0703J1-纳米科学与技术
070302-分析化学

纳米探针与成像分析
同步辐射纳米生物分析方法

2007-09--2012-07   中国科学院高能物理研究所   理学博士
2003-09--2007-07   四川大学化学学院   理学学士

   

2023-04~现在, 国家纳米科学中心, 研究员
2018-06~2023-03,国家纳米科学中心, 副研究员
2015-07~2018-05,中国科学院高能物理研究所, 副研究员
2012-07~2015-06,中国科学院高能物理研究所, 助理研究员

   

（1） 高能所所长奖学金 优秀奖, 研究所（学校）, 2012

[1] 王亚玲, 陈春英, 赵宇亮, 鲁婧怡. 过渡金属氧化物纳米探针、制备方法及应用. CN: CN113416538A, 2021-09-21.

[2] 陈春英, 王亚玲, 陈曦, 赵宇亮. 四氧化三锰纳米颗粒制备方法及用途. CN: CN112933251A, 2021-06-11.

[3] 王亚玲, 陈春英, 赵宇亮. 金钆复合纳米探针、制备方法及应用. CN: CN112816513A, 2021-05-18.

[4] 陈春英, 王亚玲, 刘野, 郭梦雨, 陈曦, 胡栩豪, 赵宇亮. 一种锰纳米佐剂、其制备方法及用途. CN: CN112791181A, 2021-05-14.

[5] 王亚玲, 陈春英, 赵宇亮. 含铁纳米探针、制备方法及同步辐射用途. CN: CN112708415A, 2021-04-27.

[6] 陈春英, 鲁婧怡, 王亚玲. 一种钴基模拟酶及其制备方法和应用. CN: CN111921563A, 2020-11-13.

   

[1] Jiajia Meng, Yanyan Cui, Yaling Wang. Efficient luminescence emission in both visible and NIR-II regions by Er3+ partitioning doping and interfacial energy transfer. JOURNAL OF ALLOYS AND COMPOUNDS. 2023, 947: http://dx.doi.org/10.1016/j.jallcom.2023.169597.
[2] Ping Zhang, Yanyan Cui, Yaling Wang. Designing temporal- and spatial-control multifunctional nanoformulations for synergistic photodynamic–enhanced tumour immunotherapy. NANO TODAY. 2023, 49: http://dx.doi.org/10.1016/j.nantod.2023.101816.
[3] Chen, Xi, Gao, Susu, Wang, Xin, Guo, Mengyu, Cui, Yanyan, Chen, Ziwei, Liu, Ying, Wang, Yaling. Advances in the biological mechanism and application of manganese-based nanoformulations for enhanced immunotherapy. NANO TODAYnull. 2022, 46: http://dx.doi.org/10.1016/j.nantod.2022.101583.
[4] Zhang, Bin, Wang, Yadong, Xu, Chao, Wang, Yue, Wang, Xiaolin, Wang, Fuchao, Wang, Yaling, Yin, Hongzong. An integrated optical and chromogenic probe for tumor cell imaging. JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS[J]. 2022, 215: http://dx.doi.org/10.1016/j.jpba.2022.114766.
[5] Cao, Mingjing, Zhang, Kai, Zhang, Shuhan, Wang, Yaling, Chen, Chunying. Advanced Light Source Analytical Techniques for Exploring the Biological Behavior and Fate of Nanomedicines. ACS CENTRAL SCIENCE[J]. 2022, 8(8): http://dx.doi.org/10.1021/acscentsci.2c006801063.
[6] Meng, Jiajia, Cui, Yanyan, Wang, Yaling. Rare earth-doped nanocrystals for bioimaging in the near-infrared region. JOURNAL OF MATERIALS CHEMISTRY Bnull. 2022, 10(42): 8596-8615, [7] Zhang, Chunyu, Zhang, Kai, Cui, Yanyan, Guo, Yuecong, Wang, Chuan, Xu, Chao, Yao, Qingqiang, Zhao, Yuliang, Chen, Chunying, Wang, Yaling. Multifunctional Nanoprobe for 3D Nanoresolution Imaging of Intact Cell HER2 Protein with Hard X-ray Tomography. ANALYTICAL CHEMISTRY. 2022, [8] Cui, Yanyan, Chen, Xi, Cheng, Yan, Lu, Xinyi, Meng, Jiajia, Chen, Ziwei, Li, Mengke, Lin, Chengcheng, Wang, Yaling, Yang, Jian. CuWO4 Nanodots for NIR-Induced Photodynamic and Chemodynamic Synergistic Therapy. ACS APPLIED MATERIALS & INTERFACES[J]. 2021, 13(19): 22150-22158, http://dx.doi.org/10.1021/acsami.1c00970.
[9] Mao, Lichun, Chen, Ziwei, Wang, Yaling, Chen, Chunying. Design and application of nanoparticles as vaccine adjuvants against human corona virus infection. JOURNAL OF INORGANIC BIOCHEMISTRY[J]. 2021, 219: http://dx.doi.org/10.1016/j.jinorgbio.2021.111454.
[10] Zhang, Chunyu, Yao, Shengkun, Xu, Chao, Chang, Yanan, Zong, Yunbing, Zhang, Kai, Zhang, Xiangzhi, Zhang, Lijuan, Chen, Chunying, Zhao, Yuliang, Jiang, Huaidong, Gao, Xueyun, Wang, Yaling. 3D Imaging and Quantification of the Integrin at a Single-Cell Base on a Multisignal Nanoprobe and Synchrotron Radiation Soft X-ray Tomography Microscopy. ANALYTICAL CHEMISTRY[J]. 2021, 93(3): 1237-1241, https://www.webofscience.com/wos/woscc/full-record/WOS:000613922400005.
[11] Wang, Yaling, Xie, Yuping, Luo, Jia, Guo, Mengyu, Hu, Xuhao, Chen, Xi, Chen, Ziwei, Lu, Xinyi, Mao, Lichun, Zhang, Kai, Wei, Liangnian, Ma, Yunfei, Wang, Ruixin, Zhou, Jia, He, Chunyan, Zhang, Yufang, Zhang, Ye, Chen, Sisi, Shen, Lijuan, Chen, Yun, Qiu, Nasha, Liu, Ying, Cui, Yanyan, Liao, Guoyang, Liu, Ye, Chen, Chunying. Engineering a self-navigated MnARK nanovaccine for inducing potent protective immunity against novel coronavirus. NANO TODAY[J]. 2021, 38: 101139-101139, http://dx.doi.org/10.1016/j.nantod.2021.101139.
[12] Cui, Yanyan, Cheng, Yan, Jiang, Yurong, Yang, Jian, Wang, Yaling. One step approach for hybrid photocatalyst synthesis: Synergetic photocatalytic water pollutant degradation. JOURNAL OF ALLOYS AND COMPOUNDS[J]. 2020, 817: http://dx.doi.org/10.1016/j.jallcom.2019.152752.
[13] Wang, Yaling, Cai, Rong, Chen, Chunying. The Nano-Bio Interactions of Nanomedicines: Understanding the Biochemical Driving Forces and Redox Reactions. ACCOUNTS OF CHEMICAL RESEARCHnull. 2019, 52(6): 1507-1518, https://www.webofscience.com/wos/woscc/full-record/WOS:000472683000003.
[14] Cheng, Yan, Shah, Navid Hussain, Yang, Jian, Zhang, Kai, Cui, Yanyan, Wang, Yaling. Bi-Based Z-Scheme Nanomaterials for the Photocatalytic Degradation of Organic Dyes. ACS APPLIED NANO MATERIALS[J]. 2019, 2(10): 6418-6427, [15] Zhang, Yong, Zhang, Chunyu, Xu, Chao, Wang, Xiaolin, Liu, Chang, Waterhouse, Geoffrey I N, Wang, Yaling, Yin, Hongzong. Ultrasmall Au nanoclusters for biomedical and biosensing applications: A mini-review. TALANTAnull. 2019, 200: 432-442, http://dx.doi.org/10.1016/j.talanta.2019.03.068.
[16] 王亚玲. AuGd Integrated Nanoprobe for Optical/MRI/CT Triple-modal In Vivo Tumor Imaging.. Nanoscale. 2017, [17] 赵宇亮. Ultrasmall Superparamagnetic Iron Oxide Nanoparticle for T 2-Weighted Magnetic Resonance Imaging. ACS APPLIED MATERIALS & INTERFACES[J]. 2017, 9(34): 28959-28966, http://www.corc.org.cn/handle/1471x/2177044.
[18] Cui, Yanyan, Wang, Yaling, Zhao, Lina. Cysteine-Ag Cluster Hydrogel Confirmed by Experimental and Numerical Studies. SMALL[J]. 2015, 11(38): 5118-5125, http://ir.ihep.ac.cn/handle/311005/228768.
[19] 王亚玲. Facile Approach to Observe and Quantify The αIIbβ3 Integrin on a Single-cell.. Anal. Chem.. 2015, [20] Wang, Yaling, Cui, Yanyan, Liu, Ru, Gao, Fuping, Gao, Liang, Gao, Xueyun. Bio-inspired peptide-Au cluster applied for mercury (II) ions detection. SCIENCE CHINA-CHEMISTRY[J]. 2015, 58(5): 819-824, http://dx.doi.org/10.1007/s11426-015-5379-9.
[21] 王亚玲. Label-Free Au Cluster Used for in Vivo 2D and 3D Computed Tomography of Murine Kidneys.. Anal. Chem.. 2015, [22] Liu, Ru, Wang, Yaling, Yuan, Qing, An, Deyi, Li, Jingyuan, Gao, Xueyun. The Au clusters induce tumor cell apoptosis via specifically targeting thioredoxin reductase 1 (TrxR1) and suppressing its activity. CHEMICAL COMMUNICATIONS[J]. 2014, 50(73): 10687-10690, http://ir.ihep.ac.cn/handle/311005/224878.
[23] 赵宇亮. Blue two-photon fluorescence metal cluster probe precisely marking cell nuclei of two cell lines. CHEMICAL COMMUNICATIONS[J]. 2013, 49(91): 10724-10726, http://ir.ihep.ac.cn/handle/311005/224324.
[24] 赵宇亮. Bifunctional peptides that precisely biomineralize Au clusters and specifically stain cell nuclei. CHEMICAL COMMUNICATIONS[J]. 2012, 48(6): 871-873, http://ir.ihep.ac.cn/handle/311005/224074.
[25] 王亚玲. Serial Silver Clusters Bio-Mineralized By One Peptide. ACS Nano. 2012, [26] Yaling Wang, Chunying Chen. DNA nanostructure-enabled precise control over the intermembrane spacing between cells. SCIENCE BULLETIN. http://dx.doi.org/10.1016/j.scib.2023.04.005.

   

（ 1 ） 超顺磁-荧光双信号分子探针的构建及其用于乳腺癌分子标志物定量检测和乳腺癌组织成像研究, 负责人, 国家任务, 2014-01--2016-12
（ 2 ） 同步辐射X射线三维细胞成像研究肿瘤结构及标志分子表达水平, 负责人, 国家任务, 2016-01--2020-12
（ 3 ） 基于同步辐射技术开展单细胞整合素三维分布及定量分析研究, 负责人, 国家任务, 2017-01--2020-12
（ 4 ） 多尺度纳米材料与暴露模型开发及预测毒理研究方法, 负责人, 国家任务, 2020-01--2022-12
（ 5 ） 分子特异性 X 射线成像新型探针及原位标记技术, 负责人, 国家任务, 2022-12--2027-11
（ 6 ） QS-21 基纳米颗粒新佐剂的免疫保护增效机制与安全性研究, 负责人, 地方任务, 2022-12--2024-12