基本信息
李梅  女  博导  中国科学院生物物理研究所
email: meili@ibp.ac.cn
address: 北京朝阳区大屯路15号3201房间
postalCode:

招生信息

   
招生专业
071010-生物化学与分子生物学
071011-生物物理学
招生方向
光合作用相关(膜)蛋白的结构生物学研究

教育背景

2004-09--2007-06   中国科学院生物物理研究所   博士
1999-09--2003-03   中国科学院生物物理研究所   硕士
1991-09--1995-06   天津市南开大学   学士

工作经历

   
工作简历
2016-12~现在, 中国科学院生物物理研究所, 研究员
2007-07~现在, 中国科学院生物物理研究所, 副研究员
2004-09~2007-06,中国科学院生物物理研究所, 博士
2000-04~现在, 中国科学院生物物理研究所, 助理研究员
1999-09~2003-03,中国科学院生物物理研究所, 硕士
1995-07~现在, 中国科学院生物物理研究所, 研究实习员
1991-09~1995-06,天津市南开大学, 学士

专利与奖励

   
专利成果
( 1 ) 一组拟南芥磷酸核酮糖激酶的突变体, 2020, 第 1 作者, 专利号: CN111172130A

( 2 ) 来自赤子爱胜蚓的蚯蚓纤溶酶多种组分的制备方法, 2007, 第 3 作者, 专利号: CN1308446

出版信息

   
发表论文
(1) Structural insights into photosynthetic cyclic electron transport, MOLECULAR PLANT, 2023, 通讯作者
(2) Structural basis for the assembly and quinone transport mechanisms of the dimeric photosynthetic RC–LH1 supercomplex, Nature Communications, 2022, 通讯作者
(3) Structure of Arabidopsis SOQ1 lumenal region unveils C-terminal domain essential for negative regulation of photoprotective qH, NATURE PLANTS, 2022, 通讯作者
(4) Supramolecular assembly of chloroplast NADH dehydrogenase-like complex with photosystem I from Arabidopsis thaliana, Molecular Plant, 2022, 通讯作者
(5) 高等植物光系统复合物结构生物学研究进展, Advances in structural biology of photosystem complexes in higher plants, 自然杂志, 2021, 通讯作者
(6) Structural basis of LhcbM5-mediated state transitions in green algae, NATURE PLANTS, 2021, 通讯作者
(7) Structural insights into catalytic mechanism and product delivery of cyanobacterial acyl-acyl carrier protein reductase, NATURE COMMUNICATIONS, 2020, 通讯作者
(8) Photosynthetic Phosphoribulokinase Structures: Enzymatic Mechanisms and the Redox Regulation of the Calvin-Benson-Bassham Cycle, PLANT CELL, 2020, 通讯作者
(9) Assembly of eukaryotic photosystem II with diverse light-harvesting antennas, CURRENT OPINION IN STRUCTURAL BIOLOGY, 2020, 通讯作者
(10) Structural analysis and comparison of light-harvesting complexes I and II, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2020, 通讯作者
(11) Structural basis for electron transport mechanism of complex I-like photosynthetic NAD(P)H dehydrogenase, NATURE COMMUNICATIONS, 2020, 通讯作者
(12) Structural Insights into Substrate Selectivity, Catalytic Mechanism, and Redox Regulation of Rice Photosystem II Core Phosphatase, MOLECULAR PLANT, 2019, 第 4 作者
(13) Antenna arrangement and energy transfer pathways of a green algal photosystem-I-LHCI supercomplex, NATURE PLANTS, 2019, 通讯作者
(14) Structure of the maize photosystem I supercomplex with light-harvesting complexes I and II, SCIENCE, 2018, 通讯作者
(15) Structural roles of lipid molecules in the assembly of plant PSII2LHCII supercomplex, BIOPHYSICS REPORTS, 2018, 第 4 作者
(16) Structural roles of lipid molecules in the assembly of plant PSII-LHCII supercomplex, Structural roles of lipid molecules in the assembly of plant PSII-LHCII supercomplex, 生物物理学报:英文版, 2018, 第 4 作者
(17) A possible molecular basis for photoprotection in the minor antenna proteins of plants, BIOCHIMICAETBIOPHYSICAACTABIOENERGETICS, 2018, 第 7 作者
(18) Structure, assembly and energy transfer of plant photosystem II supercomplex, BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2018, 通讯作者
(19) Structure and assembly mechanism of plant C2S2M2-type PSII-LHCII supercomplex, SCIENCE, 2017, 通讯作者
(20) Identification of residues important for the activity of aldehyde-deformylating oxygenase through investigation into the structure-activity relationship, BMC BIOTECHNOLOGY, 2017, 第 4 作者
(21) Structure of C-terminal Domain of Peptidyl-prolyl cis-trans Isomerase from Pseudomonas syringae pv. Tomato str. DC3000 at 1.6 angstrom Resolution, PROTEIN AND PEPTIDE LETTERS, 2017, 通讯作者
(22) Crystal Structures of Putative Sugar Kinases from Synechococcus Elongatus PCC 7942 and Arabidopsis Thaliana, PLOS ONE, 2016, 通讯作者
(23) Crystal Structures of Arabidopsis thaliana Oxalyl- CoA Synthetase Essential for Oxalate Degradation, Crystal Structures of Arabidopsis thaliana Oxalyl- CoA Synthetase Essential for Oxalate Degradation, 分子植物:英文版, 2016, 第 3 作者
(24) Structure-oriented substrate specificity engineering of aldehyde-deformylating oxygenase towards aldehydes carbon chain length, BIOTECHNOLOGY FOR BIOFUELS, 2016, 第 4 作者
(25) Structure of spinach photosystem II-LHCII supercomplex at 3.2 angstrom resolution, NATURE, 2016, 通讯作者
(26) Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases, Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases, 蛋白质与细胞:英文版, 2015, 第 2 作者
(27) Structural mechanism underlying the specific recognition between the arabidopsis state-transition phosphatase tap38/pph1 and phosphorylated light-harvesting complex protein lhcb1, PLANT CELL, 2015, 第 3 作者
(28) Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases, Structural insights into the catalytic mechanism of aldehyde-deformylating oxygenases, PROTEIN CELL, 2015, 
(29) Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation, PROTEIN & CELL, 2015, 通讯作者
(30) Crystal Structure Analysis of Extrinsic PsbP Protein of Photosystem II Reveals a Manganese-Induced Conformational Change, MOLECULAR PLANT, 2015, 
(31) Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation, Structural implications of Dpy30 oligomerization for MLL/SET1 COMPASS H3K4 trimethylation, 蛋白质与细胞:英文版, 2015, 第 2 作者
(32) Crystal Structure Analysis of Extrinsic PsbP Protein of Photosystem II Reveals a Manganese- Induced Conformational Change, Crystal Structure Analysis of Extrinsic PsbP Protein of Photosystem II Reveals a Manganese- Induced Conformational Change, 分子植物:英文版, 2015, 第 3 作者
(33) Crystal structures of the PsbS protein essential for photoprotection in plants, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2015, 
(34) Crystal Structure of a Multilayer Packed Major Light-Harvesting Complex: Implications for Grana Stacking in Higher Plants, MOLECULAR PLANT, 2014, 通讯作者
(35) Structure of 2-haloacid dehalogenase from Pseudomonas syringae pv. tomato DC3000, ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2013, 通讯作者
(36) Spectroscopic Study of the Light-Harvesting CP29 Antenna Complex of Photosystem II-Part I, JOURNAL OF PHYSICAL CHEMISTRY B, 2013, 第 3 作者
(37) Structure of the catalytic domain of a state transition kinase homolog from Micromonas algae, PROTEIN & CELL, 2013, 第 3 作者
(38) Recombinant hemangiopoietin promotes cell adhesion and binds heparin in its multimeric form, MOLECULAR MEDICINE REPORTS, 2013, 第 3 作者
(39) Architecture and function of plant light-harvesting complexes II, CURRENT OPINION IN STRUCTURAL BIOLOGY, 2013, 第 3 作者
(40) 杜氏盐藻类驱动蛋白钙调素结合蛋白马达区的表达与纯化, Expression and purification of KCBP motor domain from Dunaliella salina, 郑州大学学报:医学版, 2011, 第 6 作者
(41) Structural insights into energy regulation of light-harvesting complex CP29 from spinach, NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2011, 
(42) Conformational Changes of rBTI from Buckwheat upon Binding to Trypsin: Implications for the Role of the P(8)' Residue in the Potato Inhibitor I Family, PLOS ONE, 2011, 第 3 作者
(43) Crystal structure of uroporphyrinogen III synthase from Pseudomonas syringae pv. tomato DC3000, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2011, 第 6 作者
(44) Crystal structures of SULT1A2 and SULT1A1*3: Insights into the substrate inhibition and the role of Tyr149 in SULT1A2, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 第 4 作者
(45) Crystal structure of the PSPTO-PSP protein from Pseudomonas syringae pv. tomato str. DC3000 in complex with D-glucose, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2010, 第 3 作者
(46) Crystal structures of Pseudomonas syringae pv. tomato DC3000 quinone oxidoreductase and its complex with NADPH, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2009, 第 4 作者
(47) Protein crystallization, PHOTOSYNTHESIS RESEARCH, 2009, 第 1 作者
(48) 决明子中一种新的降脂蛋白的纯化与生化特性, 中国科学:C辑, 2008, 第 2 作者
(49) Purification and characterization of a novel cholesterol-lowering protein from the seeds of Senna obtusifolia, SCIENCE IN CHINA SERIES C-LIFE SCIENCES, 2008, 第 2 作者
(50) Crystal structure studies on sulfur oxygenase reductase from Acidianus tengchongensis, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 第 1 作者
(51) 决明子中一种新的降脂蛋白的纯化与生化特性, 中国科学:C辑, 2008, 第 2 作者
(52) Purification and characterization of a novel cholesterol-lowering protein from the seeds of Senna obtusifolia, SCIENCEINCHINASERIESCLIFESCIENCES, 2008, 第 2 作者
(53) Crystal structure study on human s100a13 at 2.0 angstrom resolution, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2007, 通讯作者
(54) B链羧端去三肽(B28-B30)与去四肽(B27-B30)胰岛素的制备及去三肽胰岛素的初步晶体学研究, 自然科学进展, 1999, 第 2 作者

科研活动

   
科研项目
( 1 ) 光系统I及相关膜蛋白复合物的结构、组装及动态调控, 负责人, 国家任务, 2020-01--2024-12
( 2 ) 光合作用能量转换及动态调控的结构基础, 负责人, 中国科学院计划, 2018-08--2023-07