电子邮件： wywang@sioc.ac.cn
通信地址： 上海市浦东新区海科路100号13号楼
邮政编码：
研究领域
利用诱导性干细胞, 类脑，脑芯片和Crispr/Cas9基因编辑等技术进行疾病机理和治疗方面的研究和开发。目前实验室具体的研究方向为：
1: 利用来自于患者的诱导性多能干细胞/胚胎干细胞（iPSCs/ESC),类脑，肿瘤类器官，脑芯片技术，结合小鼠疾病模型研究神经系统疾病的分子细胞机理并寻找可行的治疗靶标。
2: 遗传性疾病的个体化干细胞/基因治疗的研究和探索；结合基因编辑和干细胞技术发展基于干细胞的药物筛选和药效评价体系。
3:二代测序和大数据深度分析以挖掘不同疾病在分子细胞水平的共通机理，或者同一疾病在分子细胞水平的异质性：聚焦于神经退行性疾病和脑胶质瘤干细胞。
4: 神经系统基因组稳定性在脑衰老，高级功能及其脑疾病中的变化及其贡献。
教育背景
工作经历
工作简历
社会兼职
2017-04-01-今,复旦大学附属华山医院双聘教授,
教授课程
出版信息
1. Jie Liu, Jing Gao, Yufang Yang, Lin Guo, Guoming Ma, Mingfeng Guan, Congcong Xia, Jia He, Yi Wu, Jun Xu, Gang Pei, Jian Zhao, Jianchen He, Yaoyang Zhang, Wenyuan Wang*. Astrocyte-specific secretome profiling reveals its correlation with neurological disorders （under review).
2. Kejing Zhang, Ailian Wang, Keke Zhong, Shuyuan Qi, Chen Wei, Xiaoqiu Shu, Wen-Yo Tu, Wentao Xu, Yatao Xiao, Aizhong Chen, Lei Bai, Jianmin Zhang, Naihe Jing, Wenyuan Wang*, Chengyong Shen*. UBQLN2-HSP70 axis reduces poly-Gly-Ala aggregates and alleviates behavioral defects in the C9orf72 disease model. (Neuron).
3. Min-Min Lou, Xiao-Qiang Tang, Guang-Ming Wang, Jia He, Fang Luo, Ming-Feng Guan, Fei Wang, Huan Zou, Jun-Ying Wang, Qun Zhang, Ming-Jian Xu, Qi-Li Shi, Li-Bing Shen, Guo-Ming Ma, Yi Wu, Yao-Yang Zhang, Ai-bin Liang, Ting-Hua Wang, Liu-Lin Xiong, Jian Wang*, Jun Xu*, Wenyuan Wang*. Long noncoding RNA BS-DRL1 modulates DNA damage response and genome stability in central nervous system by interacting with HMGB1. Nature Communication
4. Luo F, Luo SS, Qian WJ, Zhang L, Chen C，Wang GL, Xu MM, Wang ZF, Wang J, Wang WY*. Developmental Deficits and Early Signs of Neurodegeneration Revealed by PD Patients Derived Dopamine Neurons. Stem Cell Research. 2020
5. Zhang Q, Wu JF, Shi QL, Li MY, Wang CJ, Wang X, Wang WY*, Wu Y*. The neuronal activation of deep cerebellar nuclei Is essential for environmental enrichment-Induced post-stroke motor recovery. Aging & Disease. 2019
6. Shen L, Shi QL，Wang WY* . Double agents: genes with both oncogenic and tumor-suppressor functions. Oncogenesis. 2018
7. Li D, Jones EM, Sawaya MR, Furukawa H, Luo F, Ivanova M, Sievers SA, Wang W, Yaghi OM, Liu C, Eisenberg DS. Structure-based design of functional amyloid materials. Journal of the American Chemical Society. 2014..
8. Qiu HY, Lee SB, Shang YL, Wang WY, Au KF, Kamiya S, Barmada SJ, Finkbeiner S, Liu H, Carlton, C, Tang A, Oldham M, Wang H, Shorter J, Tourtellotte W, Chen B, Tsai LH, Huang EJ. Familial ALS Mutation FUS-R521C Causes Profound Dendritic and Synaptic Phenotype Due to DNA Damage Repair and RNA Splicing Defects. The Journal of Clinical investigation. 2014
9. Wang WY, Pan L, Qiu HY, Lee S, Su S, Quinn E, Sasaki M, Jimenez J, Brown R Jr, Hayward LJ, Huang EJ, Tsai LH. Interaction of FUS and HDAC1 regulations DNA damage response and repair in neurons. Nature Neuroscience, 2013
10. Wang WY, Kwon E, Tsai LH. microRNAs in Learning, Memory and neurological disorders. Learning and Memory, 2012,19: 259-368.
11. Graff J, Guan JS, Rei D, Wang WY, Hennig K, Nieland TJF, Fass DM, Kao PF, Tsai LH. An epigenetic blockade of cognitive functions in the neurodegenerative brain. Nature 483, 2012.
12. Kwon E, Wang WY & Li-Huei Tsai. Validation of schizophrenia associated genes CSMD1, C10orf26, CACNA1C, and TCF4 as miR-137 targets. Molecular Psychiatry, 2011, doi: 10.1038/mp.2011.170
13. Shen B, Xiang Z., Miller B., Louie G., Wang WY, Noel J.P., Gage FG. and Wang L. Genetically Encoding Unnatural Amino Acids in Neural Stem Cells and Optically Reporting Voltage-sensitive Domain Changes in Differentiated Neurons. Stem Cells, 2011, 29: 1231-1240
14. Gao J*, Wang WY*, Mao YW, Gräff J, Guan JS, Pan L, Mak G, Kim D, Su SC, Tsai LH. A novel pathway regulates memory and plasticity via SIRT1 and miR-134. Nature. 2010, 466:1105-1109. (* Equal Contribution. Highlighted by Nature Neuroscience Review; Selected as EDITORS’ Choice of Science; recommended by F1000.)
15. Wang WY, Takimoto JK, Louie DV, Baiga TJ, Noel JP, Lee KF, Slesinger PA, Wang L. Genetically encoding unnatural amino acids for cellular and neuronal studies. Nature Neuroscience. 2007, 10: 1063-1072. (Reported by Economist as a Science &Technology breakthrough)
16. Parrish AR, Wang WY, Wang L. Manipulating proteins for neuroscience. Current Opinion in Neurobiology. 2006, 16: 585-592.
17. Liu X, Ying G, Wang WY, Dong J, Wang Y, Ni Z and Zhou CF. Entorhinal deafferentation induces upregulation of SPARC in the mouse hippocampus. 2005, Molecular Brain Research. 141: 58-65.
18. Dong JH, Ying GX, Liu X, Wang WY, Wang Y, Ni ZM, Zhou CF. Expression of thymosin beta4 mRNA by activated microglia in the denervated hippocampus. Neuroreport, 2005, 16: 1629-1633.
19. Wang WY, J. H. Dong, X. Liu, Y. Wang, G. X. Ying and C. F. Zhou. Vascular endothelial Growth factor and its receptor Flk-1 are expressed in the hippocampus following entorhinal deafferentation. Neuroscience. 2005.134: 1167-1178.
20. Dong JH, Ying GX, Liu X, Wang WY, Wang Y, Ni ZM, Zhou CF. Lesion-induced gelsolin upregulation in the hippocampus following entorhinal deafferentation. Hippocampus. 2005, 16: 91-100.
21. Wang Y, Ying GX，Liu X, Wang WY, Dong JH, Zhou CF. Induction of ephrin-B1 and EphB receptors during denervation-induced plasticity in the adult mouse hippocampus. Europe Journal of Neuroscience. 2005, 21: 2336-46.
22. Ying GX, Liu X, Wang WY, Wang Y, Dong J, Jin H, Huang C, Zhou CF. Regulated transcripts in the hippocampus following transections of the entorhinal afferents. Biochemical and Biophysical Research Communications. 2004. 322: 210-216.