070302-分析化学

中药药效物质基础；中药先进制造工艺与二次开发；中药资源利用与大健康产品开发

2007-09--2013-03   中科院大连化学物理研究所   分析化学博士
2003-09--2007-07   浙江大学药学院   理学学士

   

2020-10~现在, 中科院大连化学物理研究所, 课题组长
2019-04~现在, 中科院大化所中国医药城生物医药创新研究院, 副院长
2016-09~2019-03,中科院大化所中国医药城生物医药创新研究院, 院长助理
2015-07~现在, 中科院大连化学物理研究所, 副研究员
2013-03~2015-07,中科院大连化学物理研究所, 助理研究员

   

[1] 梁鑫淼, 赵耀鹏, 刘艳芳, 王纪霞, 王长健, 王志伟, 杜娜娜, 张秀莉, 郭志谋, 王超然. 一种2-(2,2-二芳基乙基)-环胺衍生物或盐及合成和应用与组合物. CN: CN110372571A, 2019-10-25.

[2] 梁鑫淼, 张鹏宇, 张秀莉, 王纪霞, 刘艳芳, 王超然, 周维佳. β 2 -肾上腺素受体拮抗剂及应用. CN: CN109893651A, 2019-06-18.

[3] 梁鑫淼, 王超然, 郭秀洁, 张秀莉, 郭志谋, 薛兴亚. 一种延胡索提取物中叔胺碱和季铵碱的分类制备方法. CN: CN104415573A, 2015-03-18.

[4] 梁鑫淼, 王超然, 郭秀洁, 张秀莉, 郭志谋, 薛兴亚. 一种延胡索提取物中叔胺碱和季铵碱的分类制备方法. CN: CN104415573A, 2015-03-18.

[5] 梁鑫淼, 龙珍, 张秀莉, 王超然, 郭志谋. 一种强极性碱性化合物的分离分析或分离制备方法. CN: CN103878036A, 2014-06-25.

[6] 梁鑫淼, 王超然, 张秀莉, 张岩, 王志伟, 奥利维尔·希维利, 柯燕雄, 王藜恩. 小檗碱类化合物的用途和制备方法. CN: CN103816152A, 2014-05-28.

[7] 梁鑫淼, 龙珍, 张秀莉, 王超然, 郭志谋. 一种山莨菪中生物碱的前处理方法. CN: CN102850343A, 2013-01-02.

[8] 梁鑫淼, 郭志谋, 沈爱金, 王超然. 一种强阳离子交换色谱固定相及其制备方法. CN: CN102614845A, 2012-08-01.

   

（1） 基于超高效液相色谱-四极杆-静电场轨道阱高分辨质谱的刺五加注射液化学成分分析, Investigation of the chemical components of Ciwujia injection using ultra-high performance liquid chromatography-quadrupole-electrostatic field orbitrap high-resolution mass spectrometry, 色谱, 2023, 第 7 作者
（2） Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitrap HRMS, Comprehensive profiling and characterization of the absorbed components and metabolites in mice serum and tissues following oral administration of Qing-Fei-Pai-Du decoction by UHPLC-Q-Exactive-Orbitrap HRMS, CHINESE JOURNAL OF NATURAL MEDICINES, 2021, 第 7 作者
（3） 基于化学模式识别技术的枳实HPLC定量指纹图谱研究, An HPLC Fingerprint Research on Citrus aurantium Based on Chemical Pattern Recognition Technology, 分析测试学报, 2021, 第 5 作者
（4） A broad-spectrum substrate for the human UDP-glucuronosyltransferases and its use for investigating glucuronidation inhibitors, INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES, 2021, 第 6 作者
（5） Hydrophilic interaction liquid chromatography for removal of pesticide residues in ginseng extracts, CHINESE JOURNAL OF CHROMATOGRAPHY, 2021, 通讯作者
（6） Identification and target-pathway deconvolution of FFA4 agonists with anti-diabetic activity from Arnebia euchroma (Royle) Johnst, PHARMACOLOGICAL RESEARCH, 2021, 第 6 作者
（7） 亲水作用液相色谱脱除人参提取物中农药残留, Hydrophilic interaction liquid chromatography for removal of pesticide residues in ginseng extracts, 色谱, 2021, 第 6 作者
（8） Inhibition of drug-metabolizing enzymes by Qingfei Paidu decoction: Implication of herb-drug interactions in COVID-19 pharmacotherapy, FOOD AND CHEMICAL TOXICOLOGY, 2021, 第 4 作者
（9） Deciphering the metabolic fates of a green fluorescent protein (GFP)-like fluorophore: Metabolite identification, isoenzyme contribution and species differences, DYES AND PIGMENTS, 2020, 第 6 作者
（10） 人参中农药残留现状及脱除工艺研究, Research on Pesticide Residues in Ginseng and Pesticide Removal Methods, 广东化工, 2020, 第 5 作者
（11） 延胡索中叔胺碱和季铵碱类组分的高效分离及镇痛活性鉴定, Efficient liquid chromatography separation of tertiary and quaternary alkaloids from Rhizoma Corydalis and antagonistic activity test, 天然产物研究与开发, 2020, 第 2 作者
（12） 清肺排毒汤对大鼠整体代谢及肠道菌群的调节作用研究, Investigation of modulating effect of Qingfei Paidu Decoction on host metabolism and gut microbiome in rats, 中国中药杂志, 2020, 第 4 作者
（13） 基于化学模式识别的栀子UPLC定量指纹图谱研究, UPLC quantitative fingerprint research on Gardeniae Fructus based on chemical pattern recognition technology, 中国中药杂志, 2020, 第 7 作者
（14） 荷叶化学成分及其药理活性研究, Studies on the Chemical Constituents and Pharmacological Activities of LotusLeaves, 广东化工, 2020, 第 4 作者
（15） Purification of tertiary and quaternary alkaloids from Rhizoma Corydalis using reversed-phase/weak cation-exchange mixed-mode class separation combined with preparative C18 and silica based strong cation-exchange chromatography, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2019, 通讯作者
（16） 生物碱的高效液相色谱分离分析与纯化制备研究进展, Research Progress on High Performance Liquid Chromatography in Analysis and Preparation of Alkaloids, 分析测试学报, 2019, 第 3 作者
（17） 蛹虫草中抗肿瘤活性成分及作用机制研究进展, Research Progress on Anti-Tumor Active Ingredients and Anti-Tumor Mechanism of Cordyceps militaris, 食品与营养科学, 2019, 第 4 作者
（18） A Natural Product with High Affinity to Sigma and 5-HT7 Receptors as Novel Therapeutic Drug for Negative and Cognitive Symptoms of Schizophrenia, NEUROCHEMICAL RESEARCH, 2019, 第 3 作者
（19） Strong electrostatic repulsive interaction used for fast and effective alkaloid enrichment from plants, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2019, 第 8 作者
（20） Identification of Alkaloids from Corydalis yanhusuo W. T. Wang as Dopamine D-1 Receptor Antagonists by Using CRE-Luciferase Reporter Gene Assay, MOLECULES, 2018, 第 4 作者
（21） Discovery of novel antagonists on beta(2)-adrenoceptor from natural products using a label-free cell phenotypic assay, NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2018, 第 6 作者
（22） On-line comprehensive two-dimensional liquid chromatography tandem mass spectrometry for the analysis of Curcuma kwangsiensis, TALANTA, 2018, 第11作者
（23） Recent development in liquid chromatography stationary phases for separation of Traditional Chinese Medicine components, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2016, 第 6 作者
（24） Practical method for the definition of chromatographic peak parameters in preparative liquid chromatography, JOURNAL OF SEPARATION SCIENCE, 2016, 第 7 作者
（25） The Antinociceptive Properties of the Corydalis yanhusuo Extract, PLOS ONE, 2016, 第 7 作者
（26） Discovery of N—methyltetrahydroprotoberberines with κ—opioid receptor agonists—opioid receptor agonist activities from corydalis yanhusuo W.T.Wang by using two—dimensional liquid chromatography, JOURNAL OF ETHNOPHARMACOLOGY, 2015, 第 2 作者
（27） Purification of bufadienolides from the skin of Bufo bufo gargarizans Cantor with positively charged C18 column, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 第 3 作者
（28） Efficient purification of active bufadienolides by a class separation method based on hydrophilic solid-phase extraction and reversed-phase high performance liquid chromatography, JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2014, 第 4 作者
（29） A novel method for characterization and comparison of reversed-phase column selectivity, JOURNAL OF CHROMATOGRAPHY A, 2014, 第 2 作者
（30） GPCR-based drug discovery from Traditional Chinese Medicine, 2014 shanghai international conference on traditional chinese medicine and natural medicine, 2014, 第 3 作者
（31） A Novel Analgesic Isolated from a Traditional Chinese Medicine, CURRENT BIOLOGY, 2014, 第 2 作者
（32） Discovery of N-methyltetrahydroprotoberberines with kappa-opioid receptor agonists-opioid receptor agonist activities from corydalis yanhusuo W. T. Wang by using two-dimensional liquid chromatography, JOURNAL OF ETHNOPHARMACOLOGY, 2014, 第 2 作者
（33） Overloading study of basic compounds with a positively charged C18 column in liquid chromatography, JOURNAL OF CHROMATOGRAPHY A, 2013, 第 1 作者
（34） Efficient purification of high-purity compounds from the stem of Lonicera japonica Thunb using two-dimensional preparative chromatography, JOURNAL OF SEPARATION SCIENCE, 2013, 第 5 作者
（35） The herbalome-an attempt to globalize Chinese herbal medicine, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2012, 第 7 作者
（36） Natural products purification and drug discovery, THE 6TH SHANGHAI INTERNATIONAL SYMPOSIUM ON ANALYTICAL CHEMISTRY, 2012, 第 3 作者
（37） A non-aqueous solid phase extraction method for alkaloid enrichment and its application in the determination of hyoscyamine and scopolamine, ANALYST, 2012, 第 2 作者
（38） Strong cation exchange column allow for symmetrical peak shape and increased sample loading in the separation of basic compounds, JOURNALOFCHROMATOGRAPHYA, 2012, 第 2 作者
（39） High-performance purification of quaternary alkaloids from Corydalis yanhusuo W. T. Wang using a new polar-copolymerized stationary phase, JOURNAL OF SEPARATION SCIENCE, 2011, 第 1 作者
（40） Separation of structurally similar protoberberine alkaloids from Corydalis yanhusuo W.T.Wang in reversed-phase high-performance liquid chromatography with chaotropic salts, 37TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES　, 2011, 第 1 作者
（41） Application of matrix solid-phase dispersion methodology to the extraction of endogenous peptides from porcine hypothalamus samples for MS and LC-MS analysis, JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES, 2011, 第 2 作者
（42） Separation Materials Based on Polar-copolymerized Approach, 37TH INTERNATIONAL SYMPOSIUM ON HIGH PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 2 作者
（43） Application of matrix solid-phase dispersion methodology to the extraction of endogenous peptides from porcine hypothalamus samples for MS and LC–MS analysis, JOURNAL OF CHROMATOGRAPHY B, 2011, 第 2 作者
（44） Development and validation of a solid phase extraction method for the enrichment of alkaloids enabling the preparation of alkaloids from Scopolia tangutica Maxim, 37TH INTERNATIONAL SYMPOSIUM ON HIGH-PERFORMANCE LIQUID PHASE SEPARATIONS AND RELATED TECHNIQUES, 2011, 第 2 作者
（45） 离线二维液相色谱-串联质谱法检测姜黄中姜黄素类和倍半萜类化合物, Separation and characterization of curcuminoids and sesquiterpenes from C.longa L.by using 2D-LC-MS, 中国科学：化学, 2010, 第 4 作者
（46） Purification of polar compounds from Radix isatidis using conventional C18 column coupled with polar-copolymerized C18 column, JOURNAL OF SEPARATION SCIENCE, 2010, 第 4 作者
（47） Polar-copolymerized approach based on horizontal polymerization on silica surface for preparation of polar-modified stationary phases, JOURNAL OF CHROMATOGRAPHY A, 2010, 第 2 作者
（48） 离线二维液相色谱-质谱分离鉴定板蓝根中的微量化合物, Identification and Characterization of the low-abundant constituents of Radix isatidis by off-line 2D-LC coupled with Q-TOF MS, 24th international symposium on microscale bioseparations, 2009, 第 5 作者
（49） 中药物质基础的高效液相色谱分离分析方法研究, The study of high-performance liquid chromatography methods for the separation and analysis of traditional chinese medicines, 中国科学：B辑, 2009, 第 5 作者
（50） 基于表面水平聚合的极性/非极性共聚固定相制备, One-step process for preparation of polar/non-polar copolymerized stationary phases by using surface horizontal polymerization, 24th international symposium on microscale bioseparations, 2009, 第 5 作者
（51） 中药物质基础的高效液相色谱分离分析方法研究, 中国科学 B, 2009, 第 5 作者
（52） 离线二维液相色谱-质谱分离鉴定板蓝根中的微量化合物, Identification and Characterization of the low-abundant constituents of Radix isatidis by off-line 2D-LC coupled with Q-TOF MS, 24th international symposium on microscale bioseparations, 2009, 第 5 作者
（53） 基于表面水平聚合的极性/非极性共聚固定相制备, One-step process for preparation of polar/non-polar copolymerized stationary phases by using surface horizontal polymerization, 24th international symposium on microscale bioseparations, 2009, 第 5 作者

   

（ 1 ） 基于表面正电荷型反相固定相的碱性化合物色谱分离研究, 负责人, 国家任务, 2015-01--2017-12