Yejun Han PhD, Prof
Telephone: 18810182857
Address: 1 Beiertiao, Zhongguancun, Haidian, Beijing, China

Postcode: 100190


Research Areas

Biosynthetic Engineering, Enzymatic Engineering, Bioprocess Engineering


1. From February 2013 to present: 

Professor, Principle Investigator, National Key Laboratory of Biochemical Engineering, Institute of Process Engineering, Chinese Academy of Sciences    

2. From October 2010 to February 2013: 

Postdoctoral research scholar, Department of Chemical and Biomolecular Engineering, North Carolina State University, USA

3. From October 2008 to  September 2010: 

Postdoctoral research scholar, Energy Biosciences Institute,University of Illinois at Urbana-Champaign, USA 

4. From September 2005 to September 2008: 

Ph.D. in Biochemical Engineering, Institute of Process Engineering,Chinese Academy of Sciences   

5. From September 2001 to July 2004: 

Masters of Science in Microbiology, Nanjing Agricultural University, China

6. From September 1997 to July 2001: 

Bachelor of Engineering in Food Science and Engineering, Laiyang Agricultural University, China  

Honors & Distinctions

The Outstanding Contribution Award, “Min-Enze Energy & Chemical Industry Award” (the Third Session). Chinese Academy of Engineering & SINOPEC. 2017.



[1].          Xiaojing Jia,  Yejun Han*. The extracellular endo-β-1,4-xylanase with multidomain from the extreme thermophile Caldicellulosiruptor lactoaceticus is specific for insoluble xylan degradation. Biotechnology for Biofuels. 2019. 12:143

[2].          Xiaojing Jia, Robert Kelly, Yejun Han*. Simultaneous biosynthesis of (R)-acetoin and ethylene glycol from D-xylose through in vitro metabolic engineering. Metabolic Engineering Communications. MEC_2018_23. 2018.

[3].          Xiaowei Peng, Robert M. Kelly, and Yejun Han*. Sequential processing with fermentative Caldicellulosiruptor kronotskyensis and chemolithoautotrophic Cupriavidus necator for converting rice straw and CO2 to polyhydroxybutyrate. Biotechnology and Bioengineering. 2018. 10.1002/bit.26578

[4].          Jianjun Ding, Xiaowei Peng*, Yejun Han*. Electricity production and microbial community of anaerobic sludge. The Chinese Journal of Process Engineering. 2018. 10.12034/j.issn.1009-606X.218152

[5].          Hong Su, Yejun Han*. Review on electroautotrophic microorganisms: uptaking extracellular electron and catalyzing CO2 fixation and biosynthesis. Progress in Chemistry. 2018. 0.7536/PC180623.

[6].          Xiaojing Jia, Xiaowei Peng, Ying Liu, Yejun Han*. Conversion of cellulose and hemicellulose of biomass simultaneously to acetoin by thermophilic simultaneous saccharification and fermentation. Biotechnology for Biofuels. 2017.

[7].          Daniel Wefers, Jia Dong, Ahmed M. Abdel-Hamid, Hans Müller Paul, Gabriel V. Pereira, Yejun Han, Dylan Dodd, Ramiya Baskaran, Beth Mayer, Roderick I. Mackie and Isaac Cann*. Enzymatic mechanism for arabinan degradation and transport in the thermophilic bacterium Caldanaerobius polysaccharolyticus.  Applied and Environmental Microbiology. 2017. doi: 10.1128/AEM.00794-17.

[8].          Xiaojing Jia, Ying Liu, Yejun Han*. A thermophilic cell-free cascade enzymatic reaction for acetoin synthesis from pyruvate. Scientific Reports. 2017. 10.1038/s41598-017-04684-8.

[9].          Xiaowei Peng, Chao Li*, Jing Liu, Zili Yi, Yejun Han*. Changes in composition, cellulose degradability and biochemical methane potential of Miscanthus species during the growing season. Bioresource Technology. 2017 (235): 389–395.

[10].       Andrew J. Loder#, Yejun Han#, Aaron B. Hawkins#, Hong Lian, Gina L. Lipscomb, Gerrit J. Schut, Matthew W. Keller, Michael W.W. Adams, Robert M. Kelly*. Reaction kinetic analysis of the 3-hydroxypropionate/4-hydroxybutyrate CO2 fixation cycle in extremely thermoacidophilic archaea. Metabolic Engineering. 2016. (# co-first author)

[11].       Shuofu Mi, Hongqiang Li, Shuying Li, Yejun Han*. The synergism of hot water pretreatment and enzymatic hydrolysis in depolymerization of lignocellulosic content of palm kernel cake. Journal of Molecular Catalysis B: Enzymatic. 2016. 134: 37-42.

[12].       Hong Lian, Benjamin M. Zeldes, Gina L. Lipscomb, Aaron. B. Hawkins, Yejun Han, Andrew J. Loder, Declan Nishiyama, Michael W.W. Adams, and Robert M. Kelly*. Ancillary contributions of heterologous biotin protein ligase and carbonic anhydrase for CO2 incorporation into 3-hydroxypropionate by metabolically engineered Pyrococcus furiosus. Biotechnology & Bioengineering. 2016. 9999:1-9.

[13].       Xiaowei Peng,  Hong Su, Shuofu Mi, Yejun Han*.  A multifunctional thermophilic glycoside hydrolase from Caldicellulosiruptor owensensis with potential applications in production of biofuels and biochemicals. Biotechnololgy for Biofuels. 2016. doi: 10.1186/s13068-016-0509-y.

[14].       Xiaojing Jia, Weibo Qiao, Wenli Tian, Xiaowei Peng, Yejun Han*. Biochemical characterization of extra- and intracellular endoxylanase from thermophilic bacterium Caldicellulosiruptor kronotskyensis. Scientific Reports. 2016. doi: 10.1038/srep21672.

[15].       Xiaowei Peng, Weibo Qiao, Shuofu Mi, Xiaojing Jia, Hong Su, Yejun Han*. Characterization of hemicellulase and cellulase from the extremely thermophilic bacterium Caldicellulosiruptor owensensis and their potential application for bioconversion of lignocellulosic biomass without pretreatment. Biotechnololgy for Biofuels. 2015. doi: 10.1186/s13068-015-0313-0.

[16].       Hong Su, Weihua Qiu, Qing Kong, Shuofu Mi, Yejun Han*. Thermostable pectate lyase from Caldicellulosiruptor kronotskyensis provides an efficient addition for plant biomass deconstruction. Journal of Molecular Catalysis B: Enzymatic,  2015,121:104-112.

[17].       Xiaojing Jia, Shuofu Mi, Jinzhi Wang, Weibo Qiao, Xiaowei Peng, Yejun Han*. Insight into glycoside hydrolases for debranched xylan degradation from extremely thermophilic bacterium Caldicellulosiruptor lactoaceticus. PLoS One. 2014. doi: 10.1371/journal.pone.0106482.

[18].       Shuofu Mi, Xiaojing Jia, Jinzhi Wang, Weibo Qiao, Xiaowei Peng, Yejun Han*. Biochemical characterization of two thermostable xylanolytic enzymes encoded by a gene cluster of Caldicellulosiruptor owensensis. PLoS One. 2014. doi: 10.1371/journal.pone.0105264.

[19].       Weibo Qiao, Shuge Tang, Shuofu Mi, Xiaojing Jia, Xiaowei Peng, Yejun Han*. Biochemical characterization of a novel thermostable GH11 xylanase with CBM6 domain from Caldicellulosiruptor kronotskyensis. Journal of Molecular Catalysis B: Enzymatic.  2014, 107: 8-16.

[20].       Takuji Oyama,George E. Schmitz, Dylan Dodd, Yejun Han, Alanna Burnett, Naoko Nagasawa, Roderick I. Mackie, Haruki Nakamura, Kosuke Morikawa, Isaac Cann*. Mutational and structural analyses of Caldanaerobius polysaccharolyticus Man5B reveal novel active site residues for Family 5 glycoside hydrolases. PLoS One. 2013. DOI: 10.1371/journal.pone.0080448.

[21].       Aaron S. Hawkins, Yejun Han, and Michael W.W. Adams, Robert M. Kelly*. Novel enzymes for catalysis of 4-hydroxybutyrate-CoA ligation for CO2 fixaion pathways. The Journal of Biological Chemistry. 2013. 288(6):4012-4022.

[22].       Xiaoyun Su, Yejun Han, Dylan Dodd, Young Hwan Moon, Shosuke Yoshida, Roderick I. Mackie, and Isaac K. O. Cann*. Reconstitution of a thermostable hemicellulase mixture from the bacterium Caldicellulosiruptor bescii. Applied and Environmental Microbiology. 2013. 79(5):1481-1490.

[23].       Yejun Han#, Vinayak Agarwal#, Dylan Dodd#, Jason Kim, Brian Bae, Roderick I. Mackie, Satish K. Nair, and Isaac K.O. Cann*. Biochemical and structural insights into xylan utilization by the thermophilic bacterium Caldanaerobius polysaccharolyticus. The Journal of Biological Chemistry. 2012. 287(42): 34946-34960 (# co-first author).

[24].       Yejun Han, Aaron S. Hawkins, Michael W.W. Adams and Robert M. Kelly*. Epimerase (Msed_0639) and mutase (Msed_0638, Msed_2055) convert (S)-methylmalonyl-CoA to succinyl-CoA in the Metallosphaera sedula 3-hydroxypropionate/4-hydroxybutyrate cycle. Applied and Environmental Microbiology. 2012. 78(17): 6194-6202.

[25].       Aaron S. Hawkins, Yejun Han, Hong Lian, Andrew J. Loder, Angeli L. Menon, Ifeyinwa J. Iwuchukwu, Matthew Keller, Therese T. Leuko, Michael W.W. Adams, and Robert M. Kelly*. Extremely thermophilic routes to microbial electrofuels. American Chemical Society Catalysis. 2011, 1 (9):1043–1050. 

[26].       Yejun Han and Hongzhang Chen*. Improvement of corn stover bioconversion efficiency by using plant glycoside hydrolase. Bioresource Technology. 2011. 102(7): 4787-4792.

[27].       Mirjam A. Kabel,  Carl J. Yeoman, Yejun Han, Dylan Dodd, Charles A. Abbas, Jan A. M. de Bont, Mark Morrison, Isaac K.O. Cann, Roderick I. Mackie*. Biochemical characterization and relative expression levels of multiple carbohydrate esterases of the xylanolytic rumen bacterium Prevotella ruminicola 23 grown on an ester-enriched substrate. Applied and Environmental Microbiology. 2011. 77(16): 5671-5681.

[28].       Yejun Han, Dylan Dodd, Charles W. Hespen, Samuel Ohene-Adjei, Charles M. Schroeder, Roderick I. Mackie, and Isaac K.O. Cann*. Comparative analyses of two thermophilic enzymes exhibiting both β-1,4 mannosidic and β-1,4 glucosidic cleavage activities from Caldanaerobius polysaccharolyticus. Journal of Bacteriology. 2010. 192(16): 4111-4121.

[29].       Yejun Han and Hongzhang Chen*. Biochemical characterization of a maize stover β-exoglucanase and its use in lignocellulose conversion. Bioresource Technology. 2010. 101(15): 6111-6117.

[30].       Yejun Han and Hongzhang Chen*. A β-xylosidase from cell wall of maize: purification, properties and its use in hydrolysis of plant cell wall. Journal of Molecular Catalysis B: Enzymatic. 2010. 63: 135-140.

[31].       Yejun Han and Hongzhang Chen*. Synergism between hydrophobic proteins of corn stover and cellulase in lignocellulose hydrolysis. Biochemical Engineering Journal. 2009. 48: 218-224.

[32].       Yejun Han and Hongzhang Chen*. Characterization of β-glucosidase from corn stover and its application in simultaneous saccharification and fermentation. Bioresource Technology. 2008. 99(15): 6081-6087.

[33].       Hongzhang Chen*, Yejun Han, and Jian Xu. Simultaneous saccharification and fermentation of steam exploded wheat straw pretreated with alkaline peroxide. Process Biochemistry. 2008. 43(12): 1462-1466.

[34].       Yejun Han and Hongzhang Chen*. Synergism between corn stover protein and cellulase. Enzyme and Microbial Technology. 2007. 41: 638–645.