Research Areas

Using cellular systems, pharmacological approaches and animal genetics to study the hormonal and pathophysiological regulations contributing to metabolic diseases such as osteoporosis, fatty liver, diabetes and obesity.


Ph.D. Graduate Student                                Advisor: Prof. Lin Chen                                     

Sep 2006 – July 2009     Guangzhou Institute of Biomedicine and Health, CAS, China

M.S. Graduate Student                           Advisor: Prof. Dongsheng Yao

Sep 2001 - July 2004                                    Jinan University, China                                                                            

B.S., Undergraduate Student 

Sep 1997 - July 2001                           Normal University of South China                                                                   


Principle Investigator

Jan 2013 – Present    Shenzhen Institutes of Advanced Technology, CAS, China

Postdoctoral Fellow                                     Advisor: Prof. Xu Cao

Dec 2011 – Dec 2012       Johns Hopkins University, School of Medicine, MD, USA

Postdoctoral Fellow                                 Advisors: Prof. Nancy E. Lane

Nov 2009- Nov 2011        University of California, Davis Medical Center, CA, USA


  1. Huang T#, Yan G#,Guan M*. Zinc Homeostasis in Bone: Zinc Transporters and Bone Diseases. Int J Mol Sci.2020 Feb 12;21(4). pii: E1236.
  2. Gao A, Liao Q, Xie L, Wang G, Zhang W, Wu Y, Li P,Guan M, Pan H, Tong L, Chu PK, Wang H*.Tuning the surface immunomodulatory functions of polyetheretherketone for enhanced osseointegration. Biomaterials.2020 Feb;230:119642.
  3. Sun M, Hu L, Wang S, Huang T, Zhang M, Yang M, Zhen W, Yang D, Lu W,Guan M*, Peng S*.Circulating MicroRNA-19b Identified From Osteoporotic Vertebral Compression Fracture Patients Increases Bone Formation. J Bone Miner Res.2020 Feb;35(2):306-316.
  4. Chen L, Wu M, Zhang S, Tan W,Guan M, Feng L, Chen C, Tao J, Chen L, Qu L.Estrogen-related receptor γ regulates hepatic triglyceride metabolism through phospholipase A2 G12B. FASEB J.2019 Jul;33(7):7942-7952.
  5. Near-infrared light control of bone regeneration with biodegradable photothermal osteoimplant.Tong L, Liao Q, Zhao Y, Huang H, Gao A, Zhang W, Gao X, Wei W,Guan M, Chu PK, Wang H*. Biomaterials. 2019 Feb;193:1-11.
  6. Xuekun Fu, Yunyan Li, Tongling Huang, Zhiwu Yu, Kun Ma,Meng Yang, Qingli Liu, Haobo Pan, Huaiyu Wang, Junfeng Wang*,Min Guan*.Runx2/Osterix and Zinc Uptake Synergize to Orchestrate Osteogenic Differentiation and Citrate containing-Bone Apatite Formation. Advanced Science. 2018 Jan 28;5(4):1700755.
  7. Pingchao Li, Fengling Feng, Enxiang Pan, Xiaozhen Fan, Qing Yang,Min Guan, Ling Chen⁎, Caijun Sun*.Scavenger receptor-mediated Ad5 entry and acLDL accumulation in monocytes/macrophages synergistically trigger innate responses against viral infection. Virology.2018 Jun;519:86-98. doi: 10.1016/j.virol.2018.04.005.
  8. Tongling Huang, Renzhong Liu, Xuekun Fu,Dongsheng Yao, Yang Lei, Meng Yang, Qingli Liu, William W. Lu,Chuanyue Wu,Min Guan*. Aging reduces an ERRα-directed mitochondrial glutaminase expression suppressing glutamine anaplerosis and osteogenic capacity of mesenchymal stem cells. Stem cells.2017 Feb;35(2):411-424.
  9. Qingli Liu, Meng Yang, Renzhong Liu, Yang Lei, Xuekun Fu, Caijun Sun, Haobo Pan, Chi-Wai Wong,Min Guan*. Activation of farnesoid X receptor promotes triglycerides lowering by inhibiting Phospholipase A2 G12B inhyperlipidemicmice. Molecular and Cellular Endocrinology2016 Nov 15;436:93-101. 
  10. Zhao, Yuetao; Tong, Liping; Li, Yong; Pan, Haobo; Zhang, Wei;Guan, Min; Li, Weihao; Chen, Yixin; Li, Qing; Li, Zhongjun; Wang, Huaiyu*; Yu, Xuefeng*; Chu, Paul*.Lactose-Functionalized Gold Nanorods for Sensitive and Rapid Serological Diagnosis of Cancer. ACSApplied Materials & Interfaces.2016 Mar 9;8(9):5813-20.
  11. Yan Chen, Ting Wang,Min Guan, FKL Leung, Cao Xu, Wang Ting, Weiwei Zhao, Xiaohua Pan, and W W Lu*.Bone turnover and articular cartilage differences localized to subchondral cysts in knees with advanced osteoarthritis. Osteoarthritis and Cartilage.2015 Dec;23(12):2174-83.
  12. Yao W*#,Min Guan#, Jia JJ, Dai WW, Lay YE, Amugongo S, Liu RW, Olivos D, Lam KS, Nolta J, Olvera D, Ritchie RO, Lane NE. Reversing bone loss by directing mesenchymal stem cell to the bone. Stem cells2013 Sep;31(9):2003-2014.# co-first author
  13. Min Guan, Wei Yao*, Ruiwu Liu, Kit S Lam, Jan Nolta, Junjing Jia,Brian Panganiban, Liping Meng, Ping Zhou, Mohammad Shahnazari, Robert O Ritchie & Nancy E Lane. Directing mesenchymal stem cells to bone to augment bone formation and increase bone mass. Nature medicine.2012 Feb 5; 18(3):456-62.
  14. Min Guan#, Linbing Qu#, Wenjuan Tan, Ling Chen*, ChiWai Wong*. Hepatocyte nuclear factor-4 alpha regulates liver triglyceride metabolism in part through secreted phospholipase A2 GXIIB. Hepatology. 2011 Feb; 53(2):458-66.
  15. Zhendong Zhong, Cassandra R. Zylstra-Diegel, Cassie A. Schumacher, Jacob J. Baker, April C. Carpenter, Sujata Rao, Wei Yao,Min Guan, Jill A. Helms, Nancy E. Lane, Richard A. Lang, Bart O. Williams*. Wntless functions in mature osteoblasts to regulate bone mass. Proc Natl Acad Sci USA.2012 Aug 14;109 (33):E2197-204.
  16. Junjing Jia, Wei Yao,Min Guan, Weiwei Dai, Mohammad Shahnazari, Rekha Kar, Lynda Bonewald, Jean X. Jiang and Nancy E. Lane*. Glucocorticoid Dose Determines Osteocyte Cell Fate. FASEB J.2011 Oct;25(10):3366-76.
  17. Wei Yao*, Weiwei Dai, Mohammad Shahnazari, Aaron Pham, Zhiqiang Chen, Haiyan Chen,Min Guan, Nancy E. Lane. Inhibition of the Progesterone Nuclear Receptor during the Bone Linear Growth Phase Increases Peak Bone Mass in Female Mice. PLOS ONE2010;7(5):e11410.

Research Interests

Using cellular systems, pharmacological approaches and animal genetics to study the hormonal and pathophysiological regulations contributing to metabolic diseases such as osteoporosis, fatty liver, diabetes and obesity.



杨萌  博士研究生  071010-生物化学与分子生物学  


黄童龄  博士研究生  071010-生物化学与分子生物学  

钟丽红  硕士研究生  071010-生物化学与分子生物学  

Honors & Distinctions

             2011   The American Society of Bone and Mineral Research (ASBMR) Travel Award

2011   Alice L. Jee Memorial Young Investigator Award

2011   ASBMR Young Investigator Award

2011   UC Davis Medical Center Postdoctoral Scholar Award

2014   Overseas High-Caliber Personnel (Level B) in Shenzhen.

2015   Youth Innovation Promotion Association, Chinese Academy of Sciences

2017   Youth innovation talent of Guangdong Special Support Program