基本信息
刘祥军  男  硕导  中国科学院化学研究所
email: xjliu@iccas.ac.cn
address: 北京市海淀区中关村北一街2号
postalCode: 100190

招生信息

   
招生专业
070302-分析化学
招生方向
分子探针,分子识别材料
分离材料

教育背景

2002-09--2007-06   中国科学院化学研究所   博士
1996-09--2000-07   西安交通大学   学士

工作经历

   
工作简历
2009-12~现在, 中国科学院化学研究所, 副研究员
2007-07~2009-12,中国科学院化学研究所, 助理研究员
2002-09~2007-06,中国科学院化学研究所, 博士
1996-09~2000-07,西安交通大学, 学士

教授课程

分析化学实验-仪器分析
分析化学实验(基础化学实验II)
基础化学实验II(分析化学实验)

专利与奖励

   
奖励信息
(1) 中国分析测试协会科学技术奖(CAIA奖), 二等奖, 国家级, 2017

出版信息

   
发表论文
(1) Immunomodulatory Effects of Lycium barbarum Polysaccharide Extract and Its Uptake Behaviors at the Cellular Level, Molecules, 2020, 第 7 作者
(2) FnCas12a/crRNA Assisted Dumbbell-PCR Detection of IsomiRs with Terminal and Inner Sequence Variants, Chem. Commun., 2020, 第 4 作者
(3) Detection of Circulating Tumor-Related Materials by Aptamer Capturing and Endogenous Enzyme-Signal Amplification, Anal. Chem., 2020, 第 6 作者
(4) Thiazole Orange Styryl Derivatives as Fluorescent Probes for G-quadruplex DNA, ACS Appl. Bio Mater., 2020, 通讯作者
(5) Ratiometric detection and imaging of hydrogen sulfide in mitochondria based on a cyanine/naphthalimide hybrid fluorescent probe, Analyst, 2020, 通讯作者
(6) Prion Protein Targeted by a Prostate Cancer Cell Binding Aptamer, a Potential Tumor Marker?, ACS Appl. Bio Mater., 2020, 第 4 作者
(7) Mitochondria-Targeted Ratiometric Fluorescent pH Probe, ACS Appl. Bio Mater., 2019, 第 1 作者
(8) Dual-Monitoring Glycosylation and Local pH in Live Cells by Metabolic Oligosaccharide Engineering with a Ratiometric Fluorescent Tag, Anal. Chem., 2019, 第 6 作者
(9) A Nucleus-Targeting DNA Aptamer for Dead Cell Indication, ACS Sens., 2019, 第 6 作者
(10) The Mechanism of the Selective Antiproliferation Effect of Guanine-Based Biomolecules and Its Compensation, ACS Chem. Biol., 2019, 第 6 作者
(11) Comparative Study of the Chemical Constituents and Bioactivities of the Extracts from Fruits, Leaves and Root Barks of Lycium barbarum, Molecules, 2019, 第 5 作者
(12) Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers, Advanced Science, 2019, 第 5 作者
(13) In vitro selection of DNA aptamers recognizing drug-resistant ovarian cancer by cell-SELEX, Talanta, 2019, 第 9 作者
(14) Oxidative degradation of polyamines by serum supplement causes cytotoxicity on cultured cells, Scientific Reports, 2018, 第 6 作者
(15) Flow Cytometric Bead Sandwich Assay Based on a Split Aptamer, ACS Appl. Mater. Interfaces, 2018, 第 3 作者
(16) Thiazole orange modified carbon dots for ratiometric fluorescence detection of G-quadruplex and double-stranded DNA, ACS Appl. Mater. Interfaces, 2018, 通讯作者
(17) Microbead-Based Platform for Multiplex Detection of DNA and Protein, ACS Appl. Mater. Interfaces, 2017, 第 1 作者
(18) Quinacridone derivative as a new photosensitizer: photodynamic effects in cells and in vivo, Dyes and Pigments, 2017, 第 4 作者
(19) Development of squaraine based G-quadruplex ligands using click chemistry, Scientific Reports, 2017, 第 4 作者
(20) Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo, EBioMedicine, 2017, 第 5 作者
(21) Detection of G-quadruplex structures formed by G-rich sequences from rice genome and transcriptome using combined probes, Anal. Chem., 2017, 第 6 作者
(22) Triplex-quadruplex structural scaffold: a new binding structure of aptamer, Scientific Reports, 2017, 第 5 作者
(23) A Cyanine Dye to Probe Mitophagy: Simultaneous Detection of Mitochondria and Autolysosomes in Live Cells, J. Am. Chem. Soc., 2016, 第 5 作者
(24) Intercellular Connections Related to Cell–Cell Crosstalk Specifically Recognized by an Aptamer, Angew. Chem., Int. Ed., 2016, 第 6 作者
(25) Activity Enhancement of G-Quadruplex/Hemin DNAzyme by Flanking d(CCC), Chem. Eur. J., 2016, 第 4 作者
(26) Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes, Dyes and Pigments, 2016, 第 5 作者
(27) Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides, Chem. Sci., 2015, 第 3 作者
(28) Ratiometric fluorescent silver nanoclusters for the determination of mercury and copper ions, Anal. Methods, 2015, 第 1 作者
(29) Activity enhancement of G-quadruplex/hemin DNAzyme by spermine, RSC Adv., 2014, 第 4 作者
(30) Fluorescence Light-Up Probe for Parallel G-Quadruplexes, Anal. Chem., 2014, 第 4 作者
(31) Dicyanomethylene-Functionalized Squaraine as a Highly Selective Probe for Parallel G-Quadruplexes, Anal. Chem., 2014, 第 4 作者
(32) Dual-Emission Silica Nanoparticles as a Ratiometric Nanosensor for Cu2+, Anal. Chem., 2014, 第 1 作者
(33) A guanidine derivative of naphthalimide with excited-state deprotonation coupled intramolecular charge transfer properties and its application, J. Mater. Chem. C, 2013, 第 4 作者
(34) One-step real time RT-PCR for detection of microRNAs, Talanta, 2013, 第 4 作者
(35) A pH sensitive ratiometric fluorophore and its application for cellular pH measurement, J. Mater. Chem. B, 2013, 第 4 作者
(36) A turn-on fluorescent sensor for zinc and cadmium ion based on perylene tetracarboxylic diimide, Analyst, 2013, 第 1 作者
(37) Selective isolation of G-quadruplexes by affinity chromatography, J. Chromatogr. A, 2012, 第 2 作者
(38) Visual Detection of Hg2+ with High Selectivity Using Thymine Modified Gold Nanoparticles, Anal. Sci., 2010, 第 1 作者
(39) Specific mercury(II) adsorption by thymine based sorbent, Talanta, 2009, 第 1 作者
(40) Highly Selective Phthalocyanine-Thymine Conjugate Sensor for Hg2+ Based on Target Induced Aggregation, Anal. Chem., 2009, 第 1 作者
(41) Determination of methotrexate in human serum by high-performance liquid chromatography combined with pseudo template molecularly imprinted polymer, J. Chromatogr. A, 2009, 第 1 作者
(42) Molecularly Imprinted Polymer for Metsulfuron-Methyl by One-step Swelling and Polymerization Method, Talanta, 2007, 第 1 作者
(43) 三甲氧苄啶分子印迹整体柱的制备及色谱性能, 高等学校化学学报, 2007, 第 1 作者
(44) Molecularly Imprinted Polymer for Sulfamethoxazole and Molecular Recognition Properties in Aqueous Mobile Phase, Anal. Chim. Acta, 2006, 第 1 作者

科研活动

   
科研项目
( 1 ) 核酸适配体功能化的磁性核壳纳米材料的制备及应用研究, 主持, 国家级, 2013-01--2016-12
( 2 ) 重大疾病蛋白质标志物发现的新方法研究, 参与, 国家级, 2011-01--2015-12