General
Xinzheng Zhang  Professor
Institute of Biophysics, Chinese Academy of Sciences
Email:xzzhang@ibp.ac.cn
Telephone:010-64888490
Address: 15 Datun Road, Chaoyang District, Beijing, China
Postcode: 100101

Research Areas

Cryo electron microscopy (cryo-EM); cryo-EM structure of micromolecules; virus structure and virus entry.

Education

1999.9-2003.7: B.S., Peking University
2003.7-2008.9: Ph.D, Peking University

Experience

   
Work Experience
2009.1-2014.9: Postdoctoral Research, Purdue University.
2014.10-present: Professor, CAS Institute of Biophysics.
Teaching Experience
three-dimensional reconstruction of biological macromolecular complexes

Publications

   
Papers

1. Jialing Wang#, Shuai Yuan#, Dongjie Zhu#, Hao Tang, Nan Wang, Wenyuan Chen, Qiang Gao, Yuhua Li, Junzhi Wang, Hongrong Liu, Xinzheng Zhang*, Zihe Rao* & Xiangxi Wang*.Structure of the herpes simplex virus type 2 Ccapsid with capsid-vertex-specific component. Nature Communications, 2018 Sep 10;9(1):3668.

2.Xiaowei Pan#, Jun Ma#, Xiaodong Su#, Peng Cao, Wenrui Chang, Zhenfeng Liu, Xinzheng Zhang*, Mei Li*.Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II. Science, 2018, 360(6393):1109-1113

3.Dongjie Zhu, Xiangxi Wang, Qianglin Fang, James L Van Etten, Michael G Rossmann, Zihe Rao, Xinzheng Zhang. Pushing the resolution limit by correcting the Ewald sphere effect in single-particle Cryo-EM reconstructions. Nature Communications, 2018, 9:1552.

4.Shuai Yuan#, Jialing Wang#, Dongjie Zhu#, Nan Wang, Qiang Gao, Wenyuan Chen, Hao Tang, Junzhi Wang*, Xinzheng Zhang*, Hongrong Liu*, Zihe Rao*, Xiangxi Wang*. Cryo-EM structure of a herpesvirus capsid at 3.1 Å. Science, 2018, 360(6384), eaao7283.(*corresponding author)

5. Xiaodong Su#, Jun Ma#, Xuepeng Wei#, Peng Cao#, Dongjie Zhu, Wenrui Chang, Zhenfeng Liu*, Xinzheng Zhang*, Mei Li*. Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex. Science, 2017, 357 (6353): 815-820.(*corresponding author)

6. Liang Liu#, Xueyan Li#, Jun Ma#, Zongqiang Li#, Lilan You, Jiuyu Wang, Min Wang, Xinzheng Zhang*, Yanli Wang*. The Molecular Architecture for RNA-Guided RNA Cleavage by Cas13a. Cell, 2017, 170(4):714-726.e10.(*corresponding author)

7.Yuan Yuan#, Duanfang Cao#, Yanfang Zhang#, Jun Ma#, Jianxun Qi, Qihui Wang, Guangwen Lu,Ying Wu, Jinghua Yan, Yi Shi*, Xinzheng Zhang* & George F. Gao*.Cryo-EM structures of MERS-CoV and SARS-CoV spike glycoproteins reveal the dynamic receptor binding domains, Nature Communications, 2017, Apr 10;8:15092.(*corresponding author)

8.Wang J, Ma J, Cheng Z, Meng X, You L, Wang M, Zhang X*, Wang Y*.A CRISPR evolutionary arms race: structural insights into viral anti-CRISPR/Cas responses. Cell Res., 2016, 26:1165-1168.(*corresponding author)

9. Wei XP, Su XD, Cao P, Liu XY, Chang WR, Li M*, Zhang XZ*, Liu ZF*. Structure of spinach photosystem II-LHCII supercomplex at 3.2 Å resolution. Nature. 534(7605):69-74(2016). (*corresponding author)

10.Sun L#, Zhang XZ#, Gao S#, Rao PA, Padilla-Sanchez V, Chen ZG, Sun SY, Xiang Y, Subramaniam S, Rao VB, Rossmann MG. Cryo-EM structure of the bacteriophage T4 portal protein assembly at near-atomic resolution. Nature Communication. 6(7): 548 (2015). (# co-first author)
11. Zhang XZ, Sun L, Rossmann MG. Temperature dependent conformational change of Dengue virus. Current Opinion in Virology, 12:109-112 (2015).
12.Zhang XZ, Sheng J, Austion SK, Hoornweg TE, Smit JM, Kuhn RJ, Diamond MS, Rossmann MG. Structure of acidic pH dengue virus showing the fusogenic glycoprotein trimers. J. Virol. 89(1):743-50 (2015).
13.Sun L#, Young LN#, Zhang XZ#, Boudko SP, Fokine A, Zbornik E, Roznowski AP, Molineux IJ, Rossmann MG, Fane BA. Icosahedral bacteriophage ΦX174 forms a tail for DNA transport during infection. Nature, 505(7483):432-5 (2014). (#co-first author)
14. Zhang XZ, Sheng J, Plevka P, Kuhn RJ, Diamond MS, Rossmann MG. Dengue structure differs at the temperatures of its human and mosquito host. Proc. Natl. Acad. Sci. 110(17): 6795-6799 (2013).  
15. Zhang XZ, Sun S, Xiang Y, Wong J, Klose T, Raoult D, Rossmann MG. Structure of Sputnik, a virophage, at 3.5-Å resolution. Proc. Natl. Acad. Sci. 109(45):18431-6(2012).
16. Zhang XZ, Xiang Y, Dunigan DD, Klose T, Chipman PR, Van Etten JL, Rossmann MG. Three-dimensional structure and function of the Paramecium bursaria chlorella virus capsid. Proc. Natl. Acad. Sci. 108(36):14837-42 (2011).

Personal homepage

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