招生信息

   
招生专业
100701-药物化学
招生方向
创新药物研究,高效合成方法学研究

教育背景

2006-09--2011-07   中国科学院上海药物研究所   博士
2002-09--2006-07   中国药科大学   学士学位

工作经历

   
工作简历
2022-06~现在, 中国科学院上海药物研究所, 博士导师
2019-10~现在, 中国科学院上海药物研究所, 研究员
2013-10~2019-09,中国科学院上海药物研究所, 副研究员/硕士导师
2013-07~2013-09,中国科学院上海药物研究所, 助理研究员
2011-07~2013-07,中国科学院上海药物研究所, 博士后
2006-09~2011-07,中国科学院上海药物研究所, 博士
2002-09~2006-07,中国药科大学, 学士学位
社会兼职
2015-05-07-今,中国化学会会员,
2015-03-01-今,中国药学会高级会员,
2014-04-25-今,美国化学会会员,

教授课程

抗高血压药
糖尿病药物
心脏疾病用药和血脂药物

专利与奖励

   
奖励信息
(1) 爱思唯尔2021中国高被引学者, 其他, 2022
(2) 上海市三八红旗手, , 省级, 2022
(3) 中国药学会科学技术奖一等奖, 一等奖, 其他, 2021
(4) 2019年度上海药学科技奖(基础研究类)一等奖(第三完成人), 一等奖, 其他, 2020
(5) 上海市科学技术进步奖一等奖, 一等奖, 省级, 2020
(6) 上海药物研究所优秀青年科技工作者, 研究所(学校), 2016
(7) 中国药学会-施维雅青年药物化学奖, 市地级, 2016
(8) 赛诺菲—上海生科院优秀青年人才奖励基金, 市地级, 2015
(9) 中国科学院青年创新促进会会员, , 部委级, 2015
(10) 上海市青年科技启明星, , 省级, 2015
(11) “中国科学院王宽诚教育基金国际会议项目”资助, , 部委级, 2014
(12) 上海药物研究所“三八红旗手”, , 研究所(学校), 2013
(13) 上海市药学会生药学、药物化学、天然药化、中药学青年论文报告会优秀论文二等奖, 二等奖, 省级, 2011
(14) “第七届全国化学生物学学术会议”优秀报展奖, , 国家级, 2011
(15) 2011年中科院上海药物研究所学术年会优秀展报奖, , 研究所(学校), 2011
(16) 中国科学院三好学生奖, , 部委级, 2011
(17) 中国科学院三好学生标兵, , 部委级, 2011
(18) 中国科学院院长优秀奖, , 部委级, 2011
(19) 112010年“施慧达杯” 第十届全国青年药学工作者最新科研成果交流会论文三等奖, 三等奖, 国家级, 2010
(20) 2010年中科院上海药物研究所学术年会论文三等奖, 三等奖, 研究所(学校), 2010
(21) 中科院三好学生奖, , 院级, 2010
(22) 上海市科技系统优秀共青团员, , 市地级, 2009
专利成果
( 1 ) 新型四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途, 2023, 第 3 作者, 专利号: PCT/CN2023/095615

( 2 ) 一类喹啉类化合物及其制备方法、药物组合物和用途, 2022, 第 2 作者, 专利号: PCT/CN2022/142988

( 3 ) 吲哚取代四氢异喹啉类化合物与他汀类化合物的联合应用, 2022, 第 2 作者, 专利号: 2022115595828

( 4 ) 新型四氢异喹啉类化合物、其制备方法、包含此类化合物的药物组合物及其用途, 2022, 第 3 作者, 专利号: 2022105572849

( 5 ) 一类五环三萜类碳苷化合物及其制备方法和用途, 2022, 第 2 作者, 专利号: CN113896757A

( 6 ) 一类噁二唑类化合物及其制备方法、药物组合物和用途, 2021, 第 2 作者, 专利号: CN113861178A

( 7 ) 酮酰胺类化合物及其制备方法、药物组合物和用途, 2021, 第 7 作者, 专利号: CN113015726A

( 8 ) 3,4,5-三取代吡唑类化合物、制备方法、药物组合物及用途, 2021, 第 3 作者, 专利号: CN106279023B

( 9 ) 苯甲酰胺类化合物及其制备方法、药物组合物和用途, 2021, 第 5 作者, 专利号: CN112812077A

( 10 ) 一类丙烯酸类化合物及其制备方法、药物组合物和用途, 2021, 第 4 作者, 专利号: CN112204018A

( 11 ) 一类丙烯酸类化合物及其制备方法、药物组合物和用途, 2019, 第 3 作者, 专利号: CN110483432A

( 12 ) 一种噻吩3,2-d并嘧啶-4-酮类化合物的药物新用途, 2019, 第 3 作者, 专利号: CN110240603A

( 13 ) 新型手性配体、金属螯合物、多种非天然氨基酸、马拉维诺及其关键中间体的合成方法, 2019, 第 2 作者, 专利号: CN109790114A

( 14 ) 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途, 2018, 第 3 作者, 专利号: CN108779096A

( 15 ) 新型手性配体、金属螯合物、多种非天然氨基酸、马拉维诺及其关键中间体的合成方法, 2018, 第 2 作者, 专利号: CN107879963A

( 16 ) 一种C,O‑螺环芳基糖苷类化合物及其制备和应用, 2018, 第 3 作者, 专利号: CN107709332A

( 17 ) 反吲哚啉环丙胺类化合物及其制备方法、药物组合物和用途, 2017, 第 5 作者, 专利号: CN107459476A

( 18 ) 一种苯g杂芳基并a,g喹嗪类化合物的药物用途及其制备方法, 2017, 第 5 作者, 专利号: CN107303298A

( 19 ) 苯基a吲哚2,3-g并喹嗪类化合物、其制备方法、药物组合物及其应用, 2017, 第 5 作者, 专利号: CN107286158A

( 20 ) 一种DPPIV抑制剂的盐型及其制备方法, 2017, 第 2 作者, 专利号: CN107216340A

( 21 ) 一种DPPIV抑制剂马来酸盐的多晶型及其制备方法, 2017, 第 2 作者, 专利号: CN107216339A

( 22 ) 一类氟取代的环丙胺类化合物及其制备方法、药物组合物和用途, 2017, 第 3 作者, 专利号: CN107200706A

( 23 ) 一种C,O-螺环芳基糖苷类化合物及其制备和应用, 2017, 第 3 作者, 专利号: CN106317068A

( 24 ) 3,4,5-三取代吡唑类化合物、制备方法、药物组合物及用途, 2017, 第 3 作者, 专利号: CN106279023A

( 25 ) 一种化合物的A晶型及其制备方法, 2016, 第 2 作者, 专利号: CN105985353A

( 26 ) 噻吩3,2-d并嘧啶-4-酮类化合物、其制备方法、药物组合物及用途, 2013, 第 5 作者, 专利号: CN103130819A

( 27 ) 2-((2-(3-氨基哌啶-1)-4-氧噻吩3,2-d嘧啶-3(4H)-甲基)苯甲腈多晶型体、其制备方法及其药理用途, 2012, 第 3 作者, 专利号: CN102659813A

出版信息

   
发表论文
(1) Versatile Pd(II) Complexes of Chiral Proline-Derived Ligand: Application for Dynamic Kinetic Resolution of α-Amino Acids and Their Antibacterial Activities., JOURNAL OF ORGANIC CHEMISTRY, 2023, 第 2 作者
(2) Construction of Vinyl-Substituted N-Heterocycles via Rh(III)- Catalyzed C-H Functionalization/Annulation of Pyrazolidinones, ADVANCED SYNTHESIS & CATALYSIS, 2023, 通讯作者
(3) Cobalt(II)-Catalyzed C(sp3)-C(sp3) Coupling for the Direct Stereoselective Synthesis of 2-Deoxy-C-glycosides from Glycals., Angewandte Chemie International Edition, 2023, 通讯作者
(4) Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial, CELL METABOLISM, 2022, 第 1 作者
(5) Structure-Based Design of Tropane Derivatives as a Novel Series of CCR5 Antagonists with Broad-Spectrum Anti-HIV-1 Activities and Improved Oral Bioavailability, JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(6) A Novel SphK1 Inhibitor Suppresses Growth of Solid Tumor and Inhibits the Lung Metastasis of Triple-negative Breast Cancer., JOURNAL OF MEDICINAL CHEMISTRY, 2022, 通讯作者
(7) Cu(II) Complexes with Proline-Derived Schiff Base Ligand: Chemical Resolution of N,C-Unprotected ?-Amino Acids and Their Antibacterial Activity, JOURNAL OF ORGANIC CHEMISTRY, 2022, 第 2 作者
(8) A propolis-derived small molecule ameliorates metabolic syndrome in obese mice by targeting the CREB/CRTC2 transcriptional complex, NATURE COMMUNICATIONS, 2022, 第 2 作者
(9) 5-Aminonaphthalene derivatives as selective nonnucleoside nuclear receptor binding SET domain-protein 2 (NSD2) inhibitors for the treatment of multiple myeloma, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(10) Synthesis of Pyrazolo1,2-acinnolines via Rhodium(III)-Catalyzed 4+2 Annulation Reactions of Pyrazolidinones with Sulfoxonium Ylides, ADVANCED SYNTHESIS & CATALYSIS, 2021, 通讯作者
(11) Discovery of novel ceramide analogs with favorable pharmacokinetic properties and combination with AKT inhibitor against colon cancer, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(12) Allosteric Modulators Enhancing GLP‑1 Binding to GLP-1R via a Transmembrane Site., ACS Chemical Biology, 2021, 第 1 作者
(13) Direct C4-Acetoxylation of Tryptophan and Tryptophan-Containing Peptides via Palladium(II)-Catalyzed C-H Activation, ORGANIC LETTERS, 2021, 通讯作者
(14) Ir(I)-Catalyzed C-H Glycosylation for Synthesis of 2-Indolyl-C-Deoxyglycosides, ADVANCED SYNTHESIS & CATALYSIS, 2021, 通讯作者
(15) Rational Design and Development of Novel CDK9 Inhibitors for the Treatment of Acute Myeloid Leukemia, JOURNAL OF MEDICINAL CHEMISTRY, 2021, 通讯作者
(16) Optimizing chemical reaction conditions using deep learning: a case study for the Suzuki-Miyaura cross-coupling reaction, ORGANIC CHEMISTRY FRONTIERS, 2020, 通讯作者
(17) Ir(III)-Catalyzed direct C-H functionalization of N-phenylacetamide with α-diazo quinones: a novel strategy for producing 2-hydroxy-2’-amino-1,2’-biaryl scaffolds., Chemical Communications, 2020, 第 2 作者
(18) 先导化合物结构优化策略(八)——药物转运体及其相关药物设计策略, Lead compound optimization strategy(8)-drug transporters and related drug design strategies, 药学学报, 2020, 第 2 作者
(19) 先导化合物结构优化策略七肽类分子结构修饰与改造, 药学学报, 2020, 第 2 作者
(20) Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease, SCIENCE, 2020, 第 19 作者
(21) Rhodium(III)-Catalyzed C-H Alkenylation: Access to Maleimide-Decorated Tryptophan and Tryptophan-Containing Peptides, ORGANIC LETTERS, 2020, 通讯作者
(22) Design, synthesis, and biological evaluation of 1,2,5-oxadiazole-3-carboximidamide derivatives as novel indoleamine-2,3-dioxygenase 1 inhibitors., EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 第 3 作者
(23) Design, synthesis and biological evaluation of 6-deoxy O-spiroketal C-arylglucosides as novel renal sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the treatment of type 2 diabetes, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2019, 第 3 作者
(24) Green and Facile Assembly of Diverse Fused N -Heterocycles Using Gold-Catalyzed Cascade Reactions in Water, MOLECULES, 2019, 第 7 作者
(25) Recent Advances in the Addition of Amide/Sulfonamide Bonds to Alkynes, MOLECULES, 2019, 第 5 作者
(26) Gold-catalyzed Rapid Construction of Nitrogen-containing Heterocyclic Compound Library with Scaffold Diversity and Molecular Complexity, ADVANCED SYNTHESIS & CATALYSIS, 2019, 第 7 作者
(27) Rhodium(III)-Catalyzed 4+2 Annulation via C-H Activation: Synthesis of Multi-Substituted Naphthalenone Sulfoxonium Ylides, MOLECULES, 2019, 通讯作者
(28) Design, synthesis, and biological evaluation of novel tetrahydroprotoberberine derivatives (THPBs) as proprotein convertase subtilisin/kexin type 9 (PCSK9) modulators for the treatment of hyperlipidemia, ACTA PHARMACEUTICA SINICA B, 2019, 通讯作者
(29) Design,synthesis,and biological evaluation of novel tetrahydroprotoberberine derivatives(THPBs) as proprotein convertase subtilisin/kexin type 9(PCSK9)modulators for the treatment of hyperlipidemia, ACTA PHARMACEUTICA SINICA B, 2019, 通讯作者
(30) Regio-selective and stereo-selective hydrosilylation of internal alkynes catalyzed by ruthenium complexes, RSC ADVANCES, 2018, 第 5 作者
(31) Identification of novel inhibitors of histone acetyltransferase hMOF through high throughput screening, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 2 作者
(32) A novel series of 4-methyl substituted pyrazole derivatives as potent glucagon receptor antagonists: Design, synthesis and evaluation of biological activities, BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 第 3 作者
(33) Configurationally Stable (S)- and (R)--Methylproline-Derived Ligands for the Direct Chemical Resolution of Free Unprotected (3)-Amino Acids, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2018, 第 3 作者
(34) Design, synthesis, and biological evaluation of 2-(phenoxyaryl)-3-urea derivatives as novel P2Y(1) receptor antagonists, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 6 作者
(35) 先导化合物结构优化策略(六)——改善化合物血浆稳定性, Lead compound optimization strategy (6)-improving the plasma stability, 药学学报, 2018, 第 2 作者
(36) Structure-Based Design of 1-Heteroary1-1,3-propanediamine Derivatives as a Novel Series of CC-Chemokine Receptor 5 Antagonists, JOURNAL OF MEDICINAL CHEMISTRY, 2018, 第 7 作者
(37) Crystal structure of the human 5-HT1B serotonin receptor bound to an inverse agonist, CELL DISCOVERY, 2018, 第 14 作者
(38) Design, synthesis, and structure-activity relationships of novel 4,7,12,12a-tetrahydro-5H-thieno3′,2′:3,4pyrido1,2-bisoquinoline and 5,8,12,12a-tetrahydro-6H-thieno2′,3′:4,5pyrido2,1-aisoquinoline derivatives as cellular activators of adenosine 5′-monophosphate-activated protein kinase (AMPK), BIOORGANIC & MEDICINAL CHEMISTRY, 2018, 第 4 作者
(39) 不对称合成手性3,5-二取代脯氨酸及其衍生物, Asymmetric Synthesis of 3,5-Disubstituted Prolines, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 通讯作者
(40) Construction of highly enantiopure beta,beta-diaryl substituted glycine containing two contiguous stereocenters via asymmetric 1,6-conjugate addition, TETRAHEDRON, 2018, 通讯作者
(41) 不对称合成手性3,5-二取代脯氨酸及其衍生物, Asymmetric Synthesis of 3,5-Disubstituted Prolines, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2018, 通讯作者
(42) Chemical Resolution of C,N-Unprotected alpha-Substituted beta-Amino Acids Using Stable and Recyclable Proline-Derived Chiral Ligands, JOURNAL OF ORGANIC CHEMISTRY, 2018, 通讯作者
(43) Discovery of thiophene-containing biaryl amide derivatives as novel glucagon receptor antagonists, CHEMICAL BIOLOGY & DRUG DESIGN, 2018, 第 7 作者
(44) Palladium-catalyzed ortho-alkoxylation of N-benzoyl α-amino acid derivatives at room temperature., J. Org. Chem., 2017, 第 1 作者
(45) Catalytic and catalyst-free diboration of alkynes, ORGANIC CHEMISTRY FRONTIERS, 2017, 第 6 作者
(46) Design, synthesis and biological evaluation of thienopyrimidine hydroxamic acid based derivatives as structurally novel histone deacetylase (HDAC) inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 1 作者
(47) Recent approaches for asymmetric synthesis of alpha-amino acids via homologation of Ni(II) complexes, AMINOACIDS, 2017, 第 3 作者
(48) Analysis of crystallorgraphic structures of Ni(II) complexes of α-amino acid Schiff bases: elucidation of the substitutent effect on stereochemical preferences., Dalton Trans., 2017, 第 1 作者
(49) Analysis of crystallographic structures of Ni(II) complexes of a-amino acid Schiff bases: elucidation of the substituent effect on stereochemical preferences, DALTON TRANSACTIONS, 2017, 第 2 作者
(50) Asymmetric Synthesis of Chiral a-Substituted Mercaptoglycine Derivatives via α-Sulfenylation of Ni(ll) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, Asymmetric Synthesis of Chiral a-Substituted Mercaptoglycine Derivatives via α-Sulfenylation of Ni(ll) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, 中国化学:英文版, 2017, 第 4 作者
(51) Design, Synthesis, and Pharmacological Evaluation of Novel Multisubstituted Pyridin-3-amine Derivatives as Multitargeted Protein Kinase Inhibitors for the Treatment of Non-Small Cell Lung Cancer, JOURNAL OF MEDICINAL CHEMISTRY, 2017, 第 4 作者
(52) Aspirin Inhibits Cancer Metastasis and Angiogenesis via Targeting Heparanase, CLINICAL CANCER RESEARCH, 2017, 第 7 作者
(53) Asymmetric Synthesis of Chiral alpha-Substituted Mercaptoglycine Derivatives via alpha-Sulfenylation of Ni(II) Complex of Glycine and S-Substituted 4-Methylbenzenesulfonothioate, CHINESE JOURNAL OF CHEMISTRY, 2017, 通讯作者
(54) The Second-generation of Highly Potent Hepatitis C Virus (HCV) NS3/4A Protease Inhibitors: Evolutionary Design Based on Tailor-made Amino Acids, Synthesis and Major Features of Bio-activity, CURRENT PHARMACEUTICAL DESIGN, 2017, 第 3 作者
(55) 金属催化的碳-杂键对炔键的加成反应研究进展, Research Progress in Metal-Catalyzed Addition of Carbon-Hetero Bonds to Alkynes, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 第 6 作者
(56) 金属催化的碳-杂键对炔键的加成反应研究进展, Research Progress in Metal-Catalyzed Addition of Carbon-Hetero Bonds to Alkynes, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2017, 第 6 作者
(57) Ruthenium(II)-Catalyzed Redox-Neutral 3+2 Annulation of Indoles with Internal Alkynes via C-H Bond Activation: Accessing a Pyrroloindolone Scaffold, JOURNAL OF ORGANIC CHEMISTRY, 2017, 第 4 作者
(58) Rhodium(III)-Catalyzed Site-Selective C-H Alkylation and Arylation of Pyridones Using Organoboron Reagents, ORGANIC LETTERS, 2016, 第 2 作者
(59) The Application of Sulfonyl in Drug Design., Chin. J. Org. Chem., 2016, 第 1 作者
(60) Nickel-Catalyzed ortho-C‑H Thiolation of N‑Benzoyl α‑Amino Acid Derivatives., J. Org. Chem., 2016, 第 1 作者
(61) Advanced asymmetric synthesis of (1R,2S)-1-amino-2-vinylcyclopropanecarboxylic acid by alkylation/cyclization of newly designed axially chiral Ni(II) complex of glycine Schiff base, AMINO ACIDS, 2016, 第 7 作者
(62) Purely Chemical Approach for Preparation of D-α-amino Acids via (S)-to-(R)-interconversion of Unprotected Tailor-made α-amino Acids., J. Org. Chem., 2016, 第 1 作者
(63) Design, synthesis, structure–activity relationships, and docking studies of pyrazole-containing derivatives as a novel series of potent glucagon receptor antagonists, BIOORGANIC & MEDICINAL CHEMISTRY, 2016, 第 6 作者
(64) Design, Synthesis and Biological Evaluation of Indoline and Indole Derivatives as Potent and Selective α1A-Adrenoceptor Antagonists, Journal of Medicinal Chemistry,, 2016, 
(65) Cu(II)-catalyzed C6-selective C-H thiolation of 2-pyridones using air as the oxidant, RSC ADVANCES, 2016, 第 2 作者
(66) Recent progress in the small-molecule therapeutics for Ebola virus (EBOV) disease treatment. Synthetic profiles of three unique drugs: favipiravir, BCX-4430, and brincidofovir., European Journal of Organic Chemistry., 2016, 
(67) Highly selective intramolecular addition of c-n and s-n bonds to alkynes catalyzed by palladium: a practical access to two distinct functional indoles, RSC ADVANCES, 2016, 第 6 作者
(68) Next Generation of Fluorine-Containing Pharmaceuticals, Compounds Currently in Phase II-III Clinical Trials of Major Pharmaceutical Companies: New Structural Trends and Therapeutic Areas, CHEMICAL REVIEWS, 2016, 第 2 作者
(69) Asymmetric Synthesis of Aromatic and Heteroaromatic -Amino Acids Using a Recyclable Axially Chiral Ligand, EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, 2016, 第 3 作者
(70) 先导化合物结构优化策略(五) ——降低药物hERG心脏毒性, 药学学报, 2016, 第 2 作者
(71) Recyclable Ligands for the Non-Enzymatic Dynamic Kinetic Resolution of Challenging a-Amino Acids., Angewandte Chemie International Edition., 2015, 
(72) Highly Efficient Chemical Dynamic Thermodynamic Resolution and S/R Interconversion of Unprotected Unnatural Tailor-Made α-Amino Acids., J. Org. Chem., 2015, 第 1 作者
(73) Two disparate ligand binding sites in the human P2Y 1 receptor, NATURE, 2015, 第 6 作者
(74) Asymmetric synthesis of α-(1-oxoisoindolin-3-yl)glycine: synthetic and mechanistic challenges., ChemComm., 2015, 
(75) Palladium-catalyzed intramolecular addition of C-N bond to alkynes: a novel approach to 3-diketoindoles, RSC ADVANCES, 2015, 第 4 作者
(76) 通过串联反应不对称合成氧化吲哚螺环化合物的研究进展, Asymmetric Synthesis of Spirooxindoles via Organocascade Strategies, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2015, 第 3 作者
(77) Asymmetric Synthesis of (2S,3S)‑α-(1-Oxoisoindolin-3-yl)glycines under Low-Basicity "Kinetic" Control., Journal of Organic Chemistry., 2015, 
(78) Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors, EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2014, 第 3 作者
(79) (R)-3-Amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: Design, synthesis, biological evaluation, and molecular modeling, BIOORGANIC & MEDICINAL CHEMISTRY, 2014, 第 3 作者
(80) Fluorine in Pharmaceutical Industry: Fluorine-Containing Drugs Introduced to the Market in the Last Decade (2001-2011), CHEMICAL REVIEWS, 2014, 第 1 作者
(81) Chemical Kinetic Resolution of Unprotected β-Substituted-β-Amino Acids Using Recyclable Chiral Ligands., ANGEW. CHEM. INT. ED., 2014, 
(82) 先导化合物结构优化策略三通过化学修饰改善水溶性, 药学学报, 2014, 第 2 作者
(83) 先导化合物结构优化策略四改善化合物的血脑屏障通透性, 药学学报, 2014, 第 3 作者
(84) 先导化合物结构优化策略(二) —— 结构修饰降低潜在毒性, 药学学报, 2014, 第 2 作者
(85) Lead compound optimization strategy (1) ——Change metabolic pathways and optimize metabolism stability., 2013, 第 1 作者
(86) Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes, BIOORGANICMEDICINALCHEMISTRY, 2013, 第 1 作者
(87) 含氟氨基酸和内酰胺的合成研究进展, 有机化学, 2013, 第 2 作者
(88) 磷酸酯前药在药物研究中的应用, 药学学报, 2013, 第 2 作者
(89) Synthesis of bis-α,α’-amino acids through diastereoselective bisalkylations of chiral Ni(II)-complexes of glycine., Org. Biomol. Chem., 2013, 第 1 作者
(90) 先导化合物结构优化策略一改变代谢途径提高代谢稳定性, 药学学报, 2013, 第 1 作者
(91) Diastereoselective Michael Reaction of Chiral Nickel(II) Glycinate with Nitroalkenes for Asymmetric Synthesis of β-Substituted α,γ-Diaminobutyric Acid Derivatives in Water., Amino Acids, 2012, 第 1 作者
(92) Discovering Novel α-aminoacyl Containing Proline Derivatives with Potent and Selective Inhibitory Activity Against Dipeptidyl Peptidase IV: Design, Synthesis, Biological Evaluation, and Molecular Modeling., 2012, 第 1 作者
(93) 氰基在药物分子设计中的应用, Application of Nitrile in Drug Design, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2012, 通讯作者
(94) Application of Fluorine in Drug Design, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2011, 通讯作者
(95) 氟原子在药物分子设计中的应用, Application of Fluorine in Drug Design, 有机化学, 2011, 第 1 作者
(96) Asymmetric Synthesis of Sterically and Electronically Demanding Linear ω-Trifluoromethyl Containing Amino Acids via Alkylation of Chiral Equivalents of Nucleophilic Glycine and Alanine., J. Org. Chem., 2011, 第 1 作者
(97) Highly diastereo- and enantioselective synthesis of syn-β-substituted tryptophans via asymmetric Michael addition of a chiral equivalent of nucleophilic glycine and sulfonylindoles., 2011, 第 1 作者
(98) Application of Nickel(II) Complexes to the Efficient Synthesis of ?- or ?-Amino Acids, CHIMIA, 2011, 第 1 作者
(99) Most Efficient Routes for the Synthesis of α,β-Diamino Acid-Derived Compounds., Curr. Pharma. Design, 2010, 第 1 作者
(100) Highly Enantio- and Diastereoselective Mannich Reaction of a Chiral Nickel(II) Glycinate with an α-Imino Ester for Asymmetric Synthesis of a 3-Aminoaspartate., Synthesis, 2010, 第 1 作者
(101) β-氨基酸的合成:等当体方法的应用, Synthesis of β-Amino Acid--The Applications of β-Amino Acid Equivalents, 有机化学, 2009, 第 2 作者
(102) Highly Diastereoselective Conjugate Addition-Elimination of Chiral Ni(II) Glycinate with Activated Allylic Acetates for Asymmetric Synthesis of Glutamic Acid Derivatives., 2009, 第 1 作者
(103) Highly Enantio- and Diastereoselective Mannich Reactions of a Chiral Ni(II) Glycine with Amino Sulfones. Efficient Asymmetric Synthesis of Aromatic α, β-Diamino Acids., J. Org. Chem., 2008, 第 1 作者
(104) Application of Ni(II) chelate to amino acid synthesis, CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2008, 通讯作者
(105) Ni(Ⅱ)螯合物在氨基酸合成中的应用, Application of Ni(Ⅱ) Chelate to Amino Acid Synthesis, 有机化学, 2008, 第 1 作者
(106) One-Pot, Large-Scale Synthesis of Nickel(II) Complexes Derived from 2-[N-(a-Picolyl)amino]benzophenone (PABP) and a- or b-Amino Acids., J. Org. Chem., 2007, 第 1 作者
(107) ChemInform Abstract: Highly Selective Intramolecular Addition of C—N and S—N Bonds to Alkynes Catalyzed by Palladium: A Practical Access to Two Distinct Functional Indoles., CHEMINFORM, 第 6 作者
(108) ChemInform Abstract: Asymmetric Synthesis of Chiral Heterocyclic Amino Acids via the Alkylation of the Ni(II) Complex of Glycine and Alkyl Halides., CHEMINFORM, 第 2 作者
发表著作
( 1 ) 高等药物化学, Advanced Medicinal Chemistry, 化学工业出版社, 2011-11, 第 5 作者
( 2 ) 实用药物化学, The Practice of Medicinal Chemistry, 科学出版社, 2012-06, 第 5 作者
( 3 ) 新药研发案例, Case Study on Drug Discovery and Development, 化学工业出版社, 2014-06, 第 5 作者
( 4 ) 药学前沿精品讲坛, 科学出版社, 2015-12, 第 5 作者
( 5 ) 《高等药物化学——创新药物研究原理与案例》(第12章 首创性药物和跟随性药物), 人民卫生出版社, 2021-08, 第 1 作者

科研活动

   
科研项目
( 1 ) 组蛋白乙酰转移酶hMOF抑制剂的发现及抗肿瘤作用机制研究, 负责人, 国家任务, 2015-01--2018-12
( 2 ) 新型胰高血糖素受体拮抗剂先导化合物的发现及抗糖尿病作用机制研究, 负责人, 地方任务, 2015-04--2018-03
( 3 ) 镍螯合物诱导不对称合成手性非天然氨基酸的研究, 负责人, 国家任务, 2014-01--2016-12
( 4 ) 中科院青年创新促进会, 负责人, 国家任务, 2015-01--2018-12
( 5 ) HDAC抑制剂DC421059临床前研究, 负责人, 国家任务, 2014-01--2016-12
( 6 ) 抗糖尿病候选药物SGLT2抑制剂DC892081的临床前研究, 负责人, 地方任务, 2017-07--2020-06
( 7 ) 新型抗艾滋病药物DC521022 的临床前研究, 负责人, 中国科学院计划, 2016-10--2018-10
( 8 ) 抗糖尿病药物DC892081的临床前个性化特征研究, 负责人, 中国科学院计划, 2015-10--2018-12
( 9 ) GLP-1受体变构激动剂先导化合物的发现与作用机制研究, 负责人, 国家任务, 2022-01--2025-12
( 10 ) CREB/CRTC2互作抑制剂的先导化合物发现及作用机制研究, 负责人, 国家任务, 2019-01--2022-12