海洋生物活性物质研究

海洋生物资源综合利用

   

070703-海洋生物学
086000-生物与医药
070702-海洋化学

海洋生物天然产物及生物制品
海洋生物工程
化学海洋学与应用海洋化学

2008-08--2013-07   中国科学院海洋研究所   博士
2004-10--2008-07   河北工业大学   学士

   

2016-03~2017-04,美国加州大学河滨分校, 博士后
2015-01~现在, 中国科学院海洋研究所, 副研究员
2013-07~2014-12,中国科学院海洋研究所, 助理研究员

   

（1） 中国科学院海洋研究所海洋生物制品创新团队, 一等奖, 市地级, 2016
（2） 山东省技术发明奖, 二等奖, 省级, 2015
（3） 中国科学院院长优秀奖, 院级, 2013
（4） 山东省研究所优秀科技创新成果奖, 三等奖, 省级, 2013

[1] 邢荣娥, 杨皓月, 刘松, 于华华, 秦玉坤, 李克成, 李鹏程. 一种高产壳聚糖酶的菌株及其应用. CN: CN112662572A, 2021-04-16.

[2] 于华华, 郝文桐, 李克成, 李荣锋, 马玉珍, 邢荣娥, 刘松, 李鹏程. 复杂序列壳二糖的制备方法. CN: CN112538507A, 2021-03-23.

[3] 邢荣娥, 徐超杰, 刘松, 秦玉坤, 李克成, 杨皓月, 于华华, 李鹏程. 一种硫酸酯-季铵盐壳聚糖纳米粒作为载体的应用. CN: CN112402621A, 2021-02-26.

[4] 李克成, 邢荣娥, 刘松, 杨皓月, 秦玉坤, 王雪芹, 李鹏程. 一种贝壳改性的方法. CN: CN111530436A, 2020-08-14.

[5] 刘松, 尹秀晶, 邢荣娥, 秦玉坤, 李克成, 李鹏程. 一种小麦抗逆制剂及其应用. CN: CN111171086A, 2020-05-19.

[6] 邢荣娥, 徐超杰, 刘松, 秦玉坤, 李克成, 杨皓月, 于华华, 李鹏程. 具有增强抗原提呈细胞提呈抗原作用的壳聚糖衍生物纳米粒及制备. CN: CN110974805A, 2020-04-10.

[7] 李克成, 李鹏程, 邢荣娥, 刘松, 于华华, 陈晓琳, 秦玉坤, 李荣锋, 王雪芹. 一种N-乙酰化壳六糖抑制肿瘤细胞增殖的应用. CN: CN107753501B, 2020-04-07.

[8] 邢荣娥, 刘勇亮, 杨皓月, 李克成, 秦玉坤, 刘松, 于华华, 李鹏程. 一种从凡纳滨对虾虾壳中提取甲壳素的方法. CN: CN110862465A, 2020-03-06.

[9] 王雪芹, 于华华, 邢荣娥, 陈晓琳, 刘松, 李荣锋, 李克成, 秦玉坤, 李鹏程. 一种富含支链氨基酸的牡蛎寡肽及其制备方法. CN: CN110140970A, 2019-08-20.

[10] 李克成, 李鹏程, 邢荣娥, 刘松, 秦玉坤, 陈晓琳. 一种溶液中壳寡糖的固相萃取方法. 中国: CN107694150A, 2018-02-16.

[11] 李鹏程, 金秋, 于华华, 李克成, 李荣锋, 王雪芹, 秦玉坤, 陈晓琳, 邢荣娥, 刘松. 壳聚糖作为胰脂肪酶抑制剂的用途. 中国: CN106619698A, 2017-05-10.

[12] 李鹏程, 杨悦, 邢荣娥, 刘松, 于华华, 陈晓琳, 李克成, 秦玉坤, 岳洋, 范兆乾. 一种不同分子量β-C-6-硫酸酯-壳聚糖类化合物及其制备方法. 中国: CN105949352A, 2016-09-21.

[13] 邢荣娥, 何晓飞, 李克成, 秦玉坤, 刘松, 于华华, 李鹏程. 一种抑制新城疫病毒制剂及其应用. 中国: CN104857012A, 2015-08-26.

[14] 李鹏程, 李俨, 刘松, 秦玉坤, 邢荣娥, 于华华, 李克成, 邹平, 杨皓月, 何晓飞, 周苗苗, 岳阳. 一种具有杀虫活性的化合物及其制备和应用. 中国: CN104788587A, 2015-07-22.

[15] 邢荣娥, 何晓飞, 李克成, 秦玉坤, 刘松, 于华华, 李鹏程. 一种抑制新城疫病毒的制剂. 中国: CN104784196A, 2015-07-22.

[16] 邢荣娥, 何晓飞, 秦玉坤, 李克成, 刘松, 李鹏程. 一种β-壳聚糖的制备方法. 中国: CN104693318A, 2015-06-10.

[17] 邢荣娥, 何晓飞, 李克成, 秦玉坤, 刘松, 李鹏程. 一种不同分子量β-壳聚糖的制备方法. 中国: CN104693319A, 2015-06-10.

[18] 李克成, 李鹏程, 周苗苗, 刘松, 邢荣娥, 于华华, 秦玉坤. 一种快速制备超高浓度壳聚糖溶液的方法. 中国: CN104629099A, 2015-05-20.

[19] 李克成, 李鹏程, 岳洋, 刘卫翔, 邢荣娥, 刘松, 于华华, 秦玉坤. 一种壳聚糖及其衍生物的应用. 中国: CN104492202A, 2015-04-08.

[20] 刘松, 周苗苗, 李克成, 李鹏程, 邢荣娥, 于华华, 秦玉坤. 一种几丁寡糖制备方法. 中国: CN104072634A, 2014.10.01.

[21] 刘松, 周苗苗, 李克成, 李鹏程, 邢荣娥, 于华华, 秦玉坤. 一种微波-酶法耦合降解壳聚糖的方法. 中国: CN104098715A, 2014-10-15.

[22] 李鹏程, 邹平, 刘松, 邢荣娥, 于华华, 李克成, 秦玉坤. 一种黄瓜抗低温调节剂. 中国: CN104026131A, 2014-09-10.

[23] 邢荣娥, 刘松, 于华华, 秦玉坤, 李克成, 陈晓琳, 李鹏程. 壳聚糖硫酸酯类化合物作为制备防治急性肾衰药物中的应用. 中国: CN103977020A, 2014-08-13.

[24] 邢荣娥, 刘松, 关小红, 李克成, 于华华, 秦玉坤, 陈晓琳, 李鹏程. 一种利用贝壳制备磷酸氢钙的方法. 中国: CN103848408A, 2014-06-11.

[25] 邢荣娥, 何晓飞, 李克成, 刘松, 李鹏程. 一种制备超高脱乙酰度壳聚糖的方法. 中国: CN103709269A, 2014-04-09.

[26] 李鹏程, 李克成, 邢荣娥, 刘松, 于华华, 秦玉坤. 一种不同乙酰度的N-乙酰化壳六糖的分离纯化方法. 中国: CN103613684A, 2014-03-05.

[27] 李鹏程, 李克成, 邢荣娥, 刘松, 于华华, 秦玉坤, 李荣锋, 孟祥涛, 李冰. 一种单一聚合度壳寡糖制备方法. 中国: CN102653569A, 2012.09.05.

[28] 李鹏程, 李克成, 邢荣娥, 刘松, 于华华, 秦玉坤, 李荣峰. 一种乙酰化壳三糖的制备方法. 中国: CN102827212A, 2012-12-19.

[29] 刘松, 李鹏程, 邢荣娥, 李荣锋, 李克成, 冯金华, 李冰, 于华华. 一种卡拉胶藻渣有机肥料及其制备方法. 中国: CN102372506A, 2012-03-14.

   

[1] Qian Wang, Song Liu, Kecheng Li, Ronge Xing, Xiaolin Chen, Pengcheng Li. A Computational Biology Study on the Structure and Dynamics Determinants of Thermal Stability of the Chitosanase from Aspergillus fumigatus. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2023, 24: https://doaj.org/article/2ed70004c5d043498b4e7b9b1cb5e836.
[2] Wentong Hao, Kecheng Li, Song Liu, Huahua Yu, Pengcheng Li, Ronge Xing. Pleiotropic Modulation of Chitooligosaccharides on Inflammatory Signaling in LPS-Induced Macrophages. POLYMERS[J]. 2023, 15: https://doaj.org/article/cf1b89c7ecb6490da3601194694689a7.
[3] Chaojie Xu, Ronge Xing, Song Liu, Yukun Qin, Kecheng Li, Huahua Yu, Pengcheng Li. The synthesis, characterization and immunological activity of mucopolysaccharide-quaternized chitosan nanoparticles. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2022, 220: 258-266, http://dx.doi.org/10.1016/j.ijbiomac.2022.08.069.
[4] Hao, Wentong, Li, Kecheng, Ge, Xiangyun, Yang, Haoyue, Xu, Chaojie, Liu, Song, Yu, Huahua, Li, Pengcheng, Xing, Ronge. The Effect of N-Acetylation on the Anti-Inflammatory Activity of Chitooligosaccharides and Its Potential for Relieving Endotoxemia. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 23(15): http://dx.doi.org/10.3390/ijms23158205.
[5] Li, Xiaomin, Xing, Ronge, Xu, Chaojie, Liu, Song, Qin, Yukun, Li, Kecheng, Yu, Huahua, Li, Pengcheng. Immunostimulatory effect of quaternary degree and acetyl group of quaternized chitosan on macrophages RAW 264.7. JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2022, 40(3): 1160-1170, http://dx.doi.org/10.1007/s00343-021-1098-6.
[6] Fan, Zhaoqian, Qin, Yukun, Liu, Song, Xing, Ronge, Yu, Huahua, Li, Kecheng, Li, Pengcheng. Fluoroalkenyl-Grafted Chitosan Oligosaccharide Derivative: An Exploration for Control Nematode Meloidogyne Incognita. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES[J]. 2022, 23(4): http://dx.doi.org/10.3390/ijms23042080.
[7] Xu, Chaojie, Xing, Ronge, Liu, Song, Qin, Yukun, Li, Kecheng, Yu, Huahua, Li, Pengcheng. The immunostimulatory effects of hydroxypropyltrimethyl ammonium chloride chitosan-carboxymethyl chitosan nanoparticles. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2021, 181: 398-409, http://dx.doi.org/10.1016/j.ijbiomac.2021.03.148.
[8] Li, Xiaomin, Xing, Ronge, Xu, Chaojie, Liu, Song, Qin, Yukun, Li, Kecheng, Yu, Huahua, Li, Pengcheng. Immunostimulatory effect of chitosan and quaternary chitosan: A review of potential vaccine adjuvants. CARBOHYDRATE POLYMERS[J]. 2021, 264: http://dx.doi.org/10.1016/j.carbpol.2021.118050.
[9] He, Xiaofei, Xing, Ronge, Liu, Song, Qin, Yukun, Li, Kecheng, Yu, Huahua, Li, Pengcheng. The improved antiviral activities of amino-modified chitosan derivatives on Newcastle virus. DRUG AND CHEMICAL TOXICOLOGY[J]. 2021, 44(4): 335-340, http://dx.doi.org/10.1080/01480545.2019.1620264.
[10] Yin, Xiujing, Liu, Song, Qin, Yukun, Xing, Ronge, Li, Kecheng, Yu, Chunlin, Chen, Xiaolin, Li, Pengcheng. Metabonomics analysis of drought resistance of wheat seedlings induced by beta-aminobutyric acid-modified chitooligosaccharide derivative. CARBOHYDRATE POLYMERS[J]. 2021, 272: http://dx.doi.org/10.1016/j.carbpol.2021.118437.
[11] Hao, Wentong, Li, Kecheng, Li, Pengcheng. Review: Advances in preparation of chitooligosaccharides with heterogeneous sequences and their bioactivity. CARBOHYDRATE POLYMERS[J]. 2021, 252: http://dx.doi.org/10.1016/j.carbpol.2020.117206.
[12] 尹秀晶, 刘松, 秦玉坤, 邢荣娥, 于春林, 李克成, 李鹏程. 新型壳寡糖γ-氨基丁酸衍生物的制备及其对小麦幼苗抗旱作用的研究. 海洋科学[J]. 2020, 44(5): 42-52, http://lib.cqvip.com/Qikan/Article/Detail?id=7101742450.
[13] Yang Yue, Xing Ronge, Liu Song, Qin Yukun, Li Kecheng, Yu Huahua, Li Pengcheng. PI3K/Akt pathway is involved in the activation of RAW 264.7 cells induced by hydroxypropyltrimethyl ammonium chloride chitosan. JOURNAL OF OCEANOLOGY AND LIMNOLOGY[J]. 2020, 38(3): 834-840, http://lib.cqvip.com/Qikan/Article/Detail?id=7101692474.
[14] Li, K C, Zhang, X Q, Yu, Y, Xing, R E, Liu, S, Li, P C. Effect of chitin and chitosan hexamers on growth and photosynthetic characteristics of wheat seedlings. PHOTOSYNTHETICA[J]. 2020, 58(3): 819-826, https://doaj.org/article/1bc610cea3b74a1bbe269e6cb38c5046.
[15] 邢荣娥, 秦玉坤, 李克成, 刘松, 李鹏程. 具有抑制植物病原真菌活性的含氮、硫、磷壳聚糖衍生物的研究进展. 海洋科学[J]. 2020, 44(7): 135-142, http://lib.cqvip.com/Qikan/Article/Detail?id=7102292964.
[16] Li, Kecheng, Xing, Ronge, Liu, Song, Li, Pengcheng. Chitin and Chitosan Fragments Responsible for Plant Elicitor and Growth Stimulator. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2020, 68(44): 12203-12211, https://www.webofscience.com/wos/woscc/full-record/WOS:000589379300003.
[17] Yang, Yue, Xing, Ronge, Liu, Song, Qin, Yukun, Li, Kecheng, Yu, Huahua, Li, Pengcheng. Chitosan, hydroxypropyltrimethyl ammonium chloride chitosan and sulfated chitosan nanoparticles as adjuvants for inactivated Newcastle disease vaccine. CARBOHYDRATE POLYMERS[J]. 2020, 229: http://dx.doi.org/10.1016/j.carbpol.2019.115423.
[18] Zhang, Enhui, Xing, Ronge, Liu, Song, Qin, Yukun, Li, Kecheng, Li, Pengcheng. Advances in chitosan-based nanoparticles for oncotherapy. CARBOHYDRATE POLYMERSnull. 2019, 222: 115004-, http://dx.doi.org/10.1016/j.carbpol.2019.115004.
[19] Liu, Hong, Chen, Xiaolin, Song, Lin, Li, Kecheng, Zhang, Xiaoqian, Liu, Song, Qin, Yukun, Li, Pengcheng. Polysaccharides from Grateloupia filicina enhance tolerance of rice seeds (Oryza sativa L.) under salt stress. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 124: 1197-1204, http://dx.doi.org/10.1016/j.ijbiomac.2018.11.270.
[20] Li, Kecheng, Green, Andrew R, Dinges, Meredith M, Larive, Cynthia K. H-1 NMR characterization of chitin tetrasaccharide in binary H2O:DMSO solution: Evidence for anomeric end-effect propagation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 129: 744-749, [21] Zhang, Enhui, Xing, Ronge, Liu, Song, Li, Kecheng, Qin, Yukun, Yu, Huahua, Li, Pengcheng. Vascular targeted chitosan-derived nanoparticles as docetaxel carriers for gastric cancer therapy. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2019, 126: 662-672, http://ir.qdio.ac.cn/handle/337002/155298.
[22] Green, Andrew R, Li, Kecheng, Lockard, Blake, Young, Robert P, Mueller, Leonard J, Larive, Cynthia K. Investigation of the Amide Proton Solvent Exchange Properties of Glycosaminoglycan Oligosaccharides. JOURNAL OF PHYSICAL CHEMISTRY B[J]. 2019, 123(22): 4653-4662, https://www.webofscience.com/wos/woscc/full-record/WOS:000470938100005.
[23] Yang, Yue, Xing, Ronge, Liu, Song, Qin, Yukun, Li, Kecheng, Yu, Huahua, Li, Pengcheng. Hydroxypropyltrimethyl ammonium chloride chitosan activates RAW 264.7 macrophages through the MAPK and JAK-STAT signaling pathways. CARBOHYDRATE POLYMERS[J]. 2019, 205: 401-409, http://dx.doi.org/10.1016/j.carbpol.2018.10.101.
[24] Liu, Yongliang, Xing, Ronge, Liu, Song, Qin, Yukun, Li, Kecheng, Yu, Huahua, Li, Pengcheng. Effects of chitooligosaccharides supplementation with different dosages, molecular weights and degrees of deacetylation on growth performance, innate immunity and hepatopancreas morphology in Pacific white shrimp (Litopenaeus vannamei). CARBOHYDRATE POLYMERS[J]. 2019, 226: http://ir.qdio.ac.cn/handle/337002/163247, http://www.irgrid.ac.cn/handle/1471x/6861253, http://ir.qdio.ac.cn/handle/337002/163248, http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcApp=PARTNER_APP&SrcAuth=LinksAMR&KeyUT=WOS:000488245300006&DestLinkType=FullRecord&DestApp=ALL_WOS&UsrCustomerID=3a85505900f77cc629623c3f2907beab.
[25] Yang, Yue, Xing, Ronge, Liu, Song, Qin, Yukun, Li, Kecheng, Yu, Huahua, Li, Pengcheng. Immunostimulatory Effects of Chitooligosaccharides on RAW 264.7 Mouse Macrophages via Regulation of the MAPK and PI3K/Akt Signaling Pathways. MARINE DRUGS[J]. 2019, 17(1): https://doaj.org/article/57348593077f4513b397e54b46756a33.
[26] Kecheng Li, Andrew R Green, Meredith M Dinges, Cynthia K Larive. 1H NMR characterization of chitin tetrasaccharide in binary H2O:DMSO solution: Evidence for anomeric end-effect propagation. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES. 2019, 129: 744-749, http://dx.doi.org/10.1016/j.ijbiomac.2019.02.062.
[27] Zhang, Xiaoqian, Li, Kecheng, Xing, Ronge, Liu, Song, Chen, Xiaolin, Yang, Haoyue, Li, Pengcheng. miRNA and mRNA Expression Profiles Reveal Insight into Chitosan-Mediated Regulation of Plant Growth. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2018, 66(15): 3810-3822, https://www.webofscience.com/wos/woscc/full-record/WOS:000430642200009.
[28] Qin, Yukun, Liu, Weixiang, Xing, Ronge, Liu, Song, Li, Kecheng, Li, Pengcheng. Cyclization Reaction of Acyl Thiourea Chitosan: Enhanced Antifungal Properties via Structural Optimization. MOLECULES[J]. 2018, 23(3): https://doaj.org/article/942fbf0fe3aa48db98d05da4cceefd9a.
[29] Zong, Haiying, Li, Kecheng, Liu, Song, Song, Lin, Xing, Ronge, Chen, Xiaolin, Li, Pengcheng. Improvement in cadmium tolerance of edible rape (Brassica rapa L.) with exogenous application of chitooligosaccharide. CHEMOSPHERE[J]. 2017, 181: 92-100, http://ir.qdio.ac.cn/handle/337002/137087.
[30] Zhang, Xiaoqian, Li, Kecheng, Liu, Song, Zou, Ping, Xing, Ronge, Yu, Huahua, Chen, Xiaolin, Qin, Yukun, Li, Pengcheng. Relationship between the Degree of Polymerization of Chitooligomers and Their Activity Affecting the Growth of Wheat Seedlings under Salt Stress. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY[J]. 2017, 65(2): 501-509, https://www.webofscience.com/wos/woscc/full-record/WOS:000392458900028.
[31] Jin, Qiu, Yu, Huahua, Wang, Xueqin, Li, Kecheng, Li, Pengcheng. Effect of the molecular weight of water-soluble chitosan on its fat-/cholesterol-binding capacities and inhibitory activities to pancreatic lipase. PEERJ[J]. 2017, 5: http://ir.qdio.ac.cn/handle/337002/137049.
[32] Zong Haiying, Li Kecheng, Liu Song, Song Lin, Xing Ronge, Chen Xiaolin, Li Pengcheng. Improvement in cadmium tolerance of edible rape ( Brassica rapa L.) with exogenous application of chitooligosaccharide. CHEMOSPHERE[J]. 2017, [33] Zhang, Xiaoqian, Li, Kecheng, Xing, Ronge, Liu, Song, Li, Pengcheng. Metabolite Profiling of Wheat Seedlings Induced by Chitosan: Revelation of the Enhanced Carbon and Nitrogen Metabolism'. FRONTIERS IN PLANT SCIENCE[J]. 2017, 8: https://doaj.org/article/8b8df46229534629b034fe741090e9f8.
[34] Xing, Ronge, Liu, Yongliang, Li, Kecheng, Yu, Huahua, Liu, Song, Yang, Yue, Chen, Xiaolin, Li, Pengcheng. Monomer composition of chitooligosaccharides obtained by different degradation methods and their effects on immunomodulatory activities. CARBOHYDRATE POLYMERS[J]. 2017, 157: 1288-1297, http://dx.doi.org/10.1016/j.carbpol.2016.11.001.
[35] Li, Kecheng, Xing, Ronge, Liu, Song, Qin, Yukun, Li, Pengcheng. Access to N-Acetylated Chitohexaose with Well-Defined Degrees of Acetylation. BIOMED RESEARCH INTERNATIONAL[J]. 2017, 2017: http://ir.qdio.ac.cn/handle/337002/137099.
[36] Zhang, Enhui, Xing, Ronge, Liu, Song, Li, Kecheng, Qin, Yukun, Yu, Huahua, Li, Pengcheng. Comparison in docetaxel-loaded nanoparticles based on three different carboxymethyl chitosans. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES[J]. 2017, 101: 1012-1018, http://ir.qdio.ac.cn/handle/337002/137032.
[37] Xiaofei He, Kecheng Li, Ronge Xing, Song Liu, Linfeng Hu, Pengcheng Li. The production of fully deacetylated chitosan by compression method. EGYPTIAN JOURNAL OF AQUATIC RESEARCH[J]. 2016, 42(1): 75-81, http://dx.doi.org/10.1016/j.ejar.2015.09.003.
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（ 1 ） 单一乙酰度壳寡糖单体的构建及诱导植物抗盐研究, 主持, 国家级, 2015-01--2017-12
（ 2 ） 壳六糖抗肿瘤活性构效关系与机制研究, 主持, 省级, 2015-10--2018-09
（ 3 ） 海洋农用生物制剂-壳寡糖促进植物生长的碳氮代谢调控机制研究, 主持, 省级, 2017-01--2018-12
（ 4 ） 特医食品中氨基寡糖营养素标准品的规模制备与高效精准检测技术研究, 主持, 省级, 2019-01--2021-12
（ 5 ） 扇贝绿色加工与高值化利用技术集成与示范, 主持, 国家级, 2019-11--2022-12
（ 6 ） 壳聚糖链中复杂序列寡糖片段的分离纯化与核磁共振（NMR）结构解析, 主持, 国家级, 2020-01--2023-12

（1）Access to single chitosan oligosaccharides facilitates identification of key components responsible for biological activity   2019-10-21
（2）1H and 15N NMR Characterization of A Homogeneous Chitin Tetrasaccharide in Binary H2O/DMSO Solution   2018-08-27
（3）Preparation, analysis and biological activities of single chitooligosaccharides    2017-06-25
（4）Preparation and antioxidant activity of chitooligosaccharides composed of well-defined glucosamine and N-acetylglucosanmine units   2015-06-22