基本信息
刘欣  女  博导  中国科学院北京基因组研究所(国家生物信息中心)
电子邮件: liuxin@big.ac.cn
通信地址: 北京市朝阳区北辰西路1号院104号楼
邮政编码: 100101

招生信息

   
招生专业
071007-遗传学
招生方向
复杂疾病的遗传流行病学研究

教育背景

1997-09--2002-02   美国约翰霍普金斯大学   博士学位
1988-09--1993-07   山东医科大学   学士学位

工作经历

   
工作简历
2015-01~现在, 中国科学院北京基因组研究所, 研究员
2007-01~2015-01,美国西北大学, 助理教授
2004-02~2006-12,美国加州大学旧金山分校, 博士后
2002-02~2003-12,美国约翰霍普金斯大学布隆博格公共卫生学院, 博士后
1997-09~2002-02,美国约翰霍普金斯大学, 博士学位
1988-09~1993-07,山东医科大学, 学士学位

教授课程

精准医疗基础与临床
遗传流行病学
生物统计学

出版信息

   
发表论文
(1) Clinical and Genetic Characterization of EBV-associated T/NK lymphoproliferativediseases, Journal of Allergy and Clinical Immunology, 2022, 第 10 作者
(2) NBAS, a gene involved in cytotoxic degranulation, is recurrently mutated in pediatric hemophagocytic lymphohistiocytosis, JOURNAL OF HEMATOLOGY & ONCOLOGY, 2022, 通讯作者
(3) Germline variants in UNC13D and AP3B1 are enriched in COVID-19 patients experiencing severe cytokine storms, EUROPEAN JOURNAL OF HUMAN GENETICS, 2021, 第 9 作者
(4) Ecological principle meets cancer treatment: treating children with acute myeloid leukemia with low-dose chemotherapy, NATIONAL SCIENCE REVIEW, 2019, 第 13 作者
(5) Integrated genomic analysis identifies deregulated JAK/STAT-MYC-biosynthesis axis in aggressive NK-cell leukemia, CELL RESEARCH, 2018, 第 38 作者
(6) Genome-wide association study of maternal genetic effects and parent-of-origin effects on food allergy, MEDICINE, 2018, 通讯作者
(7) PDGFRB mutation and tyrosine kinase inhibitor resistance in Ph-like acute lymphoblastic leukemia, BLOOD, 2018, 通讯作者
(8) Genome-wide approach identifies a novel gene-maternal pre-pregnancy BMI interaction on preterm birth, NATURE COMMUNICATIONS, 2017, 第 8 作者
(9) Epigenome-wide association study links site-specific DNA methylation changes with cow's milk allergy, JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY, 2016, 第 9 作者
(10) Racial Disparity in the Associations of Cotinine with Insulin Secretion: Data from the National Health and Nutrition Examination Survey, 2007-2012, PLOS ONE, 2016, 第 5 作者
(11) Blood methylomics in response to arsenic exposure in a low-exposed US population, JOURNAL OF EXPOSURE SCIENCE AND ENVIRONMENTAL EPIDEMIOLOGY, 2014, 第 1 作者
(12) Maternal preconception body mass index and offspring cord blood DNA methylation: Exploration of early life origins of disease, ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2014, 通讯作者
(13) Microsomal epoxide hydrolase (EPHX1) polymorphisms are associated with aberrant promoter methylation of ERCC3 and hematotoxicity in benzene-exposed workers, ENVIRONMENTAL AND MOLECULAR MUTAGENESIS, 2013, 第 9 作者
(14) Longitudinal trajectory of vitamin D status from birth to early childhood in the development of food sensitization, PEDIATRIC RESEARCH, 2013, 通讯作者
(15) Individual variation and longitudinal pattern of genome-wide DNA methylation from birth to the first two years of life, EPIGENETICS, 2012, 第 2 作者
(16) Associations between gene polymorphisms in fatty acid metabolism pathway and preterm delivery in a US urban black population, HUMAN GENETICS, 2012, 通讯作者
(17) Gene-Vitamin D Interactions on Food Sensitization: A prospective birth cohort study, ALLERGY, 2011, 
(18) Fine-Mapping of Prostate Cancer Aggressiveness Loci on Chromosome 7q22-35, PROSTATE, 2011, 第 1 作者
(19) Association between short sleep duration and the risk of sensitization to food and aero allergens in rural Chinese adolescents, CLINICAL AND EXPERIMENTAL ALLERGY, 2011, 

科研活动

   
科研项目
( 1 ) ****启动, 负责人, 研究所自主部署, 2015-01--2017-12
( 2 ) 中国科学院“**择优”, 负责人, 中国科学院计划, 2016-01--2018-12
( 3 ) 儿童噬血细胞综合征的遗传突变研究, 负责人, 国家任务, 2016-01--2019-12
( 4 ) 职业人群队列建立及精准医学研究, 负责人, 中国科学院计划, 2015-09--2018-12
( 5 ) 慢性活动性EB病毒感染的遗传变异研究, 负责人, 国家任务, 2019-01--2022-12
( 6 ) 白血病形成及其在药物作用下的细胞异质性演化, 参与, 国家任务, 2019-01--2023-12
( 7 ) 靶点基因在难治复发AML中的演化及新靶点的发现, 负责人, 国家任务, 2021-12--2024-11