基本信息
蒋洪 男 博导 中国科学院上海有机化学研究所
电子邮件: hongjiang@sioc.ac.cn
通信地址: 中国上海市浦东新区海科路100号13号楼538室
邮政编码: 201203
电子邮件: hongjiang@sioc.ac.cn
通信地址: 中国上海市浦东新区海科路100号13号楼538室
邮政编码: 201203
招生信息
招生专业
0703Z1-化学生物学071010-生物化学与分子生物学071009-细胞生物学
招生方向
环二核苷酸和NAD及其代谢酶的生物功能和调控机制蛋白翻译后修饰,细胞代谢调控免疫反应,神经退行性疾病
教育背景
1998-09--2003-06 中国科学技术大学 博士1994-09--1998-08 中国科学技术大学 学士
工作经历
工作简历
2009-09~2015-05,康奈尔大学(Cornell University), 助理研究员2006-09~2009-08,康奈尔大学(Cornell University), 访问科学家2003-09~2006-08,华盛顿大学(Washington University in St. Louis), 博士后1998-09~2003-06,中国科学技术大学, 博士1994-09~1998-08,中国科学技术大学, 学士
教授课程
蛋白质翻译后修饰
出版信息
发表论文
(1) Protein Lipidation: Occurrence, Mechanisms, Biological Functions, and Enabling Technologies, Chem Rev., 2018, 第 1 作者(2) Lysine fatty acylation promotes lysosomal targeting of TNF-α, Sci Rep., 2016, 第 1 作者(3) Chemical genetic discovery of PARP targets reveals a role for PARP-1 in transcription elongation, Science, 2016, 第 3 作者(4) Identifying the functional contribution of the defatty-acylase activity of SIRT6, Nat Chem Biol., 2016, 第 3 作者(5) Identification of ADP-ribosylation Sites of CD38 Mutants by Precursor Ion Scanning Mass Spectrometry., Anal. Biochem., 2013, 第 1 作者(6) SIRT6 Regulates TNF-alpha Secretion through Hydrolysis of Long-Chain Fatty Acyl Lysine., Nature, 2013, 第 1 作者(7) YBR246W is Required for the Third Step of Diphthamide Biosynthesis., J. Am. Chem. Soc., 2012, 第 4 作者(8) Chemogenomic Approach Identified Yeast YLR143W as Diphthamide Synthetase., Proc. Natl. Acad. Sci. U S A., 2012, 第 4 作者(9) ATRA-induced HL-60 Myeloid Leukemia Cell Differentiation Depends on the CD38 Cytosolic Tail Needed for Membrane Localization, but CD38 Enzymatic Activity is Unnecessary., Exp. Cell Res., 2011, 第 2 作者(10) Clickable NAD Analogues for Labeling Substrate Proteins of Poly(ADP-ribose) Polymerases., J. Am. Chem. Soc., 2010, 第 1 作者(11) A Study on the Reactions of NADH Models with Electron-Deficient Alkenes. A Probe for the Extreme of Concerted Electron-Hydrogen Atom Transfer Mechanism., Tetrahedron Lett. , 2009, 第 3 作者(12) Investigating the ADP-ribosyltransferase Activity of Sirtuins with NAD Analogs and 32P-NAD., Biochemistry, 2009, 第 2 作者(13) Mechanism-Based Small Molecule Probes for Labeling CD38 on Live Cells., J. Am. Chem. Soc., 2009, 第 1 作者(14) The Partial Substrate Dethiaacetyl -Coenzyme A Mimics All Critical Carbon Acid Reactions in the Condensation Half-Reaction Catalyzed by Thermoplasma acidophilum Citrate Synthase., Biochemistry, 2009, 第 3 作者(15) Structural Basis for Enzymatic Evolution from a Dedicated ADP-ribosyl Cyclase to a Multi-functional NAD Hydrolase., J. Biol. Chem., 2009, 第 4 作者(16) Covalent and Non-Covalent Intermediates of an NAD Utilizing Enzyme - Human CD38., Chem. Biol. , 2008, 第 3 作者(17) Multiple Active Site Histidine Protonation States in Acetobacter aceti N5-Carboxyaminoimidazole Ribonucleotide Mutase Detected by REDOR NMR., Biochemistry, 2007, 第 2 作者(18) Structure of a NADH-Insensitive Hexameric Citrate Synthase that Resists Acid Inactivation., Biochemistry, 2006, 第 4 作者(19) Photo-induced Coupling Reaction of 1,1-Diphenyl-2,2-dicyano-ethylene with 10-Methyl-9,10-dihydroacridine., Chinese Chem. Lett., 2004, 第 1 作者(20) Novel Photo-induced Coupling Reactions of 9-Fluorenylidenemalononitrile or 1,1-Diphenyl-2,2-dicyanoethylene with 10-Methyl-9,10-dihydroacridine. A Study on the Photophysics of the Reaction., Chinese J. Chem., 2003, 第 1 作者(21) Novel Photo-induced Coupling Reaction of 9-Fluorenylidenemalononitrile with 10-Methyl-9,10-dihydroacridine., Chem. Commun., 2002, 第 1 作者
科研活动
科研项目
( 1 ) 基于具有点击化学活性的环二核苷酸探针分子深入研究环 二核苷酸的生理功能, 负责人, 国家任务, 2018-01--2021-12( 2 ) 未知赖氨酸长链脂肪酰转移酶的鉴定和生物功能, 负责人, 国家任务, 2018-01--2020-12