0703Z1-化学生物学

质谱分析、临床质谱、组学分析

2000-08--2005-06   中国科学院化学研究所   理学博士
1996-08--2000-06   首都师范大学   理学学士

   

2012-03~现在, 中国科学院化学研究所, 理学博士
2006-03~2012-02,美国印第安纳大学医学院, 理学博士
2005-08~2006-03,美国克利夫兰临床医院, 理学博士
2000-08~2005-06,中国科学院化学研究所, 理学博士
1996-08~2000-06,首都师范大学, 理学学士

质谱分析
前沿化学实验

   

（ 1 ） 1-氯-4-肼基酞嗪反应性基质在单糖MALDI MSI原位分析中的应用, 2023, 第 3 作者, 专利号: CN116660360A

（ 2 ） DHB-Zn MOF纳米材料作为基质在质谱分析检测中的应用, 2022, 第 4 作者, 专利号: CN114720550A

（ 3 ） 用于特异性检测鞘磷脂酶的比率型荧光纳米脂质体探针、试剂盒及检测方法, 2021, 第 3 作者, 专利号: CN113817457A

（ 4 ） 一种用于活体微透析质谱联用实时在线分析技术的新型接口, 2021, 第 1 作者, 专利号: CN113237981A

（ 5 ） 一种质谱分析装置, 2020, 第 4 作者, 专利号: CN210037730U

（ 6 ） 用于基质辅助激光解析电离质谱成像的喷雾系统和方法, 2019, 第 1 作者, 专利号: CN106404885B

（ 7 ） 聚多巴胺修饰的银纳米颗粒在质谱分析检测中的应用, 2019, 第 2 作者, 专利号: CN109632938A

（ 8 ） 金属-氮掺杂多孔碳材料在质谱分析检测中的应用, 2019, 第 1 作者, 专利号: CN109490404A

（ 9 ） 用于基质辅助激光解析电离质谱成像的喷雾系统和分析生物样本的方法, 2017, 第 1 作者, 专利号: CN106404885A

   

（1） Measurement of degree of hydrolysis and molecular weight distribution of protein hydrolysates by liquid chromatography-mass spectrometry, Talanta, 2023, 通讯作者
（2） Liposomes embedded with PEGylated iron oxide nanoparticles enable ferroptosis and combination therapy in cancer, Liposomes embedded with PEGylated iron oxide nanoparticles enable ferroptosis and combination therapy in cancer, NATIONAL SCIENCE REVIEW, 2023, 第 15 作者
（3） Polymer-capped gold nanoparticles as nanozymes with improved catalytic activity for the monitoring of serum ciprofloxacin, ANALYST, 2022, 第 4 作者
（4） Design and synthesis of a deep tissue penetrating near-infrared two-photon fluorescence probe for the specific detection of NQO1, CHEMICAL COMMUNICATIONS, 2022, 通讯作者
（5） CYP311A1 in the anterior midgut is involved in lipid distribution and microvillus integrity in Drosophila melanogaster, CELLULAR AND MOLECULAR LIFE SCIENCES, 2022, 第 4 作者
（6） Abplatin((IV)) inhibited tumor growth on a patient derived cancer model of hepatocellular carcinoma and its comparative multi-omics study with cisplatin, JOURNAL OF NANOBIOTECHNOLOGY, 2022, 通讯作者
（7） Real-time analysis of metabolites invivo by online extraction electrospray ionization mass spectrometry coupled to microdialysis, ANALYTICA CHIMICA ACTA, 2022, 通讯作者
（8） A dual-mode strategy combining SERS with MALDI FTICR MS based on core-shell silver nanoparticles for dye identification and semi-quantification in unearthed silks from Tang Dynasty, TALANTA, 2022, 通讯作者
（9） Open-flow microperfusion combined with mass spectrometry for in vivo liver lipidomic analysis, ANALYST, 2021, 通讯作者
（10） Deubiquitinase Ubp3 enhances the proteasomal degradation of key enzymes in sterol homeostasis, JOURNAL OF BIOLOGICAL CHEMISTRY, 2021, 第 8 作者
（11） Facile Method for Specifically Sensing Sphingomyelinase in Cells and Human Urine Based on a Ratiometric Fluorescent Nanoliposome Probe, Anal Chem, 2021, 通讯作者
（12） Distribution of perfluorooctane sulfonate in mice and its effect on liver lipidomic, TALANTA, 2021, 通讯作者
（13） Co-NC as adsorbent and matrix providing the ability of MALDI MS to analyze volatile compounds, Co-NC as adsorbent and matrix providing the ability of MALDI MS to analyze volatile compounds, CHINESE CHEMICAL LETTERS, 2021, 通讯作者
（14） 新疆尉犁县克亚克库都克烽燧遗址出土的纺织品染料的科学分析, Scientific Analysis of Textile Dyes Unearthed from Keyakekuduke Beacon Tower Site in Yuli,Xinjiang, 西部皮革, 2021, 第 9 作者
（15） Red Emissive Carbon Dots Prepared from Polymers as an Efficient Nanocarrier for Coptisine Delivery in vivo and in vitro, CHEMMEDCHEM, 2021, 通讯作者
（16） Co-Incorporated Mesoporous Carbon Material-Assisted Laser Desorption/Ionization Ion Source as an Online Interface of In Vivo Microdialysis Coupled with Mass Spectrometry, ANALYTICAL CHEMISTRY, 2020, 通讯作者
（17） Neutral Human Milk Oligosaccharides Are Associated with Multiple Fixed and Modifiable Maternal and Infant Characteristics, NUTRIENTS, 2020, 第 2 作者
（18） Lysophosphatidic acid promotes thrombus stability by inducing rapid formation of neutrophil extracellular traps: A new mechanism of thrombosis, JOURNAL OF THROMBOSIS AND HAEMOSTASIS, 2020, 第 9 作者
（19） Co-Incorporated Mesoporous Carbon Material-Assisted Laser Desorption/lonization Ion Source as an Online Interface of In Vivo Microdialysis Coupled with Mass Spectrometry, ANALYTICAL CHEMISTRY, 2020, 通讯作者
（20） Combination of electrospray deposition technology of TiO2 nanoparticles and MALDI FTICR MSI for identification of fingerprint morphology and latent components, TALANTA, 2019, 通讯作者
（21） Developing IR-780 as a Novel Matrix for Enhanced MALDI MS Imaging of Endogenous High-Molecular-Weight Lipids in Brain Tissues, ANALYTICAL CHEMISTRY, 2019, 通讯作者
（22） The Optimization and Production of Ginkgolide B Lipid Microemulsion, OPEN CHEMISTRY, 2019, 第 3 作者
（23） Gut Microbial Metabolite Trimethylamine N-Oxide Is Related to Thrombus Formation in Atrial Fibrillation Patients, AMERICAN JOURNAL OF THE MEDICAL SCIENCES, 2019, 第 5 作者
（24） Polydopamine-capped AgNPs as a novel matrix overcoming the ion suppression of phosphatidylcholine for MALDI MS comprehensive imaging of glycerophospholipids and sphingolipids in impact-induced injured brain, ANALYST, 2019, 通讯作者
（25） 阿尔茨海默症脑组织基质辅助激光解吸电离质谱成像分析研究新进展, Research Progress of Matrix Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Alzheimer’s Disease Brain, 分析化学, 2019, 第 3 作者
（26） Loss of FKBP5 Affects Neuron Synaptic Plasticity: An Electrophysiology Insight, NEUROSCIENCE, 2019, 其他（合作组作者）
（27） Comparative Study of the Chemical Constituents and Bioactivities of the Extracts from Fruits, Leaves and Root Barks of Lycium barbarum, MOLECULES, 2019, 通讯作者
（28） Strongly prolonged hydroxyl radical production for Fenton-like reactions: The golden touch of Cu, SEPARATION AND PURIFICATION TECHNOLOGY, 2019, 第 3 作者
（29） 阿尔茨海默症脑组织基质辅助激光解吸电离质谱成像分析研究新进展, Research Progress of Matrix Assisted Laser Desorption Ionization Mass Spectrometry Imaging of Alzheimer's Disease Brain, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2019, 通讯作者
（30） Near-infrared fluorescent carbon dots encapsulated liposomes as multifunctional nano-carrier and tracer of the anticancer agent cinobufagin in vivo and in vitro, COLLOIDS AND SURFACES B-BIOINTERFACES, 2019, 通讯作者
（31） Ecological Research on Flos Sophorae Dregs Fermentation for Animal Feed, EKOLOJI, 2018, 第 4 作者
（32） Multi-component identification and target cell-based screening of potential bioactive compounds in toad venom by UPLC coupled with high-resolution LTQ-Orbitrap MS and high-sensitivity Qtrap MS, ANALYTICAL AND BIOANALYTICAL CHEMISTRY, 2018, 通讯作者
（33） Metal-organic frameworks as affinity agents to enhance the microdialysis sampling efficiency of fatty acids, ANALYST, 2018, 通讯作者
（34） Organic washes of tissue sections for comprehensive analysis of small molecule metabolites by MALDI MS imaging of rat brain following status epilepticus, METABOLOMICS, 2018, 通讯作者
（35） Fabrication of polymer-modified magnetic nanoparticle based adsorbents for the capture and release of quinolones by manipulating the metal-coordination interaction, JOURNAL OF SEPARATION SCIENCE, 2018, 第 3 作者
（36） Silver nanoparticles as matrix for MALDI FTICR MS profiling and imaging of diverse lipids in brain, TALANTA, 2018, 通讯作者
（37） One-Pot Catalytic Cleavage of C = S Double Bonds by Pd Catalysts at Room Temperature, INORGANIC CHEMISTRY, 2018, 第 9 作者
（38） Photoluminescence Enhancement of Carbon Dots by Surfactants at Room Temperature, CHEMISTRY-A EUROPEAN JOURNAL, 2018, 通讯作者
（39） MALDIMSI在脂质组学研究中的应用, Application of MALDI MSI in Lipidomics Research, 分析测试学报, 2017, 第 6 作者
（40） Blocking gp130 signaling suppresses autotaxin expression in adipocytes and improves insulin sensitivity in diet-induced obesity, JOURNAL OF LIPID RESEARCH, 2017, 第 7 作者
（41） Lysophosphatidic Acid Is Associated with Atherosclerotic Plaque Instability by Regulating NF-kappa B Dependent Matrix Metalloproteinase-9 Expression via LPA(2) in Macrophages, FRONTIERS IN PHYSIOLOGY, 2017, 第 3 作者
（42） Comprehensive qualification and quantification of triacylglycerols with specific fatty acid chain composition in horse adipose tissue, human plasma and liver tissue, TALANTA, 2017, 通讯作者
（43） Aberrant Lipid Metabolism in Hepatocellular Carcinoma Revealed by Liver Lipidomics, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2017, 通讯作者
（44） The Lipidomic Analyses in Low and Highly Aggressive Ovarian Cancer Cell Lines, LIPIDS, 2016, 通讯作者
（45） The Lipidomic Analyses in Low and Highly Aggressive Ovarian Cancer Cell Lines, LIPIDS, 2016, 通讯作者
（46） High resolution mass spectrometry coupled with multivariate data analysis revealing plasma lipidomic alteration in ovarian cancer in Asian women, TALANTA, 2016, 通讯作者
（47） Strongly enhanced Fenton degradation of organic pollutants by cysteine: An aliphatic amino acid accelerator outweighs hydroquinone analogues, WATER RESEARCH, 2016, 第 2 作者
（48） Combination of ESI and MALDI mass spectrometry for qualitative, semi-quantitative and in situ analysis of gangliosides in brain, SCIENTIFIC REPORTS, 2016, 通讯作者
（49） Electrospray deposition device used to precisely control the matrix crystal to improve the performance of MALDI MSI, SCIENTIFIC REPORTS, 2016, 通讯作者
（50） Using Nanoliposomes To Construct a FRET-Based Ratiometric Fluorescent Probe for Sensing Intracellular pH Values, ANALYTICAL CHEMISTRY, 2016, 通讯作者
（51） Cavity-confined acceleration of iron cycle for the Fenton-like reaction by beta-CD-benzoquinone host-guest complex under visible irradiation, CATALYSIS COMMUNICATIONS, 2015, 第 2 作者
（52） Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease, LIPIDS IN HEALTH AND DISEASE, 2015, 第 2 作者
（53） Type I Interferons Function as Autocrine and Paracrine Factors to Induce Autotaxin in Response to TLR Activation, PLOS ONE, 2015, 第 3 作者
（54） Ultra-high-performance liquid chromatography electrospray ionization tandem mass spectrometry for accurate analysis of glycerophospholipids and sphingolipids in drug resistance tumor cells, JOURNAL OF CHROMATOGRAPHY A, 2015, 通讯作者
（55） A uniform 2,5-dihydroxybenzoic acid layer as a matrix for MALDI-FTICR MS-based lipidomics, ANALYST, 2015, 通讯作者
（56） Hypercoagulation and elevation of blood triglycerides are characteristics of Kawasaki disease, LIPIDS IN HEALTH AND DISEASE, 2015, 第 2 作者
（57） 功能脂质组谱分析, Functional lipidome analysis by mass spectrometry, 中国科学. 化学, 2014, 第 3 作者
（58） Mass Spectrometry Methodology in Lipid Analysis, INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2014, 通讯作者
（59） 转动光谱学与微波光谱技术研究进展, Recent Advances on Rotational Spectroscopy and Microwave Spectroscopic Techniques, 分析化学, 2014, 第 4 作者
（60） Recent Advances on Rotational Spectroscopy and Microwave Spectroscopic Techniques, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2014, 第 4 作者
（61） Polystyrene Spheres-Assisted Matrix-Assisted Laser Desorption Ionization Mass Spectrometry for Quantitative Analysis of Plasma Lysophosphatidylcholines, ANALYTICAL CHEMISTRY, 2013, 通讯作者
（62） Elevated and secreted phospholipase A? activities as new potential therapeutic targets in human epithelial ovarian cancer, THE FASEB JOURNAL, 2012, 第 1 作者
（63） A novel sample preparation method of matrix-assisted laser desorption/ionization time of flight mass spectrometry for polystyrene, CHINESE CHEMICAL LETTERS, 2007, 第 2 作者
（64） 有机硼化合物的质谱分析, Mass Spectrometric Analysis for Organic Boron Compounds, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2007, 第 2 作者
（65） 三苯胺偶氮化合物的MALDI-TOF质谱研究, Analysis of Triphenylamine Azo Compounds by MALDI-TOF MS, 质谱学报, 2007, 第 2 作者
（66） 有机硼化合物的质谱分析, Mass Spectrometric Analysis for Organic Boron Compounds, CHINESE JOURNAL OF ANALYTICAL CHEMISTRY, 2007, 第 2 作者
（67） Elevated and secreted phospholipase A 2 activities as new potential therapeutic targets in human epithelial ovarian cancer, THE FASEB JOURNAL, 第 2 作者

Mass Spectrometry in the Analysis of Fatty Acids and Derivatives, Elservier, 2017-09, 第 5 作者
Plasma Lipidomic Alteration in Ovarian Cancer, Springer, 2017-10, 第 4 作者

   

（ 1 ） 活体肿瘤微环境复杂组分的实时在线及组学分析方法学研究, 负责人, 国家任务, 2016-01--2019-12
（ 2 ） 天然高分子材料及温泉矿物质萃取新技术, 负责人, 境内委托项目, 2014-01--2018-12
（ 3 ） 基于功能脂类组学的结直肠癌早期筛查技术研究, 参与, 地方任务, 2013-06--2016-05
（ 4 ） 母婴样品人乳寡糖、单糖以及短链脂肪酸检测技术服务, 负责人, 境内委托项目, 2018-01--2019-11
（ 5 ） 精确定性定量及单细胞脂质组学技术开发, 负责人, 国家任务, 2019-07--2024-06
（ 6 ） 蛋白水解度、分子量分布检测方法的开发, 负责人, 境内委托项目, 2021-08--2022-12

（1）基质辅助激光解吸电离质谱成像技术MALDI-MSI 及应用进展   第十九届北京分析测试学术报告会暨展览会   2021-09-27
（2）采用靶细胞提取法结合质谱筛选中药蟾酥中抗肿瘤活性成分华蟾酥毒基及其体内外载药释药和抗肿瘤活性研究   2018年中国质谱学术大会   2018-11-23
（3）The methodology and application of MALDI MSI for in situ analysis of tissue section lipids   中国心脏大会（2018）暨国际冠心病会议   2018-08-02
（4）新型金属氮掺杂多孔碳材料用于MALDI MS分析挥发性有机物   第三届全国质谱分析学术报告会   2017-12-08
（5）ABERRANT LIPID METABOLISM IN HEPATOCELLULAR CARCINOMA   第十七届北京分析测试学术报告会暨展览会   2017-10-10
（6）甘油磷脂与鞘脂质谱分析及其在癌细胞耐药中的机理研究   第十四届全国青年分析测试学术报告   2016-07-29