基本信息
陈晔光  男  博导  广州国家实验室
电子邮件: ygchen@mail.tsinghua.edu.cn
通信地址: 广州市生物岛广州实验室C栋12楼
邮政编码:

招生信息

   
招生专业
071009-细胞生物学
招生方向
类器官,成体干细胞,信号通路

教育背景

1991-09--1996-02   美国爱因斯坦学院   博士研究生
1988-09--1990-06   美国纽约Fordham University   硕士研究生
1983-09--1986-07   江西大学   研究生硕士
1979-09--1983-07   江西大学   本科学士学位

工作经历

   
工作简历
2022-03~现在, 广州国家实验室, 研究员
2019-03~2022-02,生物岛实验室(原广州再生医学与健康广东省实验室), 中心主任、研究员
2002-07~现在, 清华大学, 教授
2000-08~2002-07,美国加州大学Riverside分校, Assistant Professor
1996-03~2000-07,美国纪念斯隆-凯特琳癌症中心, 博士后
1991-09~1996-02,美国爱因斯坦学院, 博士研究生
1988-09~1990-06,美国纽约Fordham University, 硕士研究生
1986-10~1988-08,中国科学院动物研究所, 研究助理
1983-09~1986-07,江西大学, 研究生硕士
1979-09~1983-07,江西大学, 本科学士学位

教授课程

细胞生物学
生命职业伦理和科学道德规范
肿瘤生物学专题讨论课
现代生命科学

专利与奖励

   
奖励信息
(1) 发展中国家科学院院士, , 国家级, 2020
专利成果
( 1 ) 三维培养系统在巴马猪和食蟹猴肠上皮类器官中的应用, 2022, 第 1 作者, 专利号: CN114181886A

( 2 ) 肠上皮类器官无生长因子培养方法, 2021, 第 1 作者, 专利号: CN108085296B

( 3 ) 缀合物及其在降解β-catenin蛋白中的应用, 2020, 第 1 作者, 专利号: CN111298106A

( 4 ) 二维培养系统在小鼠肠上皮干细胞体外培养中的应用, 2018, 第 1 作者, 专利号: CN108588010A

( 5 ) 培养基及其用途, 2018, 第 1 作者, 专利号: CN108085296A

( 6 ) Blebbistatin在促进干细胞存活和维持干细胞干性中的应用, 2013, 第 1 作者, 专利号: CN102940631A

( 7 ) APPOPTOSIN AND USES THEREOF FOR TREATING NEURODEGENERATIVE DISEASE AND CANCER, 2012, 第 6 作者, 专利号: US20120071629(A1)

( 8 ) Dpys12基因在制备抑制或促进早期神经发生的药物中的应用, 2009, 第 1 作者, 专利号: CN101361984A

( 9 ) 一种与TGF-β信号通路相关药物的筛选模型及其专用载体, 2008, 第 1 作者, 专利号: CN101182535A

( 10 ) 抗SARS病毒的siRNA及其应用, 2005, 第 1 作者, 专利号: CN1609117A

( 11 ) 一种抗SARS病毒的siRNA及其应用, 2005, 第 1 作者, 专利号: CN1609116A

出版信息

   
发表论文
(1) 中国细胞器互作研究的进展和趋势, 中国科学:生命科学, 2022, 第 4 作者
(2) Non-muscle myosin heavy chain 9 maintains intestinal homeostasis by preventing epithelium necroptosis and colitis adenoma formation, STEM CELL REPORTS, 2021, 通讯作者
(3) A resident stromal cell population actively restrains innate immune response in the propagation phase of colitis pathogenesis in mice, SCIENCE TRANSLATIONAL MEDICINE, 2021, 第 14 作者
(4) Recent advances in tissue stem cells, Recent advances in tissue stem cells, SCIENCE CHINA-LIFE SCIENCES, 2021, 通讯作者
(5) Single-cell transcriptome analysis reveals differential nutrient absorption functions in human intestine, JOURNAL OF EXPERIMENTAL MEDICINE, 2020, 通讯作者
(6) 前言, 中国细胞生物学学报, 2019, 第 1 作者
(7) Feedback regulation of TGF-beta signaling, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2018, 通讯作者
(8) Haploid embryonic stem cells can be enriched and maintained by simple filtration, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 第 7 作者
(9) 2D- and 3D-Based Intestinal Stem Cell Cultures for Personalized Medicine, CELLS, 2018, 通讯作者
(10) Activin/Smad2 and Wnt/beta-catenin up-regulate HAS2 and ALDH3A2 to facilitate mesendoderm differentiation of human embryonic stem cells, JOURNAL OF BIOLOGICAL CHEMISTRY, 2018, 通讯作者
(11) CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis, CXXC5 suppresses hepatocellular carcinoma by promoting TGF-β-induced cell cycle arrest and apoptosis, 分子细胞生物学报:英文版, 2018, 第 6 作者
(12) 肠上皮干细胞研究进展, Intestinal stem cells: current understanding of functions and regulation, 中国科学:生命科学, 2018, 第 2 作者
(13) Monolayer culture of intestinal epithelium sustains Lgr5(+) intestinal stem cells, CELL DISCOVERY, 2018, 通讯作者
(14) BMP signaling in homeostasis,transformation and inflammatory response of intestinal epithelium, SCIENCE CHINA-LIFE SCIENCES, 2018, 通讯作者
(15) HER2/EGFR-AKT Signaling Switches TGF beta from Inhibiting Cell Proliferation to Promoting Cell Migration in Breast Cancer, CANCER RESEARCH, 2018, 通讯作者
(16) CXXC5 suppresses hepatocellular carcinoma by promoting TGF-beta-induced cell cycle arrest and apoptosis, JOURNAL OF MOLECULAR CELL BIOLOGY, 2018, 通讯作者
(17) BMP restricts stemness of intestinal Lgr5 + stem cells by directly suppressing their signature genes, Nature Communications, 2017, 通讯作者
(18) 胚胎干细胞向中内胚层分化的调控机制, Regulation of mesendoderm differentiation of embryonic stem cells, 生命科学, 2017, 第 2 作者
(19) TGF beta induced factor homeobox 1 promotes colorectal cancer development through activating Wnt/beta-catenin signaling, ONCOTARGET, 2017, 第 5 作者
(20) Metformin inhibits ALK1-mediated angiogenesis via activation of AMPK, ONCOTARGET, 2017, 第 8 作者
(21) A novel peptide stapling strategy enables the retention of ring-closing amino acid side chains for the Wnt/beta-catenin signalling pathway, CHEMICAL SCIENCE, 2017, 通讯作者
(22) AMPK downregulates ALK2 via increasing the interaction between Smurfl and Smad6, leading to inhibition of osteogenic differentiation, BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH, 2017, 第 8 作者
(23) Smad7 enables STAT3 activation and promotes pluripotency independent of TGF-beta signaling, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2017, 第 17 作者
(24) TGF-beta Signaling from Receptors to Smads, COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY, 2016, 通讯作者
(25) Signaling Control of Differentiation of Embryonic Stem Cells toward Mesendoderm, JOURNAL OF MOLECULAR BIOLOGY, 2016, 通讯作者
(26) Smad7 Protein Interacts with Receptor-regulated Smads (R-Smads) to Inhibit Transforming Growth Factor-beta (TGF-beta/Smad Signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 2016, 第 7 作者
(27) Internalization of the TGF-beta type I receptor into caveolin-1 and EEA1 double-positive early endosomes, CELL RESEARCH, 2015, 第11作者
(28) The non-muscle-myosin-II heavy chain Myh9 mediates colitis-induced epithelium injury by restricting Lgr5+stem cells, NATURE COMMUNICATIONS, 2015, 通讯作者
(29) Internalization of the TGF-β type I receptor into caveolin-1 and EEA1 double-positive early endosomes, Cell Research, 2015, 第11作者
(30) Small C-terminal Domain Phosphatase 3 Dephosphorylates the Linker Sites of Receptor-regulated Smads (R-Smads) to Ensure Transforming Growth Factor beta (TGF beta)-mediated Germ Layer Induction in Xenopus Embryos, JOURNAL OF BIOLOGICAL CHEMISTRY, 2015, 第 9 作者
(31) Myc-interacting zinc-finger protein 1 positively regulates Wnt signalling by protecting Dishevelled from Dapper1-mediated degradation, BIOCHEMICAL JOURNAL, 2015, 通讯作者
(32) 小肠干细胞的命运调控, Regulation of Intestinal Stem Cell Fate, 中国科学. 生命科学, 2014, 第 2 作者
(33) Maternal Eomesodermin regulates zygotic nodal gene expression for mesendoderm induction in zebrafish embryos, JOURNAL OF MOLECULAR CELL BIOLOGY, 2014, 第 6 作者
(34) Visualization of the post-Golgi vesicle-mediated transportation of TGF-beta receptor II by quasi-TIRFM, JOURNAL OF BIOPHOTONICS, 2014, 第 4 作者
(35) Yin Yang 1 (YY1) synergizes with Smad7 to inhibit TGF-beta signaling in the nucleus, SCIENCE CHINA-LIFE SCIENCES, 2014, 第 7 作者
(36) Dapper1 promotes autophagy by enhancing the Beclin1-Vps34-Atg14L complex formation, CELL RESEARCH, 2014, 第 1 作者
(37) Yin Yang 1 (YY1) synergizes with Smad7 to inhibit TGF-β signaling in the nucleus, Science China. Life Sciences, 2014, 第 7 作者
(38) Enrichment of the beta-catenin-TCF complex at the S and G2 phases ensures cell survival and cell cycle progression, JOURNAL OF CELL SCIENCE, 2014, 第11作者
(39) NEDD4L regulates convergent extension movements in Xenopus embryos via Disheveled-mediated non-canonical Wnt signaling, DEVELOPMENTAL BIOLOGY, 2014, 通讯作者
(40) Structural Insights into the TRIM Family of Ubiquitin E3 Ligases, CELL RESEARCH, 2014, 第 8 作者
(41) Myotubularin-related Protein 4 (MTMR4) Attenuates BMP/Dpp Signaling by Dephosphorylation of Smad Proteins, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 第 3 作者
(42) Araf Kinase Antagonizes Nodal-Smad2 Activity in Mesendoderm Development by Directly Phosphorylating the Smad2 Linker Region, NATURE COMMUNICATIONS, 2013, 第 5 作者
(43) Functions of BMP signaling in embryonic stem cell fate determination, EXPERIMENTAL CELL RESEARCH, 2013, 通讯作者
(44) Four Amino Acids within a Tandem QxVx Repeat in a Predicted Extended alpha-Helix of the Smad-Binding Domain of Sip1 Are Necessary for Binding to Activated Smad Proteins, PLOS ONE, 2013, 第 6 作者
(45) Mediator MED15 modulates transforming growth factor beta (TGFb)/Smad signaling and breast cancer cell metastasis, Journal of Molecular Cell Biology, 2013, 第 7 作者
(46) Deacetylase Rpd3 Facilitates Checkpoint Adaptation by Preventing Rad53 Overactivation, MOLECULAR AND CELLULAR BIOLOGY, 2013, 通讯作者
(47) Design of stapled alpha-helical peptides to specifically activate Wnt/beta-catenin signaling, CELL RESEARCH, 2013, 通讯作者
(48) Disruption of the Dapper3 Gene Aggravates Ureteral Obstruction-mediated Renal Fibrosis by Amplifying Wnt/beta-catenin Signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 2013, 第 10 作者
(49) Design of stapled α-helical peptides to specifically activate Wnt/β-catenin signaling, Cell Research, 2013, 第 7 作者
(50) Mediator MED15 modulates transforming growth factor beta (TGF)/Smad signaling and breast cancer cell metastasis, JOURNAL OF MOLECULAR CELL BIOLOGY, 2013, 第 7 作者
(51) Appoptosin is a Novel Proapoptotic Protein and Mediates Cell Death in Neurodegeneration, JOURNAL OF NEUROSCIENCE, 2012, 第 15 作者
(52) PICK1 promotes caveolin-dependent degradation of TGF-beta type I receptor, CELL RESEARCH, 2012, 通讯作者
(53) BMP4 Signaling Acts via Dual-Specificity Phosphatase 9 to Control ERK Activity in Mouse Embryonic Stem Cells, CELL STEM CELL, 2012, 第 1 作者
(54) Where PI3K/Akt Meets Smads: The Crosstalk Determines Human Embryonic Stem Cell Fate, CELL STEM CELL, 2012, 通讯作者
(55) Regulation of TGF-beta receptor activity, CELL AND BIOSCIENCE, 2012, 通讯作者
(56) PICK1 promotes caveolin-dependent degradation of TGF-β type I receptor, Cell Research, 2012, 第 6 作者
(57) Identification of Novel Rare Mutations of DACT1 in Human Neural Tube Defects, HUMAN MUTATION, 2012, 第 13 作者
(58) p21-activated Kinase 2 (PAK2) Inhibits TGF-beta Signaling in Madin-Darby Canine Kidney (MDCK) Epithelial Cells by Interfering with the Receptor-Smad Interaction, JOURNAL OF BIOLOGICAL CHEMISTRY, 2012, 第 7 作者
(59) Follistatin-like 1 (Fstl1) is a bone morphogenetic protein (BMP) 4 signaling antagonist in controlling mouse lung development, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 通讯作者
(60) TSC-22 Promotes Transforming Growth Factor beta-Mediated Cardiac Myofibroblast Differentiation by Antagonizing Smad7 Activity, MOLECULAR AND CELLULAR BIOLOGY, 2011, 通讯作者
(61) Smad6 promotes neuronal differentiation in the intermediate zone of the dorsal neural tube by inhibition of the Wnt/beta-catenin pathway, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 第 8 作者
(62) Protein Kinase A-mediated 14-3-3 Association Impedes Human Dapper1 to Promote Dishevelled Degradation, JOURNAL OF BIOLOGICAL CHEMISTRY, 2011, 
(63) Smad7: not only a regulator, but also a cross-talk mediator of TGF-beta signalling, BIOCHEMICAL JOURNAL, 2011, 通讯作者
(64) Selective removal of dishevelled by autophagy A role of p62, AUTOPHAGY, 2011, 通讯作者
(65) Dishevelled: The hub of Wnt signaling, CELLULAR SIGNALLING, 2010, 通讯作者
(66) MTMR4 Attenuates Transforming Growth Factor β (TGFβ) Signaling by Dephosphorylating R-Smads in Endosomes, Journal of Biological Chemistry, 2010, 第 6 作者
(67) Regulation of embryonic stem cell self-renewal and differentiation by TGF-β family signaling, Science China. Life Sciences, 2010, 第 2 作者
(68) The Suppression of CRMP2 Expression by Bone Morphogenetic Protein (BMP)-SMAD Gradient Signaling Controls Multiple Stages of Neuronal Development*, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 第 5 作者
(69) Retinoic acid regulates bone morphogenic protein signal duration by promoting the degradation of phosphorylated Smad1, PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2010, 第 9 作者
(70) Genome-wide mapping of SMAD target genes reveals the role of BMP signaling in embryonic stem cell fate determination, GENOME RESEARCH, 2010, 第11作者
(71) Autophagy negatively regulates Wnt signalling by promoting Dishevelled degradation, NATURE CELL BIOLOGY, 2010, 通讯作者
(72) Regulation of embryonic stem cell self-renewal and differentiation by TGF-beta family signaling, SCIENCE CHINA-LIFE SCIENCES, 2010, 通讯作者
(73) Smad2 mediates Activin/Nodal signaling in mesendoderm differentiation of mouse embryonic stem cells, CELL RESEARCH, 2010, 通讯作者
(74) Monomeric type I and type III transforming growth factor-beta receptors and their dimerization revealed by single- molecule imaging, CELL RESEARCH, 2010, 第 8 作者
(75) Xenopus Skip Modulates Wnt/beta-Catenin Signaling and Functions in Neural Crest Induction, JOURNAL OF BIOLOGICAL CHEMISTRY, 2010, 第 10 作者
(76) Specific Activation of Mitogen-activated Protein Kinase by Transforming Growth Factor-beta Receptors in Lipid Rafts Is Required for Epithelial Cell Plasticity, MOLECULAR BIOLOGY OF THE CELL, 2009, 通讯作者
(77) A special issue on TGF-beta signaling, CELL RESEARCH, 2009, 通讯作者
(78) 抑制性Smad蛋白对TGF-β超家族信号转导的调控及其生理意义, Regulation of TGF-β Superfamily Signaling by Inhibitory Smads, 细胞生物学杂志, 2009, 第 3 作者
(79) A special issue TGF-β signaling, Cell Research, 2009, 第 1 作者
(80) Endocytic regulation of TGF-beta signaling, CELL RESEARCH, 2009, 通讯作者
(81) Regulation of TGF-beta signaling by Smad7, ACTA BIOCHIMICA ET BIOPHYSICA SINICA, 2009, 通讯作者
(82) Human BAMBI Cooperates with Smad7 to Inhibit Transforming Growth Factor-beta Signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 2009, 通讯作者
(83) Finale: The Last Minutes of Smads, CELL, 2009, 通讯作者
(84) MicroRNA miR-24 inhibits erythropoiesis by targeting activin type I receptor ALK4, Blood, 2008, 第 1 作者
(85) Study of interaction between Smad7 and DNA by single-molecule force spectroscopy, BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2008, 第 6 作者
(86) Severe acute respiratory syndrome-associated coronavirus nucleocapsid protein interacts with Smad3 and modulates transforming growth factor-beta signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 通讯作者
(87) The Pseudoreceptor BMP and Activin Membrane-bound Inhibitor Positively Modulates Wnt/beta-Catenin Signaling, JOURNAL OF BIOLOGICAL CHEMISTRY, 2008, 通讯作者
(88) Dapper在胚胎发育和信号调控中的作用, Progress in the research of Dapper in development and signaling pathway, 生命科学, 2007, 第 3 作者
(89) 利用功能基因组学方法研究SMAD去磷酸化—TGF-β超家族信号转导的终止机制, Termination of TGF-β Superfamily Signaling Through SMAD Dephosphorylation—A Functional Genomic View, 遗传学报, 2007, 第 2 作者
(90) 利用功能基因组学方法研究SMAD去磷酸化-TGF-β超家族信号转导的终止机制, Termination of TGF-β Superfamily Signaling Through SMAD Dephosphorylation—A Functional Genomic View, Journal of Genetics and Genomics, 2007, 第 2 作者
(91) 双杂交系统筛选与AID相互作用蛋白的初步研究, A Study of AID and Interacting Protein by Yeast Two-hybrid, 厦门大学学报:自然科学版, 2005, 第 7 作者
(92) Interaction of Stathmin-Like 2 Protein with the APP Intracellular Domain, Interaction of Stathmin-Like 2 Protein with the APP Intracellular Domain, 清华大学学报:自然科学英文版, 2005, 第 7 作者
(93) β-淀粉样前体蛋白胞内端与JKTBP2蛋白的相互作用, THE INTERACTION OF THE INTRACELLULAR DOMAIN OF β-AMYLOID PRECURSOR PROTEIN WITH JKTBP2, 实验生物学报, 2005, 第 6 作者
发表著作
( 1 ) 分子细胞生物学(第3版), MOLECULAR CELL BIOLOGY, 高等教育出版社, 2019-08, 第 1 作者

科研活动

   
科研项目
( 1 ) 卵子发生和胚胎发育的调控, 负责人, 国家任务, 2020-01--2024-12
( 2 ) HER2/EGFR信号调控TGF-β在控制细胞增殖与EMT和细胞迁移之间的功能转换及机制, 负责人, 国家任务, 2018-01--2022-12