基本信息
秦洪强  男  博导  中国科学院大连化学物理研究所
电子邮件: qinhq@dicp.ac.cn
通信地址: 大连市中山路457号化物所1809组
邮政编码: 116023

研究领域

蛋白质翻译后修饰方法研究

蛋白质糖基化及其在转化医学中的应用
新型蛋白质结构活性探针反应研究

蛋白质氧化与疾病关联性研究

招生信息

有机化学、应用化学、化学生物学背景


招生专业
070302-分析化学
招生方向
蛋白质糖基化,蛋白-蛋白相互作用及蛋白质分泌组学,化学生物学

教育背景

2007-09--2013-07   中国科学院大连化学物理研究所   理学博士
2003-09--2007-07   天津大学   理学学士

工作经历

2013.07-2018.06  中国科学院大连化学物理研究所   副研究员 

2018.07---             中国科学院大连化学物理研究所   研究员 

专利与奖励

出版信息

   
发表论文
[1] Ji, Yanli, Sun, Lin, Chen, Yao, Qin, Hongqiang, Xuan, Weimin. Sirtuin-Derived Covalent Binder for the Selective Recognition of Protein Crotonylation. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, 61(31): http://dx.doi.org/10.1002/anie.202205522.
[2] Chen, Yao, Tang, Feng, Qin, Hongqiang, Yue, Xuyang, Nie, Yongzhan, Huang, Wei, Ye, Mingliang. Endo-M Mediated Chemoenzymatic Approach Enables Reversible Glycopeptide Labeling for O-GlcNAcylation Analysis. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2022, http://dx.doi.org/10.1002/anie.202117849.
[3] Zhang, Jinrui, Zhang, Ge, Zhang, Wenjing, Bai, Lu, Wang, Luning, Li, Tiantian, Yan, Li, Xu, Yang, Chen, Dan, Gao, Wenting, Gao, Chuanzhou, Chen, Chaoqun, Ren, Menglin, Jiao, Yuexia, Qin, Hongqiang, Sun, Yu, Zhi, Lili, Qi, Yangfan, Zhao, Jinyao, Liu, Quentin, Liu, Han, Wang, Yang. Loss of RBMS1 promotes anti-tumor immunity through enabling PD-L1 checkpoint blockade in triple-negative breast cancer. CELL DEATH AND DIFFERENTIATION. 2022, http://dx.doi.org/10.1038/s41418-022-01012-0.
[4] Liu, Luyao, Zhu, Bin, Fang, Zheng, Zhang, Na, Qin, Hongqiang, Guo, Zhimou, Liang, Xinmiao, Yao, Zhenzhen, Ye, Mingliang. Automated Intact Glycopeptide Enrichment Method Facilitating Highly Reproducible Analysis of Serum Site-Specific N-Glycoproteome. ANALYTICAL CHEMISTRY[J]. 2021, 93(20): 7473-7480, http://dx.doi.org/10.1021/acs.analchem.1c00645.
[5] 刘璐瑶, 秦洪强, 叶明亮. 完整糖基化肽段的富集与质谱解析新技术研究进展. 色谱[J]. 2021, 39(10): 1045-1054, http://lib.cqvip.com/Qikan/Article/Detail?id=7105506360.
[6] Yue, Xuyang, Qin, Hongqiang, Chen, Yao, Fang, Zheng, Liu, Luyao, Zhu, He, Liu, Xiaoyan, Zhou, Jiahua, Tian, Kailu, Qiao, Xiaoqiang, Ye, Mingliang. Highly Efficient Enrichment of O-GalNAc Glycopeptides by Using Immobilized Metal Ion Affinity Chromatography. ANALYTICAL CHEMISTRY[J]. 2021, 93(21): 7579-7587, http://dx.doi.org/10.1021/acs.analchem.0c05236.
[7] 毛家维, 王科云, 刘璐瑶, 秦洪强, 叶明亮. 提高开放性检索鉴定灵敏度的互补离子谱图策略. 质谱学报[J]. 2020, 41(1): 11-18, https://kns.cnki.net/KCMS/detail/detail.aspx?dbcode=CJFQ&dbname=CJFDLAST2020&filename=ZPXB202001002&v=MTY4MTJybzlGWm9SOGVYMUx1eFlTN0RoMVQzcVRyV00xRnJDVVI3cWVaK1J2RmluZ1ZyeklQejNUYkxHNEhOSE0=.
[8] Li, Minmin, Xiong, Yuting, Lu, Wenqi, Wang, Xue, Liu, Yunhai, Na, Bing, Qin, Haijuan, Tang, Mingliang, Qin, Hongqiang, Ye, Mingliang, Liang, Xinmiao, Qing, Guangyan. Functional Nanochannels for Sensing Tyrosine Phosphorylation. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY[J]. 2020, 142(38): 16324-16333, https://www.webofscience.com/wos/woscc/full-record/WOS:000575684100026.
[9] Zhang, Na, An, Jun, Qin, Hongqiang, Wang, Yan, Fang, Zheng, Ji, Yinqun, Ye, Mingliang. A Mass-Spectrometry-Based Antibody-Free Approach Enables the Quantification of D-Dimer in Plasma. JOURNAL OF PROTEOME RESEARCH[J]. 2020, 19(8): 3143-3152, https://www.webofscience.com/wos/woscc/full-record/WOS:000562081000022.
[10] 周家华, 秦洪强, 叶明亮. 羰基化蛋白质组学分析进展. 分析测试学报[J]. 2020, 39(1): 82-88, http://lib.cqvip.com/Qikan/Article/Detail?id=7101155751.
[11] Wang, Shuyue, Qin, Hongqiang, Mao, Jiawei, Fang, Zheng, Chen, Yao, Zhang, Xiaolei, Hu, Lianghai, Ye, Mingliang. Profiling of Endogenously Intact N-Linked and O-Linked Glycopeptides from Human Serum Using an Integrated Platform. JOURNAL OF PROTEOME RESEARCH[J]. 2020, 19(4): 1423-1434, https://www.webofscience.com/wos/woscc/full-record/WOS:000526337800007.
[12] Jia, Xiaochen, Qin, Hongqiang, Bose, Santosh Kumar, Liu, Tongmei, He, Jinxia, Xie, Shangqiang, Ye, Mingliang, Yin, Heng. Proteomics analysis reveals the defense priming effect of chitosan oligosaccharides in Arabidopsis-Pst DC3000 interaction. PLANT PHYSIOLOGY AND BIOCHEMISTRY[J]. 2020, 149: 301-312, http://dx.doi.org/10.1016/j.plaphy.2020.01.037.
[13] Wang, Shuyue, Qin, Hongqiang, Dong, Jing, Hu, Lianghai, Ye, Mingliang. Multi-histidine functionalized material for the specific enrichment of sialylated glycopeptides. JOURNAL OF CHROMATOGRAPHY A[J]. 2020, 1627: http://dx.doi.org/10.1016/j.chroma.2020.461422.
[14] Sheng, Qianying, Wang, Cunli, Li, Xiaopei, Qin, Hongqiang, Ye, Mingliang, Xiong, Yuting, Wang, Xue, Li, Xiuling, Lan, Minbo, Li, Junyan, Ke, Yanxiong, Qing, Guangyan, Liang, Xinmiao. Highly Efficient Separation of Methylated Peptides Utilizing Selective Complexation between Lysine and 18-Crown-6. ANALYTICAL CHEMISTRY[J]. 2020, 92(23): 15663-15670, https://www.webofscience.com/wos/woscc/full-record/WOS:000596727600052.
[15] Li, Yanan, Qin, Hongqiang, Ye, Mingliang. An overview on enrichment methods for cell surface proteome profiling. JOURNAL OF SEPARATION SCIENCEnull. 2020, 43(1): 292-312, https://www.webofscience.com/wos/woscc/full-record/WOS:000488151300001.
[16] Qin, Hongqiang, Dong, Xuefang, Mao, Jiawei, Chen, Yao, Dong, Mingming, Wang, Liming, Guo, Zhimou, Liang, Xinmiao, Ye, Mingliang. Highly Efficient Analysis of Glycoprotein Sialylation in Human Serum by Simultaneous Quantification of Glycosites and Site-Specific Glycoforms. JOURNAL OF PROTEOME RESEARCH[J]. 2019, 18(9): 3439-3446, [17] Mao, Jiawei, You, Xin, Qin, Hongqiang, Wang, Chenye, Wang, Liming, Ye, Mingliang. A New Searching Strategy for the Identification of O-Linked Glycopeptides. ANALYTICAL CHEMISTRY[J]. 2019, 91(6): 3852-3859, http://cas-ir.dicp.ac.cn/handle/321008/165732.
[18] Hongqiang Qin. Proteomics Analysis of Site-specific Glycoforms by a Virtual Multistage Mass Spectrometry Metho. Analytica Chimica Acta. 2019, [19] Qin, Hongqiang, Chen, Yao, Mao, Jiawei, Cheng, Kai, Sun, Deguang, Dong, Mingming, Wang, Lu, Wang, Liming, Ye, Mingliang. Proteomics analysis of site-specific glycoforms by a virtual multistage mass spectrometry method. ANALYTICA CHIMICA ACTA[J]. 2019, 1070: 60-68, http://cas-ir.dicp.ac.cn/handle/321008/171875.
[20] You, Xin, Qin, Hongqiang, Ye, Mingliang. Recent advances in methods for the analysis of protein o-glycosylation at proteome level. JOURNAL OF SEPARATION SCIENCE[J]. 2018, 41(1): 248-261, http://cas-ir.dicp.ac.cn/handle/321008/168498.
[21] Tian, Yu, Han, Zhao, Ma, Kexin, Qin, Hongqiang, Zhang, Rixin, Sun, Deguang, Wang, Haibo, Dong, Chengyong, Dong, Bing, Wang, Liming, Ye, Mingliang, Liang, Rui. LCN1 is highly expressed in cholangiocarcinoma patients and indicates poor prognosis. INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE[J]. 2018, 11(10): 10917-10922, http://www.corc.org.cn/handle/1471x/2373132.
[22] You, Xin, Qin, Hongqiang, Mao, Jiawei, Tian, Yu, Dong, Mingming, Guo, Zhimou, Liang, Xinmiao, Wang, Liming, Jin, Yan, Ye, Mingliang. Highly Efficient Identification of O-GalNAc Glycosylation by an Acid-Assisted Glycoform Simplification Approach. PROTEOMICS[J]. 2018, 18(17): https://www.webofscience.com/wos/woscc/full-record/WOS:000443407000005.
[23] You, Xin, Yao, Yating, Mao, Jiawei, Qin, Hongqiang, Liang, Xinmiao, Wang, Liming, Ye, Mingliang. Chemoenzymatic Approach for the Proteomics Analysis of Mucin-Type Core-1 O-Glycosylation in Human Serum. ANALYTICAL CHEMISTRY[J]. 2018, 90(21): 12714-12722, http://cas-ir.dicp.ac.cn/handle/321008/166628.
[24] Wu, Sijin, Zhang, Keren, Qin, Hongqiang, Niu, Mingshan, Zhao, Weijie, Ye, Mingliang, Zou, Hanfa, Yang, Yongliang. Caffeic acid phenethyl ester (CAPE) revisited: Covalent modulation of XPO1/CRM1 activities and implication for its mechanism of action. CHEMICAL BIOLOGY & DRUG DESIGN[J]. 2017, 89(5): 655-662, https://www.webofscience.com/wos/woscc/full-record/WOS:000399734600001.
[25] Dong, Xuefang, Qin, Hongqiang, Mao, Jiawei, Yu, Dongping, Li, Xiuling, Shen, Aijin, Yan, Jingyu, Yu, Long, Guo, Zhimou, Ye, Mingliang, Zou, Hanfa, Liang, Xinmiao. In-Depth Analysis of Glycoprotein Sialylation in Serum Using a Dual-Functional Material with Superior Hydrophilicity and Switchable Surface Charge. ANALYTICAL CHEMISTRY[J]. 2017, 89(7): 3966-3972, http://cas-ir.dicp.ac.cn/handle/321008/169302.
[26] Dong, Mingming, Bian, Yangyang, Wang, Yan, Dong, Jing, Yao, Yating, Deng, Zhenzhen, Qin, Hongqiang, Zou, Hanfa, Ye, Mingliang. Sensitive, Robust, and Cost-Effective Approach for Tyrosine Phosphoproteome Analysis. ANALYTICAL CHEMISTRY[J]. 2017, 89(17): 9307-9314, http://cas-ir.dicp.ac.cn/handle/321008/149957.
[27] Cong, Yuting, Hu, Lianghai, Zhang, Zhang, Gao, Yin, Dong, Mingming, Qin, Hongqiang, Ye, Mingliang, Gu, Jingkai, Zou, Hanfa. Analysis of therapeutic monoclonal antibody glycoforms by mass spectrometry for pharmacokinetics study. TALANTA[J]. 2017, 165: 664-670, http://cas-ir.dicp.ac.cn/handle/321008/169566.
[28] Qin, Hongqiang, Cheng, Kai, Zhu, Jun, Mao, Jiawei, Wang, Fangjun, Dong, Mingming, Chen, Rui, Guo, Zhimou, Liang, Xinmiao, Ye, Mingliang, Zou, Hanfa. Proteomics Analysis of O-GaINAc Glycosylation in Human Serum by an Integrated Strategy. ANALYTICAL CHEMISTRY[J]. 2017, 89(3): 1469-1476, http://cas-ir.dicp.ac.cn/handle/321008/169606.
[29] Wu, Jian, Qin, Hongqiang, Li, Ting, Cheng, Kai, Dong, Jiaqiang, Tian, Miaomiao, Chai, Na, Guo, Hao, Li, Jinjing, You, Xin, Dong, Mingming, Ye, Mingliang, Nie, Yongzhan, Zou, Hanfa, Fan, Daiming. Characterization of site-specific glycosylation of secreted proteins associated with multi-drug resistance of gastric cancer. ONCOTARGET[J]. 2016, 7(18): 25315-25327, http://cas-ir.dicp.ac.cn/handle/321008/148378.
[30] Peng, Jiaxi, Zhang, Hongyan, Li, Xin, Liu, Shengju, Zhao, Xingyun, Wu, Jing, Kang, Xiaohui, Qin, Hongqiang, Pan, Zaifa, Wu, Renan. Dual-Metal Centered Zirconium-Organic Framework: A Metal-Affinity Probe for Highly Specific Interaction with Phosphopeptides. ACS APPLIED MATERIALS & INTERFACES[J]. 2016, 8(51): 35012-35020, http://cas-ir.dicp.ac.cn/handle/321008/151845.
[31] Dong, Mingming, Bian, Yangyang, Dong, Jing, Wang, Keyun, Liu, Zheyi, Qin, Hongqiang, Ye, Mingliang, Zou, Hanfa. Selective Enrichment of Cysteine-Containing Phosphopeptides for Subphosphoproteome Analysis. JOURNAL OF PROTEOME RESEARCH[J]. 2015, 14(12): 5341-5347, http://cas-ir.dicp.ac.cn/handle/321008/147856.
[32] Yao, Yating, Huang, Junfeng, Cheng, Kai, Pan, Yanbo, Qin, Hongqiang, Ye, Mingliang, Zou, Hanfa. Specific Enrichment of Peptides with N-Terminal Serine/Threonine by a Solid-Phase Capture-Release Approach for Efficient Proteomics Analysis. ANALYTICAL CHEMISTRY[J]. 2015, 87(22): 11353-11360, https://www.webofscience.com/wos/woscc/full-record/WOS:000365151000027.
[33] 张章, 孙德光, 丛宇婷, 毛家维, 黄俊峰, 秦洪强, 刘静, 黄光, 王立明, 叶明亮, 邹汉法. Amine Chemistry Method for Selective Enrichment of N‑Linked Glycopeptides for Glycoproteomics Analysis. JOURNAL OF PROTEOME RESEARCH[J]. 2015, 14(1): 3892-, http://cas-ir.dicp.ac.cn/handle/321008/143750.
[34] 黄俊峰, 万昊, 姚亚婷, 李吉楠, 程凯, 毛家维, 陈津, 王, 秦洪强, 张维冰, 叶明亮, 邹汉法. Highly Efficient Release of Glycopeptides from Hydrazide Beads by Hydroxylamine Assisted PNGase F Deglycosylation for N‑Glycoproteome Analysis. ANALYTICAL CHEMISTRY[J]. 2015, 87: 10199-, http://cas-ir.dicp.ac.cn/handle/321008/147820.
[35] 由昕, 秦洪强, 叶明亮, 邹汉法. AN INTEGRATED METHOD FOR DETERMINATION OF SITE-SPECIFIC GLYCOFORMS IN EPITHELIAL-MESENCHYMAL TRANSITION (EMT) PROCESS. 43rd international symposium on high performance liquid phase separations and related techniquesnull. 2015, http://cas-ir.dicp.ac.cn/handle/321008/143429.
[36] 秦洪强, 程凯, 朱俊, 由昕, 毛家维, 叶明亮, 邹汉法. Development of Methods for Site-Specifi Analysis of N-Linked Protein Glycosylation. hupo 2015 world congressnull. 2015, http://cas-ir.dicp.ac.cn/handle/321008/143433.
[37] 陈贵夫, 王峰, 王业红, 张晓辰, 秦洪强, 邹汉法, 徐杰. Imine—linked conjugated organic polymer bearing bis(imino) pyridine ligands and its catalytic application in C–C coupling reactions. CHINESE JOURNAL OF CATALYSIS催化学报[J]. 2015, 35(1): 540-, http://cas-ir.dicp.ac.cn/handle/321008/144546.
[38] Huang, Junfeng, Wan, Hao, Yao, Yating, Li, Jinan, Cheng, Kai, Mao, Jiawei, Chen, Jin, Wang, Yan, Qin, Hongqiang, Zhang, Weibing, Ye, Mingliang, Zou, Hanfa. Highly Efficient Release of Glycopeptides from Hydrazide Beads by Hydroxylamine Assisted PNGase F Deglycosylation for N-Glycoproteome Analysis. ANALYTICAL CHEMISTRY[J]. 2015, 87(20): 10199-10204, https://www.webofscience.com/wos/woscc/full-record/WOS:000363348300008.
[39] 张章, 丛宇婷, 黄俊峰, 秦洪强, 刘静, 黄光, 叶明亮, 邹汉法. AN AMINE CHEMISTRY METHOD FOR SELECTIVE ENRICHMENT OF N-LINKED GLYCOPEPTIDES FOR GLYCOPROTEOMICS ANALYSIS. 31st international symposium on microscale bioseparationnull. 2015, http://cas-ir.dicp.ac.cn/handle/321008/143489.
[40] 姚亚婷, 黄俊峰, 程凯, 潘彦博, 秦洪强, 叶明亮, 邹汉法. Specific Enrichment of Peptides with N‑Terminal Serine/Threonine by a Solid-Phase Capture-Release Approach for Efficient Proteomics Analysis. ANALYTICAL CHEMISTRY[J]. 2015, 87: 11353-, http://cas-ir.dicp.ac.cn/handle/321008/147819.
[41] Zhang, Zhang, Sun, Deguang, Cong, Yuting, Mao, Jiawei, Huang, Junfeng, Qin, Hongqiang, Liu, Jing, Huang, Guang, Wang, Liming, Ye, Mingliang, Zou, Hanfa. Amine Chemistry Method for Selective Enrichment of N-Linked Glycopeptides for Glycoproteomics Analysis. JOURNAL OF PROTEOME RESEARCH[J]. 2015, 14(9): 3892-3899, http://cas-ir.dicp.ac.cn/handle/321008/146549.
[42] 李瑞宾, ZhaoxiaJi, 秦洪强, XuedongKang, BingbingSun, MeiyingWang, ChongHyunChang, XiangWang, HaiyuanZhang, 邹汉法, AndreENel, TianXia. Interference in Autophagosome Fusion by Rare Earth Nanoparticles Disrupts Autophagic Flux and Regulation of an Interleukin-1β Producing Inflammasome. ACS NANO[J]. 2014, 8(10): 10280-, http://cas-ir.dicp.ac.cn/handle/321008/144329.
[43] Huang, Guang, Sun, Zhen, Qin, Hongqiang, Zhao, Liang, Xiong, Zhichao, Peng, Xiaojun, Ou, Junjie, Zou, Hanfa. Preparation of hydrazine functionalized polymer brushes hybrid magnetic nanoparticles for highly specific enrichment of glycopeptides. ANALYST[J]. 2014, 139(9): 2199-2206, http://www.irgrid.ac.cn/handle/1471x/858830.
[44] Li, Ruibin, Ji, Zhaoxia, Qin, Hongqiang, Kang, Xuedong, Sun, Bingbing, Wang, Meiying, Chang, Chong Hyun, Wang, Xiang, Zhang, Haiyuan, Zou, Hanfa, Nel, Andre E, Xia, Tian. Interference in Autophagosome Fusion by Rare Earth Nanoparticles Disrupts Autophagic Flux and Regulation of an Interleukin-1 beta Producing Inflammasome. ACS NANO[J]. 2014, 8(10): 10280-10292, http://cas-ir.dicp.ac.cn/handle/321008/145608.
[45] Huang, Junfeng, Qin, Hongqiang, Dong, Jing, Song, Chunxia, Bian, Yangyang, Dong, Mingming, Cheng, Kai, Wang, Fangjun, Sun, Deguang, Wang, Liming, Ye, Mingliang, Zou, Hanfa. In Situ Sample Processing Approach (iSPA) for Comprehensive Quantitative Phosphoproteome Analysis. JOURNAL OF PROTEOME RESEARCH[J]. 2014, 13(9): 3896-3904, http://cas-ir.dicp.ac.cn/handle/321008/144524.
[46] 秦洪强, 黄俊峰, 孙珍, 王方军, 叶明亮, 邹汉法. 原位富集-选择性标记技术用于蛋白质翻译后修饰的定量分析. The 5th Asia Oceania Mass Spectrometry Conference & The 33rd Chinese Mass Spectrometry Society Annual Conferencenull. 2014, http://cas-ir.dicp.ac.cn/handle/321008/143594.
[47] Liu, Jing, Wang, Fangjun, Zhu, Jun, Mao, Jiawei, Liu, Zheyi, Cheng, Kai, Qin, Hongqiang, Zou, Hanfa. Highly efficient N-glycoproteomic sample preparation by combining C-18 and graphitized carbon adsorbents. ANALYTICAL AND BIOANALYTICAL CHEMISTRY[J]. 2014, 406(13): 3103-3109, http://cas-ir.dicp.ac.cn/handle/321008/145575.
[48] Dong, Mingming, Ye, Mingliang, Cheng, Kai, Dong, Jing, Zhu, Jun, Qin, Hongqiang, Bian, Yangyang, Zou, Hanfa. Identification of phosphopeptides with unknown cleavage specificity by a de novo sequencing assisted database search strategy. PROTEOMICS[J]. 2014, 14(21-22): 2410-2416, http://cas-ir.dicp.ac.cn/handle/321008/144419.
[49] Deng, Zhenzhen, Ye, Mingliang, Bian, Yangyang, Liu, Zheyi, Liu, Fangjie, Wang, Chunli, Qin, Hongqiang, Zou, Hanfa. Multiplex isotope dimethyl labeling of substrate peptides for high throughput kinase activity assay via quantitative MALDI MS. CHEMICAL COMMUNICATIONS[J]. 2014, 50(90): 13960-13962, http://cas-ir.dicp.ac.cn/handle/321008/144507.
[50] Huang, Guang, Xiong, Zhichao, Qin, Hongqiang, Zhu, Jun, Sun, Zhen, Zhang, Yi, Peng, Xiaojun, Ou, Junjie, Zou, Hanfa. Synthesis of zwitterionic polymer brushes hybrid silica nanoparticles via controlled polymerization for highly efficient enrichment of glycopeptides. ANALYTICA CHIMICA ACTA[J]. 2014, 809: 61-68, http://dx.doi.org/10.1016/j.aca.2013.11.049.
[51] Wu, Yue, Wang, Fangjun, Liu, Zheyi, Qin, Hongqiang, Song, Chunxia, Huang, Junfeng, Bian, Yangyang, Wei, Xiaoluan, Dong, Jing, Zou, Hanfa. Five-plex isotope dimethyl labeling for quantitative proteomics. CHEMICAL COMMUNICATIONS[J]. 2014, 50(14): 1708-1710, http://cas-ir.dicp.ac.cn/handle/321008/143851.
[52] Fang, Chunli, Xiong, Zhichao, Qin, Hongqiang, Huang, Guang, Liu, Jing, Ye, Mingliang, Feng, Shun, Zou, Hanfa. One-pot synthesis of magnetic colloidal nanocrystal clusters coated with chitosan for selective enrichment of glycopeptides. ANALYTICA CHIMICA ACTA[J]. 2014, 841: 99-105, http://dx.doi.org/10.1016/j.aca.2014.05.037.
[53] Li, Ruibin, Wu, Renan, Zhao, Liang, Qin, Hongqiang, Wu, Jianlin, Zhang, Jingwen, Bao, Ruyi, Zou, Hanfa. In vivo detection of magnetic labeled oxidized multi-walled carbon nanotubes by magnetic resonance imaging. NANOTECHNOLOGY[J]. 2014, 25(49): http://cas-ir.dicp.ac.cn/handle/321008/145725.
[54] Chen, Guifu, Wang, Feng, Wang, Yehong, Zhang, Xiaochen, Qin, Hongqiang, Zou, Hanfa, Xu, Jie. Imine-linked conjugated organic polymer bearing bis(imino)pyridine ligands and its catalytic application in C-C coupling reactions. CHINESE JOURNAL OF CATALYSIS[J]. 2014, 35(4): 540-545, http://dx.doi.org/10.1016/S1872-2067(14)60021-8.
[55] 陈贵夫, 王峰, 王业红, 张晓辰, 秦洪强, 邹汉法, 徐杰. 一种嵌有双亚胺基吡啶配体的全共轭有机聚合物材料及其在C-C偶联反应中的应用. 催化学报[J]. 2014, 35(4): 540-545, http://lib.cqvip.com/Qikan/Article/Detail?id=49148613.
[56] Chen Guifu, Wang Feng, Wang Yehong, Zhang Xiaochen, Qin Hongqiang, Zou Hanfa, Xu Jie. 一种嵌有双亚胺基吡啶配体的全共轭有机聚合物材料及其在C-C偶联反应中的应用. 催化学报[J]. 2014, 35(4): 540-545, http://lib.cqvip.com/Qikan/Article/Detail?id=49148613.
[57] Pan, Yanbo, Ye, Mingliang, Zheng, Hao, Cheng, Kai, Sun, Zhen, Liu, Fangjie, Liu, Jing, Wang, Keyun, Qin, Hongqiang, Zou, Hanfa. Trypsin-Catalyzed N-Terminal Labeling of Peptides with Stable Isotope-Coded Affinity Tags for Proteome Analysis. ANALYTICALCHEMISTRY[J]. 2014, 86(2): 1170-1177, http://cas-ir.dicp.ac.cn/handle/321008/145495.
[58] 邹汉法, 王方军, 叶明亮, 朱俊, 孙珍, 秦洪强, 黄俊峰. Solid-phase based technologies and methods for glycoproteome and phsophoproteome analysis. 39TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONSnull. 2013, 34-, http://159.226.238.44/handle/321008/116938.
[59] 张轶, 胡争艳, 秦洪强, 卫晓鸾, 程凯, 刘芳洁, 吴仁安, 邹汉法. Highly Efficient Extraction of the Cellular Nucleic Acid Associated Protein in Vitro with Magnetic Oxidized Carbon Nanotube. 39TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONSnull. 2013, 119-, http://159.226.238.44/handle/321008/116937.
[60] Liu, Fangjie, Ye, Mingliang, Wang, Chunli, Hu, Zhengyan, Zhang, Yi, Qin, Hongqiang, Cheng, Kai, Zou, Hanfa. Polyacrylamide Gel with Switchable Trypsin Activity for Analysis of Proteins. ANALYTICAL CHEMISTRY[J]. 2013, 85(15): 7024-7028, http://www.irgrid.ac.cn/handle/1471x/720995.
[61] Xu, Bo, Chen, Chen, Wang, Fangjun, Bian, Yangyang, Cheng, Kai, Qin, Hongqiang, Song, Chunxia, Zhu, Jun, Liu, Jing, Ye, Mingliang, Zou, Hanfa. High specific phosphopeptides enrichment by titanium silicalite with post-treatment of desilication. ANALYTICAL METHODS[J]. 2013, 5(12): 2939-2946, http://www.irgrid.ac.cn/handle/1471x/721029.
[62] Qin, Hongqiang, Hu, Zhengyan, Wang, Fangjun, Zhang, Yi, Zhao, Liang, Xu, Guiju, Wu, Renan, Zou, Hanfa. Facile preparation of ordered mesoporous silica-carbon composite nanoparticles for glycan enrichment. CHEMICAL COMMUNICATIONS[J]. 2013, 49(45): 5162-5164, http://www.irgrid.ac.cn/handle/1471x/721074.
[63] Xiong, Zhichao, Qin, Hongqiang, Wan, Hao, Huang, Guang, Zhang, Zhang, Dong, Jing, Zhang, Lingyi, Zhang, Weibing, Zou, Hanfa. Layer-by-layer assembly of multilayer polysaccharide coated magnetic nanoparticles for the selective enrichment of glycopeptides. CHEMICALCOMMUNICATIONS[J]. 2013, 49(81): 9284-9286, http://www.irgrid.ac.cn/handle/1471x/858638.
[64] Wan, Hao, Qin, Hongqiang, Xiong, Zhichao, Zhang, Weibing, Zou, Hanfa. Facile synthesis of yolk-shell magnetic mesoporous carbon microspheres for efficient enrichment of low abundance peptides. NANOSCALE[J]. 2013, 5(22): 10936-10944, http://159.226.238.44/handle/321008/119175.
[65] Zhu, Jun, Wang, Fangjun, Cheng, Kai, Song, Chunxia, Qin, Hongqiang, Hu, Lianghai, Figeys, Daniel, Ye, Mingliang, Zou, Hanfa. Analysis of human serum phosphopeptidome by a focused database searching strategy. JOURNAL OF PROTEOMICS[J]. 2013, 78: 389-397, http://dx.doi.org/10.1016/j.jprot.2012.10.006.
[66] 邹汉法, 秦洪强, 王方军, 吴仁安. Highly efficient extraction of biological samples with mesoporous adsorbents for protein and peptides analysis. the 5th international symposium on microchemistry and microsystemsnull. 2013, 10-, http://159.226.238.44/handle/321008/120178.
[67] 胡争艳, 张轶, 赵樑, 秦洪强, 吴仁安, 邹汉法. Highly Efficient Cleavage of Protein Corona on Fe3O4 Nanoparticles by a Magnetic Tryptic Nanorazor. the 5th international symposium on microchemistry and microsystemsnull. 2013, 19-, http://159.226.238.44/handle/321008/120174.
[68] 徐博, 周丽萍, 王方军, 秦洪强, 朱俊, 邹汉法. Selective capture of phosphopeptides by the hierarchical Ti-aluminophosphate-5 molecular sieves. the 5th international symposium on microchemistry and microsystemsnull. 2013, 18-, http://159.226.238.44/handle/321008/120176.
[69] Bian, Yangyang, Ye, Mingliang, Wang, Chunli, Cheng, Kai, Song, Chunxia, Dong, Mingming, Pan, Yanbo, Qin, Hongqiang, Zou, Hanfa. Global Screening of CK2 Kinase Substrates by an Integrated Phosphoproteomics Workflow. SCIENTIFIC REPORTS[J]. 2013, 3: http://www.irgrid.ac.cn/handle/1471x/858648.
[70] 宋春侠, 孙珍, 秦洪强, 叶明亮, 张丽华, 张玉奎, 邹汉法. 修饰蛋白质组学分离鉴定新技术新方法. 科学通报[J]. 2013, 58(30): 1-, http://159.226.238.44/handle/321008/119541.
[71] Wang, Fangjun, Cheng, Kai, Wei, Xiaoluan, Qin, Hongqiang, Chen, Rui, Liu, Jing, Zou, Hanfa. A six-plex proteome quantification strategy reveals the dynamics of protein turnover. SCIENTIFIC REPORTS[J]. 2013, 3: http://www.irgrid.ac.cn/handle/1471x/721015.
[72] Pan, Yanbo, Ye, Mingliang, Zhao, Liang, Cheng, Kai, Dong, Mingming, Song, Chunxia, Qin, Hongqiang, Wang, Fangjun, Zou, Hanfa. N-Terminal Labeling of Peptides by Trypsin-Catalyzed Ligation for Quantitative Proteomics. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2013, 52(35): 9205-9209, http://www.irgrid.ac.cn/handle/1471x/720966.
[73] Zhang, Yi, Hu, Zhengyan, Qin, Hongqiang, Liu, Fangjie, Cheng, Kai, Wu, Renan, Zou, Hanfa. Cell Nucleus Targeting for Living Cell Extraction of Nucleic Acid Associated Proteins with Intracellular Nanoprobes of Magnetic Carbon Nanotubes. ANALYTICAL CHEMISTRY[J]. 2013, 85(15): 7038-7043, http://www.irgrid.ac.cn/handle/1471x/720971.
[74] Qin, Hongqiang, Wang, Fangjun, Wang, Peiyuan, Zhao, Liang, Zhu, Jun, Yang, Qihua, Wu, Renan, Ye, Mingliang, Zou, Hanfa. Phosphoric acid functionalized mesoporous organo-silica (EPO) as the adsorbent for in situ enrichment and isotope labeling of endogenous phosphopeptides. CHEMICAL COMMUNICATIONS[J]. 2012, 48(7): 961-963, http://www.irgrid.ac.cn/handle/1471x/721703.
[75] Zhao, Liang, Qin, Hongqiang, Hu, Zhengyan, Zhang, Yi, Wu, Renan, Zou, Hanfa. A poly(ethylene glycol)-brush decorated magnetic polymer for highly specific enrichment of phosphopeptides. CHEMICAL SCIENCE[J]. 2012, 3(9): 2828-2838, http://www.irgrid.ac.cn/handle/1471x/721719.
[76] 秦洪强, 王方军, 张轶, 胡争艳, 宋春侠, 吴仁安, 叶明亮, 邹汉法. Isobaric Cross-Sequence Labeling of Peptides by Using Site-Selective Dimethylation Reaction. 38TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2012, 120-, http://159.226.238.44/handle/321008/117214.
[77] Wang, Fangjun, Zhu, Jun, Hu, Lianghai, Qin, Hongqiang, Ye, Mingliang, Zou, Hanfa. Comprehensive analysis of the N and C terminus of endogenous serum peptides reveals a highly conserved cleavage site pattern derived from proteolytic enzymes. PROTEIN & CELL[J]. 2012, 3(9): 669-674, http://www.irgrid.ac.cn/handle/1471x/721441.
[78] Zhao, Liang, Qin, Hongqiang, Wu, Renan, Zou, Hanfa. Recent advances of mesoporous materials in sample preparation. JOURNAL OF CHROMATOGRAPHY A[J]. 2012, 1228: 193-204, http://dx.doi.org/10.1016/j.chroma.2011.09.051.
[79] Xu, Bo, Zhou, Lipeng, Wang, Fangjun, Qin, Hongqiang, Zhu, Jun, Zou, Hanfa. Selective capture of phosphopeptides by hierarchical Ti-aluminophosphate-5 molecular sieves. CHEMICAL COMMUNICATIONS[J]. 2012, 48(12): 1802-1804, http://www.irgrid.ac.cn/handle/1471x/721440.
[80] Zhang, Zhenbin, Lin, Hui, Ou, Junjie, Qin, Hongqiang, Wu, Renan, Dong, Jing, Zou, Hanfa. Preparation of phenyl-silica hybrid monolithic column with "one-pot" process for capillary liquid chromatography. JOURNAL OF CHROMATOGRAPHY A[J]. 2012, 1228: 263-269, http://dx.doi.org/10.1016/j.chroma.2011.07.048.
[81] Zhang, Yi, Hu, Zhengyan, Qin, Hongqiang, Wei, Xiaoluan, Cheng, Kai, Liu, Fangjie, Wu, Renan, Zou, Hanfa. Highly Efficient Extraction of Cellular Nucleic Acid Associated Proteins in Vitro with Magnetic Oxidized Carbon Nanotubes. ANALYTICAL CHEMISTRY[J]. 2012, 84(23): 10454-10462, http://www.irgrid.ac.cn/handle/1471x/721410.
[82] 秦洪强, 王方军, 张轶, 胡争艳, 宋春侠, 吴仁安, 叶明亮, 邹汉法. Isobaric Cross-Sequence Labeling of Peptides for Quantification of Proteins by MS/MS. ASIA OCEANIA HUMAN PROTEOME ORGANIZATION 6TH CONGRESS null. 2012, 232-, http://159.226.238.44/handle/321008/116980.
[83] 邹汉法, 秦洪强, 王方军, 吴仁安. Size-selective Extraction of Biological Samples with Mesoporous Adsorbents for Protein and Peptides Analysis. 19TH INTERNATIONAL SYMPOSIUM EXHIBIT & WORKSHOPS ON ELECTRO- AND LIQUID PHASE-SEPARATION TECHNIQUESnull. 2012, 6-, http://159.226.238.44/handle/321008/117144.
[84] Sun, Zhen, Qin, Hongqiang, Wang, Fangjun, Cheng, Kai, Dong, Mingming, Ye, Mingliang, Zou, Hanfa. Capture and Dimethyl Labeling of Glycopeptides on Hydrazide Beads for Quantitative Glycoproteomics Analysis. ANALYTICAL CHEMISTRY[J]. 2012, 84(20): 8452-8456, http://www.irgrid.ac.cn/handle/1471x/721429.
[85] 徐博, ZhouLipeng, 王方军, 秦洪强, 朱俊, 邹汉法. Selective Capture of Phosphopeptides by the Hierarchical Tialuminophosphate-. ASIA OCEANIA HUMAN PROTEOME ORGANIZATION 6TH CONGRESS null. 2012, 295-, http://159.226.238.44/handle/321008/116978.
[86] Zhang, Zhenbin, Wang, Fangjun, Xu, Bo, Qin, Hongqiang, Ye, Mingliang, Zou, Hanfa. Preparation of capillary hybrid monolithic column with sulfonate strong cation exchanger for proteome analysis. JOURNAL OF CHROMATOGRAPHY A[J]. 2012, 1256: 136-143, http://dx.doi.org/10.1016/j.chroma.2012.07.071.
[87] Qin, Hongqiang, Wang, Fangjun, Zhang, Yi, Hu, Zhengyan, Song, Chunxia, Wu, Renan, Ye, Mingliang, Zou, Hanfa. Isobaric cross-sequence labeling of peptides by using site-selective N-terminus dimethylation. CHEMICAL COMMUNICATIONS[J]. 2012, 48(50): 6265-6267, http://www.irgrid.ac.cn/handle/1471x/721369.
[88] Xiong, Zhichao, Zhao, Liang, Wang, Fangjun, Zhu, Jun, Qin, Hongqiang, Wu, Renan, Zhang, Weibing, Zou, Hanfa. Synthesis of branched PEG brushes hybrid hydrophilic magnetic nanoparticles for the selective enrichment of N-linked glycopeptides. CHEMICAL COMMUNICATIONS[J]. 2012, 48(65): 8138-8140, http://www.irgrid.ac.cn/handle/1471x/721275.
[89] 邹汉法, 秦洪强, 赵樑, 吴仁安. Highly Selective Extraction of Biological Samples with the Adsorbents of Mesoporous Materials. THE 27TH INTERNATIONAL SYMPOSIUM ON MICROSCALE BIOSEPARATIONS AND ANALYSESnull. 2012, 37-, http://159.226.238.44/handle/321008/117234.
[90] Sun, Zhen, Chen, Rui, Cheng, Kai, Liu, Hongwei, Qin, Hongqiang, Ye, Mingliang, Zou, Hanfa. A new method for quantitative analysis of cell surface glycoproteome. PROTEOMICS[J]. 2012, 12(22): 3328-3337, http://www.irgrid.ac.cn/handle/1471x/721362.
[91] 吴仁安, 张宇, 秦洪强, 闵乾昊, 邹汉法. Mesoporous Materials for Sample Preparation in Bioanalysis. JONIT CONGRESS 2011 FINAL PROGRAMnull. 2011, 37-0, http://159.226.238.44/handle/321008/115945.
[92] 吴仁安, 张宇, 秦洪强, 闵乾昊, 邹汉法. Mesoporous Materials for Sample Preparation in Bioanalysis. 26TH INTERNATIONAL SYMPOSIUM ON MICROSCALE BIOSEPARATIONSnull. 2011, 37-, http://159.226.238.44/handle/321008/117465.
[93] Qin, Hongqiang, Zhao, Liang, Li, Ruibin, Wu, Renan, Zou, Hanfa. Size-Selective Enrichment of N-Linked Glycans Using Highly Ordered Mesoporous Carbon Material and Detection by MALDI-TOF MS. ANALYTICAL CHEMISTRY[J]. 2011, 83(20): 7721-7728, http://www.irgrid.ac.cn/handle/1471x/456645.
[94] Qin, Hongqiang, Gao, Peng, Wang, Fangjun, Zhao, Liang, Zhu, Jun, Wang, Aiqin, Zhang, Tao, Wu, Renan, Zou, Hanfa. Highly Efficient Extraction of Serum Peptides by Ordered Mesoporous Carbon. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION[J]. 2011, 50(51): 12218-12221, http://www.irgrid.ac.cn/handle/1471x/457107.
[95] 王方军, 徐博, 秦洪强, 邹汉法. Solid-phase isotope labeling and multidimensional separation for proteome and phosphoproteome quantification. 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUESnull. 2011, 138-, http://159.226.238.44/handle/321008/117422.
[96] Wu, Minghuo, Wu, Renan, Li, Ruibing, Qin, Hongqiang, Dong, Jing, Zhang, Zhenbin, Zou, Hanfa. Polyhedral Oligomeric Silsesquioxane as a Cross-linker for Preparation of Inorganic-Organic Hybrid Monolithic Columns. ANALYTICAL CHEMISTRY[J]. 2010, 82(13): 5447-5454, http://159.226.238.44/handle/321008/103143.
[97] 张宇, 秦洪强, 吴仁安, 邹汉法. Ti-SBA-15介孔材料用于磷酸化肽的高效富集. 色谱[J]. 2010, 28(2): 123-127, http://lib.cqvip.com/Qikan/Article/Detail?id=33012691.
[98] Min, Qianhao, Wu, Renan, Zhao, Liang, Qin, Hongqiang, Ye, Mingliang, Zhu, JunJie, Zou, Hanfa. Size-selective proteolysis on mesoporous silica-based trypsin nanoreactor for low-MW proteome analysis. CHEMICAL COMMUNICATIONS[J]. 2010, 46(33): 6144-6146, http://159.226.238.44/handle/321008/103187.
[99] Dong, Mingming, Wu, Minghuo, Wang, Fangjun, Qin, Hongqiang, Han, Guanghui, Gong, Jing, Wu, Renan, Ye, Mingliang, Liu, Zhen, Zou, Hanfa. Coupling Strong Anion-Exchange Monolithic Capillary with MALDI-TOF MS for Sensitive Detection of Phosphopeptides in Protein Digest. ANALYTICAL CHEMISTRY[J]. 2010, 82(7): 2907-2915, http://dx.doi.org/10.1021/ac902907w.
[100] Zhang, Yu, Chen, Chen, Qin, Hongqiang, Wu, Renan, Zou, Hanfa. The synthesis of Ti-hexagonal mesoporous silica for selective capture of phosphopeptides. CHEMICAL COMMUNICATIONS[J]. 2010, 46(13): 2271-2273, http://159.226.238.44/handle/321008/103055.
[101] 秦洪强, 吴仁安, 潘陈松, 陈锐, 赵梁, 邹汉法. Profiling of N-linked Glycans from Human Serum with Oxidative Ordered Mesoporous Carbon. the 24th international symposium on micro-scale bioseparation,null. 2009, 264/1-, http://159.226.238.44/handle/321008/113854.
[102] 董铭铭, 吴明火, 王方军, 秦洪强, 韩广辉, 董靖, 吴仁安, 叶明亮, 刘震, 邹汉法. Enrichment of Phosphopeptides by a Novel SAX Capillary Monolithic Column for Sensitive MALDI-TOF MS Analysis. the 24th international symposium on micro-scale bioseparation,null. 2009, 259/1-, http://159.226.238.44/handle/321008/113840.

科研活动

   
科研项目
( 1 ) 血清内源性多肽定量分析方法的建立及其用于抑郁症疾病标记物的筛, 主持, 国家级, 2015-01--2017-12
( 2 ) 蛋白糖基化修饰在胃癌多药耐药中特征性改变及其作用机制研究, 主持, 国家级, 2015-01--2018-12
( 3 ) 基于非天然糖代谢标记的分泌蛋白质糖基化精细分析新方法研究, 主持, 国家级, 2018-01--2021-12

合作情况

第四军医大学、大连医科大学、大连理工大学等单位

指导学生

现指导学生

周家华  博士研究生  070302-分析化学  

刘莉  硕士研究生  070302-分析化学  

王佳怡  硕士研究生  070302-分析化学  

陈尧  博士研究生  070302-分析化学