基本信息
张延平  女  硕导  中国科学院微生物研究所
电子邮件: zhangyp@im.ac.cn
通信地址: 北京市朝阳区北辰西路一号院3号中科院微生物研究所F313
邮政编码: 100101

招生信息

   
招生专业
071005-微生物学
招生方向
微生物生理与代谢工程;合成生物技术

教育背景

2000-09--2006-06   清华大学   博士学位
1996-09--2000-06   清华大学   学士学位

工作经历

   
工作简历
2016-10~现在, 中国科学院微生物研究所, 项目研究员
2010-09~2016-09,中国科学院微生物研究所, 副研究员
2006-07~2010-08,中国科学院微生物研究所, 助理研究员
2000-09~2006-06,清华大学, 博士学位
1996-09~2000-06,清华大学, 学士学位
社会兼职
2018-04-01-今,北京微生物学会, 理事

教授课程

代谢工程
合成生物学与生物技术

专利与奖励

   
专利成果
( 1 ) 一种新的α-酮异戊酸脱羧酶在生物合成1,2,4-丁三醇中的应用, 2018, 第 1 作者, 专利号: 201410524271.7
( 2 ) 1,2,4-丁三醇的生物合成方法, 2014, 第 3 作者, 专利号: 201210457975.8
( 3 ) 一种将多个基因同时导入微生物基因组的方法, 2014, 第 1 作者, 专利号: 201210196996.9
( 4 ) 一种酿酒酵母工程菌及其在生产乙醇中的应用, 2013, 第 1 作者, 专利号: 201210180994.0
( 5 ) 蓝藻整合表达载体及其应用, 2014, 第 3 作者, 专利号: 201210480928.5
( 6 ) 一种稳定联产异丙醇和丁醇的工程菌及其构建方法与应用, 2013, 第 3 作者, 专利号: 201110084263.1
( 7 ) 一种联产丁醇、异丙醇及乙醇的重组菌及其应用, 2012, 第 1 作者, 专利号: 201110050004.7
( 8 ) 一种利用蓝藻将CO2生物转化为异丙醇的技术, 2013, 第 3 作者, 专利号: 201110038190.2
( 9 ) 自动调控氧化还原电位的装置及其应用, 2010, 第 1 作者, 专利号: 201010593474.3
( 10 ) 利用木糖生产丁醇的工程菌株及其构建方法和应用, 2019, 第 2 作者, 专利号: 201910299026.3
( 11 ) 一种提高大肠杆菌生产丁醇的方法, 2019, 第 3 作者, 专利号: 201610035150.5
( 12 ) 一种丁酸产量低且丁醇产量高的工程菌及其构建方法与应用, 2019, 第 3 作者, 专利号: 201610034891.1
( 13 ) 一种构建高产丁醇菌株的方法与应用, 2018, 第 4 作者, 专利号: 201510924308.x

出版信息

   
发表论文
(1) Production of fuels and chemicals from renewable resources using engineered Escherichia coli, Biotechnology Advances, 2019, 通讯作者
(2) Discovery of potential genes contributing to the biosynthesis of short-chain fatty acids and lactate in gut microbiota from systematic investigation in E. coli, npj Biofilms and Microbiomes, 2019, 通讯作者
(3) Design and development of a “Y-shaped” microbial consortium capable of simultaneously utilizing biomass sugars for efficient production of butanol, Metabolic Engineering, 2019, 通讯作者
(4) Development of a longevous two-species biophotovoltaics with constrained electron flow, Nature Communications, 2019, 通讯作者
(5) Biological Carbon Fixation: From Natural to Synthetic, Journal of CO2 Utilization, 2018, 通讯作者
(6) Engineering Redox Homeostasis to Develop Efficient Alcohol-Producing Microbial Cell Factories, Microbial Cell Factories, 2017, 通讯作者
(7) Reexamination of the physiological role of PykA in Escherichia coli revealed that it negatively regulates the intracellular ATP levels under anaerobic conditions, Applied and Environmental Microbiology, 2017, 第 4 作者
(8) 新一代糖化酶高产菌株的选育及其工业应用, 微生物学报, 2017, 通讯作者
(9) A systematically chromosomally engineered Escherichia coli efficiently produces butanol, Metabolic Engineering, 2017, 第 7 作者
(10) Synthetic pathway optimization for improved 1,2,4-butanetriol production, Journal of Industrial Microbiology & Biotechnology, 2016, 通讯作者
(11) Elucidating the contribution of multiple aldehyde/alcohol dehydrogenases to butanol and ethanol production in Clostridium acetobutylicum, Scientific reports, 2016, 通讯作者
(12) Engineering Saccharomyces cerevisiae to produce a high ethanol-titer-ethanol from a cellulosic hydrolysate by in situ reducing the ethanol-mediated inhibition on of xylose metabolismin situ, Process Biochemistry, 2016, 通讯作者
(13) Introducing extra NADPH consumption ability significantly increases the photosynthetic efficiency and biomass production of cyanobacteria, Metabolic Engineering, 2016, 第 4 作者
(14) Synthetic pathway optimization for improved 1,2,4-butanetriol production, Journal of Industrial Microbiology & Biotechnology, 2015, 通讯作者
(15) Engineering Escherichia coli cell factories for n-butanol production, Advances in Biochemical Engineering / Biotechlogy, 2015, 通讯作者
(16) Fermentation and genomic analysis of acetone-uncoupled butanol production by Clostridium tetanomorphum, Applied Microbiology and Biotechnology, 2015, 通讯作者
(17) Introducing transglutaminase with its precursor region into Clostridium acetobutylicum improves its tolerance to oxidative stress and solvent production, Process Biochemistry, 2015, 第 3 作者
(18) Production of optically pure d-lactate from CO2 by blocking the PHB and acetate pathways and expressing d-lactate dehydrogenase in cyanobacterium Synechocystis sp. PCC 6803, Process Biochemistry, 2014, 第 4 作者
(19) Design and construction of a non-natural malate to 1,2,4-butanetriol pathway creates possibility to produce 1,2,4-butanetriol from glucose, Scientific Reports, 2014, 通讯作者
(20) Metabolic changes of Klebsiella oxytoca in response to low oxidoreduction potential revealed by comparative proteomic profiling integrated with metabolic flux analysis, Applied and Environmental Microbiology, 2014, 通讯作者
(21) A functional recT gene for recombineering of Clostridium, Journal of Biotechnology, 2014, 通讯作者
(22) Engineering stress tolerance of Escherichia coli by stress-induced mutagenesis (SIM)-based adaptive evolution, Biotechnology Journal, 2014, 第 3 作者
(23) Genome Sequence of Klebsiella oxytoca M5al, a Promising Strain for Nitrogen Fixation and Chemical Production, Genome announcement, 2013, 通讯作者
(24) Engineering the antioxidative properties of lactic acid bacteria for improving its robustness, Current Opinion in Biotechnology, 2013, 第 1 作者
(25) Identification and characterization of two functionally unknown genes involved in butanol tolerance of Clostridium acetobutylicum, PLos One, 2012, 第 2 作者
(26) Introducing a single secondary alcohol dehydrogenase into butanol-tolerant Clostridium acetobutylicum Rh8 switches ABE fermentation to high level IBE fermentation, Biotechnology for Biofuels, 2012, 第 4 作者
(27) Designing and creating a modularized synthetic pathway in cyanobacterium Synechocystis enables production of acetone from carbon dioxide, Metabolic Engineering, 2012, 第 3 作者
(28) Development of an anhydrotetracycline-inducible gene expression system for solvent-producing Clostridium acetobutylicum: A useful tool for strain engineering, Metabolic Engineering, 2012, 第 3 作者
(29) Engineering the robustness of industrial microbes through synthetic biology, Trends in Microbiology, 2012, 第 3 作者
(30) Controlling the oxidoreduction potential of the culture of Clostridium acetobutylicum leads to an earlier initiation of solventogenesis, thus increasing solv ent productivity, Applied Microbiology and Biotechnology, 2012, 通讯作者
(31) Engineering the robustness of Clostridium acetobutylicum by introducing glutathione biosynthetic capability, Metabolic Engineering, 2011, 通讯作者
(32) Group II intron-anchored gene deletion in Clostridium, PLos One, 2011, 第 3 作者
(33) Formic acid triggers the "acid crash" of acetone-butanol-ethanol fermentation of Clostridium acetobutylicum, Applied and Environmental Microbiology, 2011, 第 1 作者
(34) Engineering Clostridium Strain to Accept Unmethylated DNA., PLos One, 2010, 第 3 作者
(35) Proteomic analyses to reveal the protective role of glutathione in stress resistance of Lactococcus lactis., Applied and Environmental Microbiology, 2010, 第 1 作者
(36) The importance of engineering physiological functionality into microbes, Trends in Biotechnology, 2009, 第 1 作者
(37) Introduction of an NADH regeneration system into Klebsiella oxytoca leads to an enhanced oxidative and reductive metabolism of glycerol, Metabolic Engineering, 2009, 第 1 作者

科研活动

   
科研项目
( 1 ) 王宽诚人才奖-卢嘉锡青年人才奖青年创新促进会会员及优秀会员创新交叉团队, 主持, 部委级, 2014-01--2017-12
( 2 ) 工业酵母菌种的基因组全局扰动, 主持, 国家级, 2012-01--2015-12
( 3 ) beta-丙氨酸的生物催化转化工艺, 参与, 部委级, 2016-01--2018-12
( 4 ) 细胞氧化还原水平对黄原胶合成影响研究, 主持, 部委级, 2018-01--2019-12
( 5 ) 青年创新促进会人才项目, 主持, 部委级, 2014-01--2017-12
( 6 ) 广西特色非粮生物质资源化利用技术开发, 参与, 部委级, 2019-01--2020-12