基本信息
刘祥军  男  硕导  中国科学院化学研究所
电子邮件: xjliu@iccas.ac.cn
通信地址: 北京市海淀区中关村北一街2号
邮政编码: 100190

招生信息

   
招生专业
070302-分析化学
招生方向
分子探针,分子识别材料
分离材料

教育背景

2002-09--2007-06   中国科学院化学研究所   博士
1996-09--2000-07   西安交通大学   学士

工作经历

   
工作简历
2009-12~现在, 中国科学院化学研究所, 副研究员
2007-07~2009-12,中国科学院化学研究所, 助理研究员
2002-09~2007-06,中国科学院化学研究所, 博士
1996-09~2000-07,西安交通大学, 学士

教授课程

分析化学实验-仪器分析
分析化学实验(基础化学实验II)
基础化学实验II(分析化学实验)

专利与奖励

   
奖励信息
(1) 中国分析测试协会科学技术奖(CAIA奖), 二等奖, 国家级, 2017
专利成果
( 1 ) 靶标为碱性磷酸酶异源二聚体的核酸适体及其衍生物和应用, 2022, 第 4 作者, 专利号: CN115058429A

( 2 ) 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途, 2022, 第 2 作者, 专利号: CN114436960A

( 3 ) 一种用于靶向治疗的光活性核酸适体偶联药物及其制备方法与用途, 2022, 第 2 作者, 专利号: CN114436960A

( 4 ) 一种基于萘酰亚胺-吲哚衍生物的细胞内质网荧光探针及其应用, 2021, 第 4 作者, 专利号: CN112010838B

( 5 ) 一种基于苯并噻唑联杂环的半花菁类化合物及其制备方法与应用, 2021, 第 5 作者, 专利号: CN111217806B

( 6 ) 一种核酸适体识别并结合CD171及其相关功能的应用研究, 2019, 第 4 作者, 专利号: CN109913462A

( 7 ) 基于核酸适配体的肿瘤检测方法及试剂盒, 2019, 第 6 作者, 专利号: CN109682973A

( 8 ) 核酸适配体在识别并结合碱性磷酸酶异源二聚体中的应用, 2019, 第 5 作者, 专利号: CN109554369A

( 9 ) 方酸染料类化合物、制备方法及用途, 2018, 第 3 作者, 专利号: CN108070275A

( 10 ) 一种识别并结合人转铁蛋白受体的核酸适体序列及其应用, 2016, 第 4 作者, 专利号: CN106191069A

( 11 ) HQO作为监测活细胞中线粒体自噬过程荧光探针的应用, 2016, 第 5 作者, 专利号: CN105838354A

( 12 ) 核酸适配体在识别并结合L选择素中的应用, 2015, 第 4 作者, 专利号: CN105044322A

( 13 ) 核酸适配体在识别并结合整合素α4中的应用, 2015, 第 4 作者, 专利号: CN104988154A

( 14 ) 2,9-双苯乙烯取代的邻菲罗啉类化合物及其制备方法与应用, 2015, 第 2 作者, 专利号: CN104693199A

( 15 ) N,N-二戊烷取代的喹吖啶酮类化合物及其制备方法与应用, 2015, 第 3 作者, 专利号: CN104650080A

( 16 ) 一种识别耐阿霉素乳腺癌细胞的核酸适体及其筛选方法和应用, 2015, 第 4 作者, 专利号: CN104498500A

( 17 ) 二苯并咪唑联咔唑类化合物在用于特异性结合核酸G-四链体结构及在抗肿瘤药物中的应用, 2014, 第 3 作者, 专利号: CN103728294A

( 18 ) 特异性识别玉米素的核酸适体及其筛选方法和应用, 2012, 第 3 作者, 专利号: CN102732523A

( 19 ) 识别含对硝基苯磺酰胺基的化合物的核酸适体及其应用, 2012, 第 3 作者, 专利号: CN102618546A

( 20 ) 并杂环萘酰亚胺及其制备方法与应用, 2012, 第 3 作者, 专利号: CN102344449A

( 21 ) 胸腺嘧啶作为特异性汞离子吸附剂的应用, 2008, 第 2 作者, 专利号: CN101306350A

出版信息

   
发表论文
(1) A mitochondria-targeted fluorescent probe for imaging of endogenous carbon monoxide in living cells, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2023, 通讯作者
(2) Generation of an Aptamer Targeting Receptor-Type Tyrosine-Protein Phosphatase F, ANALYTICAL CHEMISTRY, 2023, 第 7 作者
(3) Structural Optimization and Interaction Study of a DNA Aptamer to L1 Cell Adhesion Molecule, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 第 7 作者
(4) A mitochondria-targeted near-infrared fluorescent probe for detection and imaging of HSO3- in living cells, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2022, 通讯作者
(5) p-Aminostyryl thiazole orange derivatives for monitoring mitochondrial viscosity in live cells, SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY, 2022, 通讯作者
(6) A photo-activated aptamer-drug conjugate for targeted drug delivery, Chemical Communications, 2022, 通讯作者
(7) 基于碳量子点的新型介孔纳米荧光探针的合成及用于铜离子的检测, Carbon Quantum Dots-based Mesoporous Nanomaterials for Detection of Copper Ion, 分析化学, 2022, 通讯作者
(8) Aptamer-Based Cell Nucleus Imaging via Expansion Microscopy, ANALYTICAL CHEMISTRY, 2022, 第 6 作者
(9) Aptamer-Based Cell Nucleus Imaging via Expansion Microscopy br, ANALYTICAL CHEMISTRY, 2022, 第 6 作者
(10) Transferrin receptor-mediated internalization and intracellular fate of conjugates of a DNA aptamer, MOLECULAR THERAPY-NUCLEIC ACIDS, 2022, 第 4 作者
(11) A DNA Aptameric Ligand of Human Transferrin Receptor Generated by Cell-SELEX, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 第 5 作者
(12) A 4-aminonaphthalimide-based fluorescent traceable prodrug with excellent photoinduced cytotoxicity, CHEMICAL COMMUNICATIONS, 2021, 通讯作者
(13) FnCas12a/crRNA assisted dumbbell-PCR detection of IsomiRs with terminal and inner sequence variants, CHEMICAL COMMUNICATIONS, 2020, 第 4 作者
(14) Thiazole Orange Styryl Derivatives as Fluorescent Probes for G-Quadruplex DNA, ACS APPLIED BIO MATERIALS, 2020, 通讯作者
(15) Prion Protein Targeted by a Prostate Cancer Cell Binding Aptamer, a Potential Tumor Marker?, ACS APPLIED BIO MATERIALS, 2020, 第 4 作者
(16) Detection of Circulating Tumor-Related Materials by Aptamer Capturing and Endogenous Enzyme-Signal Amplification, ANALYTICAL CHEMISTRY, 2020, 第 6 作者
(17) Immunomodulatory Effects of Lycium barbarum Polysaccharide Extract and Its Uptake Behaviors at the Cellular Level, MOLECULES, 2020, 第 7 作者
(18) Ratiometric detection and imaging of hydrogen sulfide in mitochondria based on a cyanine/naphthalimide hybrid fluorescent probe, ANALYST, 2020, 通讯作者
(19) A Mitochondria-Targeted Ratiometric Fluorescent pH Probe, ACSAPPLIEDBIOMATERIALS, 2019, 通讯作者
(20) A Nucleus-Targeting DNA Aptamer for Dead Cell Indication, ACS SENSORS, 2019, 第 6 作者
(21) In vitro selection of DNA aptamers recognizing drug-resistant ovarian cancer by cell-SELEX, TALANTA, 2019, 第 9 作者
(22) Aptameric Probe Specifically Binding Protein Heterodimer Rather Than Monomers, ADVANCED SCIENCE, 2019, 第 5 作者
(23) Comparative Study of the Chemical Constituents and Bioactivities of the Extracts from Fruits, Leaves and Root Barks of Lycium barbarum, MOLECULES, 2019, 第 5 作者
(24) Dual-Monitoring Glycosylation and Local pH in Live Cells by Metabolic Oligosaccharide Engineering with a Ratiometric Fluorescent Tag, ANALYTICAL CHEMISTRY, 2019, 第 6 作者
(25) The Mechanism of the Selective Antiproliferation Effect of Guanine-Based Biomolecules and Its Compensation, ACS CHEMICAL BIOLOGY, 2019, 第 6 作者
(26) Comparative Study of the Chemical Constituents and Bioactivities of the Extracts from Fruits, Leaves and Root Barks of Lycium barbarum, MOLECULES, 2019, 第 5 作者
(27) Flow Cytometric Bead Sandwich Assay Based on a Split Aptamer, ACS APPLIED MATERIALS & INTERFACES, 2018, 第 3 作者
(28) Oxidative degradation of polyamines by serum supplement causes cytotoxicity on cultured cells, SCIENTIFIC REPORTS, 2018, 第 6 作者
(29) Thiazole Orange-Modified Carbon Dots for Ratiometric Fluorescence Detection of G-Quadruplex and Double-Stranded DNA, ACS APPLIED MATERIALS & INTERFACES, 2018, 通讯作者
(30) Imaging of Neurite Network with an Anti-L1CAM Aptamer Generated by Neurite-SELEX, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2018, 第 6 作者
(31) Triplex-quadruplex structural scaffold: a new binding structure of aptamer, SCIENTIFIC REPORTS, 2017, 第 5 作者
(32) Development of squaraine based G-quadruplex ligands using click chemistry, SCIENTIFIC REPORTS, 2017, 第 4 作者
(33) Microbead-Based Platform for Multiplex Detection of DNA and Protein, ACS APPLIED MATERIALS & INTERFACES, 2017, 通讯作者
(34) Detection of G-Quadruplex Structures Formed by G-Rich Sequences from Rice Genome and Transcriptome Using Combined Probes, ANALYTICAL CHEMISTRY, 2017, 第 6 作者
(35) Quinacridone derivative as a new photosensitizer: Photodynamic effects in cells and in vivo, DYES AND PIGMENTS, 2017, 第 4 作者
(36) Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo, EBIOMEDICINE, 2017, 第 5 作者
(37) Dicyanomethylene Substituted Benzothiazole Squaraines: The Efficiency of Photodynamic Therapy In Vitro and In Vivo, EBIOMEDICINE, 2017, 第 5 作者
(38) Interaction of hypericin with guanine-rich DNA: Preferential binding to parallel G-Quadruplexes, DYES AND PIGMENTS, 2016, 第 5 作者
(39) Intercellular Connections Related to Cell-Cell Crosstalk Specifically Recognized by an Aptamer, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2016, 第 6 作者
(40) Activity Enhancement of G-Quadruplex/Hemin DNAzyme by Flanking d(CCC), CHEMISTRY-A EUROPEAN JOURNAL, 2016, 第 4 作者
(41) A Cyanine Dye to Probe Mitophagy: Simultaneous Detection of Mitochondria and Autolysosomes in Live Cells, JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2016, 第 5 作者
(42) 基于新铜试剂的Cu~(2+)荧光探针的合成及性能研究, Synthesis and Properties Study of a Neocuproine Based Fluorescent Sensor for Cu~(2+), 分析科学学报, 2016, 第 7 作者
(43) Ratiometric fluorescent silver nanoclusters for the determination of mercury and copper ions, ANALYTICAL METHODS, 2015, 通讯作者
(44) DNA interaction, cellular localization and cytotoxicity of quinacridone derivatives, DYES AND PIGMENTS, 2015, 第 7 作者
(45) Cytotoxicity of guanine-based degradation products contributes to the antiproliferative activity of guanine-rich oligonucleotides, CHEMICAL SCIENCE, 2015, 第 3 作者
(46) Interaction of bisbenzimidazole-substituted carbazole derivatives with G-quadruplexes and living cells, RSC ADVANCES, 2015, 第 6 作者
(47) Visible-light-induced cleavage of 4-alpha-amino acid substituted naphthalimides and its application in DNA photocleavage, ORGANIC & BIOMOLECULAR CHEMISTRY, 2015, 第 6 作者
(48) Ratiometric fluorescent silver nanoclusters for the determination of mercury and copper ions, ROYAL SOCIETY OF CHEMISTRY, 2015, 第 4 作者
(49) 一种不对称菁染料及其与不同结构DNA的相互作用, New Monomethine Cyanine Dye and Its Interaction with Different DNA Forms, 高等学校化学学报, 2014, 第 5 作者
(50) Exact tailoring of an ATP controlled streptavidin binding aptamer, RSC ADVANCES, 2014, 第 5 作者
(51) Activity enhancement of G-quadruplex/hemin DNAzyme by spermine, RSC ADVANCES, 2014, 第 4 作者
(52) Carbon Dots Based Dual-Emission Silica Nanoparticles as a Ratiometric Nanosensor for Cu2+, ANALYTICAL CHEMISTRY, 2014, 第 1 作者
(53) Well-defined nanostructured surface-imprinted polymers for highly selective magnetic separation of fluoroquinolones in human urine, ACS APPLIED MATERIALS & INTERFACES, 2014, 第 4 作者
(54) Dicyanomethylene-Functionalized Squaraine as a Highly Selective Probe for Parallel G-Quadruplexes, ANALYTICAL CHEMISTRY, 2014, 第 4 作者
(55) New Monomethine Cyanine Dye and Its Interaction with Different DNA Forms, CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2014, 第 5 作者
(56) Effects of side chains on DNA binding, cell permeability, nuclear localization and cytotoxicity of 4-aminonaphthalimides, ORGANIC & BIOMOLECULAR CHEMISTRY, 2014, 第 5 作者
(57) Fluorescence Light-Up Probe for Parallel G-Quadruplexes, ANALYTICAL CHEMISTRY, 2014, 第 4 作者
(58) A turn-on fluorescent sensor for zinc and cadmium ions based on perylene tetracarboxylic diimide, ANALYST, 2013, 第 1 作者
(59) G-quadruplex DNA aptamers for zeatin recognizing, BIOSENSORS & BIOELECTRONICS, 2013, 第 5 作者
(60) A guanidine derivative of naphthalimide with excited-state deprotonation coupled intramolecular charge transfer properties and its application, JOURNAL OF MATERIALS CHEMISTRY C, 2013, 第 4 作者
(61) A turn-on fluorescent sensor for zinc and cadmium ion based on perylene tetracarboxylic diimide, Analyst, 2013, 第 1 作者
(62) Rational design of Hg2+ controlled streptavidin-binding aptamer, CHEMICAL COMMUNICATIONS, 2013, 第 5 作者
(63) A pH sensitive ratiometric fluorophore and its application for cellular pH measurement, J. Mater. Chem. B, 2013, 第 1 作者
(64) A pH sensitive ratiometric fluorophore and its application for monitoring the intracellular and extracellular pHs simultaneously, JOURNAL OF MATERIALS CHEMISTRY B, 2013, 第 4 作者
(65) One-step real time RT-PCR for detection of microRNAs, TALANTA, 2013, 第 4 作者
(66) Selective isolation of G-quadruplexes by affinity chromatography, J CHROMATOGR A, 2012, 第 2 作者
(67) Specific interactions between adenosine and streptavidin/avidin, BIOORG. MED. CHEM.LETT., 2012, 第 5 作者
(68) Selective isolation of G-quadruplexes by affinity chromatography, JOURNAL OF CHROMATOGRAPHY A, 2012, 第 2 作者
(69) Functional-Group Specific Aptamers Indirectly Recognizing Compounds with Alkyl Amino Group, ANALYTICAL CHEMISTRY, 2012, 第 6 作者
(70) Specific interactions between adenosine and streptavidin/avidin, BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2012, 第 5 作者
(71) G-quadruplex DNA Aptamers Generated for Systemin, BIOORG. MED. CHEM., 2011, 第 5 作者
(72) Mercury(II)-mediated formation of imide-Hg-imide complexes, DALTON TRANSACTIONS, 2011, 第 3 作者
(73) A novel polychloromethylstyrene coated superparamagnetic surface molecularly imprinted core-shell nanoparticle for bisphenol A, JOURNAL OF MATERIALS CHEMISTRY, 2011, 第 6 作者
(74) Mercury(II)-mediated formation of imide-Hg-imide complexes, DALTON TRANS., 2011, 第 3 作者
(75) G-quadruplex DNA aptamers generated for systemin, BIOORGANIC & MEDICINAL CHEMISTRY, 2011, 第 5 作者
(76) Visual Detection of Hg2+ with High Selectivity Using Thymine Modified Gold Nanoparticles, ANAL. SCI., 2010, 第 1 作者
(77) Bifunctional combined aptamer for simultaneous separation and detection of thrombin, BIOSENSORS & BIOELECTRONICS, 2010, 第 2 作者
(78) Bifunctional Combined Aptamer for Simultaneous Separation and Detection of Thrombin, BIOSENS. BIOELECTRON., 2010, 第 2 作者
(79) Visual Detection of Hg2+ with High Selectivity Using Thymine Modified Gold Nanoparticles, ANALYTICAL SCIENCES, 2010, 第 1 作者
(80) Highly Selective Phthalocyanine-Thymine Conjugate Sensor for Hg2+ Based on Target Induced Aggregation, ANALYTICAL CHEMISTRY, 2009, 第 1 作者
(81) General peroxidase activity of g-quadruplex-hemin complexes and its application in ligand screening, BIOCHEMISTRY, 2009, 第 2 作者
(82) Specific dna g-quadruplexes bind to ethanolamines, BIOPOLYMERS, 2009, 第 2 作者
(83) Specific mercury(II) adsorption by thymine-based sorbent, TALANTA, 2009, 第 1 作者
(84) Determination of methotrexate in human serum by high-performance liquid chromatography combined with pseudo template molecularly imprinted polymer, JOURNAL OF CHROMATOGRAPHY A, 2009, 第 1 作者
(85) Determination of methotrexate in human serum by high-performance liquid chromatography combined with pseudo template molecularly iniprinted polymer, JOURNAL OF CHROMATOGRAPHY A, 2009, 第 1 作者
(86) 拟模板分子印迹聚合物的制备与应用研究, 分析化学, 2009, 第 2 作者
(87) A label-free fluorescence sensor for probing the interaction of oligonucleotides with target molecules, ANALYTICA CHIMICA ACTA, 2009, 第 3 作者
(88) Uniform-sized molecularly imprinted polymer for metsulfuron-methyl by one-step swelling and polymerization method, TALANTA, 2007, 第 1 作者
(89) Preparation of molecularly imprinted monolith for trimethoprim molecule and its chromatographic property, CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE, 2007, 第 1 作者
(90) 三甲氧基苄啶分子印迹整体柱的制备及色谱性能, Preparation of Molecularly Imprinted Monolith for Trimethoprim Molecule and Its Chromatographic Property, 高等学校化学学报, 2007, 第 4 作者
(91) Monolithic molecularly imprinted polymer for sulfamethoxazole and molecular recognition properties in aqueous mobile phase, ANALYTICA CHIMICA ACTA, 2006, 第 1 作者

科研活动

   
科研项目
( 1 ) 核酸适配体功能化的磁性核壳纳米材料的制备及应用研究, 负责人, 国家任务, 2013-01--2016-12
( 2 ) 重大疾病蛋白质标志物发现的新方法研究, 参与, 国家任务, 2011-01--2015-12