071005-微生物学

黄病毒，肠道病毒，抗病毒药物

2001-09--华中科技大学   博士学位
1998-09--华中科技大学   硕士学位
1994-09--山东大学   本科学位

   

2012-05~现在, 中国科学院武汉病毒研究所, 副研究员
2001-09~现在, 华中科技大学, 博士学位
1998-09~现在, 华中科技大学, 硕士学位
1994-09~现在, 山东大学, 本科学位

   

（ 1 ） 一种缺失衣壳蛋白基因的基孔肯雅病毒感染性克隆及构建方法和在制备减毒疫苗中的应用, 2019, 第 8 作者, 专利号: CN109536464A

（ 2 ） 一种带有绿色荧光蛋白基因的CA16感染性克隆及构建方法和应用, 2014, 第 7 作者, 专利号: CN103805634A

（ 3 ） 一种带有荧光素酶基因的JEV感染性克隆及构建方法和应用, 2014, 第 8 作者, 专利号: CN103497972A

   

（1） An alphavirus replicon particle delivering prefusion-stabilized spike protein provides potent immunoprotection against SARS-CoV-2 Omicron variant, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2023, 第11作者
（2） A safe replication-defective Zika virus vaccine protects mice from viral infection and vertical transmission, ANTIVIRAL RESEARCH, 2023, 第 6 作者
（3） Attenuated WNV-poly(A) exerts a broad-spectrum oncolytic effect by selective virus replication and CD8+ T cell-dependent immune response, BIOMEDICINE & PHARMACOTHERAPY, 2023, 通讯作者
（4） Berbamine hydrochloride potently inhibits SARS-CoV-2 infection by blocking S protein-mediated membrane fusion, PLOS NEGLECTED TROPICAL DISEASES, 2022, 通讯作者
（5） High-Titer Self-Propagating Capsidless Chikungunya Virus Generated in Vero Cells as a Strategy for Alphavirus Vaccine Development, JOURNAL OF VIROLOGY, 2022, 通讯作者
（6） A new screening system for entry inhibitors based on cell-to-cell transmitted syncytia formation mediated by self-propagating hybrid VEEV-SARS-CoV-2 replicon, EMERGING MICROBES & INFECTIONS, 2022, 通讯作者
（7） Sequence duplication in 3 ' UTR modulates virus replication and virulence of Japanese encephalitis virus, EMERGING MICROBES & INFECTIONS, 2022, 通讯作者
（8） Increased morbidity of obese mice infected with mouse-adapted SARS-CoV-2, CELL DISCOVERY, 2021, 通讯作者
（9） Rational design of West Nile virus vaccine through large replacement of 3 ' UTR with internal poly(A), EMBO MOLECULAR MEDICINE, 2021, 通讯作者
（10） In Vitro Inhibition of Alphaviruses by Lycorine, In Vitro Inhibition of Alphaviruses by Lycorine, VIROLOGICA SINICA, 2021, 通讯作者
（11） Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice, Intranasal delivery of replicating mRNA encoding neutralizing antibody against SARS-CoV-2 infection in mice, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2021, 通讯作者
（12） Development and Characterization of SYBR Green I Based RT-PCR Assay for Detection of Omsk Hemorrhagic Fever Virus, Development and Characterization of SYBR Green I Based RT-PCR Assay for Detection of Omsk Hemorrhagic Fever Virus, VIROLOGICA SINICA, 2021, 通讯作者
（13） SARS-CoV-2 replicon for high-throughput antiviral screening, JOURNAL OF GENERAL VIROLOGY, 2021, 通讯作者
（14） Different Degrees of 5'-3' DAR Interactions Modulate Zika Virus Genome Cyclization and Host Specific Replication., J Virol. 2020 Feb 14;94(5)., 2020, 
（15） Different Degrees of 5'-to-3' DAR Interactions Modulate Zika Virus Genome Cyclization and Host-Specific Replication, JOURNAL OF VIROLOGY, 2020, 通讯作者
（16） A replication-defective Japanese encephalitis virus (JEV) vaccine candidate with NS1 deletion confers dual protection against JEV and West Nile virus in mice, NPJ VACCINES, 2020, 通讯作者
（17） Gemcitabine, lycorine and oxysophoridine inhibit novel coronavirus (SARS-CoV-2) in cell culture, EMERGING MICROBES & INFECTIONS, 2020, 通讯作者
（18） A nucleobase-binding pocket in a viral RNA-dependent RNA polymerase contributes to elongation complex stability, NUCLEIC ACIDS RESEARCH, 2020, 第 2 作者
（19） A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, A cell-based large-scale screening of natural compounds for inhibitors of SARS-CoV-2, SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2020, 通讯作者
（20） Short Direct Repeats in the 3′ Untranslated Region Are Involved in Subgenomic Flaviviral RNA Production, JOURNAL OF VIROLOGY, 2020, 第 7 作者
（21） Generation and characterization of Japanese encephalitis virus expressing GFP reporter gene for high throughput drug screening, ANTIVIRAL RESEARCH, 2020, 通讯作者
（22） Stringent control of the RNA-dependent RNA polymerase translocation revealed by multiple intermediate structures, NATURE COMMUNICATIONS, 2020, 第 5 作者
（23） A conformation-based intra-molecular initiation factor identified in the flavivirus RNA-dependent RNA polymerase, PLOS PATHOGENS, 2020, 第 2 作者
（24） A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles, A mouse model for SARS-CoV-2 infection by exogenous delivery of hACE2 using alphavirus replicon particles, CELL RESEARCH, 2020, 通讯作者
（25） Trans Complementation of Replication-defective Omsk Hemorrhagic Fever Virus for Antiviral Study, VIROLOGICA SINICA, 2019, 第 7 作者
（26） Infectious Chikungunya Virus (CHIKV) with a Complete Capsid Deletion: a New Approach for a CHIKV Vaccine, JOURNAL OF VIROLOGY, 2019, 第 6 作者
（27） Visualization of chikungunya virus infection in vitro and in vivo, EMERGING MICROBES & INFECTIONS, 2019, 第 8 作者
（28） Development of a replicon cell line-based high throughput antiviral assay for screening inhibitors of Zika virus, ANTIVIRAL RESEARCH, 2018, 通讯作者
（29） Human Cytomegalovirus Immediate Early 1 Protein Causes Loss of SOX2 from Neural Progenitor Cells by Trapping Unphosphorylated STAT3 in the Nucleus, JOURNAL OF VIROLOGY, 2018, 第 7 作者
（30） Recovery of the Zika virus through an in vitro ligation approach, JOURNAL OF GENERAL VIROLOGY, 2017, 通讯作者
（31） West Nile Virus NS1 Antagonizes Interferon Beta Production by Targeting RIG-I and MDA5, JOURNAL OF VIROLOGY, 2017, 第 2 作者
（32） Development of a stable japanese encephalitis virus replicon cell line for antiviral screening, ARCHIVES OF VIROLOGY, 2017, 通讯作者
（33） Generation and characterization of West Nile pseudo-infectious reporter virus for antiviral screening, ANTIVIRAL RESEARCH, 2017, 第 2 作者
（34） Visualization of a neurotropic flavivirus infection in mouse reveals unique viscerotropism controlled by host type I interferon signaling, THERANOSTICS, 2017, 第 7 作者
（35） Recovery of the Zika virus through an in vitro ligation approach, JOURNAL OF GENERAL VIROLOGY, 2017, 通讯作者
（36） Generation of a recombinant West Nile virus stably expressing the Gaussia luciferase for neutralization assay, VIRUS RESEARCH, 2016, 第 6 作者
（37） Transmembrane Domains of NS2B Contribute to both Viral RNA Replication and Particle Formation in Japanese Encephalitis Virus, JOURNAL OF VIROLOGY, 2016, 第 3 作者
（38） Later passages of neural progenitor cells from neonatal brain are more permissive for human cytomegalovirus infection (vol 87, pg 10968, 2013), JOURNAL OF VIROLOGY, 2016, 第 7 作者
（39） Development of Neutralization Assay Using an eGFP Chikungunya Virus, VIRUSES-BASEL, 2016, 第 8 作者
（40） Development and characterization of a clinical strain of Coxsackievirus A16 and an eGFP infectious clone, VIROLOGICA SINICA, 2015, 第 5 作者
（41） Genetic interaction between NS4A and NS4B for replication of Japanese encephalitis virus, JOURNAL OF GENERAL VIROLOGY, 2015, 第 2 作者
（42） MicroRNA miR-21 Attenuates Human Cytomegalovirus Replication in Neural Cells by Targeting Cdc25a, JOURNAL OF VIROLOGY, 2015, 第 9 作者
（43） Development of a stable Gaussia luciferase enterovirus 71 reporter virus, JOURNAL OF VIROLOGICAL METHODS, 2015, 第 6 作者
（44） Natural antisense transcripts of UL123 packaged in human cytomegalovirus virions, ARCHIVES OF VIROLOGY, 2014, 通讯作者
（45） Inhibition of Enterovirus 71 by Adenosine Analog NITD008, JOURNAL OF VIROLOGY, 2014, 第 3 作者
（46） Recovery of a chemically synthesized Japanese encephalitis virus reveals two critical adaptive mutations in NS2B and NS4A, JOURNAL OF GENERAL VIROLOGY, 2014, 第 3 作者
（47） Maintenance of Large Numbers of Virus Genomes in Human Cytomegalovirus-Infected T98G Glioblastoma Cells, JOURNAL OF VIROLOGY, 2014, 第 2 作者
（48） Comprehensive Analysis of Human Cytomegalovirus MicroRNA Expression during Lytic and Quiescent Infection, PLOSONE, 2014, 第 4 作者
（49） The Interface between Methyltransferase and Polymerase of NS5 Is Essential for Flavivirus Replication, PLOS NEGLECTED TROPICAL DISEASES, 2014, 第 4 作者
（50） Development and Characterization of West Nile Virus Replicon Expressing Secreted Gaussia Luciferase, Development and Characterization of West Nile Virus Replicon Expressing Secreted Gaussia Luciferase, 中国病毒学：英文版, 2013, 第 6 作者
（51） Development and Characterization of West Nile Virus Replicon Expressing Secreted Gaussia Luciferase, Development and Characterization of West Nile Virus Replicon Expressing Secreted Gaussia Luciferase, 中国病毒学：英文版, 2013, 第 6 作者
（52） Later Passages of Neural Progenitor Cells from Neonatal Brain Are More Permissive for Human Cytomegalovirus Infection, JOURNAL OF VIROLOGY, 2013, 第 7 作者
（53） A faster immunofluorescence assay for tracking infection progress of human cytomegalovirus, A faster immunofluorescence assay for tracking infection progress of human cytomegalovirus, 生物化学与生物物理学报：英文版, 2012, 第 3 作者
（54） A faster immunofluorescence assay for tracking infection progress of human cytomegalovirus, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2012, 第 3 作者
（55） Comprehensive characterization of human cytomegalovirus infection in the long-term infected t98g cell model, NEURO-ONCOLOGY, 2011, 第 1 作者
（56） Genetic analysis of West Nile virus containing a complete 3′CSI RNA deletion, VIROLOGY, 2010, 第 3 作者
（57） A safe replication-defective Zika virus vaccine protects mice from viral infection and vertical transmission, ANTIVIRAL RESEARCH, 第 6 作者

   

（ 1 ） 重要新发突发病毒宿主适应与损伤机制研究, 参与, 国家任务, 2017-07--2018-12
（ 2 ） 寨卡病毒聚合酶靶向分子设计研究, 负责人, 地方任务, 2017-01--2018-12
（ 3 ） 防治新冠病毒中药活性成分的发现及产品创制研究, 参与, 地方任务, 2022-01--2022-12