​长期从事昆虫病毒和虫媒布尼亚病毒的感染机理研究，特别是在病毒入侵机制和抗病毒药物研究中取得了一系列创新性的研究成果。截至目前，共发表SCI研究论文60余篇。其中，第一作者和通讯作者SCI论文30余篇，包括Cell Research (1)、Small (1)、Philosophical Transactions B (1)、Journal of Virology (9)等。近期的研究重点为病毒入侵细胞的分子机制、病毒与媒介/宿主昆虫免疫系统的互作机制、病毒的致病机制和抗病毒药物。

 

重要新发病毒的感染机理、致病机制和抗病毒药物。

 

071005-微生物学

分子病毒学，生物工程技术

2002-09--2008-09   中国科学院武汉病毒研究所   博士学位
1998-09--2002-07   武汉工业学院   学士学位

研究生学历

2009年获微生物学博士学位

   

2011-09~现在, 中国科学院武汉病毒研究所, 副研究员
2008-10~2011-08,中国科学院武汉病毒研究所, 助理研究员
2007-03~2007-10,荷兰wageningen大学, 访问学者

文献阅读
《分子病毒学》第四讲
《分子病毒学》第五讲

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（1） 病毒所青年年度人物, 研究所（学校）, 2015
（2） 中国科学院卢嘉锡青年人才奖, , 院级, 2012
（3） 中国科学院优秀博士学位论文, , 院级, 2010
（4） 湖北省优秀博士学位论文, , 省级, 2010

[1] 商雨, 胡志红, 邓菲, 王曼丽, 王华林. 一种杆状病毒基因组的合成方法及其在重组杆状病毒构建中的应用. CN: CN106754896B, 2019-09-17.

[2] 王华林, 王曼丽, 干盈盈, 邓菲, 胡志红. 表达gp64基因的新型基因工程重组病毒的构建方法. 中国: CN102382803A, 2012-03-21.

[3] 王华林, 董思聪, 王曼丽, 沈姝, 邓菲, 胡志红. 用于提高杆状病毒对哺乳动物细胞转导效率的方法. 中国: CN102199629A, 2011.09.28.

   

[1] Kuang, Wenhua, Zhang, Huanyu, Cai, Yan, Zhang, Guilin, Deng, Fei, Li, Hailong, Hu, Zhihong, Guo, Yu, Wang, Manli, Zhou, Yiwu, Gong, Peng. Insights into Two-Metal-Ion Catalytic Mechanism of Cap-Snatching Endonuclease of Ebinur Lake Virus in Bunyavirales. JOURNAL OF VIROLOGY[J]. 2022, 96(6): http://dx.doi.org/10.1128/jvi.02085-21.
[2] 尹梦伊, 龚鹏, Zou, Zhen, 胡志红, 王曼丽. Dual roles and evolutionary implications of P26/poxin in antagonizing intracellular cGAS-STING and extracellular melanization immunity. Nature Communications[J]. 2022, [3] 王倩然, Zou, Zhen, 王曼丽, 胡志红. The Micrococcus luteus infection activates a novel melanization pathway of cSP10, cSP4, and cSP8 in Helicoverpa armigera. Insect Biochemistry and Molecular Biology[J]. 2022, [4] Xu, Mingyue, Wang, Bo, Deng, Fei, Wang, Hualin, Wang, Manli, Hu, Zhihong, Liu, Jia. Establishment of a Reverse Genetic System of Severe Fever with Thrombocytopenia Syndrome Virus Based on a C4 Strain. VIROLOGICA SINICA[J]. 2021, 36(5): 958-967, http://dx.doi.org/10.1007/s12250-021-00359-x.
[5] Pan, Yongbing, Du, Jianhui, Liu, Jia, Wu, Hai, Gui, Fang, Zhang, Nan, Deng, Xiaojie, Song, Gang, Li, Yufeng, Lu, Jia, Wu, Xiaoli, Zhan, ShanShan, Jing, Zhaofei, Wang, Jiong, Yang, Yimin, Liu, Jianbang, Chen, Ying, Chen, Qin, Zhang, Huanyu, Hu, Hengrui, Duan, Kai, Wang, Manli, Wang, Qisheng, Yang, Xiaoming. Screening of potent neutralizing antibodies against SARS-CoV-2 using convalescent patients-derived phage-display libraries. CELL DISCOVERY[J]. 2021, 7(1): http://dx.doi.org/10.1038/s41421-021-00295-w.
[6] Leng, Ling, Cao, Ruiyuan, Ma, Jie, Lv, Luye, Li, Wei, Zhu, Yunping, Wu, Zhihong, Wang, Manli, Zhou, Yiwu, Zhong, Wu. Pathological features of COVID-19-associated liver injury-a preliminary proteomics report based on clinical samples. SIGNAL TRANSDUCTION AND TARGETED THERAPY[J]. 2021, 6(1): 229-231, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7791959/.
[7] Liu, Jia, Li, Yufeng, Liu, Qian, Yao, Qun, Wang, Xi, Zhang, Huanyu, Chen, Rong, Ren, Liang, Min, Juan, Deng, Fei, Yan, Bing, Liu, Liang, Hu, Zhihong, Wang, Manli, Zhou, Yiwu. SARS-CoV-2 cell tropism and multiorgan infection. CELL DISCOVERYnull. 2021, 7(1): https://doaj.org/article/3715a80a1d6044f5af696ca036fe44a5.
[8] Yuan, Chuanfei, Xing, Longsheng, Wang, Manli, Hu, Zhihong, Zou, Zhen. Microbiota modulates gut immunity and promotes baculovirus infection in Helicoverpa armigera. INSECT SCIENCE[J]. 2021, 28(6): 1766-1779, http://dx.doi.org/10.1111/1744-7917.12894.
[9] Fu, Dan, Zhang, Guangshun, Wang, Yuhui, Zhang, Zheng, Hu, Hengrui, Shen, Shu, Wu, Jun, Li, Bo, Li, Xin, Fang, Yaohui, Liu, Jia, Wang, Qiao, Zhou, Yunjiao, Wang, Wei, Li, Yufeng, Lu, Zhonghua, Wang, Xiaoxiao, Nie, Cui, Tian, Yujie, Chen, Da, Wang, Yuan, Zhou, Xingdong, Wang, Qisheng, Yu, Feng, Zhang, Chen, Deng, Changjing, Zhou, Liang, Guan, Guangkuo, Shao, Na, Lou, Zhiyong, Deng, Fei, Zhang, Hongkai, Chen, Xinwen, Wang, Manli, Liu, Louis, Rao, Zihe, Guo, Yu. Structural basis for SARS-CoV-2 neutralizing antibodies with novel binding epitopes. PLOS BIOLOGY[J]. 2021, 19(5): http://dx.doi.org/10.1371/journal.pbio.3001209.
[10] Chen, Tong, Duan, Xiaoyan, Hu, Hengrui, Shang, Yu, Hu, Yangbo, Deng, Fei, Wang, Hualin, Wang, Manli, Hu, Zhihong. Systematic Analysis of 42 Autographa Californica Multiple Nucleopolyhedrovirus Genes Identifies An Additional Six Genes Involved in the Production of Infectious Budded Virus. VIROLOGICA SINICA[J]. 2021, 36(4): 762-773, http://dx.doi.org/10.1007/s12250-021-00355-1.
[11] He, Lihong, Shao, Wei, Li, Jiang, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli. Systematic analysis of nuclear localization of Autographa californica multiple nucleopolyhedrovirus proteins. JOURNAL OF GENERAL VIROLOGY[J]. 2021, 102(3): https://www.webofscience.com/wos/woscc/full-record/WOS:000635958900004.
[12] Cao, Ruiyuan, Hu, Hengrui, Li, Yufeng, Wang, Xi, Xu, Mingyue, Liu, Jia, Zhang, Huanyu, Yan, Yunzheng, Zhao, Lei, Li, Wei, Zhang, Tianhong, Xiao, Dian, Guo, Xiaojia, Li, Yuexiang, Yang, Jingjing, Hu, Zhihong, Wang, Manli, Zhong, Wu. Anti-SARS-CoV-2 Potential of Artemisinins In Vitro. ACS INFECTIOUS DISEASES[J]. 2020, 6(9): 2524-2531, http://dx.doi.org/10.1021/acsinfecdis.0c00522.
[13] Liu, Jia, Li, Yufeng, Liu, Liang, Hu, Xudong, Wang, Xi, Hu, Hengrui, Hu, Zhihong, Zhou, Yiwu, Wang, Manli. Infection of human sweat glands by SARS-CoV-2. CELL DISCOVERY. 2020, 6(1): http://dx.doi.org/10.1038/s41421-020-00229-y.
[14] Li, Yimeng, Hu, Liangbo, Chen, Tong, Chang, Meng, Deng, Fei, Hu, Zhihong, Wang, Hualin, Wang, Manli. Host AAA plus ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis. JOURNAL OF VIROLOGY[J]. 2020, 94(6): https://www.webofscience.com/wos/woscc/full-record/WOS:000518387200013.
[15] Manli Wang, Ruiyuan Cao, Leike Zhang, Xinglou Yang, Jia Liu, Mingyue Xu, Zhengli Shi, Zhihong Hu, Wu Zhong, Gengfu Xiao . Remdesivir and chloroquine effectively inhibit the recently emerged novel coronavirus (2019-nCoV) in vitro. Cell Research[J]. 2020, https://www.nature.com/articles/s41422-020-0282-0.
[16] Zhang, Huanyu, Kuang, Wenhua, Chen, Cheng, Shang, Yu, Ma, Xiaoyan, Deng, Fei, Wang, Hualin, Wang, Manli, Hu, Zhihong. Per Os Infectivity Factor 5 Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway. JOURNAL OF VIROLOGY[J]. 2020, 94(15): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7375385/.
[17] Xi Wang, Ruiyuan Cao, Huanyu Zhang, Jia Liu, Mingyue Xu, Hengrui Hu, Yufeng Li, Lei Zhao, Wei Li, Xiulian Sun, Xinglou Yang, Zhengli Shi, Fei Deng, Zhihong Hu, Wu Zhong, Manli Wang. The anti-influenza virus drug, arbidol is an efficient inhibitor of SARS-CoV-2 in vitro. CELL DISCOVERY[J]. 2020, 6(1): 1-5, http://dx.doi.org/10.1038/s41421-020-0169-8.
[18] Zhang, Leike, Liu, Jia, Cao, Ruiyuan, Xu, Mingyue, Wu, Yan, Shang, Weijuan, Wang, Xi, Zhang, Huanyu, Jiang, Xiaming, Sun, Yuan, Hu, Hengrui, Li, Yufeng, Zou, Gang, Zhang, Min, Zhao, Lei, Li, Wei, Guo, Xiaojia, Zhuang, Xiaomei, Yang, XingLou, Shi, ZhengLi, Deng, Fei, Hu, Zhihong, Xiao, Gengfu, Wang, Manli, Zhong, Wu. Comparative Antiviral Efficacy of Viral Protease Inhibitors against the Novel SARS-CoV-2In Vitro. VIROLOGICA SINICA[J]. 2020, 35(6): 776-784, http://lib.cqvip.com/Qikan/Article/Detail?id=7104025370.
[19] 胡志红. Per os Infectivity Factor 5 (PIF5) Identified as a Substrate of P33 in the Baculoviral Disulfide Bond Formation Pathway. Journal of Virology. 2020, [20] Wang, Qianran, Yin, Mengyi, Yuan, Chuanfei, Liu, Xijia, Hu, Zhihong, Zou, Zhen, Wang, Manli. Identification of a Conserved Prophenoloxidase Activation Pathway in Cotton Bollworm Helicoverpa armigera. FRONTIERS IN IMMUNOLOGY[J]. 2020, 11: https://doaj.org/article/c42b39d1faf04d7394916bff3f8cccff.
[21] Jia Liu, Ruiyuan Cao, Mingyue Xu, Xi Wang, Huanyu Zhang, Hengrui Hu, Yufeng Li, Zhihong Hu, Wu Zhong, Manli Wang. Hydroxychloroquine, a less toxic derivative of chloroquine, is effective in inhibiting SARS-CoV-2 infection in vitro. Cell Discovery[J]. 2020, https://www.nature.com/articles/s41421-020-0156-0.
[22] Liu, Xiaoping, Wang, Hanzhong, Liu, Xiaoqian, Li, Yong, Chen, Jing, Zhang, Jun, Wang, Xi, Shen, Shu, Wang, Hualin, Deng, Fei, Wang, Manli, Guan, Wuxiang, Hu, Zhihong. Genomic and transcriptional analyses of novel parvoviruses identified from dead peafowl. VIROLOGY[J]. 2020, 539: 80-91, http://dx.doi.org/10.1016/j.virol.2019.10.013.
[23] Yuan, Chuanfei, Wu, Jia, Peng, Yun, Li, Yufeng, Shen, Shu, Deng, Fei, Hu, Zhihong, Zhou, Jinlin, Wang, Manli, Zou, Zhen. Transcriptome analysis of the innate immune system of Hyalomma asiaticum. JOURNAL OF INVERTEBRATE PATHOLOGY[J]. 2020, 177: http://dx.doi.org/10.1016/j.jip.2020.107481.
[24] Yimeng Li, Liangbo Hu, Tong Chen, Meng Chang, Fei Deng, Zhihong Hu, Hualin Wang, Manli Wang, Joanna L Shisler. Host AAA+ ATPase TER94 Plays Critical Roles in Building the Baculovirus Viral Replication Factory and Virion Morphogenesis. JOURNAL OF VIROLOGY. 2020, 94(6): [25] Li, Shufen, Wang, Yun, Hou, Dianhai, Guan, Zhenqiong, Shen, Shu, Peng, Ke, Deng, Fei, Chen, Xinwen, Hu, Zhihong, Wang, Hualin, Wang, Manli. Host factor heat-shock protein 90 contributes to baculovirus budded virus morphogenesis via facilitating nuclear actin polymerization. VIROLOGY[J]. 2019, 535: 200-209, http://dx.doi.org/10.1016/j.virol.2019.07.006.
[26] Shao, Wei, He, Lihong, Chen, Qingxiu, Li, Jiang, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli. Functional Characterization of the Group I Alphabaculovirus Specific Gene ac73. VIROLOGICA SINICA[J]. 2019, 34(6): 701-711, http://lib.cqvip.com/Qikan/Article/Detail?id=7100725498.
[27] Zhang, LeiKe, Wang, Bo, Xin, Qilin, Shang, Weijuan, Shen, Shu, Xiao, Gengfu, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli. Quantitative Proteomic Analysis Reveals Unfolded-Protein Response Involved in Severe Fever with Thrombocytopenia Syndrome Virus Infection. JOURNAL OF VIROLOGY[J]. 2019, 93(10): https://www.webofscience.com/wos/woscc/full-record/WOS:000466417500011.
[28] Wang, Xi, Shang, Yu, Chen, Cheng, Liu, Shurui, Chang, Meng, Zhang, Nan, Hu, Hengrui, Zhang, Fenghua, Zhang, Tao, Wang, Zhiying, Liu, Xijia, Lin, Zhe, Deng, Fei, Wang, Hualin, Zou, Zhen, Vlak, Just M, Wang, Manli, Hu, Zhihong. Baculovirus Per Os Infectivity Factor Complex: Components and Assembly. JOURNAL OF VIROLOGY[J]. 2019, 93(6): http://www.corc.org.cn/handle/1471x/2373186.
[29] Zwart, Mark P, Ali, Ghulam, van Strien, Elisabeth A, Schijlen, Elio G W M, Wang, Manli, van der Werf, Wopke, Vlak, Just M. Identification of Loci Associated with Enhanced Virulence in Spodoptera litura Nucleopolyhedrovirus Isolates Using Deep Sequencing. VIRUSES-BASEL[J]. 2019, 11(9): https://www.webofscience.com/wos/woscc/full-record/WOS:000487962400102.
[30] Wang, Manli, Hu, Zhihong. Advances in the Molecular Biology of Baculoviruses. CURRENT ISSUES IN MOLECULAR BIOLOGYnull. 2019, 34: 183-214, https://www.webofscience.com/wos/woscc/full-record/WOS:000476463100009.
[31] Shao, Wei, He, Lihong, Deng, Fei, Wang, Hualin, Vlak, Just M, Hu, Zhihong, Wang, Manli. Mito-docking: A Novel In Vivo Method to Detect Protein-Protein Interactions. SMALL METHODS[J]. 2019, 3(10): http://dx.doi.org/10.1002/smtd.201900010.
[32] Liu, Jia, Xu, Mingyue, Tang, Bo, Hu, Liangbo, Deng, Fei, Wang, Hualin, Pang, DaiWen, Hu, Zhihong, Wang, Manli, Zhou, Yiwu. Single-Particle Tracking Reveals the Sequential Entry Process of the Bunyavirus Severe Fever with Thrombocytopenia Syndrome Virus. SMALL[J]. 2019, 15(6): http://www.corc.org.cn/handle/1471x/2373193.
[33] Hou, Dianhai, Kuang, Wenhua, Luo, Sijiani, Zhang, Fenghua, Zhou, Fengqiao, Chen, Tong, Zhang, Yanfang, Wang, Hualin, Hu, Zhihong, Deng, Fei, Wang, Manli. Baculovirus ODV-E66 degrades larval peritrophic membrane to facilitate baculovirus oral infection. VIROLOGY[J]. 2019, 537: 157-164, http://dx.doi.org/10.1016/j.virol.2019.08.027.
[34] Jiang Li, Xiaoyan Duan, Qianran Wang, Lei Zhang, Fei Deng, Hualin Wang, Zhihong Hu, Manli Wang, Jun Wang. Genome Analysis of a Novel Clade II.b Alphabaculovirus Obtained from Artaxa digramma. VIRUSES. 2019, 11(10): https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6832367/.
[35] Zhou, Fengqiao, Kuang, Wenhua, Wang, Xi, Hou, Dianhai, Huang, Huachao, Sun, Xiulian, Deng, Fei, Wang, Hualin, van Oers, Monqiue M, Wang, Manli, Hu, Zhihong. The cysteine-rich region of a baculovirus VP91 protein contributes to the morphogenesis of occlusion bodies. VIROLOGY[J]. 2019, 535: 144-153, http://dx.doi.org/10.1016/j.virol.2019.06.016.
[36] Hu, Liangbo, Li, Yimeng, Ning, YunJia, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin, Wang, Manli. The Major Hurdle for Effective Baculovirus Transduction into Mammalian Cells Is Passing Early Endosomes. JOURNAL OF VIROLOGY[J]. 2019, 93(15): [37] Wang, Manli, Hu, Zhihong. Cross-talking between baculoviruses and host insects towards a successful infection. PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES[J]. 2019, 374(1767): http://www.corc.org.cn/handle/1471x/2373183.
[38] Wang Manli. Advances in Molecular Biology of Baculoviruses.. Curr Issues Mol Biol.. 2019, [39] Hu, Liangbo, Li, Yimeng, Deng, Fei, Hui, Zhihong, Wang, Hualin, Wang, Manli. Improving Baculovirus Transduction of Mammalian Cells by Incorporation of Thogotovirus Glycoproteins. VIROLOGICA SINICA[J]. 2019, 34(4): 454-466, http://lib.cqvip.com/Qikan/Article/Detail?id=7002861679.
[40] Wang, Xi, Chen, Cheng, Zhang, Nan, Li, Jiang, Deng, Fei, Wang, Hualin, Vlak, Just M, Hu, Zhihong, Wang, Manli. The group I alphabaculovirus-specific protein, AC5, is a novel component of the occlusion body but is not associated with ODVs or the PIF complex. JOURNAL OF GENERAL VIROLOGY[J]. 2018, 99(4): 585-595, https://www.webofscience.com/wos/woscc/full-record/WOS:000431022600016.
[41] Makalliwa, George Alliwa, Wang, Xi, Zhang, Huanyu, Zhang, Nan, Chen, Cheng, Li, Jiang, Deng, Fei, Wang, Hualin, Wang, Manli, Hu, Zhihong. HearNPV Pseudotyped with PIF1, 2, and 3 from MabrNPV: Infectivity and Complex Stability. VIROLOGICA SINICA[J]. 2018, 33(2): 187-196, http://lib.cqvip.com/Qikan/Article/Detail?id=675245658.
[42] Zheng Zhu, Jun Wang, Qianran Wang, Feifei Yin, Xiaoping Liu, Dianhai Hou, Lei Zhang, Haizhou Liu, Jiang Li, Basil M. Arif, Hualin Wang, Fei Deng, Zhihong Hu, Manli Wang. Genome Characteristics of the Cyclophragma Undans Nucleopolyhedrovirus: A Distinct Species in Group I of Alphabaculovirus. 中国病毒学：英文版[J]. 2018, 33(4): 359-368, http://lib.cqvip.com/Qikan/Article/Detail?id=676433515.
[43] Wang Manli. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function.. Journal of Virology. 2018, [44] Li, Yimeng, Shen, Shu, Hu, Liangbo, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin, Wang, Manli. The Functional Oligomeric State of Tegument Protein GP41 Is Essential for Baculovirus Budded Virion and Occlusion-Derived Virion Assembly. JOURNAL OF VIROLOGY[J]. 2018, 92(12): http://202.127.146.157/handle/2RYDP1HH/5291.
[45] George Alliwa Makalliwa, Xi Wang, Huanyu Zhang, Nan Zhang, Cheng Chen, Jiang Li, Fei Deng, Hualin Wang, Manli Wang, Zhihong Hu. HearNPV Pseudotyped with PIF1,2,and 3 from MabrNPV:Infectivity and Complex Stability. 中国病毒学：英文版[J]. 2018, 33(2): 187-196, http://lib.cqvip.com/Qikan/Article/Detail?id=675245658.
[46] Rao, Guibo, Fu, Yan, Li, Na, Yin, Jiayi, Zhang, Jie, Wang, Manli, Hu, Zhihong, Cao, Sheng. Controllable Assembly of Flexible Protein Nanotubes for Loading Multifunctional Modules. ACS APPLIED MATERIALS & INTERFACES[J]. 2018, 10(30): 25135-25145, http://www.corc.org.cn/handle/1471x/2373253.
[47] Zhu, Zheng, Wang, Jun, Wang, Qianran, Yin, Feifei, Liu, Xiaoping, Hou, Dianhai, Zhang, Lei, Liu, Haizhou, Li, Jiang, Arif, Basil M, Wang, Hualin, Deng, Fei, Hu, Zhihong, Wang, Manli. Genome Characteristics of the Cyclophragma Undans Nucleopolyhedrovirus: A Distinct Species in Group I of Alphabaculovirus. VIROLOGICA SINICA[J]. 2018, 33(4): 359-368, http://lib.cqvip.com/Qikan/Article/Detail?id=676433515.
[48] Zheng Zhu, Jun Wang, Qianran Wang, Feifei Yin, Xiaoping Liu, Dianhai Hou, Lei Zhang, Haizhou Liu, Jiang Li, Basil M.Arif, Hualin Wang, Fei Deng, Zhihong Hu, Manli Wang. Genome Characteristics of the Cyclophragma Undans Nucleopolyhedrovirus: A Distinct Species in Group Ⅰ of Alphabaculovirus. 中国病毒学：英文版[J]. 2018, 359-368, http://lib.cqvip.com/Qikan/Article/Detail?id=90666888504849564852484856.
[49] Wang, Jun, Hou, Dianhai, Wang, Qianran, Kuang, Wenhua, Zhang, Lei, Li, Jiang, Shen, Shu, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli. Genome analysis of a novel Group I alphabaculovirus obtained from Oxyplax ochracea. PLOS ONE[J]. 2018, 13(2): http://www.corc.org.cn/handle/1471x/2373340.
[50] Xi Wang, Chuanfei Yuan, Mengyi Yin, Qianran Wang, Zhen Zou, Longsheng Xing, Zhihong Hu, Manli Wang. Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera. PUBLIC LIBRARY OF SCIENCE. 2017, http://oa.las.ac.cn/oainone/service/browseall/read1?ptype=JA&workid=JA201902012638497ZK.
[51] Shang, Yu, Wang, Manli, Xiao, Gengfu, Wang, Xi, Hou, Dianhai, Pan, Kai, Liu, Shurui, Li, Jiang, Wang, Jun, Arif, Basil M, Vlak, Just M, Chen, Xinwen, Wang, Hualin, Deng, Fei, Hu, Zhihong. Construction and Rescue of a Functional Synthetic Baculovirus. ACS SYNTHETIC BIOLOGY[J]. 2017, 6(7): 1393-1402, http://www.corc.org.cn/handle/1471x/2373402.
[52] 汪习, 刘晓萍, George Alliwa Makalliwa, 李江, 王华林, 胡志红, 王曼丽. 口服感染因子：杆状病毒编码的一种复杂而进化保守的入侵机器. 中国科学. 生命科学[J]. 2017, 47(9): 917-927, http://sciencechina.cn/gw.jsp?action=detail.jsp&internal_id=6092724&detailType=1.
[53] Yuan, Chuanfei, Xing, Longsheng, Wang, Manli, Wang, Xi, Yin, Mengyi, Wang, Qianran, Hu, Zhihong, Zou, Zhen. Inhibition of melanization by serpin-5 and serpin-9 promotes baculovirus infection in cotton bollworm Helicoverpa armigera. PLOS PATHOGENS[J]. 2017, 13(9): https://doaj.org/article/7108044277b54862b0219d1fc5ecb539.
[54] Wang, Manli, Shen, Shu, Wang, Hualin, Hu, Zhihong, Becnel, James, Vlak, Just M. Deltabaculoviruses encode a functional type I budded virus envelope fusion protein. JOURNAL OF GENERAL VIROLOGY[J]. 2017, 98(4): 847-852, http://www.corc.org.cn/handle/1471x/2373426.
[55] Xing, Longsheng, Yuan, Chuanfei, Wang, Manli, Lin, Zhe, Shen, Benchang, Hu, Zhihong, Zou, Zhen. Dynamics of the Interaction between Cotton Bollworm Helicoverpa armigera and Nucleopolyhedrovirus as Revealed by Integrated Transcriptomic and Proteomic Analyses. MOLECULAR & CELLULAR PROTEOMICS[J]. 2017, 16(6): 1009-1028, http://dx.doi.org/10.1074/mcp.M116.062547.
[56] Huang, GuoHua, Hou, DianHai, Wang, Manli, Cheng, XiaoWen, Hu, Zhihong. Genome analysis of Heliothis virescens ascovirus 3h isolated from China. VIROLOGICA SINICA[J]. 2017, 32(2): 147-154, http://dx.doi.org/10.1007/s12250-016-3929-8.
[57] Wu, Li, Wang, Manli, Singh, Vikramjeet, Li, Haiyan, Guo, Zhen, Gui, Shuangying, York, Peter, Xiao, Tiqiao, Yin, Xianzhen, Zhang, Jiwen. Three dimensional distribution of surfactant in microspheres revealed by synchrotron radiation X-ray microcomputed tomography. ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES[J]. 2017, 12(4): 326-334, http://lib.cqvip.com/Qikan/Article/Detail?id=65748067504849554852484850.
[58] Kuang, Wenhua, Zhang, Huanyu, Wang, Manli, Zhou, NingYi, Deng, Fei, Wang, Hualin, Gong, Peng, Hu, Zhihong. Three Conserved Regions in Baculovirus Sulfhydryl Oxidase P33 Are Critical for Enzymatic Activity and Function. JOURNAL OF VIROLOGY[J]. 2017, 91(23): http://www.corc.org.cn/handle/1471x/2373360.
[59] Wang, Xi, Liu, Xiaoping, Makalliwa, George Alliwa, Li, Jiang, Wang, Hualin, Hu, Zhihong, Wang, Manli. Per os infectivity factors: a complicated and evolutionarily conserved entry machinery of baculovirus. SCIENCE CHINA-LIFE SCIENCES[J]. 2017, 60(8): 806-815, http://www.corc.org.cn/handle/1471x/2373384.
[60] Du, Ruikun, Wang, Lili, Xu, Hao, Wang, Zhiying, Zhang, Tao, Wang, Manli, Ning, Yunjia, Deng, Fei, Hu, Zhihong, Wang, Hualin, Li, Yi. A novel glycoprotein D-specific monoclonal antibody neutralizes herpes simplex virus. ANTIVIRAL RESEARCH[J]. 2017, 147: 131-141, http://www.corc.org.cn/handle/1471x/2373306.
[61] Song, Jingjiao, Wang, Xi, Hou, Dianhai, Huang, Huachao, Liu, Xijia, Deng, Fei, Wang, Hualin, Arif, Basil M, Hu, Zhihong, Wang, Manli. The Host Specificities of Baculovirus per os Infectivity Factors. PLOS ONE[J]. 2016, 11(7): https://doaj.org/article/fbdfdc27c22d4ba190c5b31cbaee1dd7.
[62] Kuang, Wenhua, Zhang, Huanyu, Hou, Dianhai, Wang, Manli, Deng, Fei, Wang, Hualin, Hu, Zhihong. P33 of Helicoverpa armigera single nucleocapsid nucleopolyhedrovirus is a functional homolog of AcP33. VIROLOGICA SINICA[J]. 2016, 31(4): 346-349, http://www.corc.org.cn/handle/1471x/2376251.
[63] Zou, Zijiao, Liu, Jinliang, Wang, Zhiying, Deng, Fei, Wang, Hualin, Hu, Zhihong, Wang, Manli, Zhang, Tao. Characterization of two monoclonal antibodies, 38F10 and 44D11, against the major envelope fusion protein of Helicoverpa armigera nucleopolyhedrovirus. VIROLOGICA SINICA[J]. 2016, 31(6): 490-499, http://www.corc.org.cn/handle/1471x/2373474.
[64] Shen, Shu, Wang, Manli, Li, Xin, Li, Shufen, van Oers, Monique M, Vlak, Just M, Braakman, Ineke, Hu, Zhihong, Deng, Fei, Wang, Hualin. Mutational and functional analysis of N-linked glycosylation of envelope fusion protein F of Helicoverpa armigera nucleopolyhedrovirus. JOURNAL OF GENERAL VIROLOGY[J]. 2016, 97: 988-999, http://dx.doi.org/10.1099/jgv.0.000404.
[65] Liu, Jinliang, Dai, Shiyu, Wang, Manli, Hu, Zhihong, Wang, Hualin, Deng, Fei. Virus like particle-based vaccines against emerging infectious disease viruses. VIROLOGICA SINICA[J]. 2016, 31(4): 279-287, https://www.webofscience.com/wos/woscc/full-record/WOS:000382007000001.
[66] Yin, Feifei, Du, Ruikun, Kuang, Wenhua, Yang, Guang, Wang, Hualin, Deng, Fei, Hu, Zhihong, Wang, Manli. Characterization of the viral fibroblast growth factor homolog of Helicoverpa armigera single nucleopolyhedrovirus. VIROLOGICA SINICA[J]. 2016, 31(3): 240-248, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8193389/.
[67] Wang, Jun, Zhu, Zheng, Zhang, Lei, Hou, Dianhai, Wang, Manli, Arif, Basil, Kou, Zheng, Wang, Hualin, Deng, Fei, Hu, Zhihong. Genome Sequencing and Analysis of Catopsilia pomona nucleopolyhedrovirus: A Distinct Species in Group I Alphabaculovirus. PLOS ONE[J]. 2016, 11(5): http://dx.doi.org/10.1371/journal.pone.0155134.
[68] Du, Ruikun, Yin, Feifei, Wang, Manli, Hu, Zhihong, Wang, Hualin, Deng, Fei. Glycoprotein E of the Japanese encephalitis virus forms virus-like particles and induces syncytia when expressed by a baculovirus. JOURNAL OF GENERAL VIROLOGY[J]. 2015, 96: 1006-1014, https://www.webofscience.com/wos/woscc/full-record/WOS:000356995000007.
[69] Ning, YunJia, Feng, Kuan, Min, YuanQin, Cao, WuChun, Wang, Manli, Deng, Fei, Hu, Zhihong, Wang, Hualin. Disruption of Type I Interferon Signaling by the Nonstructural Protein of Severe Fever with Thrombocytopenia Syndrome Virus via the Hijacking of STAT2 and STAT1 into Inclusion Bodies. JOURNAL OF VIROLOGY[J]. 2015, 89(8): 4227-4236, https://www.webofscience.com/wos/woscc/full-record/WOS:000352218400018.
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[71] Manli Wang, Xiaolong Lu, Xianzhen Yin, YajunTong, Weiwei Peng, Li Wu, Haiyan Li, Yan Yang, Jingkai Gu, Tiqiao Xiao, .... Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres. ACTAPHARMACEUTICASINICAB[J]. 2015, 5(3): 270-276, http://dx.doi.org/10.1016/j.apsb.2015.03.008.
[72] Li, Shufen, Wang, Manli, Shen, Shu, Hu, Zhihong, Wang, Hualin, Deng, Fei. The FP25K Acts as a Negative Factor for the Infectivity of AcMNPV Budded Virus. PLOS ONE[J]. 2015, 10(5): http://www.corc.org.cn/handle/1471x/2375178.
[73] Yin, Feifei, Wu, Zeguang, Fang, Wei, Wu, Chunchen, Rayner, Simon, Han, Meifang, Deng, Fei, Du, Ruikun, Liu, Jinliang, Wang, Manli, Wang, Hualin, Ning, Qin, Hu, Zhihong. Resistant mutations and quasispecies complexity of hepatitis B virus during telbivudine treatment. JOURNAL OF GENERAL VIROLOGY[J]. 2015, 96: 3302-3312, https://www.webofscience.com/wos/woscc/full-record/WOS:000367206200013.
[74] Liao, Limin, Hou, Dianhai, Huang, Huachao, Wang, Manli, Deng, Fei, Wang, Hualin, Hu, Zhihong, Zhang, Tao. Identification of the epitopes of monoclonal antibodies against P74 of Helicoverpa armigera nucleopolyhedrovirus (vol 28, pg 360, 2013). VIROLOGICA SINICA. 2015, 30(3): 238-238, https://www.webofscience.com/wos/woscc/full-record/WOS:000357040600013.
[75] Wang, Manli, Lu, Xiaolong, Yin, Xianzhen, Tong, Yajun, Peng, Weiwei, Wu, Li, Li, Haiyan, Yang, Yan, Gu, Jingkai, Xiao, Tiqiao, Chen, Min, Zhang, Jiwen. Synchrotron radiation-based Fourier-transform infrared spectromicroscopy for characterization of the protein/peptide distribution in single microspheres. ACTA PHARMACEUTICA SINICA B[J]. 2015, 5(3): 270-276, http://dx.doi.org/10.1016/j.apsb.2015.03.008.
[76] Du, Ruikun, Wang, Manli, Hu, Zhihong, Wang, Hualin, Deng, Fei. An in vitro recombination-based reverse genetic system for rapid mutagenesis of structural genes of the Japanese encephalitis virus. VIROLOGICA SINICA[J]. 2015, 30(5): 354-362, https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8200878/.
[77] Li, Shufen, Wang, Manli, Shen, Shu, Hu, Zhihong, Wang, Hualin, Deng, Fei. The FP25K Acts as a Negative Factor for the Infectivity of AcMNPV Budded Virus. PLOS ONE[J]. 2015, 10(5): http://www.corc.org.cn/handle/1471x/2375178.
[78] Yin, Feifei, Zhu, Zheng, Liu, Xiaoping, Hou, Dianhai, Wang, Jun, Zhang, Lei, Wang, Manli, Kou, Zheng, Wang, Hualin, Deng, Fei, Hu, Zhihong. The Complete Genome of a New Betabaculovirus from Clostera anastomosis. PLOS ONE[J]. 2015, 10(7): http://dx.doi.org/10.1371/journal.pone.0132792.
[79] Yin, Feifei, Wang, Manli, Tan, Ying, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. Identification and functional analysis of inter-subunit disulfide bonds of the F protein of Helicoverpa armigera nucleopolyhedrovirus. JOURNAL OF GENERAL VIROLOGY[J]. 2014, 95: 2820-2830, https://www.webofscience.com/wos/woscc/full-record/WOS:000350943800025.
[80] 戴维·J·埃克, 宁云佳, 李淑芬, 王曼丽. 搭建流行病探测网络. 环球科学[J]. 2014, 42-47, http://lib.cqvip.com/Qikan/Article/Detail?id=50003225.
[81] Ning, YunJia, Wang, Manli, Deng, Maping, Shen, Shu, Liu, Wei, Cao, WuChun, Deng, Fei, Wang, YanYi, Hu, Zhihong, Wang, Hualin. Viral suppression of innate immunity via spatial isolation of TBK1/IKK epsilon from mitochondrial antiviral platform. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2014, 6(4): https://www.webofscience.com/wos/woscc/full-record/WOS:000339916900006.
[82] Huang, Huachao, Wang, Manli, Deng, Fei, Hou, Dianhai, Arif, Basil M, Wang, Hualin, Hu, Zhihong. The ha72 Core Gene of Baculovirus Is Essential for Budded Virus Production and Occlusion-Derived Virus Embedding, and Amino Acid K22 Plays an Important Role in Its Function. JOURNAL OF VIROLOGY[J]. 2014, 88(1): 705-709, https://www.webofscience.com/wos/woscc/full-record/WOS:000329194600064.
[83] Liu, Xiaoping, Yin, Feifei, Zhu, Zheng, Hou, Dianhai, Wang, Jun, Zhang, Lei, Wang, Manli, Wang, Hualin, Hu, Zhihong, Deng, Fei. Genomic Sequencing and Analysis of Sucra jujuba Nucleopolyhedrovirus. PLOS ONE[J]. 2014, 9(10): https://doaj.org/article/d56da51ff2d247a1b71bb31a73282f39.
[84] Yun-Jia Ning, Manli Wang, Maping Deng, Shu Shen, Wei Liu, Wu-Chun Cao, Fei Deng, Yan-Yi Wang, Zhihong Hu, Hualin Wang. Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antivirai platform. 分子细胞生物学报：英文版[J]. 2014, 324-337, http://lib.cqvip.com/Qikan/Article/Detail?id=662818400.
[85] Wang, Manli, Wang, Jue, Yin, Feifei, Tan, Ying, Deng, Fei, Chen, Xinwen, Jehle, Johannes A, Vlak, Just M, Hu, Zhihong, Wang, Hualin. Unraveling the Entry Mechanism of Baculoviruses and Its Evolutionary Implications. JOURNAL OF VIROLOGY[J]. 2014, 88(4): 2301-2311, http://dx.doi.org/10.1128/JVI.03204-13.
[86] Ning Yunjia, Wang Manli, Deng Maping, Shu Shen, Wei Liu, Cao Wuchun, Fei Deng, Wang Yanyi, Hu Zhihong, Wang Hualin. Viral suppression of innate immunity via spatial isolation of TBK1/IKKε from mitochondrial antiviral platform. JOURNAL OF MOLECULAR CELL BIOLOGY[J]. 2014, 6(4): 324-337,  https://explore.openaire.eu/search/publication?articleId=od_______267::5e91f3dc5958c3d82b8b79f04162209d.
[87] Wang Manli, Hu Zhihong. Bats as Animal Reservoirs for the SARS Coronavirus: Hypothesis Proved After 10 Years of Virus Hunting. 中国病毒学：英文版[J]. 2013, 315-317, http://lib.cqvip.com/Qikan/Article/Detail?id=48282114.
[88] Manli Wang, Zhihong Hu. Bats as Animal Reservoirs for the SARS Coronavirus: Hypothesis Proved After 10 Years of Virus Hunting. 中国病毒学：英文版[J]. 2013, 315-317, http://lib.cqvip.com/Qikan/Article/Detail?id=48282114.
[89] Liao Limin, Hou Dianhai, Huang Huachao, Wang Manli, Deng Fei, Wang Hualin, Hu Zhihong, Zhang Tao. Identification of the Epitopes of Monoclonal Antibodies against P74 of Helicoverpa armigera Nucleopolyhedrovirus. 中国病毒学：英文版[J]. 2013, 360-367, http://lib.cqvip.com/Qikan/Article/Detail?id=48282120.
[90] Yin, Feifei, Wang, Manli, Tan, Ying, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. Betabaculovirus F proteins showed different efficiencies when rescuing the infectivity of gp64-null Autographa californica nucleopolyhedrovirus. VIROLOGY[J]. 2013, 436(1): 59-66, http://dx.doi.org/10.1016/j.virol.2012.10.017.
[91] Song, Jingjiao, Wang, Manli, Huang, Huachao, Luo, Xin, Deng, Fei, Wang, Hualin, Hu, Zhihong. Functional studies of per os infectivity factor 3 of Helicoverpa armigera nucleopolyhedrovirus. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 93: 374-382, [92] Shen, Shu, Gan, Yinyin, Wang, Manli, Hu, Zhihong, Wang, Hualin, Deng, Fei. Incorporation of GP64 into Helicoverpa armigera nucleopolyhedrovirus enhances virus infectivity in vivo and in vitro. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 93: 2705-2711, https://www.webofscience.com/wos/woscc/full-record/WOS:000313027500020.
[93] Song, Jingjiao, Wang, Manli, Huang, Huachao, Luo, Xin, Deng, Fei, Wang, Hualin, Hu, Zhihong. Functional studies of per os infectivity factor 3 of Helicoverpa armigera nucleopolyhedrovirus. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 93: 374-382, https://www.webofscience.com/wos/woscc/full-record/WOS:000300139500017.
[94] Shen, Shu, Gan, Yinyin, Wang, Manli, Hu, Zhihong, Wang, Hualin, Deng, Fei. Incorporation of GP64 into Helicoverpa armigera nucleopolyhedrovirus enhances virus infectivity in vivo and in vitro. JOURNAL OF GENERAL VIROLOGY[J]. 2012, 93: 2705-2711, https://www.webofscience.com/wos/woscc/full-record/WOS:000313027500020.
[95] Huang, Huachao, Wang, Manli, Deng, Fei, Wang, Hualin, Hu, Zhihong. ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex. VIROLOGY[J]. 2012, 427(2): 217-223, http://dx.doi.org/10.1016/j.virol.2012.01.022.
[96] Huachao Huang, Manli Wang, Fei Deng, Hualin Wang, Zhihong Hu. ORF85 of HearNPV encodes the per os infectivity factor 4 (PIF4) and is essential for the formation of the PIF complex. VIROLOGY[J]. 2012, 427(2): 217-223, http://dx.doi.org/10.1016/j.virol.2012.01.022.
[97] Wang Manli, Deng Fei, Li Tianxian, Hu Zhihong, Wang Hualin, Zhou Zhaorui. Production of CCHF Virus-Like Particle by a Baculovirus-Insect Cell Expression System. VIROLOGICA SINICA[J]. 2011, 26(5): 338-346,  http://www.wanfangdata.com.cn/details/detail.do?_type=perio&id=zgbdx201105006.
[98] Dong, Sicong, Wang, Manli, Qiu, Zhijuan, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. Autographa californica Multicapsid Nucleopolyhedrovirus Efficiently Infects Sf9 Cells and Transduces Mammalian Cells via Direct Fusion with the Plasma Membrane at Low pH. JOURNAL OF VIROLOGY[J]. 2010, 84(10): 5351-5359, http://www.corc.org.cn/handle/1471x/2375694.
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[102] Wang, Manli, Tan, Ying, Yin, Feifei, Deng, Fei, Vlak, Just M, Hu, Zhihong, Wang, Hualin. The F-like protein Ac23 enhances the infectivity of the budded virus of gp64-null Autographa californica multinucleocapsid nucleopolyhedrovirus pseudotyped with baculovirus envelope fusion protein F. JOURNAL OF VIROLOGY[J]. 2008, 82(19): 9800-9804, http://www.corc.org.cn/handle/1471x/2375446.
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《Insect Molecular Virology》Caister Academic Press；2019.01；参编第九章

   

（ 1 ） 杆状病毒口服感染分子机制的研究, 参与, 国家级, 2012-01--2016-12
（ 2 ） 重要病毒转录复制蛋白复合体的结构功能研究, 主持, 国家级, 2013-01--2017-12
（ 3 ） 宿主细胞因子Integrin在杆状病毒入侵哺乳动物细胞中的功能及其作, 主持, 国家级, 2014-01--2017-12
（ 4 ） 中科院青年创新促进会, 主持, 国家级, 2013-01--2016-12
（ 5 ） 关键宿主因子Hsp90介导的昆虫细胞actin核内聚合在杆状病毒BV形成中的作用机制, 主持, 国家级, 2016-01--2019-12
（ 6 ） 杆状病毒感染昆虫中肠的作用机理研究, 参与, 部委级, 2016-08--2020-12
（ 7 ） P4实验室高端用户培育计划, 主持, 部委级, 2018-08--2019-12
（ 8 ） 2019-nCoV药物筛选与评价研究, 参与, 国家级, 2020-01--2020-12
（ 9 ） 定向项目, 参与, 国家级, 2019-01--2023-12

（1）Functional Rescue of an F-null HearNPV by two Naturally Non-functional Envelope Proteins Disclose the Evolutionary Track of Baculoviridae   第29届美国病毒学会年会   Manli Wang, Feifei Yin, Ying Tan, Fei Deng, Just M Vlak2, Johannes A. Jehle, Zhihong Hu and Hualin Wang   2010-07-17
（2）The F-like protein of group I NPVs enhances the production and infectivity of the budded virus of gp64-null AcMNPV pseudotyped with the envelope fusion protein F of group II NPVs   第41届国际无脊椎动物病理学年会   Manli Wang, Ying Tan, Feifei Yin, Fei Deng, Zhihong Hu, Just M Vlak and Hualin Wang   2008-08-03

已指导学生

邹梓姣  硕士研究生  085238-生物工程  

张楠  硕士研究生  071005-微生物学  

李忆梦  博士研究生  071005-微生物学  

袁传飞  博士研究生  100102-免疫学  

王博  博士研究生  100103-病原生物学  

邵伟  博士研究生  071005-微生物学  

胡亮波  博士研究生  071005-微生物学  

汪习  博士研究生  071005-微生物学  

陈诚  硕士研究生  071005-微生物学  

现指导学生

李玉凤  硕士研究生  085238-生物工程  

马小燕  硕士研究生  071005-微生物学