化学生物学
细胞生物学
药物筛选

   

070303-有机化学
071009-细胞生物学

   

[1] 谭立, 李盈, 周少青. 一类基于有机砷的II型丙酮酸激酶抑制剂及其制备方法和用途. CN: CN113801163A, 2021-12-17.
[2] 谭立, 李盈, 周少青, 庄光磊. 一类基于有机胂的CDK抑制剂及其制备方法和用途. CN: CN112574255A, 2021-03-30.
[3] 马大为, 季玉华, 何卫明, 方超, 赵金龙, 王开亮, 夏尚华, 李征, 李盈. 一类细胞坏死抑制剂及其制备方法和用途. CN: CN112543755A, 2021-03-23.
[4] 马大为, 季玉华, 何卫明, 方超, 赵金龙, 王开亮. 一类细胞坏死抑制剂及其制备方法和用途. CN: CN112543755A, 2021-03-23.
[5] 谭立, 李盈, 秦嬴, 李德康. 一类细胞程序性坏死抑制剂及其制备方法和用途. CN: CN111978311A, 2020-11-24.

   

[1] Wang, Jingyao, Zhou, Shaoqing, Cheng, Yan, Cheng, Lin, Qin, Ying, Zhang, Zhenfeng, Bi, Aiwei, Xiang, Huaijiang, He, Xinheng, Tian, Xiaoxu, Liu, Wenbin, Zhang, Jian, Peng, Chao, Zhu, Zhengjiang, Huang, Min, Li, Ying, Zhuang, Guanglei, Tan, Li. Selective Covalent Targeting of Pyruvate Kinase M2 Using Arsenous Warheads. JOURNAL OF MEDICINAL CHEMISTRY. 2023, http://dx.doi.org/10.1021/acs.jmedchem.2c01563.
[2] Lin, Lifeng, Shi, Kaixuan, Zhou, Shaoqing, MeiChun Cai, Zhang, Caiyan, Sun, Yunheng, Zang, Jingyu, Cheng, Lin, Ye, Kaiyan, Ma, Pengfei, Shen, Peiye, Zhang, Meiying, Cheng, Yan, Qi, Chunting, Li, Ying, Yin, Xia, Zheng, Yiyan, Tan, Li, Zhuang, Guanglei, Zang, Rongyu. SOX17 and PAX8 constitute an actionable lineage-survival transcriptional complex in ovarian cancer. ONCOGENE[J]. 2022, 41(12): 1767-1779, http://dx.doi.org/10.1038/s41388-022-02210-3.
[3] Guowei Wu, Dekang Li, Wei Liang, Weimin Sun, Xingxing Xie, Yilun Tong, Bing Shan, Mengmeng Zhang, Xiaojuan Lu, Junying Yuan, Ying Li. PP6 negatively modulates LUBAC-mediated M1-ubiquitination of RIPK1 and c-FLIPL to promote TNFα-mediated cell death. CELL DEATH AND DISEASE[J]. 2022, 13(9): 1-14, https://doaj.org/article/b0e40f33ed404a358026112134298f31.
[4] Zhuang, Guanglei, Chen, Gang, Tan, Li, Tan, Lingli, Shan, Hengyue, Han, Chao, Zhang, Zhenfeng, Shen, Jiali, Zhang, Xiao, Xiang, Huaijiang, Lu, Kuankuan, Qi, Chunting, Li, Ying. Discovery of Potent OTUB1/USP8 Dual Inhibitors Targeting Proteostasis in Non-Small-Cell Lung Cancer. JOURNAL OF MEDICINAL CHEMISTRY[J]. 2022, 65(20): 13645-13659, http://dx.doi.org/10.1021/acs.jmedchem.2c00408.
[5] Cheng, Lin, Zhou, Shichao, Zhou, Shaoqing, Shi, Kaixuan, Cheng, Yan, Cai, MeiChun, Ye, Kaiyan, Lin, Lifeng, Zhang, Zhenfeng, Jia, Chenqiang, Xiang, Huaijiang, Zang, Jingyu, Zhang, Meiying, Yin, Xia, Li, Ying, Di, Wen, Zhuang, Guanglei, Tan, Li. Dual Inhibition of CDK12/CDK13 Targets Both Tumor and Immune Cells in Ovarian Cancer. CANCER RESEARCH[J]. 2022, 82(19): 3588-3602, http://dx.doi.org/10.1158/0008-5472.CAN-22-0222.
[6] Kangyun Dong, Ran Wei, Taijie Jin, Mengmeng Zhang, Jiali Shen, Huaijiang Xiang, Bing Shan, Junying Yuan, Ying Li. HOIP modulates the stability of GPx4 by linear ubiquitination. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2022, 119(44): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9636971/.
[7] Mei, Xinyu, Guo, Yuan, Xie, Zhangdan, Zhong, Yedan, Wu, Xiaofen, Xu, Daichao, Li, Ying, Liu, Nan, Zhu, ZhengJiang. RIPK1 regulates starvation resistance by modulating aspartate catabolism. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-26423-4.
[8] Meng, Huyan, Wu, Guowei, Zhao, Xinsuo, Wang, Anhui, Li, Dekang, Tong, Yilun, Jin, Taijie, Cao, Ye, Shan, Bing, Hu, Shichen, Li, Ying, Pan, Lifeng, Tian, Xiaoxu, Wu, Ping, Peng, Chao, Yuan, Junying, Li, Guohui, Tan, Li, Wang, Zhaoyin, Li, Ying. Discovery of a cooperative mode of inhibiting RIPK1 kinase. CELL DISCOVERY[J]. 2021, 7(1): [9] Shan, Hengyue, Liu, Jianping, Shen, Jiali, Dai, Jialin, Xu, Gang, Lu, Kuankuan, Han, Chao, Wang, Yaru, Xu, Xiaolong, Tong, Yilun, Xiang, Huaijiang, Ai, Zhiyuan, Zhuang, Guanglei, Hu, Junhao, Zhang, Zheng, Li, Ying, Pan, Lifeng, Tan, Li. Development of potent and selective inhibitors targeting the papain-like protease of SARS-CoV-2. CELL CHEMICAL BIOLOGY[J]. 2021, 28(6): 855-+, http://dx.doi.org/10.1016/j.chembiol.2021.04.020.
[10] Huibing Wang, Weiwei Qi, Chengyu Zou, Zhangdan Xie, Mengmeng Zhang, Masanori Gomi Naito, Lauren Mifflin, Zhen Liu, Ayaz Najafov, Heling Pan, Bing Shan, Ying Li, ZhengJiang Zhu, Junying Yuan. NEK1-mediated retromer trafficking promotes blood-brain barrier integrity by regulating glucose metabolism and RIPK1 activation. NATURE COMMUNICATIONS[J]. 2021, 12(1): http://dx.doi.org/10.1038/s41467-021-25157-7.
[11] Xu, Gang, Li, Ying, Zhang, Shengyuan, Peng, Haoran, Wang, Yunyun, Li, Dekang, Jin, Taijie, He, Zhuohao, Tong, Yilun, Qi, Chunting, Wu, Guowei, Dong, Kangyun, Gou, Jizhou, Liu, Yang, Xiao, Tongyang, Qu, Jing, Li, Liang, Liu, Liang, Zhao, Ping, Zhang, Zheng, Yuan, Junying. SARS-CoV-2 promotes RIPK1 activation to facilitate viral propagation. CELL RESEARCH[J]. 2021, 31(12): 1230-1243, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=7107624&detailType=1.
[12] Liu, Zhenying, Zhang, Shengnan, Gu, Jinge, Tong, Yilun, Li, Yichen, Gui, Xinrui, Long, Houfang, Wang, Chuchu, Zhao, Chunyu, Lu, Jinxia, He, Lin, Li, Ying, Liu, Zhijun, Li, Dan, Liu, Cong. Hsp27 chaperones FUS phase separation under the modulation of stress-induced phosphorylation. NATURE STRUCTURAL & MOLECULAR BIOLOGY[J]. 2020, 27(4): 363-+, http://dx.doi.org/10.1038/s41594-020-0399-3.
[13] Najafov, Ayaz, Mookhtiar, Adnan K, Luu, Hoang Son, Ordureau, Alban, Pan, Heling, Amin, Palak P, Li, Ying, Lu, Qingxian, Yuan, Junying. TAM Kinases Promote Necroptosis by Regulating Oligomerization of MLKL. MOLECULAR CELL[J]. 2019, 75(3): 457-+, http://dx.doi.org/10.1016/j.molcel.2019.05.022.
[14] Huang, HaiTsang, Dobrovolsky, Dennis, Paulk, Joshiawa, Yang, Guang, Weisberg, Ellen L, Doctor, Zainab M, Buckley, Dennis L, Cho, JoongHeui, Ko, Eunhwa, Jang, Jaebong, Shi, Kun, Choi, Hwan Geun, Griffin, James D, Li, Ying, Treon, Steven P, Fischer, Eric S, Bradner, James E, Tan, Li, Gray, Nathanael S. A Chemoproteomic Approach to Query the Degradable Kinome Using a Multi-kinase Degrader. CELL CHEMICAL BIOLOGY[J]. 2018, 25(1): 88-+, http://dx.doi.org/10.1016/j.chembiol.2017.10.005.
[15] Xu, Daichao, Jin, Taijie, Zhu, Hong, Chen, Hongbo, Ofengeim, Dimitry, Zou, Chengyu, Mifflin, Lauren, Pan, Lifeng, Amin, Palak, Li, Wanjin, Shan, Bing, Naito, Masanori Gomi, Meng, Huyan, Li, Ying, Pan, Heling, Aron, Liviu, Adiconis, Xian, Levin, Joshua Z, Yankner, Bruce A, Yuan, Junying. TBK1 Suppresses RIPK1-Driven Apoptosis and Inflammation during Development and in Aging. CELL[J]. 2018, 174(6): 1477-+, http://dx.doi.org/10.1016/j.cell.2018.07.041.
[16] Meng, Huyan, Liu, Zhen, Li, Xingyan, Wang, Huibing, Jin, Taijie, Wu, Guowei, Shan, Bing, Christofferson, Dana E, Qi, Chunting, Yu, Qiang, Li, Ying, Yuan, Junying. Death-domain dimerization-mediated activation of RIPK1 controls necroptosis and RIPK1-dependent apoptosis. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA[J]. 2018, 115(9): E2001-E2009, https://www.webofscience.com/wos/woscc/full-record/WOS:000426152500013.
[17] Wang, Huibing, Meng, Huyan, Li, Xingyan, Zhu, Kezhou, Dong, Kangyun, Mookhtiar, Adnan K, Wei, Huiting, Li, Ying, Sun, ShaoCong, Yuan, Junying. PELI1 functions as a dual modulator of necroptosis and apoptosis by regulating ubiquitination of RIPK1 and mRNA levels of c-FLIP. PROCEEDINGSOFTHENATIONALACADEMYOFSCIENCESOFTHEUNITEDSTATESOFAMERICA[J]. 2017, 114(45): 11944-11949, [18] Li, Ying, Yuan, Junying. Systematic Metrics Depicting Cell Death Kinetics. CELL CHEMICAL BIOLOGYnull. 2017, 24(7): 785-786, http://dx.doi.org/10.1016/j.chembiol.2017.07.006.
[19] Li, Ying, Qian, Lihui, Yuan, Junying. Small molecule probes for cellular death machines. CURRENT OPINION IN CHEMICAL BIOLOGYnull. 2017, 39: 74-82, http://dx.doi.org/10.1016/j.cbpa.2017.05.007.
[20] Ito, Yasushi, Ofengeim, Dimitry, Najafov, Ayaz, Das, Sudeshna, Saberi, Shahram, Li, Ying, Hitomi, Junichi, Zhu, Hong, Chen, Hongbo, Mayo, Lior, Geng, Jiefei, Amin, Palak, DeWitt, Judy Park, Mookhtiar, Adnan Kasim, Florez, Marcus, Ouchida, Amanda Tomie, Fan, Jianbing, Pasparakis, Manolis, Kelliher, Michelle A, Ravits, John, Yuan, Junying. RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS. SCIENCE[J]. 2016, 353(6299): 603-608, https://www.webofscience.com/wos/woscc/full-record/WOS:000381560900045.
[21] Xu, Daichao, Zhang, Tao, Xiao, Juan, Zhu, Kezhou, Wei, Ran, Wu, Zheming, Meng, Huyan, Li, Ying, Yuan, Junying. Modification of BECN1 by ISG15 plays a crucial role in autophagy regulation by type I IFN/interferon. AUTOPHAGY[J]. 2015, 11(4): 617-628, https://www.webofscience.com/wos/woscc/full-record/WOS:000354185500005.
[22] Christofferson, Dana E, Li, Ying, Yuan, Junying, Julius, D. Control of Life-or-Death Decisions by RIP1 Kinase. ANNUAL REVIEW OF PHYSIOLOGY, VOL 76null. 2014, 76: 129-150, https://www.webofscience.com/wos/woscc/full-record/WOS:000336055000008.
[23] Ying Li. Necrostatin-1: Its Discovery and Application in Cell Death Research. Necrotic Cell Death. 2014, [24] Wu Zhijie, Li Ying, Cai Yu, Yuan Junying, Yuan Chengye. A novel necroptosis inhibitor-necrostatin-21 and its SAR study. BIOORG. MED. CHEM. LETT.[J]. 2013, 23(17): 4903-4906, http://dx.doi.org/10.1016/j.bmcl.2013.06.073.
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