基本信息
赵镇文  男  博导  中国科学院化学研究所
电子邮件: zhenwenzhao@iccas.ac.cn
通信地址: 北京海淀区北一街2号
邮政编码: 100190

招生信息

   
招生专业
070302-分析化学
招生方向
脂质组学,质谱分析

教育背景

2000-08--2005-06   中国科学院化学研究所   理学博士
1996-08--2000-06   首都师范大学   理学学士

工作经历

   
工作简历
2012-03~现在, 中国科学院化学研究所, 理学博士
2006-03~2012-02,美国印第安纳大学医学院, 理学博士
2005-08~2006-03,美国克利夫兰临床医院, 理学博士
2000-08~2005-06,中国科学院化学研究所, 理学博士
1996-08~2000-06,首都师范大学, 理学学士

教授课程

前沿化学实验
质谱分析

专利与奖励

   
专利成果
( 1 ) 用于基质辅助激光解析电离质谱成像的喷雾系统和分析生物样本的方法, 2019, 第 1 作者, 专利号: 201510452507.5
( 2 ) 金属氮掺杂多孔碳材料在质谱分析中的应用, 2017, 第 1 作者, 专利号: 201710812660.3

出版信息

   
发表论文
(1) Co-Incorporated Mesoporous Carbon Material-Assisted Laser Desorption/Ionization Ion Source as an Online Interface of In Vivo Microdialysis Coupled with Mass Spectrometry, Anal Chem, 2020, 通讯作者
(2) Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro, ChenMedChem, 2020, 通讯作者
(3) Co-NC as adsorbent and matrix providing the ability of MALDI MS to analyze volatile compounds, CCL, 2020, 通讯作者
(4) Developing IR-780 as a Novel Matrix for Enhanced MALDI MS Imaging of Endogenous High-Molecular-Weight Lipids in Brain Tissues, Anal Chem, 2019, 通讯作者
(5) Polydopamine-capped AgNPs as a novel matrix overcoming the ion suppression of phosphatidylcholine for MALDI MS comprehensive imaging of glycerophospholipids and sphingolipids in impact-induced injured brain, Analyst, 2019, 通讯作者
(6) CombinationofelectrospraydepositiontechnologyofTiO2 nanoparticles andMALDIFTICRMSIforidentificationoffingerprintmorphologyand latentcomponents, Talanta, 2019, 通讯作者
(7) Organic washes of tissue sections for comprehensive analysis of small molecule metabolites by MALDI MS imaging of rat brain following status epilepticus, Metabolomics, 2018, 通讯作者
(8) Metal–organic frameworks as affinity agents to enhance the microdialysis sampling efficiency of fatty acids, Analyst, 2018, 通讯作者
(9) Photoluminescence Enhancement of Carbon Dots by Surfactants at Room Temperature, Chem. Eur. J, 2018, 通讯作者
(10) Multi-component identification and target cell-based screening of potential bioactive compounds in toad venom by UPLC coupled with high-resolution LTQ-Orbitrap MS and high-sensitivity Qtrap MS, Analytical and Bioanalytical Chemistry, 2018, 通讯作者
(11) Near-infrared fluorescent carbon dots encapsulated liposomes as multifunctional nano-carrier and tracer of the anticancer agent cinobufagin in vivo and in vitro, Colloids and Surfaces B: Biointerfaces, 2018, 通讯作者
(12) Silver Nanoparticles as Matrix for MALDI FTICR MS Profiling and Imaging of Diverse Lipids in brain, Talanta, 2018, 通讯作者
(13) Comprehensive qualification and quantification of triacylglycerols with specific fatty acid chain composition in horse adipose tissue, human plasma and liver tissue, Talanta, 2017, 通讯作者
(14) Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics, Int. J. Mol. Sci, 2017, 通讯作者
(15) MALDI MSI在脂质组学研究中的应用, 分析测试学报, 2017, 通讯作者
(16) Using Nanoliposomes To Construct a FRET-Based Ratiometric Fluorescent Probe for Sensing Intracellular pH Values, Analytical Chemistry, 2016, 通讯作者
(17) The Lipidomic Analyses in Low and Highly Aggressive Ovarian Cancer Cell Lines, Lipids, 2016, 通讯作者
(18) High resolution mass spectrometry coupled with multivariate data analysis revealing plasma lipidomic alteration in ovarian cancer in Asian women, Talanta, 2016, 通讯作者
(19) Combination of ESI and MALDI mass spectrometry for qualitative, semi-quantitative and in situ analysis of gangliosides in brain, Scientific Reports, 2016, 通讯作者
(20) A uniform 2,5-dihydroxybenzoic acid layer as a matrix for MALDI-FTICR MS-based lipidomics, Analyst, 2015, 通讯作者
(21) Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells, Journal of Chromatography A, 2015, 通讯作者
(22) 功能脂质组质谱分析, 中国科学:化学, 2014, 通讯作者
(23) Mass Spectrometry Methodology in Lipid Analysis, International Journal of Molecular Sciences, 2014, 通讯作者
(24) Polystyrene spheres-assisted matrix-assisted laser desorption ionization mass spectrometry for quantitative analysis of plasma lysophosphatidylcholines, Analytical Chemistry, 2013, 通讯作者
(25) Elevated and secreted phospholipase A(2) activities as new potential therapeutic targets in human epithelial ovarian cancer, The FASEB Journal, 2012, 第 1 作者
发表著作
Mass Spectrometry in the Analysis of Fatty Acids and Derivatives, Elservier, 2017-09, 第 5 作者
Plasma Lipidomic Alteration in Ovarian Cancer, Springer, 2017-10, 第 4 作者

科研活动

   
科研项目
( 1 ) 活体肿瘤微环境复杂组分的实时在线及组学分析方法学研究, 主持, 国家级, 2016-01--2019-12
( 2 ) 天然高分子材料及温泉矿物质萃取新技术, 主持, 院级, 2014-01--2018-12
( 3 ) 基于功能脂类组学的结直肠癌早期筛查技术研究, 参与, 省级, 2013-06--2016-05
( 4 ) 母婴样品人乳寡糖、单糖以及短链脂肪酸检测技术服务, 主持, 院级, 2018-01--2019-11
参与会议
(1)采用靶细胞提取法结合质谱筛选中药蟾酥中抗肿瘤活性成分华蟾酥毒基及其体内外载药释药和抗肿瘤活性研究   2018年中国质谱学术大会   2018-11-23
(2)The methodology and application of MALDI MSI for in situ analysis of tissue section lipids   中国心脏大会(2018)暨国际冠心病会议   2018-08-02
(3)新型金属氮掺杂多孔碳材料用于MALDI MS分析挥发性有机物   第三届全国质谱分析学术报告会   2017-12-08
(4)ABERRANT LIPID METABOLISM IN HEPATOCELLULAR CARCINOMA   第十七届北京分析测试学术报告会暨展览会   2017-10-10
(5)甘油磷脂与鞘脂质谱分析及其在癌细胞耐药中的机理研究   第十四届全国青年分析测试学术报告   2016-07-29