基本信息
郑迎迎 女 硕导 中国科学院天津工业生物技术研究所
email: zheng_yy@tib.cas.cn
address: 天津空港经济区西七道32号
postalCode:
email: zheng_yy@tib.cas.cn
address: 天津空港经济区西七道32号
postalCode:
招生信息
招生专业
086000-生物与医药071005-微生物学071011-生物物理学
招生方向
蛋白质结构与功能研究微生物酶学蛋白子及其复合体分子结构
教育背景
2007-10--2008-09 德国不莱梅国际大学 交流2006-09--中国科学院微生物研究所 博士2004-09--南京理工大学 硕士2000-09--南京理工大学 学士
工作经历
工作简历
2014-05~现在, 中国科学院天津工业生物技术研究所, 副研究员2010-09~2014-04,中国科学院天津工业生物技术研究所, 助理研究员2007-10~2008-09,德国不莱梅国际大学, 交流2006-09~现在, 中国科学院微生物研究所, 博士2004-09~现在, 南京理工大学, 硕士2000-09~现在, 南京理工大学, 学士
专利与奖励
奖励信息
(1) 天津市自然科学奖二等奖, 二等奖, 市地级, 2019
专利成果
( 1 ) Lactone hydrolase and method of degrading α-zearalenol using the same., 2017, 第 2 作者, 专利号: 15/366,370( 2 ) 内酯酶及利用内酯酶降解 α-玉米赤霉烯醇的方法, 2016, 第 2 作者, 专利号: 105123523( 3 ) 内酯酶及利用内酯酶降解 α-玉米赤霉烯醇的方法, 2015, 第 2 作者, 专利号: 201511015441.X
出版信息
发表论文
(1) Crystal Structure of a Mycoestrogen-Detoxifying Lactonase from Rhinocladiella mackenziei: Molecular Insight into ZHD Substrate Selectivity, ACS CATALYSIS, 2018, 第 1 作者(2) Structure and Function of a "Head-to-Middle" Prenyltransferase: Lavandulyl Diphosphate Synthase., Angew Chem Int Ed Engl, 2016, 第 5 作者(3) Moenomycin Biosynthesis: Structure and Mechanism of Action of the Prenyltransferase MoeN5., Angew Chem Int Ed Engl, 2016, 第 5 作者(4) Structures of Trypanosome Vacuolar Soluble Pyrophosphatases: Antiparasitic Drug Targets, ACS Chem Biol, 2016, 第 5 作者(5) Crystal structure and genetic modifications of FI-CMCase from Aspergillus aculeatus F-50., Biochem Biophys Res Commun., 2016, 第 5 作者(6) Enhanced α-Zearalenol Hydrolyzing Activity of a Mycoestrogen-Detoxifying Lactonase by Structure-Based Engineering, ACS CATALYSIS, 2016, 通讯作者(7) Crystal structures of S-adenosylhomocysteine hydrolase from the thermophilic bacterium Thermotoga maritima., J Struct Biol., 2015, 第 1 作者(8) Binding mode of the oxidized α-anomer of NAD(+) to RSP, a Rex-family repressor. Biochem Biophys Res Commun., Biochem Biophys Res Commun., 2015, 第 1 作者(9) Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from Escherichia coli reveal the catalytic and chain-length determining mechanisms., Proteins, 2015, 第 5 作者(10) Distinct structural features of Rex-family repressors to sense redox levels in anaerobes and aerobes., J Struct Biol., 2014, 第 1 作者(11) Structural and functional analysis of Bacillus subtilis YisP reveals a role of its product in biofilm production., Chem Biol., 2014, 第 1 作者(12) Structure, function and inhibition of ent-kaurene synthase from Bradyrhizobium japonicum., Sci Rep. , 2014, 第 1 作者(13) Crystallization and preliminary X-ray diffraction analysis of the S-adenosylhomocysteine hydrolase (SAHH) from Thermotoga maritima., Acta Crystallogr F Struct Biol Commun. , 2014, 第 1 作者(14) Crystal structure and substrate-binding mode of the mycoestrogen-detoxifying lactonase ZHD from Clonostachys rosea., RSC Advances., 2014, 第 4 作者(15) Functional and structural studies of pullulanase from Anoxybacillus sp. LM18-11., Proteins., 2014, 第 4 作者(16) Crystal structures of ligand-bound octaprenyl pyrophosphate synthase from escherichia coli reveal the catalytic and chain-length determining mechanisms., Proteins, 2014, 通讯作者(17) Crystallization and preliminary X-ray diffraction analysis of YisP protein from Bacillus subtilis subsp. subtilis strain 168., Acta Crystallogr Sect F Struct Biol Cryst Commun., 2013, 通讯作者(18) A novel alkaliphilic bacillus esterase belongs to the 13(th) bacterial lipolytic enzyme family., PLoS One., 2013, 第 3 作者(19) Crystal structure and substrate-binding mode of a novel pectate lyase from alkaliphilic Bacillus sp. N16-5., Biochem Biophys Res Commun., 2012, 第 1 作者(20) The substrate/product-binding modes of a novel GH120 β-xylosidase (XylC) from Thermoanaerobacterium saccharolyticum JW/SL-YS485., Biochem J., 2012, 通讯作者(21) 植酸酶的性质、应用和三维结构, 2011工业生物技术发展报告, 2011, 第 1 作者(22) Cloning, expression, and characterization of a thermostable glucoamylase from Thermoanaerobacter tengcongensis MB4., Appl Microbiol Biotechnol., 2010, 第 1 作者
科研活动
科研项目
( 1 ) 乙醇发酵途径中关键调节蛋白RSP的X光结构和功能研究, 负责人, 国家任务, 2013-01--2015-12( 2 ) 酶及其底物复合物的结构解析, 参与, 国家任务, 2011-01--2015-08( 3 ) 麻类生物脱胶用酶改造与生物酶法脱胶新工艺, 参与, 国家任务, 2012-11--2015-12( 4 ) 新型饲料用酶制剂的开发与产业化, 参与, 地方任务, 2012-10--2014-09