基本信息
周启心  女  硕导  中国科学院昆明动物研究所
电子邮件: qixin_zhou@126.com
通信地址: 云南省昆明市教场东路32号
邮政编码:

招生信息

   
招生专业
071006-神经生物学
招生方向
精神疾病动物模型与疾病机理

教育背景

2002-09--2010-06 中国科学院昆明动物研究所 博士
1995-09--2000-06 华西医科大学 医学学士

工作经历

   
工作简历
2012-12--今 中国科学院昆明动物研究所 副研究员
2012-02--2012-05 加拿大渥太华大学 访问学者
2010-07--2012-11 中国科学院昆明动物研究所 助理研究员
2000-07--2002-08 中国科学院昆明动物研究所 研究实习员

专利与奖励

   
专利成果
[1] 王妮娅, 徐林, 谭娅红, 毛榕榕, 李津南, 周启心. 阿魏酸在制备治疗血管疾病的药物中的应用. CN: CN111481533A, 2020-08-04.

[2] 徐林, 黄京飞, 周启心, 李功华, 谭继伟, 熊贵静, 韩会丽. 一种阻断突触长时程增强(LTP)的短肽及其应用. CN: CN106632601A, 2017-05-10.

[3] Chen Jijun, Xu Lin, Zhou Jun, Lu Jun, Mao Rongrong, Tian Meng, Zhou Qixin, Zhang Xuemei, Shen Yong, Jiang Zhiyong, Zuo Aixue. APPLICATION OF 5-METHYL-1,3-BENZENEDIOL OR DERIVATIVES THEREOF IN THE PREPARATION OF MEDICINES AND FUNCTIONAL FOODS FOR TREATMENT OR PREVENTION OF DEPRESSION. CN: US2010190730A1, 2010-07-29.

[4] 陈纪军, 徐林, 周俊, 吕俊, 毛榕榕, 田孟, 周启心, 张雪梅, 沈勇, 江志勇, 左爱学. 5-甲基-1,3苯二酚或其衍生物用于制备治疗或预防抑郁症的药物或功能食品中的用途. CN: CN101742992A, 2010-06-16.

出版信息

   
发表论文
[1] Zhao, YaBo, Hou, XueFei, Li, Xin, Zhu, LiSu, Zhu, Jing, Ma, GuoRui, Liu, YuXuan, Miao, YuCan, Zhou, QianYu, Xu, Lin, Zhou, QiXin. Early Memory Impairment is Accompanied by Changes in GluA1/p-GluA1 in APP/PS1 Mice. CURRENT ALZHEIMER RESEARCH[J]. 2022, 19(9): 667-673, http://dx.doi.org/10.2174/1567205020666221019124543.
[2] Hou, XueFei, Zhao, YaBo, Yang, YueXiong, Ma, Chen, Li, Meng, Li, Xin, Ma, GuoRui, Zhu, LiSu, Xu, Lin, Zhou, QiXin. High Morphine Use Disorder Susceptibility Is Predicted by Impaired Learning Ability in Mice. BRAIN SCIENCES[J]. 2022, 12(12): http://dx.doi.org/10.3390/brainsci12121650.
[3] Pan, TingTing, Liu, Chao, Li, DeMin, Zhang, TianHao, Zhang, Wei, Zhao, ShiLun, Zhou, QiXin, Nie, BinBin, Zhu, GaoHong, Xu, Lin, Liu, Hua. Retrosplenial Cortex Effects Contextual Fear Formation Relying on Dysgranular Constituent in Rats. FRONTIERS IN NEUROSCIENCE[J]. 2022, 16: http://dx.doi.org/10.3389/fnins.2022.886858.
[4] TingTing Pan, Chao Liu, DeMin Li, BinBin Nie, TianHao Zhang, Wei Zhang, ShiLun Zhao, QiXin Zhou, Hua Liu, GaoHong Zhu, Lin Xu, Shan,BaoCi. Nucleus accumbens-linked executive control networks mediating reversal learning in tree shrew brain. 动物学研究[J]. 2022, 43(4): 528-531, http://lib.cqvip.com/Qikan/Article/Detail?id=7107719547.
[5] Chai, AnPing, Chen, XueFeng, Xu, XiaoShan, Zhang, Na, Li, Meng, Li, JinNan, Zhang, Lei, Zhang, Dai, Zhang, Xia, Mao, RongRong, Ding, YuQiang, Xu, Lin, Zhou, QiXin. A Temporal Activity of CA1 Neurons Underlying Short-Term Memory for Social Recognition Altered in PTEN Mouse Models of Autism Spectrum Disorder. FRONTIERS IN CELLULAR NEUROSCIENCE[J]. 2021, 15: http://dx.doi.org/10.3389/fncel.2021.699315.
[6] Wang, NiYa, Li, JinNan, Liu, WeiLin, Huang, Qi, Li, WenXing, Tan, YaHong, Liu, Fang, Song, ZiHua, Wang, MengYue, Xie, Ning, Mao, RongRong, Gan, Ping, Ding, YuQiang, Zhang, Zhi, Shan, BaoCi, Chen, LiDian, Zhou, QiXin, Xu, Lin. Ferulic Acid Ameliorates Alzheimer's Disease-like Pathology and Repairs Cognitive Decline by Preventing Capillary Hypofunction in APP/PS1 Mice. NEUROTHERAPEUTICS[J]. 2021, 18(2): 1064-1080, http://dx.doi.org/10.1007/s13311-021-01024-7.
[7] Huang, Ying, Huang, Jing, Zhou, QiXin, Yang, ChunXian, Yang, CuiPing, Mei, WanYing, Zhang, Lei, Zhang, Qiong, Hu, Ling, Hu, YunQing, Song, NingNing, Wu, ShengXi, Xu, Lin, Ding, YuQiang. ZFP804A mutant mice display sex-dependent schizophrenia-like behaviors. MOLECULAR PSYCHIATRY. 2020, https://www.webofscience.com/wos/woscc/full-record/WOS:000597435700001.
[8] Bao, Tianhao, Ke, Yang, Wang, Yifan, Wang, Weiwei, Li, Yuehua, Wang, Yan, Kui, Xiang, Zhou, Qixin, Zhou, Han, Zhang, Cheng, Zhou, Dongming, Wang, Lin, Xiao, Chunjie. Taraxasterol suppresses the growth of human liver cancer by upregulating Hint1 expression. JOURNAL OF MOLECULAR MEDICINE-JMM[J]. 2018, 96(7): 661-672, https://www.webofscience.com/wos/woscc/full-record/WOS:000435945000006.
[9] Jiao CX, Zhou H, Yang CX, Ma C, Yang YX, Mao RR, Xu L, Zhou QX. Protective efficacy of a single salvianolic acid A treatment on photothrombosis-induced sustained spatial memory impairments. NEUROPSYCHIATRIC DISEASE AND TREATMENT[J]. 2017, 13(X): 1181-1191, http://159.226.149.26:8080/handle/152453/11485.
[10] Heng Zhou, GuiJing Xiong, Liang Jing, NingNing Song, DeLin Pu, Xun Tang, XiaoBing He, FuQiang Xu, JingFei Huang, LingJiang Li, Gal RichterLevin, RongRong Mao, QiXin Zhou, YuQiang Ding, Lin Xu. The interhemispheric CA1 circuit governs rapid generalisation but not fear memory. NATURE COMMUNICATIONS[J]. 2017, 8(1): https://doaj.org/article/6f601220edfe4f3a85ff0a10e8ee31e9.
[11] Yu, Dafu, Zhou, Heng, Zou, Lin, Jiang, Yong, Wu, Xiaoqun, Jiang, Lizhu, Zhou, Qixin, Yang, Yuexiong, Xu, Lin, Mao, Rongrong. Hippocampal Administration of Levothyroxine Impairs Contextual Fear Memory Consolidation in Rats. FRONTIERS IN CELLULAR NEUROSCIENCE[J]. 2017, 11(X): http://159.226.149.26:8080/handle/152453/12032.
[12] Lin Xu. The interhemispheric CA1 circuit governs rapid generalization but not fear memory. Nature Communications. 2017, [13] Wang, Weisheng, Ju, YunYue, Zhou, QiXin, Tang, JianXin, Li, Meng, Zhang, Lei, Kang, Shuo, Chen, ZhongGuo, Wang, YuJun, Ji, Hui, Ding, YuQiang, Xu, Lin, Liu, JingGen. The Small GTPase Rac1 Contributes to Extinction of Aversive Memories of Drug Withdrawal by Facilitating GABA(A) Receptor Endocytosis in the vmPFC. JOURNAL OF NEUROSCIENCE[J]. 2017, 37(30): 7096-7110, http://159.226.149.26:8080/handle/152453/11759.
[14] Ke, Yang, Bao, Tianhao, Zhou, Qixin, Wang, Yan, Ge, Jiayun, Fu, Bimang, Wu, Xuesong, Tang, Haoran, Shi, Zhitian, Lei, Xuefen, Zhang, Cheng, Tan, Yuqi, Chen, Haotian, Guo, Zhitang, Wang, Lin. Discs large homolog 5 decreases formation and function of invadopodia in human hepatocellular carcinoma via Girdin and Tks5. INTERNATIONAL JOURNAL OF CANCER[J]. 2017, 141(2): 364-376, https://www.webofscience.com/wos/woscc/full-record/WOS:000401737200015.
[15] Gan, Ping, Ding, ZeYang, Gan, Cheng, Mao, RongRong, Zhou, Heng, Xu, Lin, Zhou, QiXin. Corticosterone regulates fear memory via Rac1 activity in the hippocampus. PSYCHONEUROENDOCRINOLOGY[J]. 2016, 71(X): 86-93, http://dx.doi.org/10.1016/j.psyneuen.2016.05.011.
[16] Jiang, Lizhu, Mao, Rongrong, Zhou, Qixin, Yang, Yuexiong, Cao, Jun, Ding, Yuqiang, Yang, Yuan, Zhang, Xia, Li, Lingjiang, Xu, Lin. Inhibition of Rac1 Activity in the Hippocampus Impairs the Forgetting of Contextual Fear Memory. MOLECULAR NEUROBIOLOGY[J]. 2016, 53(2): 1247-1253, http://www.irgrid.ac.cn/handle/1471x/1153978.
[17] Jiang, Lizhu, Mao, Rongrong, Tong, Jianbin, Li, Jinnan, Chai, Anping, Zhou, Qixin, Yang, Yuexiong, Wang, Liping, Li, Lingjiang, Xu, Lin. Inhibition of Rac1 activity in the hippocampus impaired extinction of contextual fear. NEUROPHARMACOLOGY[J]. 2016, 109(X): 216-222, http://dx.doi.org/10.1016/j.neuropharm.2016.06.017.
[18] Zhou, Heng, Zhou, Qixin, Xu, Lin. Unilateral hippocampal inactivation or lesion selectively impairs remote contextual fear memory. PSYCHOPHARMACOLOGY[J]. 2016, 233(19-20): 3639-3646, https://www.webofscience.com/wos/woscc/full-record/WOS:000383672500013.
[19] Han, Huili, Dong, Zhifang, Jia, Yunfang, Mao, Rongrong, Zhou, Qixin, Yang, Yuexiong, Wang, Liping, Xu, Lin, Cao, Jun. Opioid addiction and withdrawal differentially drive long-term depression of inhibitory synaptic transmission in the hippocampus. SCIENTIFIC REPORTS[J]. 2015, 5(X): https://www.webofscience.com/wos/woscc/full-record/WOS:000353903700001.
[20] Yu, Dafu, Zhou, Heng, Yang, Yuan, Jiang, Yong, Wang, Tianchao, Lv, Liang, Zhou, Qixin, Yang, Yuexiong, Dong, Xuexian, He, Jianfeng, Huang, Xiaoyan, Chen, Jijun, Wu, Kunhua, Xu, Lin, Mao, Rongrong. The bidirectional effects of hypothyroidism and hyperthyroidism on anxiety- and depression-like behaviors in rats. HORMONES AND BEHAVIOR[J]. 2015, 69(X): 106-115, http://dx.doi.org/10.1016/j.yhbeh.2015.01.003.
[21] Shan, LiLi, Guo, Hao, Song, NingNing, Jia, ZhengPing, Hu, XinTian, Huang, JingFei, Ding, YuQiang, RichterLevine, Gal, Zhou, QiXin, Xu, Lin. Light exposure before learning improves memory consolidation at night. SCIENTIFIC REPORTS[J]. 2015, 5(X): https://www.webofscience.com/wos/woscc/full-record/WOS:000363315900001.
[22] Zhou, Heng, Yu, ChengLong, Wang, LiPing, Yang, YueXiong, Mao, RongRong, Zhou, QiXin, Xu, Lin. NMDA and D1 receptors are involved in one-trial tolerance to the anxiolytic-like effects of diazepam in the elevated plus maze test in rats. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR[J]. 2015, 135(X): 40-45, http://dx.doi.org/10.1016/j.pbb.2015.05.009.
[23] Jing, Liang, Duan, TingTing, Tian, Meng, Yuan, Qiang, Tan, JiWei, Zhu, YongYong, Ding, ZeYang, Cao, Jun, Yang, YueXiong, Zhang, Xia, Mao, RongRong, Richterievin, Gal, Zhou, QiXin, Xu, Lin. Despair-associated memory requires a slow-onset CA1 long-term potentiation with unique underlying mechanisms. SCIENTIFIC REPORTS[J]. 2015, 5(X): http://www.corc.org.cn/handle/1471x/2198445.
[24] Tan, JiWei, Duan, TingTing, Zhou, QiXin, Ding, ZeYang, Jing, Liang, Cao, Jun, Wang, LiPing, Mao, RongRong, Xu, Lin. Impaired contextual fear extinction and hippocampal synaptic plasticity in adult rats induced by prenatal morphine exposure. ADDICTION BIOLOGY[J]. 2015, 20(4): 652-662, http://www.corc.org.cn/handle/1471x/2201848.
[25] 刘瑶, 周启心, 徐林, 刘景根. 突触骨架重塑调控吗啡戒断负性记忆的分子机制进展. 科学通报[J]. 2014, 59(1): 15-20-, http://www.irgrid.ac.cn/handle/1471x/1153950.
[26] Jing Liang, Zhou Qixin, Xu Lin. Avoidance of potentially harmful food cannot be socially transmitted between rats. ZOOLOGICAL RESEARCH[J]. 2014, 35(4): 256−261-, http://www.irgrid.ac.cn/handle/1471x/1153952.
[27] Zhou Qixin. high-frequency stimulation induces a form of long-term depression dependent on GABAA and mACh receptors in the hippocampus.. 2013, [28] Jing Wang, Anping Chai, Qixin Zhou, Longbao Lv, Liping Wang, Yuexiong Yang, Lin Xu. Chronic Clomipramine Treatment Reverses Core Symptom of Depression in Subordinate Tree Shrews. PLOS ONE[J]. 2013, 8(12): http://dx.doi.org/10.1371/journal.pone.0080980.
[29] Jing WANG, XinLi XU, ZeYang DING, RongRong MAO, QiXin ZHOU, LongBao LV, LiPing WANG, Shuang WANG, Chen ZHANG, Lin XU, YueXiong YANG. Basal physiological parameters in domesticated tree shrews(Tupaia belangeri chinensis). 动物学研究[J]. 2013, 34(S02): 69-74, http://lib.cqvip.com/Qikan/Article/Detail?id=7105136576.
[30] Duan, TingTing, Tan, JiWei, Yuan, Qiang, Cao, Jun, Zhou, QiXin, Xu, Lin. Acute ketamine induces hippocampal synaptic depression and spatial memory impairment through dopamine D1/D5 receptors. PSYCHOPHARMACOLOGY[J]. 2013, 228(3): 451-461, http://www.irgrid.ac.cn/handle/1471x/680406.
[31] Liu, Yao, Zhou, QiXin, Hou, YuanYuan, Lu, Bin, Yu, Chuan, Chen, Jie, Ling, QingLan, Cao, Jun, Chi, ZhiQiang, Xu, Lin, Liu, JingGen. Actin Polymerization-Dependent Increase in Synaptic Arc/Arg3.1 Expression in the Amygdala Is Crucial for the Expression of Aversive Memory Associated with Drug Withdrawal. JOURNAL OF NEUROSCIENCE[J]. 2012, 32(35): 12005-12017, http://dx.doi.org/10.1523/JNEUROSCI.0871-12.2012.
[32] Liu, Yao, Zhou, QiXin, Hou, YuanYuan, Lu, Bin, Yu, Chuan, Chen, Jie, Ling, QingLan, Cao, Jun, Chi, ZhiQiang, Xu, Lin, Liu, JingGen. Actin Polymerization-Dependent Increase in Synaptic Arc/Arg3.1 Expression in the Amygdala Is Crucial for the Expression of Aversive Memory Associated with Drug Withdrawal. JOURNAL OF NEUROSCIENCE[J]. 2012, 32(35): 12005-12017, http://dx.doi.org/10.1523/JNEUROSCI.0871-12.2012.
[33] Zhou, QiXin, Mao, RongRong, Duan, TingTing, Tan, JiWei, Tian, Meng, Cao, Jun, Xu, Lin. Stress within the postseizure time window inhibits seizure recurrence. EPILEPSY & BEHAVIOR[J]. 2010, 18(3): 201-206, http://dx.doi.org/10.1016/j.yebeh.2010.04.007.
[34] Zhou Qixin. Chronic morphine treatment impairs hippocampal LTP and spatial memory via accumulation of extracellular adenosine acting on adenosine A1 receptors.. Journal of Neuroscience. 2010, [35] Mao, RongRong, Tian, Meng, Yang, YueXiong, Zhou, QiXin, Xu, Lin, Cao, Jun. Effects of pentylenetetrazol-induced brief convulsive seizures on spatial memory and fear memory. EPILEPSY & BEHAVIOR[J]. 2009, 15(4): 441-444, http://dx.doi.org/10.1016/j.yebeh.2009.05.015.

科研活动

   
科研项目
(1) 精神活性物质依赖的形成和消退,参与,部委级,2015-01--2019-12
(2) 海马突触可塑性与创伤记忆的提取,主持,国家级,2014-01--2017-12
(3) 中国科学院青年创新促进会会员,主持,院级级,2013-01--2016-12
(4) 遗忘的功能和机制研究,参与,部委级,2013-01--2017-12
(5) 学习记忆和老年痴呆的脑功能联结图谱,参与,院级级,2012-09--2016-12
(6) 神经元氯离子稳态在创伤后应激障碍(PTSD)易感性中的作用,主持,国家级,2012-01--2014-12