General

Jing Qu , Ph.D

Principal Investigator

Email: qujing@ioz.ac.cn

Research Areas

Through the comprehensive utilization of human stem cells and primate animal models, combined with novel omics technologies, we aim to reveal the tissue-specific physiological or pathological changes and their corresponding molecular mechanism and biomarkers during the occurrence of aging and its associated diseases, and screen for key genetic or epigenetic regulatory factors and small molecules that may interfere with the aging process.


Education and Research Experience

  • 1998-2002,   B.S., Lanzhou University, Lanzhou, China

  • 2002-2007,   Ph. D., Institute of Biophysics, Chinese Academy of Science, Beijing, China                    

  • 2007-2010,   Postdoc Fellow, Del E. web Neuroscience, aging and stem cell research center, Sanford/Burnham Medical Research Institute                

  • 2010-2012,   Research Associate, Gene expression lab, The Salk Institute for Biological Research                    

  • 2013-2014,  Professor, Institute of Biophysics, CAS. China.                       

  • 2014-present, Professor, State Key Laboratory of Stem Cell and Reproductive Biology, Institute of Zoology, CAS. China.


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Publications

  1. Wang S, Zheng Y, Li J, Yu Y, Zhang W, Song M, Liu Z, Min Z, Hu H, Jing Y, He X, Sun L, Esteban C, Chan P, Qiao J, Zhou Q, Belmonte JC#, Qu J#, Tang F#, Liu GH#. Single-Cell Transcriptomic Atlas of Primate Ovarian Aging. Cell. 2020. 180 (3), 585-600.e19. Cover story. (#Corresponding author)

  2. Ma S, Sun S, Geng L, Song M, Wang W, Ye Y, Ji Q, Zou Z, Wang S, He X, Li W, Rodriguez Esteban C, Long X, Guo G, Chan P, Zhou Q, Belmonte JC#, Zhang W#, Qu J#, Liu GH#. Caloric Restriction Reprograms the Single-Cell Transcriptional Landscape of Rattus Norvegicus Aging. Cell. 2020.180(5),984-1001.e22 (#Corresponding author)

  3. Liang C, Liu Z, Song M, Li W, Wu Z, Wang Z, Wang Q, Wang S, Yan K, Sun L, Hishida T, Cai Y, Izpisua Belmonte JC, Guillen P, Chan P, Zhou Q, Zhang W#, Qu J#, Liu GH#. (2020) Stabilization of Heterochromatin by CLOCK Promotes Stem Cell Rejuvenation and Cartilage Regeneration. Cell Research. 2021,31(2):187-205. (#Corresponding author)

  4. Li J, Zheng Y, Yan P, Song M, Wang S, Sun L, Liu Z, Ma S, Chan P, Zhou Q, Belmonte JC, Zhang W#, Liu GH#, Tang F#, Qu J#. A Single-cell Transcriptomic Atlas of Primate Pancreatic Islet Aging. National Science Review. 2021, 8(2): nwaa127 DOI: 10.1093/nsr/nwaa127 (#Corresponding author)

  5. Zhang W, Zhang S, Yan P, Ren J, Song M, Li J, Lei J, Pan H, Wang S, Ma X, Ma S, Li H, Sun F, Wan H, Li W, Chan P, Zhou Q, Liu GH#, Tang F#, Qu J#. A Single-Cell Transcriptomic landscape of Primate Arterial Aging. Nature Communications. 2020.11(1):2202 (#Corresponding author)

  6. Hu H, Ji Q, Song M, Ren J, Liu Z, Wang Z, Liu X, Yan K, Hu J, Wang S#, Zhang W#, Liu GH#, Qu J#. ZKSCAN3 counteracts cellular senescence by stabilizing heterochromatin. Nucleic Acids Research. 2020. 19;48(11):6001-6018. (#Corresponding author)

  7. Lei J, Wang S, Kang W, Chu Q, Liu Z, Sun L, Ji Y, Esteban CR, Yao Y, Belmonte JCI, Chan P, Liu GH#, Zhang W#, Song M#, Qu J#. FOXO3-Engineered Human Mesenchymal Progenitor Cells Efficiently Promote Cardiac Repair after Myocardial Infarction. Protein Cell. 2021, 12(2): 145-151 (#Corresponding author)

  8. Wang S#, Zheng Y, Li Q, He X, Ren R, Zhang W, Song M, Hu H, Liu F, Sun G, Sun S, Liu Z, Yu Y, Chan P, Zhao GG, Zhou Q, Liu GH#, Tang F# Qu J#. Deciphering primate retinal aging at single-cell resolution. Protein Cell. 2020. DOI: 10.1007/s13238-020-00791-x. (#Corresponding author)

  9. Bi S, Liu Z, Wu Z, Wang Z, Liu X, Wang S, Ren J, Zhang W#, Song M#, Liu GH#, Qu J#. SIRT7 antagonizes human stem cell aging as a heterochromatin stabilizer. Protein Cell. 2020. 11(7):483-504 (#Corresponding author)

  10. Yan P, Liu Z, Song M, Wu Z, Xu W, Li K, Ji Q, Wang S, Liu X, Yan K, Esteban CR, Ci W, Izpisua Belmonte JC, Xie W, Ren J, Zhang W#, Sun Q#, Qu J#, Liu GH#. Genome-wide R-loop landscapes during cell differentiation and reprogramming. Cell Reports. 2020. 32(1):107870(#Corresponding author)

  11. Zheng Y, Liu X, Le W, Xie L, Li H, Wen W, Wang S, Ma S, Huang Z, Ye J, Shi W, Ye Y, Liu Z, Song M, Zhang W, Belmonte JCI, Xiao C, Qu J#, Wang H#, Liu GH#, Su W#. A human circulating immune cell landscape in aging and COVID-19. Protein Cell. 2020. DOI: 10.1007/s13238-020-00762-2(#Corresponding author)

  12. He X, Memczak S, Qu J#, Belmonte JC#, Liu GH#. Single-cell “OMICS” in aging: a young growing field. Nature Metabolism. 2020. 2: 293–302 (#Corresponding author)

  13. Geng L, Liu Z, Wang S, Sun S, Ma S, Liu X, Chan P, Sun L, Song M#, Zhang W#, Liu GH#, Qu J#. Low-dose quercetin positively regulates mouse healthspan. Protein Cell. 2019. 10 (10), 770-775 (#Corresponding author)

  14. Zhang X, Liu Z, Liu X, Wang S, Zhang Y, He X, Sun S, Ma S, Shyh-Chang N, Liu F, Wang Q, Wang X, Liu L, Zhang W#, Song M#, Liu GH#, Qu J#. Telomere-Dependent and Telomere-Independent Roles of RAP1 in Regulating Human Stem Cell Homeostasis. Protein Cell. 2019. 10 (9), 649-667 (#Corresponding author)

  15. Yan P, Li Q, Wang L, Lu P, Suzuki K, Liu Z, Lei J, Li W, Ren R, He X, Wang S, Ding J, Chan P, Zhang W, Song M, Belmonte JC, Qu J#, Tang F#, Liu GH#.  FOXO3-engineered human ESC-derived vascular cells promote vascular protection and regeneration. Cell Stem Cell. 2019. 24(3), 447-461 (cover story) (#Corresponding author)

  16. Deng L, Ren R, Liu Z, Song M, Li J, Wu Z, Ren X, Fu L, Li W, Zhang W, Guillen P, Belmonte J, Chan P, Qu J#, Liu GH#. Stabilizing heterochromatin by DGCR8 alleviates senescence and osteoarthritis. Nature Communications. 2019.10(1):3329. (#Corresponding author)

  17. Fu L, Hu Y, Song M, Liu Z, Zhang W, Yu FX, Wu J, Wang S, Belmonte JC, Chan P, Qu J#, Tang F#, Liu GH#. Upregulation of FOXD1 by YAP alleviates senescence and osteoarthritis. PLoS Biology. 2019. 17(4):e3000201 (#Corresponding author)

  18. Ren X, Hu B, Song M, Ding Z, Dang Y, Liu Z, Zhang W, Ji Q, Ren R, Ding J, Chan P, Jiang C, Ye K, Qu J#, Tang F#, Liu GH#.Maintenance of nucleolar homeostasis by CBX4 alleviates senescence and osteoarthritis. Cell Reports. 2019. 26(13):3643-3656. (#Corresponding author)

  19. Zhang W, Song M, Qu J# Liu GH#. Epigenetic Modifications in Cardiovascular Aging and Diseases. Circulation Research. 2018. 123(7):773-786. (#Corresponding author)

  20. Ren R, Deng L, Xue Y, Suzuki K, Zhang W, Yu Y, Wu J, Sun L, Gong X, Luan H, Yang F, Ju Z, Ren X, Wang S, Tang H, Geng L, Zhang W, Li J, Qiao J, Xu T#, Qu J#, Liu GH#.Visualization of aging-associated chromatin alterations with an engineered TALE system. Cell Research. 2017. 27(4):483-504 (#Corresponding author)