General

Dr. Haobo Pan

Shenzhen Institutes of Advanced Technology , Chinese Academy of Sciences

Adress:1068 Xueyuan Boulevard, University Town of Shenzhen, Xili Nanshan,Shenzhen, P.R.China,518055.Tel: (755)86585230, Fax: (755)86585222,Email:hb.pan@siat.ac.cn


Research Areas

1. Material chemistry

2. Biomaterial synthesis and modification

3. Marine biotechnology

4. Biomaterial Zoology and Clinical Assessment

Experience

2018-Now

Honorary professor of the University of Hong Kong

2013-Now
Deputy Director of Institute of Biomedicine and Technology, Shenzhen Institute of Advanced Technology, Chinese Academy of Sciences  

                                

2016- Now
Director of Technology Center of Guangdong Province Marine Biological Materials Engineering

 

2013- Now

Director of Shenzhen Key laboratory in Marine Biomaterials.   

 

2012- Now

Director and doctoral tutor of human tissue and organ degeneration research center, the Chinese Academy of Sciences, Shenzhen Advanced Technology Research Institute

 

2013- Now

Founder and Director of Shenzhen Healthemes Co. Ltd. for Biomaterials Commercialization

 

2008- Now
Guest professor of Institute of inorganic nonmetallic materials, Tongji University   

 

2003-2007

Ph.D. in Dental Biomaterials, The University of Hong Kong.

 

2001-2003

Master in Bioceramics, The University of Missouri (USA) .

 

1997-2001

BS degree from the Department of Materials Science,Shanghai University. 

Representative Publications

(1)3D Printing of Mechanically Stable Calcium-Free Alginate-Based Scaffolds with Tunable Surface Charge to Enable Cell Adhesion and Facile Biofunctionalization. Advanced Functional Materials, 2019.

(2)Fundamental Theory of Biodegradable Metals-Definition, Criteria, and Design. Advanced Functional Materials, 2019.

(3)A functionalized TiO2/Mg2TiO4 nano-layer on biodegradable magnesium implant enables superior bone-implant integration and bacterial disinfection. Biomaterials, 2019.

(4)Tuning the Surface Immunomodulatory Functions of Polyetheretherketone for Enhanced Osseointegration. Biomaterials, 2019.

(5)Enhancement and Orchestration of Osteogenesis and Angiogenesis by a Dual-modular Design of Growth Factors Delivery Scaffolds and 26SCS Decoration. Biomaterials, 2019.

(6)3D-Bioprinted Osteoblast-Laden Nanocomposite Hydrogel Constructs with Induced Microenvironments Promote Cell Viability, Differentiation, and Osteogenesis both In Vitro and In Vivo. Advanced Science, 2018

(7)Evaluation of an injectable bioactive borate glass cement to heal bone defects in a rabbit femoral condyle model. Materials Science and Engineering: C,2017

(8)Acceleration of bone regeneration by activating Wnt/beta-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis. Scientific Reports, 2017

(9)A Bone-Implant Interaction Mouse Model for Evaluating Molecular Mechanism of Biomaterials/Bone Interaction. Tissue Eng C-METHODS. 2016 

(10)Alkaline biodegradable implants for osteoporotic bone defects—importance of microenvironment pH, Osteoporosis International, 2016.

(11)Piperazine-based polyurethane-ureas with controllable degradation as potential bone scaffolds, polymer, 2014

Developed products

Series of biomedical functional products based on the comprehensive utilization of tuna shells, tuna bone and fish head waste, like Nano strontium calcium formula and high purity natural health marine food have been developed.


Host or participate in research projects and talent programs

  • Project Leader: National Natural Science Foundation of 2019: On and off effects of osteogenesis in the alkaline microenvironment: study on formation of micro-alkaline gradient on the surface of degradable bioactive materials in the dynamic environment and the osteogenesis mechanism

  • Project Leader: "Organ Reconstruction and Manufacturing" Strategic Leading Project of Chinese Academy of Sciences (Class A, 2018, Grant Number XDA16021000): Study on the mechanism of bioactive implant materials in the repair and reconstruction of large bone defect and ligament injury

  • National Technology Department Project of 2019 (Grant Number 2018YFA0703100): In vitro precise manufacturing technology and reconstruction of functional tissues and organs

  • The National Key R&D Program of 2017 China (Grant Number 2017YFC1105000)

  • Economic, Trade and information Commission of 2017 Shenzhen Municipality "innovation and industry chain": Prevention and management of hyperlipidemia (20170502171625936)

  • Project Leader: National Natural Science Foundation of 2016: Effect of microenvironment pH on stem cells and osteoclasts during osteoporotic fracture repair - based on controllable pH on the surface of materials

  • Project Leader: Setting up project of 2016 Guangdong Province Marine Biological Materials Engineering Technology Research Center 

  • Project Leader: 2016 Chinese Academy of Sciences Frontier Science Research Project: osteogenesis microenvironment research of osteoporotic bone regeneration material 

  • Sub-project Leader: 2015 Ministry of Science and Technology 863 Project: the study of Tissue Regeneration Intelligent Hydrogel Composite System and Product Development

  • Cooperation Unit Leader: Ministry of Finance and State Oceanic Administration Project 2015: Production of 200 tons of marine fish degreasing, preservation and enrichment DHA with functional lipase industrialization

  • Project Leader: Key technical research projects in Shenzhen, Guangdong Province: New technology research and development of osteoporotic vertebral fracture repair

  • Project Leader: 2014 Shenzhen Kechuang Technology Development Project: Live Cell 3D Printing Technology

  • Project Leader: 2014 Chinese Academy of Sciences Youth Promotion Talent Project

  • Project Leader: The third batch of strategic new industry in Shenzhen, China: deep-sea tuna oil product development and demonstration

  • Project Leader: 2013 Shenzhen Key Laboratory of Marine Biomedical Materials

  • Project Leader: National Natural Science Fund Project 2012: the study of Alkaline environment on osteoblast growth and its stimulating effect on osteoporotic bone regeneration, project approval number 51272274

  • Project core members: Peacock innovation team funding in Shenzhen City for bone and joint degeneration disease prevention and control of new technologies 


Developed products in the nearly three years

Series of biomedical functional products based on the comprehensive utilization of tuna shells, tuna bone and fish head waste, like Nano strontium calcium formula and high purity natural health marine food have been developed.